LOCUS       NM_001159522            8478 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 727 (ZNF727), mRNA.
ACCESSION   NM_001159522 XM_001714410 XM_001719625 XM_001720070 XM_002342732
            XR_016680
VERSION     NM_001159522.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8478)
  AUTHORS   Wang,J., Wang,J. and Tian,C.Y.
  TITLE     Evolution of KRAB-containing zinc finger proteins and their roles
            in species evolution
  JOURNAL   Yi Chuan 38 (11), 971-978 (2016)
   PUBMED   27867147
  REMARK    Review article
REFERENCE   2  (bases 1 to 8478)
  AUTHORS   Wang,W., Cai,J., Lin,Y., Liu,Z., Ren,Q., Hu,L., Huang,Z., Guo,M.
            and Li,W.
  TITLE     Zinc fingers function cooperatively with KRAB domain for nuclear
            localization of KRAB-containing zinc finger proteins
  JOURNAL   PLoS One 9 (3), e92155 (2014)
   PUBMED   24647005
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8478)
  AUTHORS   Razin,S.V., Borunova,V.V., Maksimenko,O.G. and Kantidze,O.L.
  TITLE     Cys2His2 zinc finger protein family: classification, functions, and
            major members
  JOURNAL   Biochemistry (Mosc) 77 (3), 217-226 (2012)
   PUBMED   22803940
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115220.1 and DA235663.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001159522.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.110438.1,
                                           SRR1803612.84618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456806.3/ ENSP00000485448.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC115220.1         42338-42419
            83-382              DA235663.1         74-373
            383-383             AC115220.1         66482-66482
            384-501             DA235663.1         375-492
            502-8478            AC115220.1         74267-82243
FEATURES             Location/Qualifiers
     source          1..8478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..8478
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /note="zinc finger protein 727"
                     /db_xref="GeneID:442319"
                     /db_xref="HGNC:HGNC:22785"
     exon            1..191
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1688
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /note="zinc finger protein 727 pseudogene"
                     /codon_start=1
                     /product="putative zinc finger protein 727"
                     /protein_id="NP_001152994.1"
                     /db_xref="CCDS:CCDS55113.1"
                     /db_xref="GeneID:442319"
                     /db_xref="HGNC:HGNC:22785"
                     /translation="MRVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLG
                     LAIFKPDLITYLEQRKEPWNARRQKTVAKHPAGSLHFTAEILLEHDINDSFQKVILRK
                     SGSCDLNTLRLKKDYQRVGNCKGQKSSYNGIHQCLSATRSKTCQYNKCGKAFGLCSIF
                     TEHKKIFSREKCYKCEECGKDCRLSDFTIQKRIHTADRSYKCEECGKACKKFSNLTEH
