LOCUS       NM_001137608            2346 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 732 (ZNF732), mRNA.
ACCESSION   NM_001137608 XR_036877 XR_037067 XR_037305
VERSION     NM_001137608.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Imbeault,M., Helleboid,P.Y. and Trono,D.
  TITLE     KRAB zinc-finger proteins contribute to the evolution of gene
            regulatory networks
  JOURNAL   Nature 543 (7646), 550-554 (2017)
   PUBMED   28273063
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Wang,J., Wang,J. and Tian,C.Y.
  TITLE     Evolution of KRAB-containing zinc finger proteins and their roles
            in species evolution
  JOURNAL   Yi Chuan 38 (11), 971-978 (2016)
   PUBMED   27867147
  REMARK    Review article
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Wang,W., Cai,J., Lin,Y., Liu,Z., Ren,Q., Hu,L., Huang,Z., Guo,M.
            and Li,W.
  TITLE     Zinc fingers function cooperatively with KRAB domain for nuclear
            localization of KRAB-containing zinc finger proteins
  JOURNAL   PLoS One 9 (3), e92155 (2014)
   PUBMED   24647005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Razin,S.V., Borunova,V.V., Maksimenko,O.G. and Kantidze,O.L.
  TITLE     Cys2His2 zinc finger protein family: classification, functions, and
            major members
  JOURNAL   Biochemistry (Mosc) 77 (3), 217-226 (2012)
   PUBMED   22803940
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079140.6, HY033234.1 and AK302099.1.
            
            On May 17, 2019 this sequence version replaced NM_001137608.2.
            
            Summary: This gene encodes a kruppel-associated box-containing zinc
            finger protein (KRAB-ZFP). The encoded protein contains an
            N-terminal kruppel-associated box (KRAB) domain and sixteen
            C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent
            the largest family of mammalian transcriptional repressors, which
            function through the recruitment of the nuclear co-factor
            KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and
            induce heterochromatin formation. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302099.1, SRR5189652.158986.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419098.6/ ENSP00000415774.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC079140.6         88637-88641         c
            6-153               HY033234.1         3-150
            154-2346            AK302099.1         1-2193
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2346
                     /gene="ZNF732"
                     /note="zinc finger protein 732"
                     /db_xref="GeneID:654254"
                     /db_xref="HGNC:HGNC:37138"
     exon            1..167
                     /gene="ZNF732"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1922
                     /gene="ZNF732"
                     /note="zinc finger protein LOC654254"
                     /codon_start=1
                     /product="zinc finger protein 732"
                     /protein_id="NP_001131080.1"
                     /db_xref="CCDS:CCDS46990.1"
                     /db_xref="GeneID:654254"
                     /db_xref="HGNC:HGNC:37138"
                     /translation="MELLTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLISLG
                     VAISNPDLVIYLEQRKEPYKVKIHETVAKHPAVCSHFTQDFLPVQGIEDSFHKLILRR
                     YEKCGHENLELRKSCKRKVQKGGYNEFNQCLSTIQSKIFQCNVHVKVFSTFSNSNQRR
                     IRHTGEKHFKECGKSFQKFSDLTQHQGIHAGEKPYTCEECGKDFKWYLIFNEYEIIHT
                     GEKPFTCEECGNIFTTSSNFAKHKVHTGEKSYKYEECGKAFNRSSTLTKHKRIHAEEK
                     PFTCEECGKIITSSSNVAKHKKIHTGEKLYKCQECGKVFNRSTTLTKHNRIHTGEKPY
