LOCUS       NM_024702               3158 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 750 (ZNF750), mRNA.
ACCESSION   NM_024702
VERSION     NM_024702.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3158)
  AUTHORS   Liu,Y., Chen,Y., Batzorig,U., Li,J., Fernandez-Mendez,C.,
            Mahapatra,S., Li,F., Sam,S., Dokoshi,T., Hong,S.P., Nakatsuji,T.,
            Gallo,R.L. and Sen,G.L.
  TITLE     The transcription regulators ZNF750 and LSD1/KDM1A dampen
            inflammation on the skin's surface by silencing pattern recognition
            receptors
  JOURNAL   Immunity 57 (10), 2296-2309 (2024)
   PUBMED   39353440
  REMARK    GeneRIF: The transcription regulators ZNF750 and LSD1/KDM1A dampen
            inflammation on the skin's surface by silencing pattern recognition
            receptors.
REFERENCE   2  (bases 1 to 3158)
  AUTHORS   Hu,X.T., Wu,X.F., Sui,L.M., Ao,L.Q., Pu,C.X., Yuan,M., Xing,W. and
            Xu,X.
  TITLE     The GRHL3-regulated long non-coding RNA lnc-DC modulates
            keratinocytes differentiation by interacting with IGF2BP2 and
            up-regulating ZNF750
  JOURNAL   J Dermatol Sci 113 (3), 93-102 (2024)
   PUBMED   38383230
  REMARK    GeneRIF: The GRHL3-regulated long non-coding RNA lnc-DC modulates
            keratinocytes differentiation by interacting with IGF2BP2 and
            up-regulating ZNF750.
REFERENCE   3  (bases 1 to 3158)
  AUTHORS   Rua,A.J., Whitehead,R.D. 3rd and Alexandrescu,A.T.
  TITLE     NMR structure verifies the eponymous zinc finger domain of
            transcription factor ZNF750
  JOURNAL   J Struct Biol X 8, 100093 (2023)
   PUBMED   37655311
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3158)
  AUTHORS   Montanaro,M., Agostini,M., Anemona,L., Bonanno,E., Servadei,F.,
            Finazzi Agro,E., Asimakopoulos,A.D., Ganini,C., Cipriani,C.,
            Signoretti,M., Bove,P., Rugolo,F., Imperiali,B., Melino,G.,
            Mauriello,A. and Scimeca,M.
  TITLE     ZNF750: A Novel Prognostic Biomarker in Metastatic Prostate Cancer
  JOURNAL   Int J Mol Sci 24 (7), 6519 (2023)
   PUBMED   37047491
  REMARK    GeneRIF: ZNF750: A Novel Prognostic Biomarker in Metastatic
            Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3158)
  AUTHORS   Xia,L., Lin,H., Zhou,Y. and Lian,J.
  TITLE     ZNF750 facilitates carcinogenesis via promoting the expression of
            long non-coding RNA CYTOR and influences pharmacotherapy response
            in colon adenocarcinoma
  JOURNAL   J Zhejiang Univ Sci B 23 (7), 587-596 (2022)
   PUBMED   35794688
  REMARK    GeneRIF: ZNF750 facilitates carcinogenesis via promoting the
            expression of long non-coding RNA CYTOR and influences
            pharmacotherapy response in colon adenocarcinoma.
REFERENCE   6  (bases 1 to 3158)
  AUTHORS   Sen,G.L., Boxer,L.D., Webster,D.E., Bussat,R.T., Qu,K.,
            Zarnegar,B.J., Johnston,D., Siprashvili,Z. and Khavari,P.A.
  TITLE     ZNF750 is a p63 target gene that induces KLF4 to drive terminal
            epidermal differentiation
  JOURNAL   Dev Cell 22 (3), 669-677 (2012)
   PUBMED   22364861
  REMARK    GeneRIF: ZNF750 directly links a tissue-specifying factor, p63, to
            an effector of terminal differentiation, KLF4.