                     NRVHTGKKPYKCEECGKTFTCSSALTKHKRNHTGDRPYKCEECHKAFRCCSDLTKHKR
                     IHTGEKPYKCKECHKAFRCCSDLTKHKRIHTGEKPYKCNECGKAFMWISALSQHNRIH
                     TGEKPYICEECGKAFTYSSTLISHKRIHMELRPYKCEECGKTFKWFSDLTNHKRIHTG
                     EKPYKCEECGKSFTCSSNLIKHKRIHMEVRPYKCEECGKTFKWFPDLTNHKRIHTGEK
                     PYKCEECGKTFTCSSSLIKHKRSHTGDRPTSAKNVAKPLGGSQTLLNIR"
     exon            192..318
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /inference="alignment:Splign:2.1.0"
     exon            319..414
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /inference="alignment:Splign:2.1.0"
     exon            415..8478
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8306..8311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /note="hexamer: AATAAT"
     polyA_site      8323
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
     regulatory      8456..8461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /note="hexamer: ATTAAA"
     polyA_site      8478
                     /gene="ZNF727"
                     /gene_synonym="ZNF727P"
                     /note="major polyA site"
ORIGIN      
        1 gggctcttca atatggcaag gccttcgtct cctagcttct aggctctgag tccagtaccc
       61 gtctgtacta ttccatctct tccgctccat tagctcctcg gtgactccac catagcccct
      121 gttatcctgt gacctgcagg tactgggaga tccataggga agaaggcgga acatccggag
      181 gctgggaaat gcgagtgcta acattcaggg atgtggctgt agaattctcc ccagaagagt
      241 gggaatgcct ggactctgct cagcagcgtt tgtataggga tgtgatgtta gagaactacg
      301 gaaacctgtt ctccttgggt cttgctatct ttaagccaga cttgattacc tatctggagc
      361 aaagaaaaga gccttggaat gcgaggagac agaagacagt agccaaacac ccagctggct
      421 ctttgcattt tactgcagag atattgctgg agcacgacat aaacgattca tttcaaaaag
      481 tgatcctgag aaaatctgga agctgtgacc ttaatacttt acgtttaaag aaagactacc
      541 aacgtgtggg taattgcaag gggcagaaaa gcagttataa tggcattcat caatgtttgt
      601 cagctacccg tagcaaaacc tgtcaatata ataaatgtgg caaagctttt gggttgtgct
      661 caatcttcac tgaacataag aaaattttta gcagagagaa atgctacaaa tgtgaagaat
      721 gtggcaaaga ctgtaggttg tcagatttta ccatacagaa gagaattcat actgcagata
      781 gaagttacaa atgtgaagaa tgtggcaaag cctgtaaaaa gttctcaaac cttactgaac
      841 ataatagagt tcatactgga aagaaaccct acaaatgtga agaatgtggc aaaacattta
      901 cctgttcctc agcccttact aaacacaaga gaaatcatac tggagacaga ccctacaaat
      961 gcgaagaatg tcacaaagcc tttaggtgtt gctcagacct tactaaacat aagagaattc
     1021 atactggaga gaaaccctac aaatgtaaag aatgtcacaa agcctttagg tgttgctcag
     1081 accttactaa acataagaga attcatactg gagagaaacc ctacaaatgt aatgaatgtg
     1141 gaaaagcttt tatgtggatc tcggccctta gtcaacataa cagaattcat actggagaga
     1201 aaccctacat ttgtgaagaa tgtggcaaag cctttaccta ctcctcaacc cttattagcc
     1261 acaagagaat tcatatggaa ttgagacctt acaaatgtga agaatgtggc aaaaccttta
     1321 agtggttctc agacctgact aatcataaga gaattcacac tggagagaaa ccctacaaat
     1381 gtgaagaatg tggcaaaagc tttacctgct cctcaaacct tattaaacac aagagaattc
