LOCUS       NM_001302109            2859 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 75A (ZNF75A), transcript variant
            1, mRNA.
ACCESSION   NM_001302109
VERSION     NM_001302109.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Villa,A., Strina,D., Frattini,A., Faranda,S., Macchi,P.,
            Finelli,P., Bozzi,F., Susani,L., Archidiacono,N., Rocchi,M. and
            Vezzoni,P.
  TITLE     The ZNF75 zinc finger gene subfamily: isolation and mapping of the
            four members in humans and great apes
  JOURNAL   Genomics 35 (2), 312-320 (1996)
   PUBMED   8661144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB249528.1, BX324672.2, AC004232.1, AC025283.6, BC119652.1 and
            CR749782.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001302109.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. There are no full-length rat transcripts
            supporting this RefSeq. The exon combination used for the
            transcript record were based on alignment to full-length transcript
            JU478269.1 (from Macaca mulatta) and partial human transcripts
            BX324672.2 and BC119652.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1422099.1,
                                           SRR1660805.48950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000669516.2/ ENSP00000499415.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DB249528.1         92-113
            23-340              BX324672.2         10-327
            341-367             AC004232.1         37376-37402
            368-715             BX324672.2         355-702
            716-814             AC025283.6         9366-9464
            815-945             BX324672.2         802-932
            946-1933            BC119652.1         238-1225
            1934-2584           CR749782.1         1324-1974
            2585-2859           AC025283.6         16146-16420
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2859
                     /gene="ZNF75A"
                     /note="zinc finger protein 75A"
                     /db_xref="GeneID:7627"
                     /db_xref="HGNC:HGNC:13146"
                     /db_xref="MIM:601473"
     exon            1..147
                     /gene="ZNF75A"
                     /inference="alignment:Splign:2.1.0"
     exon            148..671
                     /gene="ZNF75A"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1877
                     /gene="ZNF75A"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 75A isoform 1"
                     /protein_id="NP_001289038.1"
                     /db_xref="CCDS:CCDS92095.1"
                     /db_xref="GeneID:7627"
                     /db_xref="HGNC:HGNC:13146"
                     /db_xref="MIM:601473"
                     /translation="MMMVDLKVAAYLDPQIRALWETKGPARESSGQSKKSPQMDCLDP
                     KSSCWHFRNFTYDEAGGPREAVSKLQELCHLWLKPEIHSKEQILELLVLEQFLTILPR
                     ETQTQMQKHHPQSIEEAVALVEHLQRESGQTWNGVAVHELGKEAVLLGETAEASSFGL
                     KPTESQPVGVSQDEEFWNTYEGLQEQLSRNTHKETEPVYERAVPTQQILAFPEQTNTK
                     DWTVTPEHVLPESQSLLTFEEVAMYFSQEEWELLDPTQKALYNDVMQENYETVISLAL
                     FVLPKPKVISCLEQGEEPWVQVSPEFKDSAGKSPTGLKLKNDTENHQPVSLSDLEIQA
                     SAGVISKKAKVKVPQKTAGKENHFDMHRVGKWHQDFPVKKRKKLSTWKQELLKLMDRH
                     KKDCAREKPFKCQECGKTFRVSSDLIKHQRIHTEEKPYKCQQCDKRFRWSSDLNKHLT
                     THQGIKPYKCSWCGKSFSQNTNLHTHQRTHTGEKPFTCHECGKKFSQNSHLIKHRRTH
                     TGEQPYTCSICRRNFSRRSSLLRHQKLHL"
     exon            672..867
                     /gene="ZNF75A"
                     /inference="alignment:Splign:2.1.0"
     exon            868..959
                     /gene="ZNF75A"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1086
                     /gene="ZNF75A"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1197
                     /gene="ZNF75A"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..2859
