LOCUS       NM_021269               4004 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 708 (ZNF708), transcript variant
            1, mRNA.
ACCESSION   NM_021269
VERSION     NM_021269.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4004)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 4004)
  AUTHORS   Rousseau-Merck,M.F., Duro,D., Berger,R. and Thiesen,H.J.
  TITLE     Chromosomal localization of two KOX zinc finger genes on chromosome
            bands 7q21-q22
  JOURNAL   Ann Genet 38 (2), 81-84 (1995)
   PUBMED   7486829
REFERENCE   3  (bases 1 to 4004)
  AUTHORS   Thiesen,H.J., Bellefroid,E., Revelant,O. and Martial,J.A.
  TITLE     Conserved KRAB protein domain identified upstream from the zinc
            finger region of Kox 8
  JOURNAL   Nucleic Acids Res 19 (14), 3996 (1991)
   PUBMED   1861988
REFERENCE   4  (bases 1 to 4004)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   5  (bases 1 to 4004)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022432.5.
            
            On Nov 23, 2018 this sequence version replaced NM_021269.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131527.1, SRR1803616.215456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267764, SAMN03267769
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356929.3/ ENSP00000349401.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC022432.5         57408-57608         c
            202-328             AC022432.5         38699-38825         c
            329-424             AC022432.5         37444-37539         c
            425-4003            AC022432.5         19359-22937         c
            4004-4004           AC022432.5         19358-19358         c
FEATURES             Location/Qualifiers
     source          1..4004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..4004
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /note="zinc finger protein 708"
                     /db_xref="GeneID:7562"
                     /db_xref="HGNC:HGNC:12945"
     exon            1..201
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1890
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 15-like 1 (KOX 8); ZNF15, ZNF15L1"
                     /codon_start=1
                     /product="zinc finger protein 708 isoform 1"
                     /protein_id="NP_067092.2"
                     /db_xref="CCDS:CCDS32980.1"
                     /db_xref="GeneID:7562"
                     /db_xref="HGNC:HGNC:12945"
                     /translation="MGPLTFMDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLG
                     IAVSNLDLITCLEQGKEPWNMKRHEMAAKPPAMCSHFAKDLRPEQYIKNSFQQVILRR
                     YGKCGYQKGCKSVDEHKLHKGGHKGLNRCVTTTQSKIVQCDKYVKVFHKYSNAKRHKI
                     RHTGKNPFKCKECGKSFCMLSQLTQHEIIHTGEKPYKCEECGKAFKKSSNLTNHKIIH
                     TGEKPYKCEECGKAFNQSSTLTRHKIIHTGEKLYKCEECGKAFNRSSNLTKHKIVHTG
                     EKPYKCEECGKAFKQSSNLTNHKKIHTGEKPYKCGECGKAFTLSSHLTTHKRIHTGEK
                     PYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHLTNHKVIHTGEKPY
                     KCEECGKAFTKSSTLTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTEDKPYKC
                     EECGKTFNYSSNFTNHKKIHTGEKPYKCEECGKSFILSSHLTTHKIIHTGEKPYKCKE
                     CGKAFNQSSTLMKHKIIHTGEKPYKCEECGKAFNQSPNLTKHKRIHTKEKPYKCK"
     exon            202..328
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..424
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..4004
