LOCUS       NM_001330574            4559 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 711 (ZNF711), transcript variant
            1, mRNA.
ACCESSION   NM_001330574 XM_017029804
VERSION     NM_001330574.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4559)
  AUTHORS   Rua,A.J. and Alexandrescu,A.T.
  TITLE     Formerly degenerate seventh zinc finger domain from transcription
            factor ZNF711 rehabilitated by experimental NMR structure
  JOURNAL   Protein Sci 33 (9), e5149 (2024)
   PUBMED   39180464
REFERENCE   2  (bases 1 to 4559)
  AUTHORS   Wang,J., Foroutan,A., Richardson,E., Skinner,S.A., Reilly,J.,
            Kerkhof,J., Curry,C.J., Tarpey,P.S., Robertson,S.P., Maystadt,I.,
            Keren,B., Dixon,J.W., Skinner,C., Stapleton,R., Ruaud,L., Gumus,E.,
            Lakeman,P., Alders,M., Tedder,M.L., Schwartz,C.E., Friez,M.J.,
            Sadikovic,B. and Stevenson,R.E.
  TITLE     Clinical findings and a DNA methylation signature in kindreds with
            alterations in ZNF711
  JOURNAL   Eur J Hum Genet 30 (4), 420-427 (2022)
   PUBMED   34992252
  REMARK    GeneRIF: Clinical findings and a DNA methylation signature in
            kindreds with alterations in ZNF711.
            Erratum:[Eur J Hum Genet. 2023 Dec 1. doi:
            10.1038/s41431-023-01499-2.. PMID: 38040915]
REFERENCE   3  (bases 1 to 4559)
  AUTHORS   Wu,G., Peng,H., Tang,M., Yang,M., Wang,J., Hu,Y., Li,Z., Li,J.,
            Li,Z. and Song,L.
  TITLE     ZNF711 down-regulation promotes CISPLATIN resistance in epithelial
            ovarian cancer via interacting with JHDM2A and suppressing SLC31A1
            expression
  JOURNAL   EBioMedicine 71, 103558 (2021)
   PUBMED   34521054
  REMARK    GeneRIF: ZNF711 down-regulation promotes CISPLATIN resistance in
            epithelial ovarian cancer via interacting with JHDM2A and
            suppressing SLC31A1 expression.
REFERENCE   4  (bases 1 to 4559)
  AUTHORS   Poeta,L., Padula,A., Lioi,M.B., van Bokhoven,H. and Miano,M.G.
  TITLE     Analysis of a Set of KDM5C Regulatory Genes Mutated in
            Neurodevelopmental Disorders Identifies Temporal Coexpression Brain
            Signatures
  JOURNAL   Genes (Basel) 12 (7), 1088 (2021)
   PUBMED   34356104
  REMARK    GeneRIF: Analysis of a Set of KDM5C Regulatory Genes Mutated in
            Neurodevelopmental Disorders Identifies Temporal Coexpression Brain
            Signatures.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4559)
  AUTHORS   Ni,W., Perez,A.A., Schreiner,S., Nicolet,C.M. and Farnham,P.J.
  TITLE     Characterization of the ZFX family of transcription factors that
            bind downstream of the start site of CpG island promoters
  JOURNAL   Nucleic Acids Res 48 (11), 5986-6000 (2020)
   PUBMED   32406922
  REMARK    GeneRIF: Characterization of the ZFX family of transcription
            factors that bind downstream of the start site of CpG island
            promoters.
REFERENCE   6  (bases 1 to 4559)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   7  (bases 1 to 4559)
  AUTHORS   Yntema,H.G., van den Helm,B., Knoers,N.V., Smits,A.P., van
            Roosmalen,T., Smeets,D.F., Mariman,E.C., van der Burgt,I., van
            Bokhoven,H., Ropers,H.H., Kremer,H. and Hamel,B.C.
  TITLE     X-linked mental retardation: evidence for a recent mutation in a
            five-generation family (MRX65) linked to the pericentromeric region
  JOURNAL   Am J Med Genet 85 (3), 305-308 (1999)
   PUBMED   10398247
REFERENCE   8  (bases 1 to 4559)
  AUTHORS   Johnston,C.M., Shimeld,S.M. and Sharpe,P.T.
  TITLE     Molecular evolution of the ZFY and ZNF6 gene families
  JOURNAL   Mol Biol Evol 15 (2), 129-137 (1998)
   PUBMED   9491611
REFERENCE   9  (bases 1 to 4559)
  AUTHORS   Colleaux,L., May,M., Belougne,J., Lepaslier,D., Schwartz,C. and
            Fontes,M.
