LOCUS       NM_007131               5611 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 75D (ZNF75D), transcript variant
            1, mRNA.
ACCESSION   NM_007131
VERSION     NM_007131.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5611)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 5611)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
REFERENCE   3  (bases 1 to 5611)
  AUTHORS   Villa,A., Strina,D., Frattini,A., Faranda,S., Macchi,P.,
            Finelli,P., Bozzi,F., Susani,L., Archidiacono,N., Rocchi,M. and
            Vezzoni,P.
  TITLE     The ZNF75 zinc finger gene subfamily: isolation and mapping of the
            four members in humans and great apes
  JOURNAL   Genomics 35 (2), 312-320 (1996)
   PUBMED   8661144
REFERENCE   4  (bases 1 to 5611)
  AUTHORS   Villa,A., Zucchi,I., Pilia,G., Strina,D., Susani,L., Morali,F.,
            Patrosso,C., Frattini,A., Lucchini,F., Repetto,M. et al.
  TITLE     ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene
            subfamily mapped in YACs 1 Mb telomeric of HPRT
  JOURNAL   Genomics 18 (2), 223-229 (1993)
   PUBMED   8288223
REFERENCE   5  (bases 1 to 5611)
  AUTHORS   Villa,A., Patrosso,C., Biunno,I., Frattini,A., Repetto,M.,
            Mostardini,M., Evans,G., Susani,L., Strina,D., Redolfi,E. et al.
  TITLE     Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26
  JOURNAL   Genomics 13 (4), 1231-1236 (1992)
   PUBMED   1505955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450472.14, BC029787.1,
            AL831984.2 and AL832801.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007131.4.
            
            Summary: This gene encodes a protein that likely functions as a
            transcription factor. The protein, which belongs to the ZNF75
            family, includes an N-terminal SCAN domain, a KRAB box, and five
            C2H2-type zinc finger motifs. Another functional gene belonging to
            this family is located on chromosome 16, while pseudogenes have
            been identified on chromosomes 11 and 12. Alternative splicing
            results in multiple transcripts variants. [provided by RefSeq, Jun
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831984.2, SRR1803614.11032.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370766.8/ ENSP00000359802.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL450472.14        3541-3562           c
            23-77               BC029787.1         1-55
            78-886              AL831984.2         1-809
            887-916             AL450472.14        2647-2676           c
            917-3956            AL831984.2         840-3879
            3957-5611           AL832801.1         1422-3076
FEATURES             Location/Qualifiers
     source          1..5611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..5611
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /note="zinc finger protein 75D"
                     /db_xref="GeneID:7626"
                     /db_xref="HGNC:HGNC:13145"
                     /db_xref="MIM:314997"
     exon            1..2342
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2614
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..3143
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /inference="alignment:Splign:2.1.0"
     CDS             2733..4265
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 82; zinc finger protein 75"
                     /codon_start=1
                     /product="zinc finger protein 75D isoform 1"
                     /protein_id="NP_009062.2"
                     /db_xref="CCDS:CCDS14648.1"
                     /db_xref="GeneID:7626"
                     /db_xref="HGNC:HGNC:13145"
                     /db_xref="MIM:314997"
                     /translation="MAMRELNADSCSSPQMGAMWETSGSVKENSSQSKKYSTKIENLG
                     PESACRHFWSFRYHEATGPLETISQLQKLCHQWLRPEIHSKEQILEMLVLEQFLSILP
                     KETQNWVQKHHPQNVKQALVLVEFLQREPDGTKNEVTAHELGKEAVLLGGTAVAPGFK
                     WKPAEPQPMGVFQKEYWNTYRVLQEQLGWNTHKETQPVYERAVHDQQMLALSEQKRIK
