LOCUS       NM_001305018            3307 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 747 (ZNF747), transcript variant
            1, mRNA.
ACCESSION   NM_001305018 XM_005255509
VERSION     NM_001305018.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   7  (bases 1 to 3307)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC305764.1, BC001361.2, AA316824.1, BM461939.1, BE327668.1 and
            CA429734.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001305018.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC305764.1, SRR3476690.485458.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465419 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000693075.1/ ENSP00000509633.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               DC305764.1         1-559
            560-2029            BC001361.2         715-2184
            2030-2437           AA316824.1         17-424
            2438-2948           BM461939.1         247-757
            2949-3303           BE327668.1         1-355               c
            3304-3307           CA429734.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..3307
                     /gene="ZNF747"
                     /note="zinc finger protein 747"
                     /db_xref="GeneID:65988"
                     /db_xref="HGNC:HGNC:28350"
     exon            1..408
                     /gene="ZNF747"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1175
                     /gene="ZNF747"
                     /note="isoform 1 is encoded by transcript variant 1; KRAB
                     domain-containing protein ZNF747"
                     /codon_start=1
                     /product="zinc finger protein 747 isoform 1"
                     /protein_id="NP_001291947.1"
                     /db_xref="CCDS:CCDS92140.1"
                     /db_xref="GeneID:65988"
                     /db_xref="HGNC:HGNC:28350"
                     /translation="MTDPSLGLTVPMAPPLAPLPPRDPNGAGSEWRKPGAVSFADVAV
                     YFSREEWGCLRPAQRALYRDVMRETYGHLGALGVGGSKPALISWVEEKAELWDPAAQD
                     PEVAKCPTEADPADSRNKEEERQREGTGALEKPDPVAAGSPGLKAPQAPFAGLEQLSK
                     ARRRSRPRFFAHPPVPRADQRHGCYVCGKSFAWRSTLVEHIYSHRGEKPFHCADCGKG
                     FGHASSLSKHRAIHRGERPHRCPECGRAFMRRTALTSHLRVHTGEKPYRCPQCGRCFG
                     LKTGMAKHQWVHRPGGEGRRGRRPGGLSVTLTPVRGDLDPPVGFQLYPEIFQECG"
     exon            409..522
                     /gene="ZNF747"
                     /inference="alignment:Splign:2.1.0"
     exon            523..3307
                     /gene="ZNF747"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2216
                     /gene="ZNF747"
                     /note="major polyA site"
     polyA_site      2312
                     /gene="ZNF747"
                     /note="major polyA site"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF747"
                     /note="hexamer: AAGAAA"
     polyA_site      2553
                     /gene="ZNF747"
                     /note="major polyA site"
     regulatory      3282..3287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF747"
                     /note="hexamer: ATTAAA"
     polyA_site      3307
                     /gene="ZNF747"
                     /note="major polyA site"
ORIGIN      
        1 gttttatttg aagacatcgt ccagttctga ccatggactc gcagccatcg gcccttagtt
       61 tccatcccct ctagtgggcc ttcgggggct ctactgacgt ccctccttcc cttggtaccg
      121 ggccggggaa gtgttctcgg gcgcgggagg ttccgcatgc ccaggcctgg ccaggggaga
      181 tgaccgatcc gtcgctgggg ctgacagtcc ccatggcgcc gcctctggcc ccgctccctc
      241 cccgggaccc aaacggggcg ggatccgagt ggagaaagcc cggggccgtg agcttcgccg
      301 acgtggccgt gtacttctcc cgggaggagt ggggctgcct gcggcccgcg cagagggccc