REFERENCE   7  (bases 1 to 3158)
  AUTHORS   Cohen,I., Birnbaum,R.Y., Leibson,K., Taube,R., Sivan,S. and
            Birk,O.S.
  TITLE     ZNF750 is expressed in differentiated keratinocytes and regulates
            epidermal late differentiation genes
  JOURNAL   PLoS One 7 (8), e42628 (2012)
   PUBMED   22936986
  REMARK    GeneRIF: ZNF750 was specifically expressed in the epidermal
            suprabasal layers and its expression was augmented during
            differentiation, both in human skin and in-vitro, peaking in the
            granular layer.
REFERENCE   8  (bases 1 to 3158)
  AUTHORS   Birnbaum,R.Y., Hayashi,G., Cohen,I., Poon,A., Chen,H., Lam,E.T.,
            Kwok,P.Y., Birk,O.S. and Liao,W.
  TITLE     Association analysis identifies ZNF750 regulatory variants in
            psoriasis
  JOURNAL   BMC Med Genet 12, 167 (2011)
   PUBMED   22185198
  REMARK    GeneRIF: Two haplotypes of ZNF750 and rare 5' regulatory variants
            of ZNF750 were found to be associated with psoriasis.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3158)
  AUTHORS   Yang,C.F., Hwu,W.L., Yang,L.C., Chung,W.H., Chien,Y.H., Hung,C.F.,
            Chen,H.C., Tsai,P.J., Fann,C.S., Liao,F. and Chen,Y.T.
  TITLE     A promoter sequence variant of ZNF750 is linked with familial
            psoriasis
  JOURNAL   J Invest Dermatol 128 (7), 1662-1668 (2008)
   PUBMED   18256691
  REMARK    GeneRIF: ZNF750 mutations could contribute to psoriasis
            susceptibility.
REFERENCE   10 (bases 1 to 3158)
  AUTHORS   Birnbaum,R.Y., Zvulunov,A., Hallel-Halevy,D., Cagnano,E., Finer,G.,
            Ofir,R., Geiger,D., Silberstein,E., Feferman,Y. and Birk,O.S.
  TITLE     Seborrhea-like dermatitis with psoriasiform elements caused by a
            mutation in ZNF750, encoding a putative C2H2 zinc finger protein
  JOURNAL   Nat Genet 38 (7), 749-751 (2006)
   PUBMED   16751772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA433713.1, BC109037.1,
            DA872185.1, CO245511.1, AK023903.1 and AI539029.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024702.2.
            
            Summary: This gene encodes a protein with a nuclear localization
            site and a C2H2 zinc finger domain. Mutations in this gene have
            been associated with seborrhea-like dermatitis with psoriasiform
            elements. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023903.1, BC109037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269394.4/ ENSP00000269394.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DA433713.1         557-564
            9-166               BC109037.1         1-158
            167-221             DA872185.1         167-221
            222-1975            BC109037.1         214-1967
            1976-2095           CO245511.1         8-127               c
            2096-3064           BC109037.1         2088-3056
            3065-3157           AK023903.1         3067-3159
            3158-3158           AI539029.1         28-28               c
FEATURES             Location/Qualifiers
     source          1..3158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3158
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="zinc finger protein 750"
