LOCUS       NM_001290208            3923 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 717 (ZNF717), transcript variant
            2, mRNA.
ACCESSION   NM_001290208 XM_005264712
VERSION     NM_001290208.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Duan,M., Hao,J., Cui,S., Worthley,D.L., Zhang,S., Wang,Z., Shi,J.,
            Liu,L., Wang,X., Ke,A., Cao,Y., Xi,R., Zhang,X., Zhou,J., Fan,J.,
            Li,C. and Gao,Q.
  TITLE     Diverse modes of clonal evolution in HBV-related hepatocellular
            carcinoma revealed by single-cell genome sequencing
  JOURNAL   Cell Res 28 (3), 359-373 (2018)
   PUBMED   29327728
  REMARK    GeneRIF: ZNF717 gene exhibited a high frequency of mutation in
            hepatocellular carcinoma at both single-cell and population levels.
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB079386.1, HY057162.1,
            DA618280.1, DR006008.1 and AC108724.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001290208.2.
            
            Summary: This gene encodes a Kruppel-associated box (KRAB)
            zinc-finger protein, which belongs to a large group of
            transcriptional regulators in mammals. These proteins bind nucleic
            acids and play important roles in various cellular functions,
            including cell proliferation, differentiation and apoptosis, and in
            regulating viral replication and transcription. A pseudogene of
            this gene was identified on chromosome 1. [provided by RefSeq, May
            2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on paralogous alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.282477.1,
                                           SRR1803611.228940.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652011.2/ ENSP00000498738.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                DB079386.1         35-96
            63-290              HY057162.1         62-289
            291-402             DA618280.1         394-505
            403-499             DR006008.1         512-608
            500-3923            AC108724.4         14275-17698
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p12.3"
     gene            1..3923
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /note="zinc finger protein 717"
                     /db_xref="GeneID:100131827"
                     /db_xref="HGNC:HGNC:29448"
                     /db_xref="MIM:618405"
     exon            1..166
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /inference="alignment:Splign:2.1.0"
     exon            167..225
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2913
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger protein 838; krueppel-like factor X17; kruppel-like
                     zinc finger factor X17"
                     /codon_start=1
                     /product="zinc finger protein 717 isoform a"
                     /protein_id="NP_001277137.1"
                     /db_xref="GeneID:100131827"
                     /db_xref="HGNC:HGNC:29448"
                     /db_xref="MIM:618405"
                     /translation="MFPVFSGCFQELQEKNKSLELVSFEEVAVHFTWEEWQDLDDAQR
                     TLYRDVMLETYSSLVSLGHYITKPEMIFKLEQGAEPWIVEETPNLRLSAVQIIDDLIE
                     RSHESHDRFFWQIVITNSNTSTQERVELGKTFNLNSNHVLNLIINNGNSSGMKPGQFN