                     HWKMASKLILPESLSLLTFEDVAVYFSEEEWQLLNPLEKTLYNDVMQDIYETVISLGL
                     KLKNDTGNDHPISVSTSEIQTSGCEVSKKTRMKIAQKTMGRENPGDTHSVQKWHRAFP
                     RKKRKKPATCKQELPKLMDLHGKGPTGEKPFKCQECGKSFRVSSDLIKHHRIHTGEKP
                     YKCQQCDRRFRWSSDLNKHFMTHQGIKPYRCSWCGKSFSHNTNLHTHQRIHTGEKPFK
                     CDECGKRFIQNSHLIKHQRTHTGEQPYTCSLCKRNFSRRSSLLRHQKLHRRREACLVS
                     PN"
     exon            3144..3336
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3428
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3555
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..5611
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5589..5594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /note="hexamer: AACAAA"
     polyA_site      5611
                     /gene="ZNF75D"
                     /gene_synonym="D8C6; ZKSCAN24; ZNF75; ZNF82; ZSCAN28"
                     /note="major polyA site"
ORIGIN      
        1 agacctgatc caatggccgc ttgatacaat ggtgtcgttc gggaaacgca gccctaacgt
       61 tggtcctaag ctgacaaatt ggtctgtgga cgccaaactt ccgtgctagg actttctgcg
      121 tgtggaccgg gggcctagtc ctgcgtgggt ccaacacaga caggagaaag ctgcctgctt
      181 ttgtgcctcc cggaggtcct ggtagaagcg aaacggggac aggagctgca gcgtcccaag
      241 cccagtgagg cgaagctact ggagacagct ctgccgggtc caaagttggg ctcaccggct
      301 ggaacttgaa accggagcac gccggactcc tgctgaagcc atcatctctc tctcctggcc
      361 ccgggcgcct tggccggcgg gcacaactgg tttcggggcc aaggtggtct ggaagcctga
      421 ctgtggcgtc tggcctgggc tcccgcgagc ggaaaaggtt cccctcctgt gagagggaaa
      481 ctatggaagt tcctacgccc ggagccagaa ctcctgctgc tcccgcccga cccaaggtct
      541 agcttggcgg cctcccacct gtgcttctga gggttctgct tccaagaggc tgctggtgcc
      601 cgggacacca gcagtttcgc catgggtgtt tcgccatggg agtttcgcca tgggtgactt
      661 tggcctgaga tgcgctccat ggagcagatt ctggagttgc tggtgttgga ggagttcctg
      721 actatcctgt cccaggacat ccacagcagg gtgcagaagc tgcaacgggc gagctgtgaa
      781 gaagctgtaa ctcttttaaa gtatatgtat gacttttaaa agagagagct tgtgaaactg
      841 agggaatagg tgagtgagag agaggtttta tctgccatct tcctcaagga ggcccagcct
      901 cccctttatt catagggttc tgggtctggt gggtccagag gactgagaca tctcgctgtc
      961 ttaattcccc attcagattt tcttgattgc cctgagtaga ccttacacgg gccagtgatt
     1021 ttttgttgtt gttgttgttg ttgtcttctc tggaaccttc atcctccaga tttcccccca
     1081 gtgcagtgaa gagtgtgcta ttgcttttgg tttccacggg gaggcagtgt cgctgtcata
     1141 gtgtccgctc tggaggtaga tcaaaggggg ctttcaactc ctggctctgc tccctactag
     1201 ctgtgcgact ttgggcaagt gacttttgct tggctgggct tcactttctg cactggtcaa
     1261 atgcagaaag ggtaatagac ccttctgggg ttgtttggag gattaaaggg agagcagtat
     1321 gtccgtaata atcgcactgc tggcacacag ctagtgcttg aaactgtgag ctgctgttag
     1381 gttaggggca gcagtctggt ctcctctgca gagatgggtc tcagttaatt gtgaacttaa
     1441 acagtttggc actgaggctt tggggtcatt gccccagggc cacccaagta agcttgtcta
     1501 attgagagga acaggagcag ctggagaatg tgggggagga accgaagacc tatgggggac
     1561 atgtgtgtac tgaaatgggc tttctcccca caccctccac acaagcacat acacacattc
     1621 actctgggtc atggcatcat aaaaaccttg agtttaaacc atccctttct cttgttgggt
     1681 ccaaatggac agactctggt tttctattga agatttacac gcagattcct gtcataattt
     1741 ttcttttcta tcgagccctg tcatgatgat aagtgatagc aggttggttc ctagatcata
     1801 caccatggac ctagcacaga agtgttttca gaagagcctt ttccttacaa aacagcatga
     1861 aagtcattga gccaatggat actgagattt caaactggag ccaatggata cttagaggag
     1921 ccctgaagtg tagagtagtt gctacttctt gttcactagg tctaattagc atgtcatcag
     1981 tgtaacagac tagtgtgttg tcttgtgaaa gagaaaggtg ataagatccc tgtgaactaa
     2041 actatgatgt agggcttgaa aattgatata caatacgcct gaggtaggat ggcgaaggtg
     2101 tattcctggt cttaccagct gaaagtaaat tgcttctggt ggtctttact aacagttatt
     2161 gagaaaaaaa gcattttcaa ggtcaagagg tacatactag gttccagggg atatgttaat
     2221 ttgctcaaga aatgaaacca catctggaac agcagctgca attggagtca tcacctggct
     2281 tagtttacaa tgacccacta ccatcttcca agatccatct gccttctgca taggccaaac
     2341 aggtccacag aactcgaccc tggaagagag agtcggggtc aggtcttcgg gaggtggagg
