LOCUS       NM_001394198            3846 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens zinc finger protein 746 (ZNF746), transcript variant
            4, mRNA.
ACCESSION   NM_001394198 XM_005249955
VERSION     NM_001394198.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3846)
  AUTHORS   Mahmoudian Esfahani,M., Mostashfi,M., Vaheb Hosseinabadi,S.,
            Hashemi,M.S., Peymani,M., Zohrabi,D., Angaji,S.A.,
            Nasr-Esfahani,M.H. and Ghaedi,K.
  TITLE     Unveiling the regulatory of miR-101-3p on ZNF746 in a Parkinson's
            disease cell model: Implications for therapeutic targeting
  JOURNAL   Neurosci Res 203, 18-27 (2024)
   PUBMED   38103579
  REMARK    GeneRIF: Unveiling the regulatory of miR-101-3p on ZNF746 in a
            Parkinson's disease cell model: Implications for therapeutic
            targeting.
REFERENCE   2  (bases 1 to 3846)
  AUTHORS   Liu,L., Zhao,W.Y. and Zheng,X.Y.
  TITLE     ZNF746 promotes M2 macrophage polarisation and favours tumour
            progression in breast cancer via the Jagged1/Notch pathway
  JOURNAL   Cell Signal 112, 110892 (2023)
   PUBMED   37730102
  REMARK    GeneRIF: ZNF746 promotes M2 macrophage polarisation and favours
            tumour progression in breast cancer via the Jagged1/Notch pathway.
REFERENCE   3  (bases 1 to 3846)
  AUTHORS   Kang,H., Park,S., Jo,A., Mao,X., Kumar,M., Park,C.H., Ahn,J.Y.,
            Lee,Y., Choi,J.Y., Lee,Y.S., Dawson,V.L., Dawson,T.M., Kam,T.I. and
            Shin,J.H.
  TITLE     PARIS undergoes liquid-liquid phase separation and
            poly(ADP-ribose)-mediated solidification
  JOURNAL   EMBO Rep 24 (11), e56166 (2023)
   PUBMED   37870275
  REMARK    GeneRIF: PARIS undergoes liquid-liquid phase separation and
            poly(ADP-ribose)-mediated solidification.
REFERENCE   4  (bases 1 to 3846)
  AUTHORS   Kim,H., Lee,J.Y., Park,S.J., Kwag,E., Koo,O. and Shin,J.H.
  TITLE     ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma
  JOURNAL   Biochem Biophys Res Commun 563, 98-104 (2021)
   PUBMED   34062393
  REMARK    GeneRIF: ZNF746/PARIS promotes the occurrence of hepatocellular
            carcinoma.
REFERENCE   5  (bases 1 to 3846)
  AUTHORS   Li,C.Y., Ou,R.W., Chen,Y.P., Gu,X.J., Wei,Q.Q., Cao,B., Zhang,L.Y.,
            Hou,Y.B., Liu,K.C., Chen,X.P., Song,W., Zhao,B., Wu,Y., Liu,Y. and
            Shang,H.F.
  TITLE     Genetic Analysis of ZNF Protein Family Members for Early-Onset
            Parkinson's Disease in Chinese Population
  JOURNAL   Mol Neurobiol 58 (7), 3435-3442 (2021)
   PUBMED   33723766
  REMARK    GeneRIF: Genetic Analysis of ZNF Protein Family Members for
            Early-Onset Parkinson's Disease in Chinese Population.
REFERENCE   6  (bases 1 to 3846)
  AUTHORS   Stevens,D.A., Lee,Y., Kang,H.C., Lee,B.D., Lee,Y.I., Bower,A.,
            Jiang,H., Kang,S.U., Andrabi,S.A., Dawson,V.L., Shin,J.H. and
            Dawson,T.M.
  TITLE     Parkin loss leads to PARIS-dependent declines in mitochondrial mass
            and respiration
  JOURNAL   Proc Natl Acad Sci U S A 112 (37), 11696-11701 (2015)
   PUBMED   26324925
  REMARK    GeneRIF: PARIS overexpression leads to reduced mitochondrial number
            and structural abnormalities
REFERENCE   7  (bases 1 to 3846)
  AUTHORS   Kim,B., Sohn,E.J., Jung,J.H., Shin,E.A., You,O.H., Im,J. and
            Kim,S.H.
