LOCUS       NM_003426               3900 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 74 (ZNF74), transcript variant 1,
            mRNA.
ACCESSION   NM_003426
VERSION     NM_003426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3900)
  AUTHORS   Germain-Desprez,D., Bazinet,M., Bouvier,M. and Aubry,M.
  TITLE     Oligomerization of transcriptional intermediary factor 1 regulators
            and interaction with ZNF74 nuclear matrix protein revealed by
            bioluminescence resonance energy transfer in living cells
  JOURNAL   J Biol Chem 278 (25), 22367-22373 (2003)
   PUBMED   12684500
REFERENCE   2  (bases 1 to 3900)
  AUTHORS   Takase,K., Ohtsuki,T., Migita,O., Toru,M., Inada,T.,
            Yamakawa-Kobayashi,K. and Arinami,T.
  TITLE     Association of ZNF74 gene genotypes with age-at-onset of
            schizophrenia
  JOURNAL   Schizophr Res 52 (3), 161-165 (2001)
   PUBMED   11705709
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3900)
  AUTHORS   Cote,F., Boisvert,F.M., Grondin,B., Bazinet,M., Goodyer,C.G.,
            Bazett-Jones,D.P. and Aubry,M.
  TITLE     Alternative promoter usage and splicing of ZNF74 multifinger gene
            produce protein isoforms with a different repressor activity and
            nuclear partitioning
  JOURNAL   DNA Cell Biol 20 (3), 159-173 (2001)
   PUBMED   11313019
REFERENCE   4  (bases 1 to 3900)
  AUTHORS   Ravassard,P., Cote,F., Grondin,B., Bazinet,M., Mallet,J. and
            Aubry,M.
  TITLE     ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human
            neural crest-derived tissues and foregut endoderm epithelia
  JOURNAL   Genomics 62 (1), 82-85 (1999)
   PUBMED   10585771
REFERENCE   5  (bases 1 to 3900)
  AUTHORS   Grondin,B., Cote,F., Bazinet,M., Vincent,M. and Aubry,M.
  TITLE     Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74
            with a hyperphosphorylated form of the RNA polymerase II largest
            subunit
  JOURNAL   J Biol Chem 272 (44), 27877-27885 (1997)
   PUBMED   9346935
REFERENCE   6  (bases 1 to 3900)
  AUTHORS   Grondin,B., Bazinet,M. and Aubry,M.
  TITLE     The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein
            tightly associated with the nuclear matrix
  JOURNAL   J Biol Chem 271 (26), 15458-15467 (1996)
   PUBMED   8663113
REFERENCE   7  (bases 1 to 3900)
  AUTHORS   Aubry,M., Demczuk,S., Desmaze,C., Aikem,M., Aurias,A., Julien,J.P.
            and Rouleau,G.A.
  TITLE     Isolation of a zinc finger gene consistently deleted in DiGeorge
            syndrome
  JOURNAL   Hum Mol Genet 2 (10), 1583-1587 (1993)
   PUBMED   8268910
REFERENCE   8  (bases 1 to 3900)
  AUTHORS   Aubry,M., Marineau,C., Zhang,F.R., Zahed,L., Figlewicz,D.,
            Delattre,O., Thomas,G., de Jong,P.J., Julien,J.P. and Rouleau,G.A.
  TITLE     Cloning of six new genes with zinc finger motifs mapping to short
            and long arms of human acrocentric chromosome 22 (p and q11.2)
  JOURNAL   Genomics 13 (3), 641-648 (1992)
   PUBMED   1639391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA791304.1, BC013395.2, BC056902.1, AC007731.16 and BG912037.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003426.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Both variants 1 and 3 encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.86723.1,
                                           SRR1803612.113983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400451.7/ ENSP00000383301.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               DA791304.1         37-402
            367-989             BC013395.2         1-623
            990-2844            BC056902.1         873-2727
            2845-3123           BC013395.2         2479-2757
            3124-3839           AC007731.16        64147-64862