     2401 gatcgaatga gggaactgat attccaagac tccccacatc ttggagcttc actcgccagg
     2461 catcccgcgc tttcctgacg tcgcttcccc tagtggtgca gcagcggaga gctttgctac
     2521 ccagagcagc agggaggcgt ggccacagag gcagaggcgt agtcgagccg aggaagagga
     2581 aagtggcctc cggggaagcc agagctgact gaagtgctct tgggaagaac aattcattga
     2641 tttggtacca acctgatgca ccctgatttg tcaaaggtgg taccaggtgg gtgtcagtgt
     2701 cacatacaag agtaaaactg ttcctagagc aaatggcgat gagagagctg aacgcggatt
     2761 catgctcaag cccccagatg ggggctatgt gggagactag tgggtctgtg aaagagaact
     2821 ccagtcagag taagaaatac agcacaaaaa tagagaatct tggtcctgag agcgcttgca
     2881 ggcacttctg gagcttccgt tatcatgaag caaccggacc gcttgagact atcagccaac
     2941 ttcagaaatt gtgccatcag tggctgaggc cagagatcca ctcaaaagag cagatcttgg
     3001 aaatgctggt gttagagcag ttcctgagca ttctgcccaa ggagacccag aactgggtgc
     3061 agaagcatca tccacagaat gtcaaacagg ctctggtcct ggtggaattc ttgcagaggg
     3121 agcctgatgg aacaaagaat gaggtcacag cccatgagct gggaaaggag gcagtgctct
     3181 tgggaggaac agcagtggcc ccaggcttca agtggaagcc agcagagccc caaccaatgg
     3241 gtgtgttcca gaaagaatat tggaatacat accgggtact acaagaacag ctgggctgga
     3301 acactcacaa agaaacccag cctgtatatg aaagagctgt gcatgatcaa cagatgttag
     3361 ccctttctga gcagaaaaga atcaaacact ggaagatggc atctaaactc atcctgcctg
     3421 agtccctgag tttgttgaca tttgaagatg tggctgtgta tttttctgag gaagagtggc
     3481 aattattgaa tcctcttgag aagactctct acaatgatgt aatgcaggat atctatgaga
     3541 ctgtcatctc tctagggtta aagctaaaaa atgacactgg aaatgatcat cctatatctg
     3601 tttctacatc agaaatacaa acatcaggat gcgaagtatc aaaaaagacc agaatgaaaa
     3661 ttgcccagaa aacaatgggc agggaaaatc ctggtgatac acacagtgta cagaaatggc
     3721 atcgagcttt tccaaggaag aaaagaaaga aacctgcaac ttgtaaacaa gagcttccaa
     3781 aacttatgga tcttcatggg aaaggcccca caggggagaa accttttaag tgtcaggaat
     3841 gtgggaaaag cttcagagtt agctctgatc ttattaaaca ccacagaatt cacactggag
     3901 agaaacccta taaatgtcaa caatgtgaca ggaggtttag atggagttca gatcttaata
     3961 agcacttcat gacccatcaa ggaataaaac catatagatg ctcatggtgt gggaaaagct
     4021 ttagtcataa cacaaatcta cacacacacc aaagaattca cacaggagag aagcccttta
     4081 aatgtgatga atgtggaaaa agattcattc agaactccca ccttattaaa caccagagaa
     4141 ctcacacagg tgagcagcct tatacgtgta gcttatgcaa gagaaacttt agtaggcgat
     4201 cgagccttct tagacaccag aaactccaca gaagaaggga agcatgtcta gtgtctccaa
     4261 actgaggaaa gttaccatgt agagcttgac tttagaagtg gtgaaagaat acaaaattat
     4321 gaggcaccca atgataggaa tctgtgatta ataaaacatt tgggaagggt acatgttaca
     4381 cttcacaaaa aggaatctaa gctgtctgtt ttattcagca ttgcatcttc tgtgcctagc
     4441 acaagagttg atacataagg agtactttat aaataaaaaa atgaaagtgt agtgatgaga
     4501 ttcctttagc tatctatcta tatgtatata tctggttatt caaagcttcc ccacccccag
     4561 tcatctaaat ttttcaggta tcaagtgctc aacagacata tgatagtcaa ggctcttagt
     4621 ctcatttttt actctttgtc aagagaaatg gaaaataaga gtacttgggc cctcttaagg
     4681 gagctcagag agaattacta aattagggac agtttcaata gttatcattc tgtctacatg
     4741 aacaatcaag accaggactc agggaacttt actctgtaac agaaagagag gattcagtgt
     4801 ttgccctggg agaattgtcc cattcttgtt gcttctctcc tgagtaccca ctaccacaat
     4861 gtcttctgtc aaggaattac aagtagcaag ggaaggtctg aatgtaagga caggcctagg
     4921 gaccttgcaa gcacttgata tctctcctct tgctgacttt gtcaacatag acatatagtg
     4981 aaatgatgag ggaggcagtc ttggccctca tccaggtatc tggttttttt ttgtagaaag
     5041 cacagataag tggtaaatgg tctttttctg actttcatta tgtggactgg atggaggctt
     5101 tcaaactggt gccatactgc tgcaggacct aaagggagcc ccatctttat ggctgatcaa
     5161 ctacaaccct atatgcctga atactctgca agaaggcctg gagattttgc aaaactgatt
     5221 tattgagaat ggcaaggaga gccttgtgaa cttttagctt tggtgcacag ctgataccag
     5281 gagggaacat cctgaagtgt cagagaaaag taaggcatat ggctcacagt gatgatgcca
     5341 gtcagagcca ggccagatgg aaattgtttt ctgatgttac tggttttctt ttccctatta
     5401 gccaaagtga ctatctctta agagaagata atgtgacgtc aagggaagtt ggaaggcatg
     5461 gatttatatc tatgtcagat cctggtttat aatgttggcc aaggcttatt tatatatgtt
     5521 tatttagtat tccataaaat tgtacttcgt aatgaaaatg acacatttta tcttaaattt
     5581 agacaataaa caaaactttg ttaccaaatc a
//