     1441 atatggaagt gagaccttac aaatgtgaag aatgtggcaa aacctttaag tggttcccag
     1501 acctgactaa tcataagaga attcacactg gagagaagcc ctacaaatgt gaagaatgtg
     1561 gcaaaacctt tacctgctcc tcaagcctta ttaaacacaa gagaagtcat actggagaca
     1621 gacctacaag tgcaaagaat gtggcaaagc ctttaggtgg ttctcagacc ttactaaaca
     1681 taaggtaatt catactggag ataaacctta caaatgtaat gaatgtggaa aagcttttac
     1741 gtggatcttg gcccttagta aacacaagag aattcatact ggagagaaac cctacatttg
     1801 tgaagaatgt ggcaaagcct ttatccgctc ctcaaccctt acaagccaca agagaattca
     1861 tatggaagag agaccttaca aatgtgaaga atgcggcaaa acctgtgttt ctcagacctg
     1921 actaatcaaa agagaattca ccctggagag aatccctaca aatctgaaga atgtaacaaa
     1981 ggctataggt ggttctgaga ccttgctaaa cataagataa ttcatattgg agagaaaccc
     2041 tacaaatgta atgaatgtgg aaaaggtttt atgtggatct cggcccttag aaaacataag
     2101 agaattcata ctggagagac accctacatc catgaagaat gtggcaaggc ctttacctac
     2161 tcctcaatcc ttattaacca caagagaatt catatggaag agggacctta caaatgcgaa
     2221 gaatgtggca aaacctttat gtggctctca gactttacta atcataagag aattcaccct
     2281 ggtgagaaac cctacaaatg tgaagaatgt ggcaaagtat tgagctcgtt ctcacacgtc
     2341 attagacata agacaattca tagtagagag aagctccaca agtgttaaaa atgtggaaaa
     2401 gcctttaaca attcgtcata ttgtgttcaa catcagagac ttactactga acaaatgtag
     2461 tataaaggta atgacttgaa gaacatttaa taacatctta gagggtctct aagaacttgc
     2521 ttcataactg ggtgcttttg tgttggatgc atatatagcc ctttactatt atgtaatgcc
     2581 attttttgtc tttttaaaaa aatctgttga tttaaagtct gttttgtcag aaactaggat
     2641 tgtaatcctt gcttttttac tgttttctat ttgcttggta gacttttccc tttattttga
     2701 gcttatttga aatgggtatc tcaattacag cataccatta gatcttggtt ctttatttgc
     2761 cactctgttt tttaatttgg gcatttaacc catgtacatt taaggtttgt attcatatgt
     2821 gtggatttga ttctgtcatg atcatcttag ctggctattt tgcacatttg tttatgtggt
     2881 ggctttatca tgtcagtggt ttgtgtactt tagtgtgttt ttgtagtgac tgtttatagt
     2941 ctttttctta tttagggctt tcttcagaag atcttttaag gcaggtcttg tggtaacaga
     3001 tttcctcagc atttgcttat ctgaatacga tcatatttat tttttgcttc tgaagcttac
     3061 tttggccgga tgtgaacttc tggattagaa ttctttttta aagaaagttg aatattggcc
     3121 attaatctct tttgacttga gggatctcag ctgcaaggtt cattgttgtc tgagcttctt
     3181 tttagaggtg acctggtctt tctctctagc tgcctttaac atattttttt ctctcatttt
     3241 gaccttggag aatctcatga ttatgtatct tggggatgac cttctcgtgg ggtatattat
     3301 tggggttctc cacatttctt gcctttgaat gttggcctct ctagtttggg gaaattctca
     3361 tggatggtat cccgaaatat gtatttcaag ttgttttcat tctctccatc actttcaagc
     3421 actctcttta attatagatt tggtttattt acataatctg ttatttcttg gaggttttgt
     3481 tcattcctct ttatactttt ttcactattc ttgtctgtct tatttcagaa agccagtctt
     3541 gaagctctga gattcttccc tctgcttggc ctattcttct attaacactt gtgattacat
     3601 tataaaggtt ttgtattgtg tttttcagtt ctatcatgtt ggccatattt ttctctagac
     3661 tggctgtttt ttccatcact tcctgcaatt atttttttct tctttgcatt gggttgcaac
     3721 ttacctttgt agatcaatga agtttgcttc tacccatatt ctgaattctg cttctgtcat