            3840-3900           BG912037.1         390-450
FEATURES             Location/Qualifiers
     source          1..3900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..3900
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /note="zinc finger protein 74"
                     /db_xref="GeneID:7625"
                     /db_xref="HGNC:HGNC:13144"
                     /db_xref="MIM:194548"
     exon            1..512
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..2413
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 520"
                     /codon_start=1
                     /product="zinc finger protein 74 isoform a"
                     /protein_id="NP_003417.2"
                     /db_xref="CCDS:CCDS42982.1"
                     /db_xref="GeneID:7625"
                     /db_xref="HGNC:HGNC:13144"
                     /db_xref="MIM:194548"
                     /translation="MEIPAPEPEKTALSSQDPALSLKENLEDISGWGLPEARSKESVS
                     FKDVAVDFTQEEWGQLDSPQRALYRDVMLENYQNLLALGPPLHKPDVISHLERGEEPW
                     SMQREVPRGPCPEWELKAVPSQQQGICKEEPAQEPIMERPLGGAQAWGRQAGALQRSQ
                     AAPWAPAPAMVWDVPVEEFPLRCPLFAQQRVPEGGPLLDTRKNVQATEGRTKAPARLC
                     AGENASTPSEPEKFPQVRRQRGAGAGEGEFVCGECGKAFRQSSSLTLHRRWHSREKAY
                     KCDECGKAFTWSTNLLEHRRIHTGEKPFFCGECGKAFSCHSSLNVHQRIHTGERPYKC
                     SACEKAFSCSSLLSMHLRVHTGEKPYRCGECGKAFNQRTHLTRHHRIHTGEKPYQCGS
                     CGKAFTCHSSLTVHEKIHSGDKPFKCSDCEKAFNSRSRLTLHQRTHTGEKPFKCADCG
                     KGFSCHAYLLVHRRIHSGEKPFKCNECGKAFSSHAYLIVHRRIHTGEKPFDCSQCWKA
                     FSCHSSLIVHQRIHTGEKPYKCSECGRAFSQNHCLIKHQKIHSGEKSFKCEKCGEMFN
                     WSSHLTEHQRLHSEGKPLAIQFNKHLLSTYYVPGSLLGAGDAGLRDVDPIDALDVAKL
                     LCVVPPRAGRNFSLGSKPRN"
     exon            513..598
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /inference="alignment:Splign:2.1.0"
     exon            599..725
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /inference="alignment:Splign:2.1.0"
     exon            726..821
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /inference="alignment:Splign:2.1.0"
     exon            822..3900
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3102..3107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /note="hexamer: AATAAA"
     polyA_site      3126
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /note="major polyA site"
     regulatory      3876..3881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /note="hexamer: AATAAA"
     polyA_site      3900
                     /gene="ZNF74"
                     /gene_synonym="COS52; hZNF7; ZFP520; ZNF520"
                     /note="major polyA site"
ORIGIN      
        1 gcagcggccg cctgctgctc tttgtggcag tcgcagtcct tttgtgggag tccggtctgt
       61 ccacttgccg gtccctcaga ccgtcggcgg tctctgtccg cttcgggacc tgtccgctgg
      121 tcgctccgcg tccgatggct cctggccgcg gaaccttagg cctggccctg gtctccgagc
      181 gcgggttcgc cgggaggagc gtgtggcggg ggtgtgccgg ggcgtgagtg cgccgagcat
      241 ggggctgagc ctggtgtggg gagtgggtat ctgcggagcc ggcctgaacc ccacctcagc
      301 cgggcgcggg gagggggctc cgtgcgtgtg atcgtgcagc tgtgagcgcg tggccgcccc
      361 gcggggctcc gctgcaggcc cctcagcccc aggagcagta ctcgctcttc agggcctgcc
      421 ctggatcctg gaggctacac agctgcccac tcctcctggg gaggctgccg tggaggccat
      481 ggagatccct gccccggagc ccgagaagac agctctttcc tctcaggatc ctgctctttc
      541 cctgaaagag aatctcgagg atatatcggg ttggggtctt cccgaagcca ggtccaagga
      601 atcggtgagt ttcaaggatg tggctgtgga cttcacccag gaggagtggg gtcaactaga
      661 ctcccctcag agggccttgt accgggatgt gatgttggag aactaccaga accttcttgc
      721 cctaggacct ccactgcaca agccagatgt gatctctcat ctggaacgag gcgaggagcc
      781 atggagcatg cagagggaag tccccagagg gccctgtcca gaatgggagc tgaaggcggt
      841 gccctctcaa cagcagggca tttgcaaaga agaaccggcc caggagccca tcatggagcg