                     /db_xref="GeneID:79755"
                     /db_xref="HGNC:HGNC:25843"
                     /db_xref="MIM:610226"
     exon            1..96
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /inference="alignment:Splign:2.1.0"
     exon            97..1714
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2450
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="protein ZNF750"
                     /codon_start=1
                     /product="zinc finger protein 750"
                     /protein_id="NP_078978.2"
                     /db_xref="CCDS:CCDS11819.1"
                     /db_xref="GeneID:79755"
                     /db_xref="HGNC:HGNC:25843"
                     /db_xref="MIM:610226"
                     /translation="MSLLKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHLFNHM
                     KYGLCKNSITLVSEQDRVPKCPKSNSLDPKQTNQPDATAKPASSKSVANGLSAFDSKL
                     QHSSAREDIKENLELQARGTHRCLGQKPALHRASPCKSPAPEAALGAQPALEGAARPS
                     AFVPVGEHRLKGPDNAEAPETLALHNPTAKAVSFHTKSAFHTPGYPWKAGSPFLPPEF
                     PHKISSTKGLGAISPYMHPTIPEYPPHFYTEHGLATIYSPYLLAGSSPECDAPLLSVY
                     GTQDPRHFLPHPGPIPKHLAPSPATYDHYRFFQQYPSNLPIPYGFYRPESAFSSYGLR
                     LPPVTGLTRDQSSHLLEEATLVYPASSPSRLNPSDPNRKHVEFESPIPEAKDSSKAGQ
                     RDTEGSKMSPRAGSAATGSPGRPSPTDFMQTSQTCEGLYDLSNKAASSALGRLYPPEQ
                     SLTAFRPVKKSTECLPAQAAETTAESPVSLNVVNGDPPAPTGSASLVSEAAPSSPDDS
                     SGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQDLPLNLSVKDPCNTQAPRP
                     AFPGRPRAAEPAAAVPQKTGTEGSEDGPSHPETKPGSLDGDGAPPTGPGEEAPDACAV
                     DSSEEQKQTAAVALCQLAAYSPRNIRVGDGDAAAPEPACRQDTPTLSSMESQEAQCDL
                     RPKGQKRTSLRDAGKSQQGAKKAKLQDTARVFTLRRRARVS"
     exon            1715..3158
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2867..2872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="hexamer: ATTAAA"
     polyA_site      2895
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="major polyA site"
     regulatory      3093..3098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="hexamer: AATAAA"
     polyA_site      3126
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="major polyA site"
     regulatory      3137..3142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="hexamer: CATAAA"
     polyA_site      3158
                     /gene="ZNF750"
                     /gene_synonym="SLDPE; ZFP750"
                     /note="major polyA site"
ORIGIN      
        1 agtttcaccc agcaagcgtg agaacaggta ctgcttcctg agcaccgcca gccaccggca
       61 ccaagaccgg ccacatccca gcactgccca cctctgctcc cagccgccag atgacggagg
      121 ctctcgccag accctcagca cgcagagctg gcttctgata gaagtgatcg ggaaagaaag
      181 caaagcggga ggtgcctctt tagaaaccac gaagtgcacg cggcgtcgac agtgatcacg
      241 ccacctggac agccagagtc caaggcataa ggaggaaaat gagtctcctc aaagagcgga
      301 agccaaaaaa gccacattac atccccaggc ctccaggaaa gcccttcaag tataaatgtt
      361 tccaatgtcc ctttacttgc aatgagaagt cacatctttt taatcacatg aagtatggtc
      421 tttgtaaaaa ctcgattact ttagtatcag agcaggatcg agttcccaag tgccctaaat
      481 ctaactcact agaccccaag caaaccaacc agcccgatgc cacggcgaag ccagcctctt
      541 ccaagtctgt cgcaaatgga ctctctgcct tcgactcgaa gcttcagcac agctctgcca