                     DCQNMLFPIKPGETQSGEKPHVCDITRRSHRHHEHLTQHHKIQTLLQTFQCNEQGKTF
                     NTEAMFFIHKRVHIVQTFGKYNEYEKACNNSAVIVQVITQVGQPTCCRKSDFTKHQQT
                     HTGEKPYECVECEKPSISKSDLMLQCKMPTEEKPYACNWCEKLFSYKSSLIIHQRIHT
                     GEKPYGCNECGKTFRRKSFLTLHERTHTGDKPYKCIECGKTFHCKSLLTLHHRTHSGE
                     KPYQCSECGKTFSQKSYLTIHHRTHTGEKPYACDHCEEAFSHKSRLTVHQRTHTGEKP
                     YECNECGKPFINKSNLRLHQRTHTGEKPYECNECGKTFHRKSFLTIHQWTHTGEKPYE
                     CNECGKTFRCKSFLTVHQRTHAGEKPYACNECGKTYSHKSYLTVHHRTHTGEKPYECN
                     ECGKSFHCKSFLTIHQRTHAGKKPYECNECEKTFINKLNLGIHKRTHTGERPYECNEC
                     GKTFRQKSNLSTHQGTHTGEKPYVCNECGKTFHRKSFLTIHQRTHTGKNRMDVMNVEK
                     LFVRNHTLLYIRELTPGKSPMNVMNVENPFIRRQIFRSIKVFTRGRNPMNVANVEKPC
                     QKSVLTVHHRTHTGEKPYECNECGKTFCHKSNLSTHQGTHSGEKPYECDECRKTFYDK
                     TVLTIHQRTHTGEKPFECKECRKTFSQKSKLFVHHRTHTGEKPFRCNECRKTFSQKSG
                     LSIHQRTHTGEKPYECKECGKTFCQKSHLSRHQQTHIGEKSDVAEAGYVFPQNHSFFP
                     "
     exon            226..352
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /inference="alignment:Splign:2.1.0"
     exon            353..445
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /inference="alignment:Splign:2.1.0"
     exon            446..3923
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3902..3907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /note="hexamer: AATAAA"
     polyA_site      3923
                     /gene="ZNF717"
                     /gene_synonym="OB1; X17; ZNF838"
                     /note="major polyA site"
ORIGIN      
        1 cttgtagctg ggccagcctg gggcttggtt ctatgtccct gcgggtcggt gcgagggcga
       61 agaggaaccc gtgggcccgg gggatcccgg ggggccggac cagtgttccc cagttgtggg
      121 agcagacgcg tgggcgcatc gcgggcgggc agggcctgaa gtgcagctat gtttccagtg
      181 ttctctggct gtttccaaga gctacaagaa aagaataaat ctctggagtt ggtgtccttt
      241 gaggaggtag ctgtgcactt cacctgggag gagtggcagg acctggatga tgctcagagg
      301 accctgtaca gggacgtgat gctggagacc tacagcagcc tggtatcatt ggggcattac
      361 attaccaaac ctgagatgat cttcaagcta gagcaaggag cagagccatg gatagtagaa
      421 gaaaccccaa acctgagact ttcagctgtc cagatcattg atgaccttat tgaaaggagc
      481 catgaaagtc atgatagatt tttctggcaa attgtaatca ccaacagcaa cacatcaact
      541 caggagagag ttgaattagg aaaaacattt aatttgaact caaaccatgt tttaaatctg
      601 attataaata atggaaacag ttcaggaatg aagcctgggc agtttaatga ttgccagaac
      661 atgcttttcc ctattaagcc tggggagaca cagtctggag agaaacctca tgtctgtgat
      721 ataaccagga gatcccacag acatcatgaa catcttactc agcatcacaa gattcaaact
      781 ctgctgcaga cttttcaatg taatgaacaa gggaaaacct tcaacacgga ggcaatgttc
      841 tttatacata agagggttca tatagtacag acctttggta aatataatga atatgagaaa
      901 gcctgtaata actcagctgt tattgtccaa gtgataactc aggtaggaca gccaacttgc
      961 tgtagaaagt ctgacttcac taaacatcag cagacacaca caggagagaa accctatgaa
     1021 tgtgttgaat gtgagaaacc ctccattagc aaatcagacc ttatgctaca gtgcaagatg
     1081 cctactgagg aaaaacctta tgcctgtaac tggtgtgaaa aattgttcag ctataagtcc
     1141 agcctcatta tccatcagag aattcacaca ggggaaaagc cctatggatg caatgaatgt
     1201 ggtaaaacct ttcgccgtaa gtcattcctc actttacatg agagaactca cacaggggat
     1261 aaaccctaca aatgtattga atgtggaaaa acttttcact gtaagtcact tctcacttta