  TITLE     Localisation of two candidate genes for mental retardation using a
            YAC physical map of the Xq21.1-21.2 subbands
  JOURNAL   J Med Genet 33 (5), 353-357 (1996)
   PUBMED   8733041
REFERENCE   10 (bases 1 to 4559)
  AUTHORS   Lloyd,S.L., Sargent,C.A., Chalmers,J., Lim,E., Habeebu,S.S. and
            Affara,N.A.
  TITLE     An X-linked zinc finger gene mapping to Xq21.1-q21.3 closely
            related to ZFX and ZFY: possible origins from a common ancestral
            gene
  JOURNAL   Nucleic Acids Res 19 (18), 4835-4841 (1991)
   PUBMED   1923752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003001.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001330574.1.
            
            Summary: This gene encodes a zinc finger protein of unknown
            function. It bears similarity to a zinc finger protein which acts
            as a transcriptional activator. This gene lies in a region of the X
            chromosome which has been associated with cognitive disability.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.1848.1,
                                           SRR1803616.205162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674551.1/ ENSP00000502839.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC003001.1         69465-69665
            202-321             AC003001.1         71377-71496
            322-580             AC003001.1         72404-72662
            581-685             AC003001.1         73021-73125
            686-1228            AC003001.1         80733-81275
            1229-1384           AC003001.1         89749-89904
            1385-1522           AC003001.1         90592-90729
            1523-1660           AC003001.1         92752-92889
            1661-1708           AC003001.1         93768-93815
            1709-1852           AC003001.1         95477-95620
            1853-4559           AC003001.1         96125-98831
FEATURES             Location/Qualifiers
     source          1..4559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..4559
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /note="zinc finger protein 711"
                     /db_xref="GeneID:7552"
                     /db_xref="HGNC:HGNC:13128"
                     /db_xref="MIM:314990"
     exon            1..201
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            202..321
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            322..580
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            581..685
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..3030
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 6 (CMPX1); dJ75N13.1 (znf6-like)"
                     /codon_start=1
                     /product="zinc finger protein 711 isoform 1"
                     /protein_id="NP_001317503.1"
                     /db_xref="CCDS:CCDS83481.1"
                     /db_xref="GeneID:7552"
                     /db_xref="HGNC:HGNC:13128"
                     /db_xref="MIM:314990"
                     /translation="MDSGGGSLGLHTPDSRMAHTMIMQDFVAGMAGTAHIDGDHIVVS
                     VPEAVLVSDVVTDDGITLDHGLAAEVVHGPDIITETDVVTEGVIVPEAVLEADVAIEE
                     DLEEDDGDHILTSELITETVRVPEQVFVADLVTGPNGHLEHVVQDCVSGVDSPTMVSE
                     EVLVTNSDTETVIQAAGGVPGSTVTIKTEDDDDDDVKSTSEDYLMISLDDVGEKLEHM
                     GNTPLKIGSDGSQEDAKEDGFGSEVIKVYIFKAEAEDDVEIGGTEIVTESEYTSGHSV
                     AGVLDQSRMQREKMVYMAVKDSSQEEDDISCAEIADEVYMEVIVGEEEGTSLPEIQLE
                     DSDVNKTVVPVVWAAAYGDERRVSRRYEDCQASGNTLDSALESRSSTAAQYLQICDGI