  TITLE     Inhibition of ZNF746 suppresses invasion and epithelial to
            mesenchymal transition in H460 non-small cell lung cancer cells
  JOURNAL   Oncol Rep 31 (1), 73-78 (2014)
   PUBMED   24145959
  REMARK    GeneRIF: these findings suggest that inhibition of ZNF746
            suppresses the invasion and epithelial to mesenchymal transition
            molecules in H460 NSCLC cells and ZNF746 may be an important target
            molecule in lung tumorigenesis.
REFERENCE   8  (bases 1 to 3846)
  AUTHORS   Sawcer,S., Hellenthal,G., Pirinen,M., Spencer,C.C.,
            Patsopoulos,N.A., Moutsianas,L., Dilthey,A., Su,Z., Freeman,C.,
            Hunt,S.E., Edkins,S., Gray,E., Booth,D.R., Potter,S.C., Goris,A.,
            Band,G., Oturai,A.B., Strange,A., Saarela,J., Bellenguez,C.,
            Fontaine,B., Gillman,M., Hemmer,B., Gwilliam,R., Zipp,F.,
            Jayakumar,A., Martin,R., Leslie,S., Hawkins,S., Giannoulatou,E.,
            D'alfonso,S., Blackburn,H., Martinelli Boneschi,F., Liddle,J.,
            Harbo,H.F., Perez,M.L., Spurkland,A., Waller,M.J., Mycko,M.P.,
            Ricketts,M., Comabella,M., Hammond,N., Kockum,I., McCann,O.T.,
            Ban,M., Whittaker,P., Kemppinen,A., Weston,P., Hawkins,C.,
            Widaa,S., Zajicek,J., Dronov,S., Robertson,N., Bumpstead,S.J.,
            Barcellos,L.F., Ravindrarajah,R., Abraham,R., Alfredsson,L.,
            Ardlie,K., Aubin,C., Baker,A., Baker,K., Baranzini,S.E.,
            Bergamaschi,L., Bergamaschi,R., Bernstein,A., Berthele,A.,
            Boggild,M., Bradfield,J.P., Brassat,D., Broadley,S.A., Buck,D.,
            Butzkueven,H., Capra,R., Carroll,W.M., Cavalla,P., Celius,E.G.,
            Cepok,S., Chiavacci,R., Clerget-Darpoux,F., Clysters,K., Comi,G.,
            Cossburn,M., Cournu-Rebeix,I., Cox,M.B., Cozen,W., Cree,B.A.,
            Cross,A.H., Cusi,D., Daly,M.J., Davis,E., de Bakker,P.I.,
            Debouverie,M., D'hooghe,M.B., Dixon,K., Dobosi,R., Dubois,B.,
            Ellinghaus,D., Elovaara,I., Esposito,F., Fontenille,C., Foote,S.,
            Franke,A., Galimberti,D., Ghezzi,A., Glessner,J., Gomez,R.,
            Gout,O., Graham,C., Grant,S.F., Guerini,F.R., Hakonarson,H.,
            Hall,P., Hamsten,A., Hartung,H.P., Heard,R.N., Heath,S., Hobart,J.,
            Hoshi,M., Infante-Duarte,C., Ingram,G., Ingram,W., Islam,T.,
            Jagodic,M., Kabesch,M., Kermode,A.G., Kilpatrick,T.J., Kim,C.,
            Klopp,N., Koivisto,K., Larsson,M., Lathrop,M., Lechner-Scott,J.S.,
            Leone,M.A., Leppa,V., Liljedahl,U., Bomfim,I.L., Lincoln,R.R.,
            Link,J., Liu,J., Lorentzen,A.R., Lupoli,S., Macciardi,F., Mack,T.,
            Marriott,M., Martinelli,V., Mason,D., McCauley,J.L., Mentch,F.,
            Mero,I.L., Mihalova,T., Montalban,X., Mottershead,J., Myhr,K.M.,
            Naldi,P., Ollier,W., Page,A., Palotie,A., Pelletier,J., Piccio,L.,
            Pickersgill,T., Piehl,F., Pobywajlo,S., Quach,H.L., Ramsay,P.P.,
            Reunanen,M., Reynolds,R., Rioux,J.D., Rodegher,M., Roesner,S.,
