LOCUS       NM_003427               2653 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 76 (ZNF76), transcript variant 1,
            mRNA.
ACCESSION   NM_003427
VERSION     NM_003427.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2653)
  AUTHORS   Ali Assar,M.F., Abd El Gayed,E.M., Abd El-Hamid Ewis,A.S.,
            Zaid,A.B. and Abd Allah Mahmoud Fouda,E.
  TITLE     Biochemical study of ZNF76 rs10947540 and SCUBE3 rs1888822 single
            nucleotide polymorphisms in the Egyptian patients with systemic
            lupus Erythematosus
  JOURNAL   J Immunoassay Immunochem 45 (5), 415-431 (2024)
   PUBMED   38982741
  REMARK    GeneRIF: Biochemical study of ZNF76 rs10947540 and SCUBE3 rs1888822
            single nucleotide polymorphisms in the Egyptian patients with
            systemic lupus Erythematosus.
REFERENCE   2  (bases 1 to 2653)
  AUTHORS   Hua,T., Wang,R.M., Zhang,X.C., Zhao,B.B., Fan,S.B., Liu,D.X. and
            Wang,W.
  TITLE     ZNF76 predicts prognosis and response to platinum chemotherapy in
            human ovarian cancer
  JOURNAL   Biosci Rep 41 (12) (2021)
   PUBMED   34793589
  REMARK    GeneRIF: ZNF76 predicts prognosis and response to platinum
            chemotherapy in human ovarian cancer.
REFERENCE   3  (bases 1 to 2653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2653)
  AUTHORS   Qi,Y.Y., Cui,Y., Lang,H., Zhai,Y.L., Zhang,X.X., Wang,X.Y.,
            Liu,X.R., Zhao,Y.F., Ning,X.H. and Zhao,Z.Z.
  TITLE     The ZNF76 rs10947540 polymorphism associated with systemic lupus
            erythematosus risk in Chinese populations
  JOURNAL   Sci Rep 11 (1), 5186 (2021)
   PUBMED   33664275
  REMARK    GeneRIF: The ZNF76 rs10947540 polymorphism associated with systemic
            lupus erythematosus risk in Chinese populations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2653)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2653)
  AUTHORS   Zheng,G. and Yang,Y.C.
  TITLE     ZNF76, a novel transcriptional repressor targeting TATA-binding
            protein, is modulated by sumoylation
  JOURNAL   J Biol Chem 279 (41), 42410-42421 (2004)
   PUBMED   15280358
  REMARK    GeneRIF: ZNF76 functions as a transcriptional repressor through its
            interaction with TBP and sumoylation modulates its transcriptional
            repression activity
REFERENCE   7  (bases 1 to 2653)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 2653)
  AUTHORS   Kubota,H., Yokota,S., Yanagi,H. and Yura,T.
  TITLE     Transcriptional regulation of the mouse cytosolic chaperonin
            subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA
            gene transcription activating factor family zinc finger proteins
  JOURNAL   J Biol Chem 275 (37), 28641-28648 (2000)
   PUBMED   10893243
REFERENCE   9  (bases 1 to 2653)
  AUTHORS   Myslinski,E., Krol,A. and Carbon,P.
  TITLE     ZNF76 and ZNF143 are two human homologs of the transcriptional
            activator Staf
  JOURNAL   J Biol Chem 273 (34), 21998-22006 (1998)
   PUBMED   9705341
REFERENCE   10 (bases 1 to 2653)
  AUTHORS   Ragoussis,J., Senger,G., Mockridge,I., Sanseau,P., Ruddy,S.,
            Dudley,K., Sheer,D. and Trowsdale,J.
  TITLE     A testis-expressed Zn finger gene (ZNF76) in human 6p21.3
            centromeric to the MHC is closely linked to the human homolog of
            the t-complex gene tcp-11
  JOURNAL   Genomics 14 (3), 673-679 (1992)
   PUBMED   1427894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC299240.1, BC002549.2, Z97832.11 and BE962441.2.
            
            On Nov 23, 2018 this sequence version replaced NM_003427.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.204925.1, BC000133.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373953.8/ ENSP00000363064.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               DC299240.1         22-573
            553-1306            BC002549.2         555-1308
            1307-1307           Z97832.11          83834-83834
            1308-1333           BC002549.2         1310-1335
            1334-1334           Z97832.11          83861-83861
            1335-2445           BC002549.2         1337-2447
            2446-2446           Z97832.11          86886-86886
            2447-2567           BC002549.2         2449-2569
            2568-2568           Z97832.11          87008-87008
            2569-2651           BC002549.2         2571-2653
            2652-2653           BE962441.2         17-18               c
FEATURES             Location/Qualifiers
     source          1..2653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..2653
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /note="zinc finger protein 76"
                     /db_xref="GeneID:7629"
                     /db_xref="HGNC:HGNC:13149"
                     /db_xref="MIM:194549"
     exon            1..107
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            108..276
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1916
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 76 (expressed in testis); zinc finger
                     protein 523"
                     /codon_start=1
                     /product="zinc finger protein 76 isoform 1"
                     /protein_id="NP_003418.2"
                     /db_xref="CCDS:CCDS4801.1"