     1321 catcacagaa ctcactcagg ggaaaagccc tatcagtgta gtgaatgtgg aaaaaccttt
     1381 agccagaagt catacctcac aatacatcat agaactcaca caggggaaaa gccctatgca
     1441 tgtgaccatt gtgaagaagc atttagccat aagtcaaggc ttactgtcca tcagagaaca
     1501 cacacagggg aaaaaccgta tgaatgtaat gagtgtggaa aaccctttat caataagtca
     1561 aacctcaggt tacatcagag aactcacaca ggggaaaaac cctatgaatg caatgaatgt
     1621 gggaaaacgt ttcaccgtaa gtcattcctc actatccatc aatggactca cacaggggaa
     1681 aaaccctacg aatgcaatga atgtgggaaa acctttcgct gtaagtcatt cctcactgtc
     1741 catcagagaa ctcatgctgg ggaaaaacca tacgcatgta acgaatgtgg aaaaacatat
     1801 agccacaagt cataccttac agtacatcac agaactcaca caggggaaaa accctatgaa
     1861 tgtaatgaat gtggaaaatc ctttcactgt aagtcattcc taactataca tcagagaact
     1921 catgctggca aaaaacccta tgaatgtaat gaatgtgaga aaacctttat caataagtta
     1981 aaccttggga tacacaagag aactcacaca ggggaaagac cctatgaatg taatgaatgt
     2041 ggaaaaacct ttcgtcagaa gtcaaatctc agcacccatc agggaactca cacaggagag
     2101 aaaccttacg tatgtaatga atgtggaaaa acctttcatc gcaagtcatt cctcaccata
     2161 caccagagaa ctcacacggg gaaaaaccgt atggatgtaa tgaatgtgga aaaacttttt
     2221 gtcagaaatc ataccttatt atacatcaga gaactcacac cggggaaaag ccctatgaat
     2281 gtaatgaatg tggaaaatcc tttcatcaga aggcaaatct tcagaagcat caaggtattc
     2341 acacggggga gaaaccctat gaatgtagca aatgtggaaa aaccttgtca gaagtcagtc
     2401 ctcactgtac atcatagaac ccataccgga gaaaaacctt atgaatgtaa tgagtgtggg
     2461 aaaacctttt gtcacaagtc aaacctcagt acgcatcagg ggactcactc aggagagaaa
     2521 ccctatgaat gtgatgaatg taggaaaact ttttacgata agacagttct caccatacat
     2581 cagagaactc acacaggtga gaagccattt gaatgtaaag aatgtaggaa aaccttctcc
     2641 cagaagtcaa aactctttgt acatcacaga actcacacag gggaaaaacc ctttagatgt
     2701 aatgaatgta ggaaaacttt ctcccagaag tcaggcctca gtatacatca gagaacacac
     2761 acaggagaaa aaccttatga atgtaaggaa tgtgggaaaa ccttttgcca gaagtcacac
     2821 ctcagcaggc atcaacaaac ccatatagga gagaaatctg acgtagctga ggcaggctat
     2881 gtgttccctc aaaatcactc ttttttccct tgaacacaca acctacacct ctctggctac
     2941 tattacagat ttctccatgc tcagtctagg agaatatgga cacaaatggt gaccattacc
     3001 tcctggccta ccaacaagaa ggtcttaacc atgctgtaac agaagtccta tcatgcaggc
     3061 tttgttgttc ccatttttac agcacacttt gcactttaat gtcacagata tggctgtttt
     3121 cctagaagct catataccaa cctctgccag cttcaaacat ttcttctgca acttcctcac
     3181 ctctcttctc ctccatagaa ttgaagagag ttagggcctt tctcaggatt aggctttgtc
     3241 tcaagggaat gttggggctg gtttgatctt ctatgtggac cactcagact ttctctgtgt
     3301 cagtaaaaag cctgttttgt tttttaaaaa tcattcatgt gttctctgga gtagcaccta
     3361 taacatcctt caagaacttt ttctttgcat tcacaacttg agtagctgat gcaagaagct
     3421 tagctttggc ctgtcttagc ttccaacatg ctttcttcac taagctcgat gatttctacc
     3481 ttttgatttg aagtgacagg tgtgcacact tcttttcaat tgaacacatg gtggccactg
     3541 cagagtgaag tggcctaatt tcattgttgt atcttgggga atggggagct agaagagaga
     3601 aacagagaca gggaaatgac tagtcaatga agcagtcaaa cacaacattt ttccatcacg
     3661 tttgctatct tccatagagt tccagcacgc tgagacaatt ccattagtaa catcagaaat
     3721 cactgatcac agatcataac agatgtgata actaaaatct ttgaaagatt gggattgcca
     3781 aaagatgtga cagagatgtg aagtgagccc atggtgttgg aaaaatggtg ctggtcaggc
     3841 ttgctgagca cttcgtggcc acaaatcttt aatttgttaa aaaggtgatg ttgccaagca
     3901 aaataaagtg aagctcaaag tga
//
