LOCUS       NM_001039127            3647 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 718 (ZNF718), transcript variant
            1, mRNA.
ACCESSION   NM_001039127
VERSION     NM_001039127.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3647)
  AUTHORS   Xu,J., Zheng,S.L., Isaacs,S.D., Wiley,K.E., Wiklund,F., Sun,J.,
            Kader,A.K., Li,G., Purcell,L.D., Kim,S.T., Hsu,F.C., Stattin,P.,
            Hugosson,J., Adolfsson,J., Walsh,P.C., Trent,J.M., Duggan,D.,
            Carpten,J., Gronberg,H. and Isaacs,W.B.
  TITLE     Inherited genetic variant predisposes to aggressive but not
            indolent prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 2136-2140 (2010)
   PUBMED   20080650
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA386535.1, BC104027.2, AL833758.1, AC253576.2, CA411757.1 and
            N73572.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039127.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.11554.1,
                                           SRR1660803.108281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000510175.6/ ENSP00000480556.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA386535.1         34-70
            38-2186             BC104027.2         1-2149
            2187-3291           AL833758.1         1945-3049
            3292-3292           AC253576.2         80814-80814         c
            3293-3498           CA411757.1         163-368             c
            3499-3644           N73572.1           1-146               c
            3645-3647           AC253576.2         80459-80461         c
FEATURES             Location/Qualifiers
     source          1..3647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..3647
                     /gene="ZNF718"
                     /note="zinc finger protein 718"
                     /db_xref="GeneID:255403"
                     /db_xref="HGNC:HGNC:26889"
     exon            1..173
                     /gene="ZNF718"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1607
                     /gene="ZNF718"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 718 isoform a"
                     /protein_id="NP_001034216.2"
                     /db_xref="CCDS:CCDS75078.1"
                     /db_xref="GeneID:255403"
                     /db_xref="HGNC:HGNC:26889"
                     /translation="MELLTFKDVAIEFSPEEWKCLDTSQQNLYRDVMLENYRNLVSLG
                     VSISNPDLVTSLEQRKEPYNLKIHETAARPPAVCSHFTQNLWTVQGIEDSFHKLIPKG
                     HEKRGHENLRKTCKSINECKVQKGGYNRINQCLLTTQKKTIQSNICVKVFHKFSNSNK
                     DKIRYTGDKTFKCKECGKSFHVLSRLTQHKRIHTGENPYTCEECGKAFNWSSILTKHK
                     RIHAREKFYKCEECGKGFTRSSHLTKHKRIHTGEKPYICEKCGKAFNQSSTLNLHKRI
                     HSAQKYYKCEECGKAFKWSSSLNEHKRIHAGEKPFSCEECGNVFTTSSDFAKHKRIHT
                     GEKPYKCEECGKSFNRSTTLTTHKRIHTGEKPYTCEECGKAFNWSSTLNVHKRIHSGK
                     NPYKCEDCGKAFKVFANLHNHKKIHTGEKPYICKQCGKAFKQSSHLNKHKKIHTVDKP
                     YKCKECGKAFKQYSNLPQHKRTHTGGKF"
     exon            174..300
                     /gene="ZNF718"
                     /inference="alignment:Splign:2.1.0"
     exon            301..396
                     /gene="ZNF718"
                     /inference="alignment:Splign:2.1.0"
     exon            397..3647
                     /gene="ZNF718"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1931..1936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF718"
                     /note="hexamer: AATATA"
     polyA_site      1954
                     /gene="ZNF718"
                     /note="major polyA site"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF718"
                     /note="hexamer: AATAAA"
     polyA_site      2020
                     /gene="ZNF718"
                     /note="major polyA site"
     regulatory      3150..3155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF718"
                     /note="hexamer: AATACA"
     regulatory      3155..3160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF718"
                     /note="hexamer: AGTAAA"
     polyA_site      3168
                     /gene="ZNF718"
                     /note="major polyA site"
     polyA_site      3179
                     /gene="ZNF718"
     regulatory      3621..3626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF718"
                     /note="hexamer: AATAAA"
     polyA_site      3647
                     /gene="ZNF718"
                     /note="major polyA site"
ORIGIN      
        1 ggcttttgct tgtagctcca gccagagctc ggttagggcc tcatcgctct gctcccgctc
