LOCUS       NM_001370215            3558 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 71 (ZNF71), transcript variant 3,
            mRNA.
ACCESSION   NM_001370215 XM_011527193
VERSION     NM_001370215.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3558)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3558)
  AUTHORS   Ye,Q., Mohamed,R., Dakhlallah,D., Gencheva,M., Hu,G., Pearce,M.C.,
            Kolluri,S.K., Marsh,C.B., Eubank,T.D., Ivanov,A.V. and Guo,N.L.
  TITLE     Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer
  JOURNAL   Int J Mol Sci 22 (7), 3752 (2021)
   PUBMED   33916522
  REMARK    GeneRIF: Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung
            Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3558)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3558)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3558)
  AUTHORS   Kim,J.H., Cheong,H.S., Park,J.S., Jang,A.S., Uh,S.T., Kim,Y.H.,
            Kim,M.K., Choi,I.S., Cho,S.H., Choi,B.W., Bae,J.S., Park,C.S. and
            Shin,H.D.
  TITLE     A genome-wide association study of total serum and mite-specific
            IgEs in asthma patients
  JOURNAL   PLoS One 8 (8), e71958 (2013)
   PUBMED   23967269
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3558)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   7  (bases 1 to 3558)
  AUTHORS   Mataki,C., Murakami,T., Umetani,M., Wada,Y., Ishii,M., Tsutsumi,S.,
            Aburatani,H., Hamakubo,T. and Kodama,T.
  TITLE     A novel zinc finger protein mRNA in human umbilical vein
            endothelial cells is profoundly induced by tumor necrosis factor
            alpha
  JOURNAL   J Atheroscler Thromb 7 (2), 97-103 (2000)
   PUBMED   11426589
REFERENCE   8  (bases 1 to 3558)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   9  (bases 1 to 3558)
  AUTHORS   Aubry,M., Marineau,C., Zhang,F.R., Zahed,L., Figlewicz,D.,
            Delattre,O., Thomas,G., de Jong,P.J., Julien,J.P. and Rouleau,G.A.
  TITLE     Cloning of six new genes with zinc finger motifs mapping to short
            and long arms of human acrocentric chromosome 22 (p and q11.2)
  JOURNAL   Genomics 13 (3), 641-648 (1992)
   PUBMED   1639391
REFERENCE   10 (bases 1 to 3558)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY138791.1, CR989498.1, AF269249.1, BC014280.2, BQ932244.1,
            CA416578.1, AC007228.1 and AA580897.1.
            
            On May 2, 2019 this sequence version replaced XM_011527193.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.39701.1,
                                           SRR1803616.94994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599599.7/ ENSP00000471138.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                HY138791.1         31-59
            30-521              CR989498.1         18-509
            522-1829            AF269249.1         247-1554
            1830-1960           BC014280.2         1681-1811
            1961-1961           BQ932244.1         434-434
            1962-2898           BC014280.2         1813-2749
            2899-2899           CA416578.1         365-365             c
            2900-3254           BC014280.2         2751-3105
            3255-3292           AC007228.1         77056-77093
            3293-3449           AA580897.1         105-261             c
            3450-3450           AC007228.1         77251-77251
            3451-3553           AA580897.1         1-103               c
            3554-3558           AC007228.1         77355-77359