      361 tgtaccggga cgtgatgcgg gagacctacg gccacctggg cgcgctcgga gtcggaggca
      421 gcaagccggc gctcatctcc tgggtggagg agaaggccga actgtgggat ccggctgccc
      481 aggatccgga ggtggcgaag tgtccgacag aagcggaccc agcagattcc agaaacaagg
      541 aagaggaaag acaaagggaa gggacgggag ccctggagaa gcccgaccct gtggccgccg
      601 ggtctcctgg gctgaaggct ccccaagccc cctttgccgg gttggagcag ctgtccaagg
      661 cccggcgccg gagtcgcccc cgcttttttg cccacccccc tgtcccccga gctgaccagc
      721 gtcacggctg ctacgtgtgc gggaagagct tcgcctggcg ctccacactg gtggagcaca
      781 tttacagcca caggggcgag aagcccttcc actgcgcaga ctgcggcaag ggcttcggcc
      841 acgcttcctc cctgagcaaa caccgggcca tccatcgtgg ggagcggccc caccgctgtc
      901 ccgagtgtgg tcgggccttc atgcgccgca cggcgctgac ttctcacctg cgcgttcaca
      961 ctggcgagaa gccctaccgc tgcccgcagt gtggccgctg cttcggcctg aagaccggca
     1021 tggccaagca ccaatgggtc catcggcccg ggggcgaggg gcgtaggggc cggcgccctg
     1081 gggggctgtc tgtgaccctg actcctgtcc gcggggacct ggacccgcct gtgggcttcc
     1141 agctgtatcc agagatattc caggaatgtg ggtgacggcc taaaaagtga ccatctagac
     1201 attgtgggcg gcccgagatg ggctcagggg cccgaacctc tgcagcggcc tgcagggagg
     1261 tcccagaatc caccgcaaga gctggcctgg ggtgcggaca gtctgatctt gggctctcag
     1321 cagcctcttc tgccagcacc ttgctccccg ctgccctggg ctctccaagg ccccctttgc
     1381 tgaggcaggg ctgaggtgag aaccccccag acctccatac agggaagcaa aagctgtttc
     1441 tcctcccaga gatgctaaga ggattgaggt agagaagaac cttgttttct ctgttgtctt
     1501 tttcttttta cttttttaat tttttgagac ggagttttgc tcttgttgcc caggctggag
     1561 tgcaatggtg cgatctcgac tcactgcaac ttccacctcc tggagtcaag cgattctcct
     1621 gcctcagcca cccaagtagc tggaattaca ggcacctgcc actatgcccg gctaactttt
     1681 tgtattttta gtagagatgg ggtttcacca tgttggctag gctggtctcg aactcctgcc
     1741 ctcaggtgat ccacccacct ctgcctccca aagtgctggg attacaggcg tgagccacct
     1801 cacctggcct tttctttttt attctttgac cttcccacaa gacaataccc attgtctgtt
     1861 ttttttgttt atttatttac ttattaagac agcatcttgc tcctcaccca ggctggaatg
     1921 cagtggtgtg aactgggctc actgcagcct agacctgctg ggctcaagga atcctcctgc
     1981 cccagcctct cagatggctg tgactacagg tgggcaacac tatgcctggc taatttttaa
     2041 atttttttgc agagatgggg ttcccactat gttgatcagg ctggtctcaa actcctcggt
     2101 tcaagcaatt cgcccacctt ggcctcccaa agtgctggga ttacagggga gccactgcac
     2161 tggccttcat tgtctttttg ctgcacaacc taaaaaacca gtgaccctgt attggatctc
     2221 gcctgcagtt gctgtattga tttgggccca ggcagtgttt ttaagtgata agaattagtg
     2281 atgaagatct aaagggatat tttgcaccaa aatccaggtt tctggcatct cttgaaaaat
     2341 ccaaagattt cgcaagttca cctaggctct cagaaagtcg cagttgttgg gagttgggcc
     2401 ggagccagaa ctcccaactt actgtggtcc ggccactcat cccatcagct cctgaccaag
     2461 catgagtagc cattcatcat ggcttgcttt tagtgttttt ggtgtttatc ttaaagtaca
     2521 gcaaagaaga aagggaagta tttcttgaac ccatgtctgt gtcaaaacag tccttgcatc
     2581 tttcctgtct ttaggtacgc accatctttg ctgtctttaa gtatgtgcca tcatgggcag
     2641 agggggctag gccaggaaca cctggtgtta gatttgtagc cagtggcaac cgtacccatc
     2701 tgtatcccca agttctacac ggaatccctc cagcacttca cgactccatt atccagctac
     2761 cactaattcc tttgtgggca gagtccagcc acgggcagcc cctgccctgc ctctggtcag
     2821 gacaacacct gcccaaggag agcaagggcc tgtgacctct gctggcctgt gcgccctcac
     2881 ctgtcaccca gctcagccct gtgtctggcc tacccaggga ggaaggaacc agatttatca
     2941 gcctgaaagg aggtagaagt tttggagaaa agacactgtt cgggtgtcaa gtaatgaact
     3001 gactttattc gaacctcatc tccaatccaa tcccaccgtg gtctctctct ccctcagctt
     3061 ttctggggcg ggttgactcg tgtgtcactt tatcacaggg gcacatgggg tgagaagagg
     3121 aaccttggca gtaggagata cctttgtacc aggttttaat ttccagtgta catctcagtc
     3181 ccctccccta accctcaaca cagcctgggg aaagcccagc ttgcaacacc agttctcagc
     3241 ccagactgac agccagatag atcttggccc tgagtttgcc aattaaagat gccgtgatta
     3301 ttaccta
//
