LOCUS       NM_001023561            4207 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 749 (ZNF749), transcript variant
            1, mRNA.
ACCESSION   NM_001023561 XM_371200
VERSION     NM_001023561.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4207)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   2  (bases 1 to 4207)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP872084.1, DB099619.1, AK122794.1 and AC004076.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001023561.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.250227.1,
                                           SRR1660809.203047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334181.5/ ENSP00000333980.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP872084.1         1-18
            19-232              DB099619.1         1-214
            233-784             AK122794.1         229-780
            785-785             AC004076.1         13302-13302
            786-2289            AK122794.1         782-2285
            2290-4207           AC004076.1         14807-16724
FEATURES             Location/Qualifiers
     source          1..4207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4207
                     /gene="ZNF749"
                     /note="zinc finger protein 749"
                     /db_xref="GeneID:388567"
                     /db_xref="HGNC:HGNC:32783"
     exon            1..269
                     /gene="ZNF749"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..2591
                     /gene="ZNF749"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 749 isoform 1"
                     /protein_id="NP_001018855.2"
                     /db_xref="CCDS:CCDS33132.2"
                     /db_xref="GeneID:388567"
                     /db_xref="HGNC:HGNC:32783"
                     /translation="MNLTEDCMVFEDVAIYFSQEEWGILNDAQRHLHSNVMLENFALL
                     SSVGCWHGAKDEEVPSKQCVSVRVLQVTIPKPALSTLKAQPCKMCSSILKDILHLAEH
                     DGTHPEQGLYTCAAEHDLHQKEQIREKLTRSDEWRPSFVNHSAHVGERNFTCTQGGKD
                     FTASSDLLQQQVLNSGWKLYRDTQDGEAFQGEQNDFNSSQGGKDFCHQHGLFEHQKTH
                     NGERPYEFSECGELFRYNSNLIKYQQNHAGERPYEGTEYGKTFIRKSNLVQHQKIHSE
                     GFLSKRSDPIEHQEILSRPTPYECTQCGKAFLTQAHLVGHQKTHTGEQPYECNKCGKF
                     FMYNSKLIRHQKVHTGERRYECSECGKLFMDSFTLGRHQRVHTGERPFECSICGKFFS
                     HRSTLNMHQRVHAGKRLYKCSECGKAFSLKHNVVQHLKIHTGERPYECTECEKAFVRK
                     SHLVQHQKIHTDAFSKRSDLIQHKRIDIRPRPYTCSECGKAFLTQAHLVGHQKIHTGE
                     RPYECTQCAKAFVRKSHLVQHEKIHTDAFSKRSDLIQHKRIDLRPRPYVCSECGKAFL
                     TQAHLDGHQKIQTGERRYECNECGKFFLDSYKLVIHQRIHTGEKPYKCSKCGKFFRYR
                     CTLSRHQKVHTGERPYECSECGKFFRDSYKLIIHQRVHTGEKPYECSNCGKFLRYRST
                     FIKHHKVCTGEKPHECSKCRELFRTKSSLIIHQQSHTGESPFKLRECGKDFNKCNTGQ
                     RQKTHTGERSYECGESSKVFKYNSSLIKHQIIHTGKRP"
     exon            270..396
                     /gene="ZNF749"
                     /inference="alignment:Splign:2.1.0"