                     /db_xref="GeneID:7629"
                     /db_xref="HGNC:HGNC:13149"
                     /db_xref="MIM:194549"
                     /translation="MESLGLHTVTLSDGTTAYVQQAVKGEKLLEGQVIQLEDGTTAYI
                     HQVTVQKEALSFEDGQPVQLEDGSMAYIHRTPREGYDPSTLEAVQLEDGSTAYIHHPV
                     AVPSESTILAVQTEVGLEDLAAEDDEGFSADAVVALEQYASKVLHDSQIPRNGKGQQV
                     GDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRT
                     HTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHV
                     RTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYK
                     HHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASA
                     AEESPPPKRPRIAYLSEVKEERDDIPAQVAMVTEEDGAPQVALITQDGAQQVSLSPED
                     LQALGSAISMVTQHGSTTLTIPSPDADLATSGTHTVTMVSADGTQTQPVTIITSGAVV
                     AEDSSVASLRHQQVALLATANGTHIAVQLEEQQTLEEAINVATAAMQQGAVTLETTVS
                     ESGC"
     exon            277..357
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            358..435
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            436..635
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            636..752
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            753..828
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            829..954
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1134
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1368
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1532
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1697
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1811
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2653
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2633..2638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /note="hexamer: AATAAA"
     polyA_site      2653
                     /gene="ZNF76"
                     /gene_synonym="D6S229E; Zfp523; ZNF523"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcgggc gggcgggcta tggcgcaggc gggttgtggg gccggcgctg gtggcggggc
       61 ccggtgcatg gcggtctgtc ggcggagtcg ccctcggggg ctgtcagatt tgtgacccag
      121 aaggaaatct ctgacctcag ctgtggctct tggtgctggc cagaagccaa cttcatgtct
      181 gagtgcacga gcagcagttt gccatggaga gcttggggct gcacacggtg acccttagtg
      241 atgggacaac agcctacgtc cagcaagctg tcaaaggaga gaagcttctt gaagggcagg
      301 tgatccagct cgaggatggg accaccgcat acattcacca ggtgacggta cagaaagaag
      361 ctctctcctt tgaggatggt cagcctgtgc agctggaaga tggcagcatg gcttacatac
      421 accgcacacc cagagaaggc tatgacccca gcaccctgga agccgtccaa ctggaagatg
      481 gctccactgc ctacattcac caccctgtgg ctgtgccatc ggagagcacc atcctggccg
      541 tacagacaga ggtgggcttg gaggacctgg cagcagagga tgatgagggc ttcagtgcag
      601 acgcagtggt ggccctggag cagtatgcca gcaaggttct tcatgacagc cagattcccc
      661 gtaatggaaa agggcagcaa gttggagaca gagcattccg ctgtggctac aagggctgtg
      721 ggcgtctcta caccaccgct catcacttaa aggtgcatga acgagctcat acaggtgacc
      781 gtccatacag atgtgacttc cccagctgtg gaaaggcctt tgccacaggc tatggactga
      841 agagccacgt tcgtacccac actggtgaga aaccatacaa gtgcccagag gagctgtgca
      901 gcaaggcctt caagacctca ggagacctgc agaagcatgt ccgtacccac actggtgaac
      961 gcccgttcca gtgccctttt gagggctgtg gccgctcctt caccacatct aacatccgca
     1021 aggtacatgt gcgcacccac acaggcgaga ggccctacac ctgcccggag ccccactgtg
     1081 gccgcggctt caccagcgcc accaactata agaatcacgt gcgcatccac acaggggaga
     1141 agccatacgt ttgcacggtg ccaggctgcg ggaaacgctt caccgagtac tcgagcttgt
     1201 ataagcacca cgtggtgcac acacactgca agccctacac ctgcagcacc tgcggcaaga
     1261 cctaccggca gacctccacc ttggccatgc acaagcgcag tgcccacggc gagctggagg
     1321 ccacggagga gagcgagcag gccctctatg agcagcagca acttgaggcc gcctctgcag
     1381 ccgaggagag tccgccaccc aaacgacccc ggatagctta cctttcggag gtgaaggaag
     1441 agagagatga catcccagcc caggtggcga tggtgactga agaagatggg gccccccagg
     1501 tggctctgat cactcaggat ggtgcccagc aggtcagcct gtccccggaa gacctgcagg
     1561 ccctggggag tgccatcagt atggtcaccc agcacggcag caccaccctc accatcccca
     1621 gtcctgatgc cgacctggcc acatctggca cacatacagt caccatggtc agcgccgatg
     1681 gcacccagac gcagcccgtc acaatcatta cctctggggc tgtggtggct gaggactcaa
     1741 gtgtagcatc tcttcgtcat caacaggtgg cactgttggc cacagccaac ggaacgcaca
     1801 ttgcagtgca gctggaggaa cagcagacct tagaggaggc catcaatgtg gccactgcgg
     1861 ccatgcagca aggggctgtg accctggaga caacagtgtc ggagagtggc tgctgagtcc
     1921 aagagggctg ggtcccacac catgctggag gaagtgccat ctgcatggcc actcttgccc
     1981 ccaagggccc aggctgtggc tgacacatag aaggtggcca cataggtctc tggggtgaga
     2041 agacagcaag aaaactgcct aactgaaggg aatgggggcc ctgctcaaga agggggccag
     2101 gcagctggaa tcaggggagt gcatcatcct cgggagctga caacagccag gctacaccag
     2161 ggcacccgcc tctcaaaatc agctgggcgc ccactctcct cctaaagaac acccttctgg
     2221 ccctcagtct gttccccttc tcaggtagag attggggctg ctatggggac tggccctgta
     2281 gggttgagcc acagacagct cttcagccca gtagcagtgg agcaggccct gtcctgccct
     2341 cccagcaata accacctccc tggaggccag ctgagatgcc tggctacttg gcaccaggga
     2401 cttcctgaca ccacagtcaa ttaattcctc aggggcctgt ggctgaagaa aaggtgccca
     2461 gcccccacca ctcctcagct gccccccaac ctctctatgg cagagaggca gggagtggcc
     2521 ctgtacatag actgctgggg attgggtttg atttgttttg ttttttttaa ttccattttg
     2581 ataatttttt tcctgctctg ggtggtggtg gcacatggat gaatgagtat ttaataaaag
     2641 ttccaaattt cca
//