FEATURES             Location/Qualifiers
     source          1..3558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3558
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /note="zinc finger protein 71"
                     /db_xref="GeneID:58491"
                     /db_xref="HGNC:HGNC:13141"
                     /db_xref="MIM:194545"
     exon            1..127
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /inference="alignment:Splign:2.1.0"
     exon            128..212
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1829
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /note="isoform 2 is encoded by transcript variant 3;
                     endothelial zinc finger protein induced by tumor necrosis
                     factor alpha; Kruppel-related zinc finger protein"
                     /codon_start=1
                     /product="endothelial zinc finger protein induced by tumor
                     necrosis factor alpha isoform 2"
                     /protein_id="NP_001357144.1"
                     /db_xref="CCDS:CCDS92695.1"
                     /db_xref="GeneID:58491"
                     /db_xref="HGNC:HGNC:13141"
                     /db_xref="MIM:194545"
                     /translation="MAAQLLTDEALESVTFRDVTVDFTQEEWQQLEPAQKDLYRDVML
                     ENYRNLVSLDWETRPEMKELDPKNDISEDKLSVVGEATGGPTRNGARGPGSEGVWEPG
                     SWPERPRGDAGAEWEPLGIPQGNKLLGGSVPACHELKAFANQGCVLVPPRLDDPTEKG
                     ACPPVRRGKNFSSTSDLSKPPMPCEEKKTYDCSECGKAFSRSSSLIKHQRIHTGEKPF
                     ECDTCGKHFIERSSLTIHQRVHTGEKPYACGDCGKAFSQRMNLTVHQRTHTGEKPYVC
                     DVCGKAFRKTSSLTQHERIHTGEKPYACGDCGKAFSQNMHLIVHQRTHTGEKPYVCPE
                     CGRAFSQNMHLTEHQRTHTGEKPYACKECGKAFNKSSSLTLHQRNHTGEKPYVCGECG
                     KAFSQSSYLIQHQRFHIGVKPFECSECGKAFSKNSSLTQHQRIHTGEKPYECYICKKH
                     FTGRSSLIVHQIVHTGEKPYVCGECGKAFSQSAYLIEHQRIHTGEKPYRCGQCGKSFI
                     KNSSLTVHQRIHTGEKPYRCGECGKTFSRNTNLTRHLRIHT"
     exon            213..339
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /inference="alignment:Splign:2.1.0"
     exon            340..3558
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2481..2486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /note="hexamer: AATAAA"
     polyA_site      2502
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /note="major polyA site"
     regulatory      3532..3537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
                     /note="hexamer: AATAAA"
     polyA_site      3558
                     /gene="ZNF71"
                     /gene_synonym="EZFIT"
ORIGIN      
        1 attgtcctgg cagagcggcg agccggtgag tgtggctgcg gggtcgcgcc caccctctac
       61 ctgtgccggg ggccggaacc tggccccggg gagggcgcgg cctcggggag acggcgtgca
      121 ggcccagcac tgttggtcac cgcaggcctg tcttcctatt caccgtgggc agcagaggga
      181 tggctgctca gctgctgact gatgaggcac tggaatcagt gacgttcagg gatgtgactg
      241 tggacttcac ccaggaggag tggcagcagc tggagcctgc ccagaaggac ctgtacaggg
      301 atgtcatgct ggagaactac aggaacctgg tctcactgga ctgggagact agacctgaaa
      361 tgaaagagtt ggatccaaag aatgacattt cggaagacaa gctctccgtt gttggggagg
      421 ccacgggggg acccacgagg aatggtgcca ggggtcctgg ctcagaagga gtgtgggaac
      481 caggcagctg gccagagagg ccgcggggag atgcaggtgc agagtgggag ccattgggaa
      541 ttccccaggg gaacaaactc ttagggggct cagtacccgc atgtcatgaa ctgaaggcat
      601 ttgccaacca aggctgtgtc ctggtcccac cacggctgga cgaccccaca gaaaaggggg
      661 cctgtccacc cgtaaggcgt ggcaagaact tctccagcac ttcagacctc agtaagcccc