                     TCEECGKAFSRSSVLNEHKRIHTGEKPYKCEQCGKAFRQSATLNKHKSIHTGEKPYTC
                     EECGKAFSRFTTLNEHKRIHTGERPHKCEECGKAFGWSTDLNKHKIIHTGEKPYKCEE
                     CGKAFGWSAYLSKHKKIHTGEKPYRCEECGKAFLCSRALNKHKTIHTGEKPYECEECG
                     KAFGWSTYLSKHKKIHTGEKPYRCEECGKAFRRSRVLNKYKTIHTGDKTPKCKGCGKA
                     FKWSSYLNQHNKIYTGEKL"
     exon            168..294
                     /gene="ZNF732"
                     /inference="alignment:Splign:2.1.0"
     exon            295..390
                     /gene="ZNF732"
                     /inference="alignment:Splign:2.1.0"
     exon            391..2346
                     /gene="ZNF732"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttttgcg ccagcgtgag ctcggttagg gtctccacgg ccgtgctttc acccctcagg
       61 gaggcgtcgg tgattcggtc acagcctcag cctccgtcgc tctgtgacct gcgggtattg
      121 gatgattcgt agctgagact ccgctacacc cctgaagtgg ggaaatggaa ctcttaacat
      181 tcagggatgt ggccatagaa ttctctccag aagagtggaa atgcctggac cctgcccagc
      241 agaatttgta tagagatgtg atgttggaga actacaggaa cctgatctcc ctgggtgttg
      301 ctatctctaa cccagacctg gtcatctatc tggagcaaag aaaggagccc tacaaagtga
      361 agatacatga gacagtagcc aaacacccag ctgtgtgttc tcatttcacc caagactttt
      421 tgccagtgca ggggatagaa gattcgttcc acaaacttat attaagaaga tatgagaaat
      481 gtggacatga gaatttagaa ttaagaaaaa gctgtaaaag gaaggtgcag aaaggaggtt
      541 ataatgaatt taatcaatgc ttgtcaacta tccagagcaa aatatttcag tgtaatgtac
      601 atgtcaaagt atttagtaca ttttcaaatt caaaccaacg taggataaga catactggag
      661 agaaacactt taaagaatgt ggcaagtcat ttcagaagtt ctcagaccta actcaacatc
      721 aaggaattca tgctggagag aaaccctaca catgtgaaga atgtggcaaa gactttaaat
      781 ggtatttaat ctttaatgaa tatgagataa ttcatactgg agagaaaccc ttcacatgtg
      841 aagaatgtgg caacatcttt accacatcct caaactttgc taaacataaa gttcatactg
      901 gagagaaatc ttacaaatat gaagaatgtg gcaaagcctt taataggtcc tcaaccctta
      961 ctaagcataa gagaattcat gctgaagaga aacccttcac atgtgaagaa tgtggcaaaa
     1021 tcattacctc atcctcaaat gttgccaaac ataagaaaat tcataccgga gagaaactct
     1081 acaaatgtca ggaatgtggc aaagtcttta ataggtccac aacccttact aaacataaca
     1141 gaattcatac tggagagaaa ccctacacat gtgaagaatg tggcaaagcc tttagtaggt
     1201 cctcagttct gaatgaacat aagagaattc atactggaga gaagccctac aaatgtgaac
     1261 aatgtggcaa agcctttaga caatccgcaa cccttaataa acataagagt attcatactg
     1321 gagagaaacc ctacacatgt gaagaatgtg gaaaagcctt tagtcggttc acaaccctta
     1381 atgaacataa gagaattcat actggagaga ggccccacaa atgtgaagag tgtggcaaag
     1441 cctttggatg gtccacagac ctgaataaac ataagataat tcatactgga gagaaacctt
     1501 acaaatgtga agagtgtggc aaagcctttg gatggtctgc atacctgagt aaacataaga
     1561 aaattcatac tggagagaaa ccttatagat gtgaagagtg tggcaaagcc tttttatgtt
     1621 ccagagccct gaataaacat aagacaattc atactggaga gaaaccttac gaatgtgaag
     1681 agtgtggcaa agcctttgga tggtccacat acctgagtaa acataagaaa attcatactg
     1741 gagagaaacc ttatagatgt gaagagtgtg gcaaagcatt tagacgttcc agagtcctga
     1801 ataaatataa gacaattcat actggagata aaacccccaa atgtaaagga tgtggcaaag
     1861 cctttaagtg gtcctcatac cttaatcaac ataataaaat ttatactgga gagaaactct
     1921 agaaatatga agaatgtggc aaagcctttg gatgatccac aaacctgaat gaacataaga
     1981 aaatttatac tggaaataaa ctatacaaat gtgaagaatg tggcaaagct tttggatggt
     2041 ccacaaccct gaatgaaagt aagaattcat actggagaaa aaccctacaa atgtaaagaa
     2101 tgtgggaaag ccttcaaaca gtccgcatac ctgaatcaac ataagaaaat tgatgctgga
     2161 gagcaaccct acaaatgtga agaatgtggc aaagctttta gatggtccac aaccctgagt
     2221 gaacataaga aaattcatat gggagatgaa tcctacaaat gtaaagaatg tgggaaagcc
     2281 tataaacggt cctcacccat aaataaacat gagaaaattc ataatggaga gaacacctac
     2341 aaatgt
//