                     NTNKVLKQKAKKRRRGETRQWQTAVIIGPDGQPLTVYPCHICTKKFKSRGFLKRHMKN
                     HPDHLMRKKYQCTDCDFTTNKKVSFHNHLESHKLINKVDKTHEFTEYTRRYREASPLS
                     SNKLILRDKEPKMHKCKYCDYETAEQGLLNRHLLAVHSKNFPHVCVECGKGFRHPSEL
                     KKHMRTHTGEKPYQCQYCIFRCADQSNLKTHIKSKHGNNLPYKCEHCPQAFGDERELQ
                     RHLDLFQGHKTHQCPHCDHKSTNSSDLKRHIISVHTKDFPHKCEVCDKGFHRPSELKK
                     HSDIHKGRKIHQCRHCDFKTSDPFILSGHILSVHTKDQPLKCKRCKRGFRQQNELKKH
                     MKTHTGRKIYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEFCKKGFRRPSEKNQHI
                     MRHHKEALM"
     exon            686..1228
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1384
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1522
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1660
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1708
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1852
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..4559
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4540..4545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /note="hexamer: AATAAA"
     polyA_site      4559
                     /gene="ZNF711"
                     /gene_synonym="CMPX1; dJ75N13.1; MRX65; MRX97; XLID97;
                     Zfp711; ZNF4; ZNF5; ZNF6"
                     /note="major polyA site"
ORIGIN      
        1 agacgcagag tagattgtga ttggctcggg ctgcggaacc tcggaaaccc gaatgtgagg
       61 accttaaggg atccacagct gccgcccccc gcagccatcc agagcgcggt cacagtccga
      121 ctggcggcac ggaggcggcg gcggcggcgg cggcggcagc ggcggcggca gcggcggcgg
      181 cagctgtagc tgcagcagca ggtaaagaga gcgttttccc aaagaaaata acatagcaca
      241 gaaggaaaaa taaaaagaaa ttgctgcaga ttttacttta tgtgagaaaa tctacaattt
      301 cttcgagaca ctcatataaa ggaagcagtc atgtttcatg agtcctcaaa actgagacaa
      361 gagaatgtag tagagtgagg ccagaagtcc ttactggttc aaagaactcc ggggaaactg
      421 ggatagaaca ttttacatta taagtagaac cctgggagcc agaggtgaat acaagtttat
      481 ctgcagagct ccgctgcagg gctgatctgg gtctggaaga aatggatgag agccagtgga
      541 tgaaattcac taatactaga catctgagtc ctctagtaat atattggtga atgaactttg
      601 ctaagtatgg attcaggcgg tggaagtctt ggattgcaca cgccagactc tagaatggcc
      661 cataccatga ttatgcaaga ttttgtggct ggaatggctg gtactgcaca tatcgatgga
      721 gaccatattg ttgtttcagt tcctgaagct gttttagttt ctgatgttgt cacagatgat
      781 gggataactc ttgatcatgg ccttgcagct gaagttgtcc atggacctga tatcatcaca
      841 gagactgatg tagtaacaga aggtgtgatt gttcctgaag cggtacttga agctgatgtt
      901 gccattgaag aggatttaga ggaagatgat ggtgatcaca tcttgacttc tgaactaatt
      961 acagaaaccg ttagggtacc agagcaggtt ttcgtggctg accttgttac tggtcctaat
     1021 ggacacttag aacatgtggt ccaagattgt gtttcaggag tcgactctcc cacaatggta
     1081 tcagaggagg ttcttgtaac taattcagat acagaaactg tgattcaagc agctggaggt
     1141 gttcctggtt ctacagttac tataaaaacc gaagatgatg atgatgatga tgtcaagagc
     1201 acttctgaag actacttaat gatatctttg gatgatgttg gagaaaaatt agagcatatg
     1261 gggaatacac cattaaaaat tggcagtgat ggttcacaag aagatgctaa agaagatggg
     1321 tttggttctg aagttataaa agtgtatata tttaaagcgg aggctgaaga tgatgttgaa
     1381 ataggtggaa cagaaattgt cacagagagt gagtacacca gtggacattc agtagctgga
     1441 gtgcttgacc agagccgaat gcagcgggag aagatggttt acatggcagt taaagattct
     1501 tctcaagaag aagatgatat cagttgcgct gaaatagcag atgaagttta catggaagtc
     1561 attgtagggg aagaggaagg aacttctctc cctgagattc agcttgagga ctctgatgtt
     1621 aataaaacag ttgtccctgt tgtctgggct gcggcatatg gagatgaaag aagagtttcc
     1681 cgaaggtatg aagattgtca agcatcagga aatactttgg actcagcatt agaaagcaga