     3781 cttaggcctt gctggtaatg taatttggtc atttggatga aagaagtcac tctggctttt
     3841 tgtgttttca acatttttgc actgattttg tctcatcttt gtgggcgtat ctttaaagtt
     3901 gctgaacttt gaatggggtt tggttttttg gatcctattt gatggtcttg agtatttgat
     3961 tgtggtaaaa ggtggattca gccaacaggc tttgttcctg ggagtttttt gttttttgtt
     4021 ttttgttttt gttttttttt ttgtggtggt ggagggggca atgctcagct cacaactcag
     4081 aggctgcata ctctaaatgc tcagctcaca acttagagtc tgcatactct aactctgggg
     4141 gagttgtatt gagccccaac tgtgttctgt ggctccttgt gatttggagt ctgccactct
     4201 gtgggactaa ggtgccacag ctgctgcaga gtgctagtgg atatggggtt tctgcctgtc
     4261 tttgggtatt cacttcagtg gcaggagcaa agcagctggg aggggagtgg gggttacctg
     4321 ctggagactg tgtgctattt cactaaaggt ggtgttggct tggggcagga tactggccag
     4381 taaaggtttt gatgccttct ctgtgccccc caagaaggaa tgattgttca gagtgtggga
     4441 ggataccctg ttctccgcac agttttacca caaaggccag ggtggggctt tctggctctc
     4501 tacccgccaa agcttcatct acaatagcaa ttgctgggag tggcaggggc atactacatt
     4561 tccattttct ggtggggcaa gcaaagccaa actcaccttt gcagacatgt gccagcaaag
     4621 taatatgggg agttgccatg gtcttggggg aagctggagt atagggaaga aacatgtgag
     4681 ctggtgcagt cacaggggct gccttgccgg agctcttcat gggtcaggca tggcccacca
     4741 gtgcagatgc tatggtatgg gctcctaggg tacctgagac tgccctgtaa gcagttgtgg
     4801 ccagactgga tccctgggag aggccagcag accaaggagt gctcagttgg atcagcttct
     4861 tctgatttgc aagaccatcc tgcagaaatt aggtccaaca gttcccctag ggctaaagtc
     4921 tcttatggga gaaagttgag cctatggaaa tggccgtcaa tggccacact ctactacagg
     4981 tgctcttgca ctaaaccctc tgggtaccac atgagctggg ttgctgcccc acctctttgc
     5041 ctgtcttctg gttgctgcat ctcagagacg tgtaggccag caatcactca gtgcagtccg
     5101 accaggatgg aggatctgtg cttttggcca aattaggggt tcactggtaa tgagcagtgg
     5161 gtagtttgtg ggacccatgg aggatggact ggccctctct ccttgggtaa actacagctc
     5221 gtttgaggtg tgaataaggc acttagggtg ttggattttt cattagtctg agggtagcaa
     5281 ggacagttct actgcagagg caatggcaaa aatattttca gttgctcttg gaggctctgt
     5341 ctagggagtt gcgaagttgc tactggctca atagctctgg caatgattgg ctagtggccc
     5401 aggcctggag aacttgccca gtgagaatat atgagaacag gcactcacgt aacagtctgg
     5461 ccacttttct gaagggctgc tgcagtatgc tgggtgtcca ctgcagtttc tagtcacctc
     5521 agattttcca gtacctgaca acattatcac cagtgaatac tgtaaaacag caacaatggc
     5581 agcatgccct tttttctaag agctccatct aagggaggta tagaccggtt tccagcccca
     5641 aagcaactgt aggaggtagc tggaaacccc tgttgaaagg tcttacccag tgaggagaac
     5701 atgactgggg acccacttaa gaaagcagtg taggctgggc gcagtggctc atgcctgtaa
     5761 ccctagcact ttgggaggcc gaggcaggtg gattgcctga gctcaggagt tcaagaccag
     5821 cctgggcaac atggtgaaat cccacctcta ctaaaataca aaaaaagaaa attagccagg
     5881 tgtggcggca tgcaccagta gtctcagcta atcgggaggc tgaggcagga gaattgcttg
     5941 aacccaggag gcagatgttg ctgtgagcgg agattgtgcc actgcactcc agcctggtga
     6001 gagagcgaga ctccgtctca aaaaaaaaaa agaaagaatg cagtctagcc acatttttgt
     6061 aggacagctc tgctgtgcag aagtaccact tccaccccca gtttatttgg actcttcaaa