      721 ccatgccctg cgaggagaag aaaacctacg actgcagcga gtgtggcaag gcctttagcc
      781 gaagctcgtc cctgataaag caccaaagga tccacacggg agaaaagccg tttgagtgtg
      841 acacctgtgg gaagcacttc atcgagcgct cgtccctcac catccaccag cgggtgcaca
      901 cgggcgagaa gccctatgcc tgcggggact gcggcaaggc cttcagccag cgcatgaacc
      961 tcactgtgca ccagcgcacg cacacgggcg agaagccgta tgtgtgcgac gtgtgtggca
     1021 aggccttccg gaagacttcc tctctcaccc agcacgagcg gatccacacg ggggagaagc
     1081 cctacgcgtg cggggactgc ggcaaggcct tcagccagaa catgcacctc atcgtgcacc
     1141 agcgcacgca caccggggag aagccgtacg tgtgccccga gtgcgggcga gccttcagcc
     1201 agaacatgca cctgaccgag caccagcgca cgcacaccgg ggagaagccg tacgcctgca
     1261 aggagtgcgg caaggccttc aacaagagct cctcgctcac cctgcaccag aggaaccaca
     1321 ccggcgagaa gccctacgtg tgcggcgagt gcggcaaggc cttcagccag agctcctacc
     1381 tcatccagca ccagcgcttc cacatcggcg tgaagccgtt cgagtgcagc gagtgcggca
     1441 aggccttcag caagaactcc tcgctcacgc agcaccagcg catccacacc ggcgagaagc
     1501 cctacgagtg ctacatctgc aagaagcact tcacggggcg ctcgtccctc atcgtgcacc
     1561 agatcgtgca caccggggag aagccctacg tgtgcggcga gtgcggcaag gccttcagcc
     1621 agagcgccta cctcatcgag caccagcgga tccacaccgg cgagaagccg tacaggtgcg
     1681 gccagtgcgg gaagtccttc atcaagaact cctccctcac tgtgcaccag cggatccaca
     1741 cgggcgagaa gccctaccga tgcggcgagt gcgggaagac cttcagccgc aacacgaacc
     1801 tgacgcgcca cctgcggatt cacacctgag cgcctctgtg cagggctctc actggcggtg
     1861 cccaggacgg acgccagatg gctgcgcgct ttgtcagcag tgctgtgaga agttctcccc
     1921 tggggtgggg actcggggtc aggggagctc aggaatgtgg ggttgtggag gggctggctg
     1981 atcacacatg ccccctcctt actgagcctc agaaagcaag cccctcggtg tctgacgtat
     2041 ctggggacac ttcaaggttc actgtagctg agccatggcc gctggtaaca gacatcaggg
     2101 ttccagacta gccctcttga gtaactgtcc tagagctggg acaggtcacg cctgcctcca
     2161 catctctgtt tcttcagcgg gaaagtggag ctggtggagg ggagggagga gacatctccc
     2221 tctttgtcag atacatcctg gagtccagat gcagcttgtc accatctgca ttttctccgt
     2281 gggttgggag cgtgagggcc ttcctatccc tccacccacc gtttccctgc agtgcacgct
     2341 ggcagccacc aagctaggaa gtggcaggag tttgccggtt gtttgtgagg ggaaaaattt
     2401 ttttttcaga gttagcaaat aacagtaact actgctttga atgccaaagt ttcttagagt
     2461 ggtctgttac gttttttaaa aataaaactt ttaattaagg gagactatgt tattttaaac
     2521 agtcttctgt tttggccagt tgtctggtca aaatcggctt cagtgattgt gggaggggca
     2581 agaaggaaaa gaaacagcag caggtttgat attcagaaag aaatatgcat ggattcaata
     2641 agtatataca tctgagcaca gattattttt atagtgattt ttgcagctaa atgtgaaggc
     2701 aactgtctta agtcccttcc tgctgctgta acaaaagacc ttagactggg taatttataa
     2761 acaatagaaa tttgtcactc atggttctgg atgctgggaa gtccaagatc aaggctctgg
     2821 cagatttggt gtctgatggg gtatgttctt cataggtagt gcttgtgtct tgatgtgtgt
     2881 cttcacgtgg ttgtaaacgg cagacttcct caggcccctt ataagggtgc taatcccagt
     2941 cacaagggcc ctgacctcat gacctcccaa aggtcctccc tcttcatact gttacattgg
     3001 ggatcaagtt tccaatatgt gaatacaggg aagcaccaac agaccatatc agtaacttcg
     3061 agtgagtttc ctaaggccga ctgaagctct gtttacacat aagagtgttc cccaaagtgc
     3121 actttctctg gggcctttta ggccatactt ttaattttgt tatttgatac tactggttgc
     3181 taatgttctg gcatttccag ttgttccaca ctccctgaca ctggtgtaca caaataaata
     3241 atacagaaaa aaaattatat cagcaagcac attctgcaaa taagaaaaac agccactcgg
     3301 gcacgtataa acaaggtgga ccgtttttca aattctggca gtcaagtggg cctcagggtg
     3361 ggtttgattc aggctctcat cattggagcc atagctgtgg ttctctgtga tgctctggct
     3421 ctcccttcat acttcttaac atcatcctca ggctggcttc ccacgtggga ttgtggtggt
     3481 ttccagcagc gagtcttgat cagacattgc tttagttgca tctgttgtgg gaataaatga
     3541 gaatatgtat gcactgca
//