     1741 agtagtacag cagcacagta ccttcaaatt tgtgacggca ttaatacaaa taaagtactt
     1801 aaacaaaaag ccaaaaagag gagaagggga gaaaccaggc agtggcaaac agctgttata
     1861 ataggtcctg atggacagcc cctcacagtg tacccttgcc atatttgcac aaaaaagttt
     1921 aaatccaggg gattcttaaa aagacacatg aagaatcatc ctgatcattt aatgagaaaa
     1981 aaatatcagt gtacagattg tgactttaca actaacaaga aagtgagttt ccataaccac
     2041 ttagaaagcc ataagctcat aaacaaagtc gacaaaaccc atgaatttac agaatacaca
     2101 cgaagataca gagaggctag tccactgagt tccaataaac ttattttaag agacaaggag
     2161 ccgaagatgc acaagtgcaa atactgtgac tatgaaactg cagaacaagg actgttaaac
     2221 aggcatttgt tggccgttca cagcaagaat tttcctcatg tttgtgttga gtgtgggaag
     2281 ggttttcgac atccttctga actcaagaaa catatgagaa cccatactgg tgagaagcca
     2341 tatcagtgtc agtattgtat tttcaggtgt gcagatcaat caaatctgaa aactcacatt
     2401 aagtctaaac atggtaacaa tttgccatat aaatgtgagc attgtcccca agcatttggt
     2461 gatgagaggg agcttcaacg ccatctggat ttgtttcaag gacataagac acaccagtgt
     2521 cctcattgtg accataagag caccaattca agtgacctta agcggcacat catatctgtc
     2581 catactaagg attttcctca caaatgtgag gtctgtgata aaggttttca tcgtccttct
     2641 gagctcaaaa agcatagtga tatccataag ggtaggaaga ttcatcagtg caggcactgt
     2701 gactttaaaa catccgatcc atttattctt agtggccata tcctttcagt tcatactaaa
     2761 gatcagccat tgaaatgtaa aaggtgcaag agaggattca gacaacaaaa tgagctaaaa
     2821 aaacatatga agacccatac tggaaggaag atttaccaat gtgagtattg tgaatacagc
     2881 actacagatg catctggctt taaacgacat gtgatatcaa tacatacaaa agactatcca
     2941 cacaggtgtg aattctgcaa gaagggattc cgaagaccat cagaaaaaaa tcagcatatt
     3001 atgaggcacc acaaagaggc tcttatgtaa taagatcaat ataaagaaag aagctattta
     3061 ggagatatga tatgctactt gggagaaaac tctcactaac tgtctcaccg ggtttcaaag
     3121 cttgatacta aaccatgact ttacattctt tgtattaaag atcttaaaat atttgaattc
     3181 acaggggatc ccatagccct ttgaaaatta cttaaagaat ttaagaagca ctatagaatg
     3241 gttacagaaa aacttcttaa gtatctgtgt aatagtatta tatgcatact taaactacag
     3301 aggggaaaag caaagacaaa tactttattt ggctgattat gttagataca aatgtttctg
     3361 agaagagaat acataattga gtttagtgat gctttgctat agcaagcaaa cccactttta
     3421 tgcaatttta gaaatggggc agggaaacaa aatgtggtca ttcatcagtc acttagtcat
     3481 tgagcctttt atattgtacc tggaaattaa attccagcaa tgacaaaagt tttgtgtatt
     3541 cattaaaaga aaactaactg gaaaacaggt tagattaatt cagtactatt aaaaaagaat
     3601 tcagagctgt taatatttta tcacaggata ggatacttaa aatatagcat tctgtgctga
     3661 gatctaaggt gaagtctata aagattaaag ttcccttttt tctgatgttc aagttgattg
     3721 ttgttcagta tggcatatat gacaaaagta tatttgagtc aaatgtggct ttctaaaatg
     3781 gatgcaacat tagcgttgca aacaaaatca gcactatatt tcttaatgat ctaaagatta
     3841 atttgagaga acacagtttt cttaaatatt ataatgtcta gagttttttt aggacagtct
     3901 tagcaagtat gattgttcta gtcttacttg ctctaatgtt taaaggtgca attttatgcc
     3961 attattgaaa ttgattttta aaatctatat accatatgat taacatgcat tttcaatatg
     4021 aggcagtgtt tatgcagtat ttaacagagc aatctgctgc caatagagtt tggaggtgga
     4081 tatttagttt acagtgtata aacttaaaat atgcatccct ttaacaacgc tttgtgttag
     4141 catgctgcaa atcaaaatgg cacttaatat taaaagctgg tttagggaaa ttttatgaaa
     4201 atcctgttca taaatgtaat gcatatgata tgtactttta agttttagtt gcttcatgtt
     4261 tacattcagc tgttcaacat aattaaaatg taattttact tcatgctata ttgtggcttt
     4321 gtgtttcaaa taatgttcac ctttctgttt ttgcaccaga taagaatcag ttccttgaga
     4381 ataaattttt tatctttctt aacttcagaa tattaaattt ggaatatcta ctaaaattgt
     4441 gtgttatgtg gctgtaaatg atgtacacgc tgtaaaataa gatcgctact gttatgtggg
     4501 attattattt ctaaatgtta ctcattgaaa tgagcataca ataaaaagca tttattgca
//