       61 cttagggaag cctcggtgat tctgccacag cctcagcctc tgtggctctg tgacctgccg
      121 gtattggatg attcgtatct aagactctgg gacactcctg aagtcgggaa atggaactct
      181 taacattcaa ggatgtggcc atagaattct ctccagaaga gtggaaatgt ctggacactt
      241 cccagcagaa tttatataga gatgtgatgt tggagaacta cagaaacctg gtctccctgg
      301 gtgttagtat ctctaaccca gacctggtca ccagtctgga gcaaagaaaa gagccctaca
      361 atttgaagat acatgaaaca gcagccagac ccccagctgt gtgttctcat ttcacccaaa
      421 acctttggac agtgcagggc atagaagatt cattccacaa acttatacca aaaggacatg
      481 agaaacgtgg acatgagaat ttaagaaaaa cttgtaaaag tataaatgag tgtaaggtgc
      541 agaaaggtgg ttataataga attaaccaat gcttattaac tacccagaaa aaaacaattc
      601 aatctaatat atgtgtcaaa gtttttcata aattttcaaa ttcaaacaaa gataagataa
      661 gatatactgg agataaaacc tttaaatgta aagaatgtgg caaatcattt cacgtgctct
      721 cacgcctaac tcaacacaaa agaattcata ctggagagaa cccctacaca tgtgaagaat
      781 gtggcaaagc ctttaattgg tcctcaattc ttactaaaca taagagaatt catgccagag
      841 agaaattcta caagtgtgaa gaatgtggta aaggctttac tcggtcctca caccttacta
      901 aacataagag aattcatact ggagagaaac cctacatatg tgaaaaatgt ggtaaagctt
      961 ttaaccaatc ctcaaccctt aatttacata agagaattca ttctgcacaa aaatactaca
     1021 aatgtgaaga atgtggtaaa gcctttaagt ggtcctcatc ccttaatgaa cataagagaa
     1081 ttcatgctgg agagaaaccc ttctcatgcg aagaatgtgg caatgtcttt accacatcct
     1141 cagactttgc taaacataag agaattcata caggagagaa accctacaaa tgtgaagaat
     1201 gtggaaaatc ctttaatagg tccacaactc ttacgacaca taagagaatc catactggag
     1261 agaaacccta cacatgtgaa gaatgtggaa aagcctttaa ttggtcctca acccttaatg
     1321 tacacaagag aattcactct ggaaaaaatc cctacaaatg tgaagattgt ggcaaagcct
     1381 ttaaagtgtt tgcaaacctg cataatcata agaaaattca tactggagag aaaccctaca
     1441 tatgtaaaca atgtggcaaa gcctttaaac agtcctcaca cttgaataaa cataagaaaa
     1501 ttcacactgt agataaaccc tacaaatgta aagaatgcgg gaaagctttt aagcagtact
     1561 ccaaccttcc tcaacataag agaactcata ctggaggaaa attttagaaa tgtgaagaat
     1621 gtgggagcct ttaagtcttc ctcagtcttt tctaatcata attcatactg gagagaaact
     1681 ctacacatga aaaaattgac aaagctttta accgcaactc aatctgttct aaacataaga
     1741 gaaatggtat tggtgagaag ccataaaaat atgaaaaatg tggaaaagcc ttcaaatgct
     1801 tgtcacatat tactgaatat aattcttact gcagaaaacc cctaggaata ttaaaagtgt
     1861 ggcaaaacct ttaaccaatg ctcatatctc tttgcacatg atagcattta tacttgagaa
     1921 aaattgtaca aatatagaaa atgtagaaaa gccattaatg cctactcatg tgttactaaa
     1981 tatcagagag tttgtactta ataaaaggat tataaatgta gtatttgttg aaagacctat
     2041 tagaaaatac aggtcttaaa agtgaagaag agtattctga agatagacaa tagaaatagt
     2101 aagagggttg tagtacctgt acttgcatca tgggtcttat tgtgcatatt tcatactaga
     2161 agaaaaccct gaagcagttg cccaaacttt ctttgacatt agagaattta tattggaaag
     2221 aaattttaca aatgtaataa atttggaaaa gcatttgttc aaaaactata gcttaaaaaa
     2281 aaccagttta tactagaaga tattttgtag atgcggtaag tatgaaaaga tagtctgaaa
     2341 ttaagactaa atgtcagaat atttacagta gaaagaaaaa ggcattaaca cttgaaacat
     2401 tacagtatat cagagtgtaa agtataaaaa aattccaaag ctgaaactgt tagataattt
     2461 ctttctatat aagttgaaaa ggagtagctt tttgaaatta ttccattgaa attatacttt
     2521 ttttacctga aaaaattata gattttttga aaagcaaatt caactctaaa attacttcat
     2581 actgattcaa cttattgttt atatgaaagc atgtgatgaa ttgttgcatc agaggtatga
     2641 gtgattcttt ttaggtgggc atcattcatg aacttttttt ttttttttga gacggagtct
     2701 cgctctgtcg cccaggctgg agtgcagtgg cgggatctcg gctcactgca agctctgcct
     2761 ccccctgggt tcacgccatt ctcctgcctc agcctcccaa gtagctggga ctacaggcgc
     2821 ccgccactac gcccggctaa ttttttgtat ttttagtaga gacggggttt caccgtttta
     2881 gccgggatgg tctcgatctc ctgacctcgt gatccgcccg cctcggcctc ccaaagtgct
     2941 gggattacag gcgtattcat gaacttttac atgaatgagt aaggacattg aaagatgcat
     3001 gagatgatgc atacatcttt gtggttgact tatcattgca tgatgcatga cgtacatgtt
     3061 cagagtaata ttcttctgca ttatagtgag agaaaaatct tgaattttag taataaattg
     3121 cttttaccag ttgcacattt atgtaataaa atacagtaaa ttttaaaatt ctcttttaag
     3181 attgtgtgtg aaccttactc aagggtgtag gtaaaaaatg gtaacagtat acttttagta
     3241 acatagttta atgacatttc tagtaatttc tttttccagt ggctttaaac agcaaataag
     3301 ttgaagaata ttgttctcat gttaaatttt tattattttt tatatttaaa tttattttta
     3361 aaaatttatg tgggtacatg gtatgtgtat acattcatgg catagatggg ttactttgat
     3421 acagacatgc aacatgtaat cacatcagag taaatgagtt attcatcacc tcaagcattt
     3481 atcctttgta ttacaaacaa tccaattata cacttcattt ttaaatgtac aattaaatta
     3541 ttttttatta caggtaattt tatgattgta tttagaatta tatcagaata taattataat
     3601 ttagacattt ctgtgtcctg aataaatatg tttttaaatg ttccata
//