            Rubio,J.P., Ruckert,I.M., Salvetti,M., Salvi,E., Santaniello,A.,
            Schaefer,C.A., Schreiber,S., Schulze,C., Scott,R.J., Sellebjerg,F.,
            Selmaj,K.W., Sexton,D., Shen,L., Simms-Acuna,B., Skidmore,S.,
            Sleiman,P.M., Smestad,C., Sorensen,P.S., Sondergaard,H.B.,
            Stankovich,J., Strange,R.C., Sulonen,A.M., Sundqvist,E.,
            Syvanen,A.C., Taddeo,F., Taylor,B., Blackwell,J.M., Tienari,P.,
            Bramon,E., Tourbah,A., Brown,M.A., Tronczynska,E., Casas,J.P.,
            Tubridy,N., Corvin,A., Vickery,J., Jankowski,J., Villoslada,P.,
            Markus,H.S., Wang,K., Mathew,C.G., Wason,J., Palmer,C.N.,
            Wichmann,H.E., Plomin,R., Willoughby,E., Rautanen,A.,
            Winkelmann,J., Wittig,M., Trembath,R.C., Yaouanq,J.,
            Viswanathan,A.C., Zhang,H., Wood,N.W., Zuvich,R., Deloukas,P.,
            Langford,C., Duncanson,A., Oksenberg,J.R., Pericak-Vance,M.A.,
            Haines,J.L., Olsson,T., Hillert,J., Ivinson,A.J., De Jager,P.L.,
            Peltonen,L., Stewart,G.J., Hafler,D.A., Hauser,S.L., McVean,G.,
            Donnelly,P. and Compston,A.
  CONSRTM   International Multiple Sclerosis Genetics Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     Genetic risk and a primary role for cell-mediated immune mechanisms
            in multiple sclerosis
  JOURNAL   Nature 476 (7359), 214-219 (2011)
   PUBMED   21833088
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3846)
  AUTHORS   Shin,J.H., Ko,H.S., Kang,H., Lee,Y., Lee,Y.I., Pletinkova,O.,
            Troconso,J.C., Dawson,V.L. and Dawson,T.M.
  TITLE     PARIS (ZNF746) repression of PGC-1alpha contributes to
            neurodegeneration in Parkinson's disease
  JOURNAL   Cell 144 (5), 689-702 (2011)
   PUBMED   21376232
  REMARK    GeneRIF: PARIS(ZNF746) is a KRAB and zinc finger protein that
            accumulates in models of parkin inactivation and in human PD brain.
REFERENCE   10 (bases 1 to 3846)
  AUTHORS   Landers,J.E., Melki,J., Meininger,V., Glass,J.D., van den
            Berg,L.H., van Es,M.A., Sapp,P.C., van Vught,P.W.,
            McKenna-Yasek,D.M., Blauw,H.M., Cho,T.J., Polak,M., Shi,L.,
            Wills,A.M., Broom,W.J., Ticozzi,N., Silani,V., Ozoguz,A.,
            Rodriguez-Leyva,I., Veldink,J.H., Ivinson,A.J., Saris,C.G.,
            Hosler,B.A., Barnes-Nessa,A., Couture,N., Wokke,J.H.,
            Kwiatkowski,T.J. Jr., Ophoff,R.A., Cronin,S., Hardiman,O.,
            Diekstra,F.P., Leigh,P.N., Shaw,C.E., Simpson,C.L., Hansen,V.K.,
            Powell,J.F., Corcia,P., Salachas,F., Heath,S., Galan,P.,
            Georges,F., Horvitz,H.R., Lathrop,M., Purcell,S., Al-Chalabi,A. and
            Brown,R.H. Jr.
  TITLE     Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3)
            gene increases survival in sporadic amyotrophic lateral sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 106 (22), 9004-9009 (2009)
   PUBMED   19451621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004932.4 and AC073314.4.
