LOCUS       NM_001355404            2798 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 724 (ZNF724), transcript variant
            1, mRNA.
ACCESSION   NM_001355404 NR_045525 XR_109586 XR_111843
VERSION     NM_001355404.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2798)
  AUTHORS   Kawamura,Y., Nakaoka,H., Nakayama,A., Okada,Y., Yamamoto,K.,
            Higashino,T., Sakiyama,M., Shimizu,T., Ooyama,H., Ooyama,K.,
            Nagase,M., Hidaka,Y., Shirahama,Y., Hosomichi,K., Nishida,Y.,
            Shimoshikiryo,I., Hishida,A., Katsuura-Kamano,S., Shimizu,S.,
            Kawaguchi,M., Uemura,H., Ibusuki,R., Hara,M., Naito,M., Takao,M.,
            Nakajima,M., Iwasawa,S., Nakashima,H., Ohnaka,K., Nakamura,T.,
            Stiburkova,B., Merriman,T.R., Nakatochi,M., Ichihara,S., Yokota,M.,
            Takada,T., Saitoh,T., Kamatani,Y., Takahashi,A., Arisawa,K.,
            Takezaki,T., Tanaka,K., Wakai,K., Kubo,M., Hosoya,T., Ichida,K.,
            Inoue,I., Shinomiya,N. and Matsuo,H.
  TITLE     Genome-wide association study revealed novel loci which aggravate
            asymptomatic hyperuricaemia into gout
  JOURNAL   Ann Rheum Dis 78 (10), 1430-1437 (2019)
   PUBMED   31289104
  REMARK    GeneRIF: The present study revealed three gout specific loci,
            CNTN5, MIR302F, ZNF724, to be clearly associated with mechanisms of
            gout development, which distinctly differ from the known gout risk
            loci that basically elevate serum uric acid level. This
            meta-analysis is the first to reveal the loci associated with
            crystal-induced inflammation, the last step in gout development
            that aggravates asymptomatic hyperuricaemia into gout.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092329.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001355404.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301230.1, DRR138512.652185.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418100.6/ ENSP00000413411.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AC092329.3         122815-122969       c
            156-282             AC092329.3         104742-104868       c
            283-378             AC092329.3         103841-103936       c
            379-2798            AC092329.3         94174-96593         c
FEATURES             Location/Qualifiers
     source          1..2798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..2798
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /note="zinc finger protein 724"
                     /db_xref="GeneID:440519"
                     /db_xref="HGNC:HGNC:32460"
     exon            1..155
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..2012
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 724 isoform 1"
                     /protein_id="NP_001342333.1"
                     /db_xref="CCDS:CCDS86737.1"
                     /db_xref="GeneID:440519"
                     /db_xref="HGNC:HGNC:32460"
                     /translation="MGPLTFMDVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFLG
                     IAVSKPDLITCLEQGKEPWNMERHEMVAKPPGMCCYFAQDLRPEQSIKASLQRIILRK
                     YEKCGHHNLQLKKGYKSVDEYKVHKGSYNGFNQCLTTTQSKIFQCDKYVKDFHKFSNS
                     NRHKTEKNPFKCKECGKSFCVLSHLTQHKRIHTTVNSYKLEECGKAFNVSSTLSQHKR
                     IHTGQKHYKCEECGIAFNKSSHLNTHKIIHTGEKSYKREECGKAFNISSHLTTHKIIH
                     TGENAYKCKECGKAFNQSSTLTRHKIIHAGEKPYICEHCGRAFNQSSNLTKHKRIHTG
                     DKPYKCEECGKAFNVSSTLTQHKRIHTGEKPYKCEECGKAFNVSSTLTQHKRIHTGEK
                     PYKCEECGKAFNTSSHLTTHKRIHTGEKPYKCEECGKAFNQFSQLTTHKIIHTGEKPY
                     KCKECGKAFKRSSNLTEHRIIHTGEKPYKCEECGKAFNLSSHLTTHKKIHTGEKPYKC
                     KECGKAFNQSSTLARHKIIHAGEKPYKCEECGKAFYQYSNLTQHKIIHTGEKPYKCEE
                     CGKAFNWSSTLTKHKVIHTGEKPYKCKECGKAFNQCSNLTTHKKIHAVEKSDK"
     exon            156..282
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /inference="alignment:Splign:2.1.0"
     exon            283..378
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /inference="alignment:Splign:2.1.0"
     exon            379..2798