      601 gggaagacat caaggaaaac ctggagctgc aagcccgggg aacccacagg tgcctgggac
      661 agaagccagc cctccacagg gcatcaccct gcaagagccc agctccggaa gccgccctcg
      721 gtgcccagcc tgctctggaa ggcgcagctc ggccttctgc atttgttcca gtcggcgagc
      781 acagactcaa ggggccagac aacgccgagg cgcccgagac actggcttta cacaacccca
      841 ctgccaaggc cgtgtctttc cacaccaagt cggccttcca cactcctggc tacccctgga
      901 aagccggctc acctttcctt ccaccagagt ttccacataa aatctcatct acaaaggggc
      961 ttggggccat ttccccttac atgcacccca caatcccaga gtacccgcct cacttttaca
     1021 cagagcacgg gctggccacc atctactcgc cttacctgct ggctgggagc tcgcctgagt
     1081 gtgacgcacc cctgctgtca gtctacggaa cccaagaccc gagacacttc ctgcctcacc
     1141 cggggccgat ccctaagcac ctggctccat ctccagccac atacgatcac tacaggtttt
     1201 tccagcaata tccctctaac ctgccgattc cttacggatt ttacaggcca gagtctgcat
     1261 tttcctccta tggtctcaga ctcccacctg tcactggcct cacccgagat cagagctctc
     1321 acctgcttga agaagccacc ctggtctatc cagcctcgag tccttccagg ttaaaccctt
     1381 cggaccccaa cagaaaacac gtcgagttcg aaagtccaat tcctgaggct aaagactcct
     1441 ccaaggctgg gcagagagac acggaagggt ccaaaatgag cccccgcgca gggagtgcag
     1501 ccacgggctc cccagggagg ccgagcccca ccgacttcat gcagacgagc cagacctgcg
     1561 aaggcctgta cgacctctcc aacaaggcag cctccagcgc actgggaaga ctctacccgc
     1621 cagagcaaag cctcacagcc ttcaggcctg ttaagaaaag cacagaatgc ctacctgccc
     1681 aggctgctga gaccacagca gagtctccag taagcctcaa tgttgtgaac ggagaccctc
     1741 ctgctccgac cggaagcgcc tctctcgtct cggaggccgc gccttccagt ccggacgaca
     1801 gctccgggat gggccccctc aacctctcca agaaatcaga gataaacctg gcagccaccc
     1861 acgaacccac gtaccaaggc agcccccagg cggaaaccgc cagcttctca gagctgcagg
     1921 accttccact caatctctcg gtgaaggacc cctgtaacac ccaggctccg aggcctgcct
     1981 tccccggtcg accacgagct gcagaacctg ctgctgctgt tccacagaag actgggacag
     2041 aaggttctga ggatgggccc agccaccctg agaccaagcc aggcagcctc gacggtgacg
     2101 gggccccacc cacaggcccc ggcgaggagg ctccagacgc atgcgcggtg gacagcagcg
     2161 aggagcagaa gcagacggca gccgtggccc tgtgccagct ggcggcctac agccccagga
     2221 acatccgggt gggcgatggg gatgctgcgg ccccggaacc tgcctgccgg caagacacac
     2281 ccacactgag ctccatggag agccaagagg cccagtgtga cctcagaccc aaaggacaaa
     2341 agaggacaag tctaagggat gctggaaaat cccagcaagg agctaagaag gcgaagctgc
     2401 aggacacggc cagagtgttc acactacgaa ggagggcccg ggtgtcctaa cgccgggttc
     2461 acacgtgtgt tcacagagct acggccacac acacgccttc caaggtggca agctacaaca
     2521 cctctgaact ggcactttca catttttaca aatgcagctg ctgcttctca aaaaaacaaa
     2581 caaacaaaca aacaaaaaac cctccaattc agtttttata aatattaagc atgaatatta
     2641 aaaggtgctt ctacttttgg ttgtaaaaac acctgaatga ctctaagact gatatgtatt
     2701 ttcaagtcta agctgtctta cagaagatct tttataaatg tttccttata aatatctcac
     2761 cattacaaca aattgtttta actgtttttc tattagctct agctgcatat ttgatgtaaa
     2821 tgacaattac tgaaaaaatg tcagaaaaaa cattttcagt actaacatta aagtgccata
     2881 tgtaaaaaag aaaaatgtga tttgtataac taaataacac acaaacatca agaggctatt
     2941 tatacaaata atttatttcc actagggaaa gtgcattact ggtgaaggta ttatcaattt
     3001 attctacttg cttataatgt tacagtgaat gttctggctt actctgcctc actttccatt
     3061 ccccaaaatg atgtgtatgt tgctaatttt ccaataaact catatgaacc ataaggaaac
     3121 ataaaatgca aataaacata aatctatgtt atccttta
//