            
            On Apr 6, 2021 this sequence version replaced XM_005249955.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2055414.1,
                                           ERR4352444.485147.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458143.7/ ENSP00000395007.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AC004932.4         2872-3168           c
            298-597             AC073314.4         73251-73550         c
            598-724             AC073314.4         73036-73162         c
            725-838             AC073314.4         71906-72019         c
            839-1030            AC073314.4         56611-56802         c
            1031-1156           AC073314.4         55969-56094         c
            1157-3846           AC073314.4         51841-54530         c
FEATURES             Location/Qualifiers
     source          1..3846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..3846
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /note="zinc finger protein 746"
                     /db_xref="GeneID:155061"
                     /db_xref="HGNC:HGNC:21948"
                     /db_xref="MIM:613914"
     exon            1..297
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2256
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /note="isoform 4 is encoded by transcript variant 4;
                     parkin-interacting sustrate; parkin-interacting substrate"
                     /codon_start=1
                     /product="zinc finger protein 746 isoform 4"
                     /protein_id="NP_001381127.1"
                     /db_xref="CCDS:CCDS94227.1"
                     /db_xref="GeneID:155061"
                     /db_xref="HGNC:HGNC:21948"
                     /db_xref="MIM:613914"
                     /translation="MAEAVAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEK
                     KLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGS
                     KGESPKVPVTFDDVAVYFSEQEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVL
                     SQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALG
                     VEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHP
                     SSACSDGTLKLNTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATR
                     FFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGG
                     VRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGF
                     GHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGS
                     GGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTER
                     SKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKTPARGQPLPTPPAPP
                     DPFKSPASKGPLASTDLVTDWTCGLSVLGPTDGGDM"
     exon            298..597
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /inference="alignment:Splign:2.1.0"
     exon            598..724
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /inference="alignment:Splign:2.1.0"
     exon            725..838
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1030
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1156
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..3846
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3825..3830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /note="hexamer: AATAAA"
     polyA_site      3846
                     /gene="ZNF746"
                     /gene_synonym="PARIS"
                     /note="major polyA site"
ORIGIN      
        1 gtgcggccgc gctgcctcca ggaagcctca cgggccttcg tctgccgggc cgcggcgccg
       61 gctcccagga tgcagtgtgg accggccggg cgctgacgga ggcggcgcga ctgcgggcgg
      121 cgcggcgcag gggcagccag cgaggagcgg cggcagagga aaggccaggc aggcgccgcc
      181 tgcggagagc accgggcggc cgggcctgcg tggtgccgcg cgcggcggcg gcgacgacga
      241 cttcctccgg gccgggcggg acagcgcagg gccatggccg aggcggtcgc ggctccgatt
      301 tctccgtgga cgatggcagc cacgattcag gccatggaga ggaagattga atcgcaggct
      361 gctcgcctgc tttccctaga aggtcgaacc gggatggccg agaagaagct ggctgattgc
      421 gagaagacag ccgtggagtt cgggaaccag ctggagggca agtgggccgt gctggggacc
      481 ctgctgcagg agtacgggct gctgcagagg cggctggaga acgtggagaa cctgctgcgc