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /note="hexamer: ATTAAA"
     polyA_site      2439
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /note="major polyA site"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /note="hexamer: AATATA"
     polyA_site      2474
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /note="major polyA site"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
                     /note="hexamer: ATTAAA"
     polyA_site      2527
                     /gene="ZNF724"
                     /gene_synonym="ZNF724P"
ORIGIN      
        1 gcctttgtct ctcgctgcag ctggagcgct tggtctcgtc ttccctgctt tgtgtcccct
       61 gctcttagag gcccagcctc tgtggccctc tgacctgcaa gcattgggag atccacagct
      121 aagacgccag ggcctcccct ggaagcctag aaatgggacc attgacattt atggatgtgg
      181 ccatagaatt ctctgtggag gagtggcaat gcctggacac tgcacagcag aatttatata
      241 ggaacgtgat gttagagaac tacagaaacc tggtcttcct gggtattgct gtctctaagc
      301 cagacctgat cacctgtctg gagcaaggca aagagccctg gaatatggag agacatgaga
      361 tggtggccaa acccccaggt atgtgttgtt attttgccca agaccttcgg ccagagcaga
      421 gcataaaagc ttctttgcaa agaataatac tgagaaaata tgaaaaatgt ggacatcaca
      481 atttacagtt aaaaaaaggc tataaaagtg tggatgagta caaggtgcac aaaggaagtt
      541 ataatggatt taaccagtgt ttgacaacta cccagagcaa aatatttcag tgtgataaat
      601 atgtgaaaga ctttcataaa ttttcaaatt caaatagaca taagactgaa aagaatcctt
      661 tcaaatgtaa agaatgtggc aagtcatttt gtgttctttc acacctaact caacataaaa
      721 gaattcacac tactgtcaat tcctacaaac ttgaagaatg tggcaaggcc tttaatgtgt
      781 cctcaaccct ttctcaacat aagagaattc atacaggaca aaaacactac aaatgtgaag
      841 aatgtggcat agcctttaac aagtcctcac accttaacac acataagata attcatactg
      901 gagagaaatc ctacaaacgt gaagaatgtg gaaaagcttt taacatatcc tcacacctta
      961 ctacacataa gataattcat actggagaga atgcctacaa atgtaaagaa tgtggcaaag
     1021 cttttaacca atcatcaacc cttactagac ataagataat tcatgctgga gagaagccct
     1081 acatatgtga acattgtggc agagctttta accaatcctc gaaccttact aaacataaga
     1141 gaattcatac tggtgataaa ccttataaat gtgaagaatg tggcaaagcc tttaatgtgt
     1201 cctcaaccct tactcaacat aagagaattc atactggaga gaaaccttac aaatgtgaag
     1261 agtgtggcaa agcctttaac gtgtcctcaa ctcttactca acataagaga attcatactg
     1321 gagaaaaacc atacaaatgt gaagaatgtg gcaaagcctt taacacatcc tcacacctca
     1381 ccacacataa aagaattcat accggagaga aaccctacaa atgtgaagaa tgtggcaaag
     1441 cctttaacca gttctcacaa cttactacac ataagataat tcatactgga gagaaaccct
     1501 acaaatgtaa agaatgtggc aaagctttta agcggtcctc aaaccttact gaacatagga
     1561 taattcatac tggagagaaa ccctacaaat gtgaagaatg tggcaaagct tttaacctat
     1621 cctcacacct tacaacacat aagaaaattc atactggaga gaaaccctac aaatgtaaag
     1681 aatgtggcaa agcttttaac caatcctcga cacttgctag acataagata attcatgctg
     1741 gagagaaacc ctacaaatgt gaagaatgtg gcaaagcttt ttaccaatac tcaaacctta
     1801 ctcaacataa gataattcat actggagaga aaccctacaa atgtgaagaa tgtggcaaag
     1861 cctttaattg gtcctcaact ctgactaaac ataaggtaat tcatactgga gagaaaccct
     1921 acaaatgtaa agaatgtggc aaagctttta accaatgctc aaaccttact acacacaaga
     1981 aaattcatgc tgtagaaaaa tctgacaaat aagaaaaatg gaccaggcgt ggtggctcac
     2041 acctgtaatc ccagcacttt gggaggccaa ggcgggtgga tcacaagatc aagagattga
     2101 gaccatcctg gccaacgaag agaattactg gagagaaacc gtacaaacct gaaagatata
     2161 acagtgcagt tgacaacacc tcaatatttc taaacacctt taaatggttg tcatacttga
     2221 ttgtaggtaa aatatagtag aggaaacctc tacaagtgtg aagaatgtgg caaaactttt
     2281 aaccaatgct gacactttat tggacaggaa atgatgtata cttgagaaaa attatgcaaa
     2341 tgtaaagaat gtgaagaagc cattaatatc tgttcacatc ttattcaata tcagagagtt
     2401 catacttaat agaagcatta aagatgaaat tactgtcaat agatttttca gaaaatataa
     2461 gcctttaaag tgaagaagag tatttatttt gaagacaagc attaaaatat caagagtgta
     2521 agctgggcat ggtggctcag gcctgtaatt tcagcacttt ggaggccaag gcaggtggtt
     2581 tacttgaggt cagaagttca agaccagcct ggccaacatg gtgaaactcc atctctaccc
     2641 aaaatacaaa aattaggtgg gtgtggtagt gcatgactaa tcccagctac tcggtggttg
     2701 agacaggaga atcgcttgaa cctgggaggc agaggttgca gtgagctgag tttgtgccac
     2761 cacactccag cctgggcact ccagctgcac tccatctc
//