      901 gcccctcggc ggggcgcagg cgtgggggcg ccaggcaggt gctctgcaga ggagtcaggc
      961 tgcgccctgg gcgcccgcac ctgccatggt ctgggacgtc cctgtagagg aattccccct
     1021 caggtgtccc ctcttcgccc agcaacgcgt tcccgagggg ggacccttgc tggacacacg
     1081 caagaacgtc caggccactg agggcagaac caaggccccc gcgagactgt gtgcagggga
     1141 aaacgcctcc acgccaagtg agccagaaaa gttcccccag gtgcgccggc agcgcggggc
     1201 gggcgccggg gagggcgagt tcgtgtgcgg cgagtgcggg aaggcgttcc gccagagctc
     1261 ctccctcacg ctgcaccggc gctggcacag ccgggagaag gcttacaagt gcgatgaatg
     1321 cggcaaggcc ttcacctgga gcaccaacct tctggagcac cggcgcatcc acaccggcga
     1381 gaagcccttc ttctgcggcg agtgcgggaa ggccttcagc tgccactcgt ccctcaacgt
     1441 gcaccagcgc atccacacgg gcgagcggcc ctacaagtgc agcgcctgcg agaaggcctt
     1501 cagctgcagc tcgctgctca gcatgcacct gcgggtgcac accggcgaga agccctaccg
     1561 gtgcggcgag tgcggcaagg ccttcaacca gcgtacacac ctcacacgcc accaccgcat
     1621 ccacacgggc gagaagccct accagtgcgg ctcctgcggc aaggccttca cctgccactc
     1681 atccctcacc gtgcatgaga agatccacag cggggacaag ccgttcaagt gcagcgactg
     1741 cgagaaggcc ttcaacagcc gctcgcgcct caccctccac cagaggacgc acacgggcga
     1801 gaagcccttc aagtgcgccg actgcgggaa gggcttcagc tgccacgcgt acctgctcgt
     1861 gcaccggcgc atccacagcg gcgagaagcc cttcaagtgc aacgagtgcg gcaaagcctt
     1921 cagctcccac gcctacctca tcgtgcaccg gcgcatccac acaggcgaga agcccttcga
     1981 ctgcagccag tgttggaagg ccttcagctg ccactcgtcc ctcatcgtgc accagcgcat
     2041 ccacaccggt gagaagccct acaagtgcag cgagtgcggc agagccttca gccagaacca
     2101 ctgtctcatt aaacatcaga aaatccactc cggggagaag tcgtttaagt gtgagaaatg
     2161 tggggagatg ttcaactgga gctcgcacct cactgagcac cagaggctgc acagcgaggg
     2221 gaagcccttg gccatccagt tcaacaaaca cctgctcagc acatactacg tgcctggcag
     2281 cctgctgggt gcaggggatg ctggactgag ggacgtggat cccatcgacg cgctggatgt
     2341 ggcaaagctc ttgtgcgtgg ttccccccag agctggcagg aatttctccc tggggagcaa
     2401 acctcgaaac taacatgatg tgctttggtg tcagtagctg ctttctgagc tactcaacaa
     2461 ggaaagcacc ctggtcctcc ctggctccta gatccagacc accttcctcc aggtgtggga
     2521 gccttgcctt atcaccccca tcaggtctgc atgccagggt gcctcctcta gttaaagtca
     2581 gtcacctccc cagaagggcc acactccagg aggagtgttg agagtcattt gaggtagtct
     2641 tgccacctgt tttccttgat gggcctggaa gttgttgaca aggggaaaga tctttcttgc
     2701 caataaaaag aagggatatc gttgggtgcc atggctcaca cctgtaatct taacactgtg
     2761 ggaggccaag gcaaggggat cacttgagcc caggagtcta ggaccagcct ggacaacatg
     2821 gtgagacctc gtctctacaa aaaatgcaaa aattagccag atgtggcggc atgtccctgt
     2881 ggtcccagct actcaggagg ctgaggtggg aggatcattt gagcctagga ggtcaaggct
     2941 gcagtgagcc atgattcaca gcactgcact gcagcctggg tgacaaagca agaccctgtg
     3001 tgaaattaaa aggaggtata tcaactgttg tatcctcgga cgggctcctg acacggcttt
     3061 aatcaggagt ttcctccata aactattatt ttcagaataa taataaaaca agaattatga
     3121 ctagcatcac tttccagtga acattattat attgctagag aggagaataa tcttgggtgg
     3181 tgggcatttg gaaaaagtga atttcctgga cttaactcat gtaaatagct ctactgcaga
     3241 gctgtgtgtt tagtgacagt gcagtcaggg gcattcccac agctgtcaca gcacggccca
     3301 gcatcattgt agccagatcc taacatgcca acatcacctc ttgccattta gcccctagtg
     3361 agaaattggg agctaccagg caggtgccca gtgcattcag ggaagatggg cacaacatca
     3421 ggatgggtgt gtctggaagc tcctcttcac tgaccagggc tgggcagggc caccctgggc
     3481 tggtgaggct gccctgcagg gcttctcact atgtagcacc agtcaccagc ccaggtcaca
     3541 gaagaagccc ctcccagcac ccactggaga ggggaagctg aagcccaggg agacgggctc
     3601 catggtggtc ccacatggag ctgttttgca aaccctggaa aaggcggctc tccctgtccc
     3661 aacactcttc agagacagga agacagagtt aatcttgaat gaatgttatt tctacttagt
     3721 cctaagcaag aataagctgc cctcttggtg atcatacttt atacggagtg ctatcgttta
     3781 tgaaatgctt tcagtatgct ttttaaatta tgcaggcaaa ataaccacac ttcagaaaat
     3841 gtggacttct gaaaaataaa atccccataa ttcttaataa aactgccttt tgcactttga
//