      541 aacaggaact tctggatcct gcggctgccc ccgggcagca agggggagtc ccctaaggtg
      601 cccgtgacct ttgatgatgt ggccgtgtat ttctccgagc aggagtgggg caagctggag
      661 gactggcaga aggagctcta caagcacgtg atgaggggca actacgagac gctggtctcc
      721 ctggactacg ccatctccaa gcccgaggtc ctctcccaga ttgaacaagg gaaggagccc
      781 tgcaactggc gccgccctgg ccccaagatt ccagatgttc ctgtggaccc cagtccaggc
      841 tcggggcccc cagttcccgc cccagacctc ttgatgcaga tcaagcagga gggtgagctc
      901 cagctccagg agcagcaggc cctgggcgtg gaggcgtggg cagccgggca gccagatatt
      961 ggggaggagc cctggggcct cagccagctg gattccggag caggagacat ctccacggat
     1021 gccacctctg gtgtccattc caacttttcc accaccatcc cgcccacctc ctggcaaacg
     1081 gatctccctc cccaccatcc ctcttcagca tgctcggacg ggaccctgaa gctcaacaca
     1141 gcagcctcca cggaagcaga tgtaaaaatt gtaataaaaa cagaagtcca ggaagaggag
     1201 gtggtggcca cacccgtaca tcctactgac ctagaggctc acgggaccct gtttggacca
     1261 ggccaagcca cacggttctt ccctagtcct gcccaggaag gagcctggga aagccagggc
     1321 agctccttcc ccagccagga ccctgtgctg gggctgcgag agcccgcccg gcctgagagg
     1381 gacatgggtg agctcagtcc tgctgtggcc caggaggaga cccctcctgg ggactggctc
     1441 ttcggagggg tccggtgggg ctggaatttc cggtgtaaac cgccagtggg cctgaacccg
     1501 aggacggggc ccgaggggct tccttactcc tccccggaca acggagaggc catcttggac
     1561 cccagccagg ccccaaggcc attcaacgaa ccctgtaaat accctggccg gaccaaaggc
     1621 tttggccaca agccagggct gaagaagcac cccgcggcgc cccccggggg ccggcccttc
     1681 acctgcgcca cgtgtgggaa gagcttccag ctgcaagtca gcctgagcgc gcaccagcgc
     1741 agctgtgggg cgcccgacgg gtcgggcccg ggcacaggcg gtggcggcag cggcagtggc
     1801 ggcggcggtg gcggcagcgg tgggggcagc gcacgggatg gcagcgccct tcggtgtggg
     1861 gagtgcggcc gttgcttcac gcgccccgcg cacctcatcc gccatcgcat gctgcacacc
     1921 ggcgagcggc ccttcccctg caccgagtgt gagaagcgct tcaccgaacg ctccaagctc
     1981 atcgaccact accgaacgca cacgggcgtg cggcccttca cctgcaccgt ctgcggcaaa
     2041 agcttcatcc gcaaggacca cctccgcaag caccagcgca accatgcagc gggcgccaag
     2101 accccggccc gaggccagcc actcccgacg ccgcccgcac ctcctgatcc cttcaagagc
     2161 cccgcctcca aaggaccttt ggcctccaca gaccttgtga ccgactggac ttgtggcctc
     2221 agcgtcctgg gacccaccga tggcggggac atgtgagcgc ctccagcccc atagcccctg
     2281 ccggccgcac gtgtaaaaag ccccgtgtgc aggcagcagg gcggcgtgga agcttcaggc
     2341 agacgcggga cggggagaac caaatgtcca agttgctgaa ctgatgatca ctggagaaag
     2401 agaaactatc caccaggaca gctgccacct ctaaaccaag tagaattctc tgtgaaatgg
     2461 gagcgccgta gaattttaag taatttaatt gcaaacctgt tttgtttttt gttttttgtt
     2521 tttttttaat tcttgaggaa aaagctggaa aatagtaata gggctattta aattttgtag
     2581 gtacttttgg ttttcagggc gtgcatttct gtcactatct cactgagtct gatagtgtgt
     2641 tggaaggttg gccagttggg gacccctggc ccactgactc ctggggatgg ggtcctgtgt
     2701 gtgcccctgc tctgcccagt tgggctgagt gggcctagcg caccaagccc ctgggcagtg
     2761 agggccattg ggtcccttgg agcacacctc agtgcagcag gaaggacccc tccgggagta
     2821 gcggttgcat ttcccagctt gcctctcctg aaaaggcccc ccaaaagtgc tggccccaac
     2881 ttttctctat tttgggccat ctgtggtacc cgtcccaagg gcacttggtg gtgtccccta
     2941 gtgtgtgact ccctggcctc ataaggacga gttgtctgaa atcccagcgt taggtctggg
     3001 gagatggaga agctgaaact ggggagctgc accacaaacg tctagctctc agcagagctg
     3061 ggagcaaagc ctggccgccc accccaacct ggggctgcct cccactccgt gagatgcttc
     3121 tgtctcctgt tcactttgtg tggtagtttc ttattttcaa aatgcatctc atttgatcat
     3181 tactgtgacc ttgggaagca gcaggacagg gatttctttt tagaggtgca aactgctcag
     3241 aggggacaca cctcagcctc tcactgtggg tacacgtggc gtgccatgag tggggaagag
     3301 caacaggcga gatgcctcat tctactggaa catcactgtg ggtgaacaga gatttccagg
     3361 ttttccctct taaaatattt gtcccacacc gacaagagtc cagtcaccag gcctcaaagg
     3421 aacttctgct tgtagcagcc gcctcccctg tgccccagcc tccttaatgt gtgcactctc
     3481 agagggcaca gctcgcgagg ctgggtttgg gggccaagtg gcttgttcat tccagcatct
     3541 aacatcataa aggtgggccc agatttcttg attcgaccac agtgctgttc ctaccacaca
     3601 aatatccatt cctgttttgt tgaagcagcc actggtcctc ttgtttcccc tgcagacgga
     3661 gggacctggc agtgcccatt cattcagccc cctcatgcat acttttatta ggcgatagac
     3721 tagttaagaa aattgtttct atgtactgta tattttgtac ctgtttacac ttctaatatt
     3781 gatataactg atattttgaa aaataagaga aaacatcctg ttaaaataaa acctaaccag
     3841 caccaa
//