                     /gene="ZNF75A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2566..2571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF75A"
                     /note="hexamer: AAGAAA"
     polyA_site      2584
                     /gene="ZNF75A"
                     /note="major polyA site"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF75A"
                     /note="hexamer: AATAAA"
     polyA_site      2859
                     /gene="ZNF75A"
ORIGIN      
        1 gctctggctc tgtacctgga cagggctgcg gtaggccagc ggtgggctgg cggttgcgct
       61 cctcagatcg gcggcctttc gggcggtggc ttgcgtttga gcctcagaaa gcgaggagcg
      121 gcctccacgg aagccaagct ggccgagtgc ttttaggaag aagatccttt tattgctttt
      181 gtacaagacc agacaggatc tcatttgtta aacgtggtac caattgggtg tcttaacaca
      241 ggagcagaac ttcctagagc agaatgatga tggtagatct gaaagtggct gcgtacttgg
      301 accctcagat cagggctttg tgggagacca aggggcctgc aagagagagc tccggtcaga
      361 gtaaaaaatc tcctcaaatg gactgtctcg atcctaagag ctcttgctgg cacttccgga
      421 atttcaccta tgatgaagca ggtggacccc gtgaggctgt cagcaaactt caagaattat
      481 gtcatctatg gctgaagcca gagatccact caaaagagca gatactggaa ctgctggtgc
      541 tggagcagtt cctgactatt ctgcccaggg agacacagac ccagatgcag aagcaccatc
      601 cacagagcat tgaggaggct gtggctctgg tagaacactt gcagagggaa tctggtcaaa
      661 catggaatgg ggttgcagtc catgagctgg gaaaggaggc agtgctcttg ggagaaacag
      721 cagaggcctc aagtttcggg ctgaagccaa cagagtccca accagtgggc gtatcccaag
      781 atgaagaatt ttggaataca tacgagggtc tgcaagaaca gctcagcagg aatactcata
      841 aagagactga gcctgtgtat gagagggctg tgcctactca acagattcta gcttttcctg
      901 agcaaacaaa caccaaagac tggacagtga cacctgagca cgtcttgcct gagtcccaga
      961 gcttgttgac atttgaagaa gtggccatgt atttttccca ggaagaatgg gagttattgg
     1021 atcccactca gaaggccctc tacaatgatg taatgcagga aaactatgag actgtcatct
     1081 ctctagcatt gtttgtgctc cccaaaccta aagtgatctc ctgtctagag caaggggaag
     1141 agccatgggt tcaagtatcc ccggagttta aggatagtgc cggaaaatct cctacagggt
     1201 taaagctcaa aaacgacact gaaaatcatc agcctgtgtc tctttctgac ttagaaatac
     1261 aagcatcagc aggcgtcata tcaaaaaagg ccaaagtaaa agttccccag aaaacagcag
     1321 gcaaagaaaa tcattttgat atgcacagag tgggaaaatg gcaccaagat tttccagtga
     1381 agaaaagaaa gaaactttca acctggaaac aagagctgct caaacttatg gatcgtcaca
     1441 agaaagattg tgcaagagag aagcctttta aatgtcagga atgtgggaaa accttcagag
     1501 ttagctctga ccttattaag caccaaagaa ttcacactga agagaaaccc tataaatgtc
     1561 aacagtgtga taagaggttt agatggagtt cagatcttaa taagcactta acaacacacc
     1621 aaggaataaa accatataaa tgttcatggt gtgggaaaag cttcagtcaa aatacaaatt
     1681 tacatacaca ccaaagaact catacaggag aaaagccctt cacatgtcat gaatgtggaa
     1741 aaaaattcag tcagaactcc caccttatta aacaccggag aacccacaca ggtgagcagc
     1801 catatacttg tagcatatgc aggagaaact tcagcaggcg gtcaagcctt cttagacacc
     1861 agaaactcca cctgtgaaga gaagcttgtc cagtgtcctc attctgaaga cattcaccaa
     1921 atggagcttg gcactaaaat ttatgtaaaa gaaaaatcac aaaccttgaa aaattttaca
     1981 tcagaaaatg ggataaacat acatttcaca gaaaataatc aagacttgct ctgcagccac
     2041 tcagtagtct tctgtggtca cagaagtaaa cattgttggc tttgtattga tctctccagt
     2101 catttttgaa cacatccaat agaaacattg gcagcatggt cttccaaaac aaaaagcagt
     2161 aacatgcatg tttaattgca taccattctc ttcacagtag caggcttacc aatttccata
     2221 gtctcatgag gccgaaatga attacaatgt aaagtgttcc aggaaccaaa ttggattttc
     2281 tttcttttgt cattggacac ggtttgcaaa gttggacatc acttgagttc cttcttaaac
     2341 ttttcggcaa cttctcttgg atcctgttat cacagttttt tactgtgatg aaatcttgtt
     2401 aaccaccact agggaatctc cagatgaact attaatgcac tgtcttatgc ctctcattgg
     2461 tgatgtttgg aaaatagaag acatctctaa tggaatcatg ggggaaacgg gttggaattt
     2521 gtagccatgg aatatatatt agatgtaaag aattttctgc aataaaagaa actagacttg
     2581 ttaatccctg ccttgcaatg tcagtaggat aaagcagcta taaaaattag tacttgccca
     2641 aggcctgaaa gagaattagt gggaattaag atcaacttct cagttttgtt tgtttacttt
     2701 ttaattggct tttctttgtt gttaagaatg agagacttaa tttccatggg agttggagtg
     2761 tgtgtgctgc aggcaggatc ctgtggctca tttggcatgg agacctggac atgtagtcag
     2821 caggagacgg ttccctaaat aaaagatttg ggcactggt
//