     exon            397..4207
                     /gene="ZNF749"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3591..3596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF749"
                     /note="hexamer: TATAAA"
     polyA_site      3618
                     /gene="ZNF749"
                     /note="major polyA site"
     regulatory      3723..3728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF749"
                     /note="hexamer: AATAAA"
     polyA_site      3743
                     /gene="ZNF749"
     regulatory      4182..4187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF749"
                     /note="hexamer: AATAAA"
     polyA_site      4207
                     /gene="ZNF749"
ORIGIN      
        1 acttctggcg gcgccctcat ggttgcgtta gcatggctac ctagggatct gttcactgat
       61 ttagagggtc ccagagctct gggtcgggac tgaggtgaaa gagcggaaaa acgcgagaag
      121 cggtgttcct tctacacaga ggctagagtg cggatcggct gagtcggctg caggcgcccc
      181 tgcctccgtc agcgtccagg tgaccgccgt tcccgccccg ctcttccctg ggtggactgg
      241 aggaggccgc gccgatgaac ctgaccgagg attgtatggt ctttgaggat gtggccatat
      301 atttctccca agaggaatgg gggatcctta atgatgctca gagacacctg cacagcaatg
      361 tgatgttgga gaactttgcg cttttgtcat cagtaggttg ttggcatgga gccaaggatg
      421 aggaggtacc ttccaagcag tgtgtttctg taagagtgtt acaggtcaca attccaaagc
      481 cagctttgtc caccctgaag gcccagccct gcaagatgtg tagctcaatt ctgaaggaca
      541 ttctgcacct ggctgagcac gatggaacac accctgagca agggctgtac acatgtgcag
      601 cagagcatga cctgcaccaa aaggagcaga ttagagagaa gctcaccaga agtgatgagt
      661 ggaggccttc atttgtgaac cacagtgctc acgtgggaga gaggaacttc acatgcacgc
      721 agggtggcaa ggattttact gccagctcag accttctcca gcaacaggtc ttaaacagtg
      781 ggtggaagct gtacagggat acccaggatg gggaagcctt tcaaggtgaa cagaatgatt
      841 tcaactccag ccaaggtggg aaagactttt gccaccaaca tgggctgttt gagcaccaaa
      901 aaacccataa tggggagagg ccttatgagt tcagtgaatg tggggaattg tttaggtaca
      961 actccaacct tattaaatat cagcaaaatc atgctggaga aaggccttat gagggcactg
     1021 aatatggaaa gacctttatt agaaagtcca acctagttca gcaccagaaa attcacagtg
     1081 aaggctttct ttcaaaaagg tctgacccca ttgaacatca ggagattctc agtagaccaa
     1141 caccttatga atgcacccag tgtgggaagg cctttcttac acaggctcat ctggttggtc
     1201 accagaaaac ccatactgga gaacagccct atgaatgcaa caagtgtggg aagtttttta
     1261 tgtataactc caaactcatc agacatcaga aagttcacac tggggagagg cgttacgagt
     1321 gcagtgaatg tgggaaattg tttatggaca gcttcacact cggtagacat cagagagttc
     1381 atactggaga aaggcctttt gaatgcagca tatgtggaaa attctttagt caccgctcca
     1441 cactcaatat gcaccagaga gttcatgctg gcaaaaggct ttataagtgt agcgaatgtg
     1501 ggaaagcctt tagcctcaaa cataatgttg ttcagcatct gaaaattcat actggagaac
     1561 ggccttatga gtgcactgaa tgtgagaagg cctttgttag aaagtcccac ctagttcagc
     1621 accagaaaat ccacactgat gcattttcaa aaaggtctga cctcattcaa cacaagagga
     1681 ttgacattag gccaaggcct tatacatgca gtgaatgtgg gaaggccttc cttacacagg
     1741 ctcatctggt tggtcaccag aaaatccata ctggagaacg gccttatgaa tgcactcaat