     6121 gccagaaggc tggaacagct aagtcacaca aacagcaaaa atggccgctc actcttccct
     6181 ttaggagctg tatcccaaag aggattcaaa actccactga tcaaagagca cctgtggtgg
     6241 tagctggaga ccctggttgg gaactgcttt gcagtgagga ggaatgagat tggggacctg
     6301 ctttaacaga cagtctggcc atgtcttttt agagcgcctg tactgtgcta ggagatcctt
     6361 tctgtccccg atcagcttgg gctcttcaac acatgaaggt tggaatggct aagttgccca
     6421 agaagcaaag atggcggccc actcctcttt ctggtagctc catcccaggg aggtaccgta
     6481 ctgctaccaa tggttggctg gaattttaag ccagtagttc ttaccctgtg gggcactgtg
     6541 gaagtgggtc ctgcagacca tcactgctca gccccctgga tttcgcctct tgcctatggg
     6601 tatgtacaag gttataacct cctgtttgct gagttgcagc tactttttct gggaagcctg
     6661 gaaagccaga gtatctgagg ctcttgaatc tctgcacagg cctcagtggc tgctctgctg
     6721 agactccaca tagctctgtg tgttaaattg aaggccttgg tgaagtgggt tcctgagggt
     6781 atctcctcac ccgaaggttg cagagatctg tgggagaatc atgggtttct agggtcacac
     6841 atgcactcac tgctttactg ggtggggagg ttcctttggc tccatgttgt tccctggtgg
     6901 cccattgtcc tgccttgctt tactccattc tccgtaagtt aagttgtttc tttcattagt
     6961 tccaatgcaa gtacctggat gtttcagttg aaggtgctgt atctatgcac accttgcatt
     7021 cttctctgtg agagctacac agtctagctc cttctacttt tttatattaa aataatttat
     7081 tttcaaaggc aaatattgat gtaatttaac tcttacattt gatgctatgt cttcattcta
     7141 gaatttatgt gaaagaacat ggtcaatggt tgctgcacca gagttaggag aagttcttcc
     7201 gtatcagatg aaaagattta tatactttcc tatggaagat taagagaaat gaaatctaag
     7261 atacatgaag aaattctaag tggaaaggcc acttagtggt tgatttacaa cagcattata
     7321 agtgacaggg tgatagaagt gtggtaagtg attaggataa tattctgcat agtaagagaa
     7381 acaatttgaa ttttagaagg aaattgcttt accatttgca aactaaggta attaaaatac
     7441 agtgagtttc aaaatgcctt tttaatgaca atgtatgaac ttaatttatt ttaataaacc
     7501 aaaattattg ttattgagtt aaggctattt tacactgaat gtgtatcttg ccactgatgt
     7561 taacttatcc catcttaccc aaggttgtag gtcaacagat ggtaacaata tactattgtg
     7621 tgactgtgga ataacatctc tagtgatttc tttgtcagtg gtctttaact taccataatt
     7681 tggagaatat gattcctaca aattaacatt tttgtttttc ttgtaactac aggttattat
     7741 gatgtttgta atgaagatga gtataatgga gctatatgtt tctgaattct gaacaactat
     7801 ttacaaaatt ttatcctact tttttctgtt gaaaatatga cttctctcgt ctgctaaaca
     7861 cgtacagacc tttagttttg atttacatca atttaaatat acaaatgtat cactgtaaaa
     7921 taaactttaa gtgtaacaga tttatagaga aaatattcgt atttgtttat ggttgtatac
     7981 ctattttgag aagaaaagaa aaatattaga gtgaaacaga taattttaca tgtgttgata
     8041 tcttgccagc aaaccagtaa tttcaaagat tttgaaagaa aatctgtttt ctctgctttg
     8101 tattaaattc atttatctga aatgttattg ctcctgactt agaatcatct tttgcaaatt
     8161 ctttttttgt ttgtttgtct gttttcttgt tgttcaccat aggcataata tatcattttc
     8221 ttgtcatcta atttcagaaa acattatttg tactatcccc tcagagatta tgaaagtgac
     8281 tgataaaatt taatggtgtt cataaaataa ttttcacatg taatttcaca ctgagtgtat
     8341 tattgtatgt tatttagtat attttacatt ttgtttcaat tagagaatgc tatttaatcc
     8401 aattttcatt tagttattga tcattttact ttgtaaaatt gatataattg attttattaa
     8461 atttattggg tcaattta
//