     1801 gtgcgaaggc ctttgttaga aagtcccacc tagttcagca tgagaaaatc cacactgatg
     1861 cattttcaaa aaggtctgac ctcattcaac acaagaggat tgacctcagg ccaaggcctt
     1921 atgtgtgtag tgaatgtggg aaggccttcc ttacacaggc tcatctagat ggtcaccaga
     1981 aaatccagac tggagaacgg cgttatgaat gcaatgaatg tgggaaattc tttttggaca
     2041 gctacaaact tgttattcat cagagaattc acactggaga aaagccttat aaatgcagca
     2101 aatgtgggaa attctttaga tatcgctgta cactgagtag acatcagaaa gttcacactg
     2161 gagaaagacc ttatgagtgt agtgaatgtg ggaaattttt tagagatagc tacaaactca
     2221 ttattcatca gagagttcat actggagaaa agccttatga atgcagcaac tgtgggaagt
     2281 ttcttagata ccgctctaca ttcattaaac atcataaagt ttgcactggg gagaagcctc
     2341 atgagtgcag taaatgtagg gaattgttta ggactaaatc gagccttatt atacatcagc
     2401 agtctcacac tggagaaagt ccttttaagt taagggaatg tgggaaagac ttcaacaaat
     2461 gtaatactgg tcagcgccaa aaaactcaca ctggagaaag gtcttatgag tgtggtgaat
     2521 ccagcaaagt gtttaaatac aactccagcc tcattaaaca tcagataatt catactggaa
     2581 aaaggcctta gtggagtgaa tgcaggaaag tcaccaaaac tgtcacctca ttcagcacca
     2641 aaaggttcac atcggaccaa gaacctatta atatatgtaa atctaatgtt gaaagagttc
     2701 agatggaaat ctgcgaggat ttcctgctgg gaactacatt aaaaacattt atgtccaggc
     2761 gtggtggctc acgcctgtaa tcccagcact ttgggaggca gaggtgggtg gatcacctga
     2821 ggtcaggagt ttgagaccag ccgggccaac atggtgaagc cccatctcta ctaaaaatac
     2881 aaaaattagc tgggcatggt ggcaggtgcc tgtaatccca gctattcagg ggactgaggc
     2941 agggagcatc acttgaacct gggaggcgga ggttgcagtg aactgagatt gttccattgc
     3001 actccagcct gggtgacagg gcgagactct gtctcaaaaa gaaaaaaatt ataattgtgg
     3061 caaattacag gtaacttaaa atctaccatc ttaacccata tttaactgta ctgttcagta
     3121 gtgttaagtc attcgcattg ttgtcaatta atatccagaa gttttttcaa cttaatgaaa
     3181 ctaaaacatt atacccttta aaccaggggt ccacaacccc caggctgcaa actggtacca
     3241 gtctgtggcc tgttaggaac cgggccagca tcactacctg agcttcacct cctgtcagat
     3301 gagcagcatt agattctcat agcagcctga gccctattgt gaactgtgcc tgtgagggat
     3361 ctaggttgtg tgctccttat gagaatctaa ctaatacctg atgatctgag gtgggacagt
     3421 tttattctga aactgtctgc cccctcctct gtccctgatg cgtggaaaaa ttggcttcca
     3481 tgaaaccagt ccctggtgcc aaagaggttg gggaccgctg ctttaaacta ctcctcttcc
     3541 tcattcccta cgccaaccag cccctgacaa tactactgta tgaattttac tataaatatc
     3601 tcatatgagg aaacttaagt tttagtcttt tgtgacttat tttgaggctt atttccctaa
     3661 atgtcttcaa ggtttatcca tgttgtagca tagcttatga ttttcatctt ttttaaaggc
     3721 cgaataaaat cccattgtag tcatgtgtcg cctaacaaga ggactgtgtt ctgagtaatc
     3781 atcttaaggt gattttgtca ttgtgtgaac aaagagtgta cttacacaaa cctgaagggc
     3841 acagcctatt acgcacctag gctatatgat atggtccatt gcgcctcaga tataaacctt
     3901 aacagcatgt tacagtattg aatattgtag gtaattgaaa cacaatgata agtaaatgtg
     3961 tatctaaaca tatctaagtt tccaaaaggt actgtaaaaa tgtatgaaaa atggtaaaaa
     4021 ctttataggg cactaacatg aacgaagctt gcgggacccc tctggttgag tcagggagtg
     4081 agttgtgagt gaatgtgaag ctctaggaca ttactgtacc ctattgtaga tgttataaac
     4141 attgtacact taggctactc taaattaatt ttttctttag taataaatta accttagtct
     4201 actgtaa
//