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3975..3980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /note="hexamer: AATAAA"
     polyA_site      4004
                     /gene="ZNF708"
                     /gene_synonym="KOX8; ZNF15; ZNF15L1"
                     /note="major polyA site"
ORIGIN      
        1 actcagacac gcagctggac cggacagggc ggcttccggg tttggcgcgg cctttgtctc
       61 ttgctgcagc cggagctccg gtctcgtctt cactgctgtt tgtcctctgc tcctagaggc
      121 ccagactctg tggctctgtg acctgcaggt attgggagat ccacagctaa gactccagga
      181 ccctctggaa gcctagaaat gggaccattg acatttatgg atgtggccat agaattctct
      241 ctggaggagt ggcagtgcct ggacacagca cagcagaatt tatataggaa tgtcatgtta
      301 gagaattata gaaacctggt attcctgggt attgctgtgt ctaatttaga cctgatcacc
      361 tgtctggagc aaggaaaaga gccctggaat atgaagagac acgagatggc agccaaaccc
      421 ccagctatgt gttctcattt tgccaaagac cttaggccag agcaatatat aaaaaattct
      481 ttccaacaag tgatactgag aagatatgga aaatgtggat atcagaaagg ctgtaaaagt
      541 gtggatgagc ataagttgca caaaggaggt cacaagggac ttaaccggtg tgtgacaact
      601 acccagagca aaatagttca gtgtgacaaa tacgtgaaag tctttcataa atattcaaat
      661 gcaaagagac ataagataag acatactgga aaaaatcctt tcaaatgtaa agaatgtggc
      721 aaatcatttt gcatgctttc acaactaact caacatgaga taattcatac tggagaaaaa
      781 ccctacaaat gtgaagaatg tggcaaagct tttaaaaagt cctcaaacct tacgaatcat
      841 aagataattc atactggaga gaaaccctac aaatgtgaag aatgtggaaa agcttttaac
      901 cagtcctcaa ctcttactag acataagata attcatactg gagagaaact ctacaaatgt
      961 gaagaatgtg gcaaagcttt taaccggtcc tcaaacctta ctaaacataa gatagttcat
     1021 actggagaga aaccctacaa atgtgaagaa tgtggcaaag cttttaaaca gtcctcaaac
     1081 cttactaatc acaagaaaat tcatactgga gagaaaccct acaaatgtgg agaatgtggc
     1141 aaagccttta ccctatcttc acaccttact acacataaga ggattcatac tggtgagaaa
     1201 ccctacaaat gtgaagaatg tggcaaagct tttagtgtat tttcaaccct tactaaacat
     1261 aagataattc atactgaaga gaaaccctac aaatgtgaag aatgtggcaa agcttttaac
     1321 cggtcctcac accttactaa tcataaggta attcatactg gagagaaacc ctacaaatgt
     1381 gaagaatgtg gtaaagcctt taccaagtcc tcaactctta cttatcataa ggtaattcat
     1441 actggaaaga aaccctacaa atgtgaagaa tgtggtaaag cctttagtat attctcaatc
     1501 cttactaaac ataaagtaat tcatactgaa gacaaaccct acaaatgtga agaatgtggc
     1561 aaaactttta actactcctc aaattttact aatcataaaa aaattcatac tggagagaaa
     1621 ccctataagt gtgaagaatg tggcaaaagc tttattctgt cctctcatct tactacacat
     1681 aagataattc atactggaga gaaaccctac aaatgtaaag aatgtggcaa agcttttaac
     1741 cagtcctcaa cccttatgaa acataagata attcatactg gagagaaacc ctacaaatgt
     1801 gaagaatgtg gcaaagcctt taaccagtcc ccaaacctta ctaaacataa gagaattcat
     1861 accaaagaga aaccctacaa atgtaaataa tgtgtcaaat cctttagtgt attttcaact
     1921 tttattaaaa cacaagataa ttcatactgg agagaaatcc tacaaatgtg ataaatgtgg
     1981 caaagccttt aactggctct taatccttat gaaacaaaag ataattcata ctagagagaa
     2041 accctacaaa tgtaaagaat gtggcaaagc atttaactgg tccctaaatc ttactaaaca
     2101 taaaaaaact taaactggag agaaactaca aagctggaag acatcacagt aattctgaca
     2161 acacctcaaa cttttctaaa cataaaataa atcatactgg tgaggaactt taaaaatgcg
     2221 aaaaatgtga caaaatcttt aaatgattgt cacacttgat tgtaggtaag ataattctta
     2281 ctagaaaaac tcttacaagt gtgaagaatg tggcaaaatt tttaatgaat actcacacct
     2341 tattgccagg aaagcattta tacttgagaa aaattgtacc aatataaaga ctgtgaaaaa
     2401 gccattaatg tctgctcaca tcttactcaa catcagagag tacttaaaaa aagtattata
     2461 aatttaatta ctgtcaaaaa gtatttcaga aaatataagc ttttaaagta tttattttga
     2521 agacaaacat tacaaataaa agaggattgt aataccttta tttgtatcac agatcttatt
     2581 gtacacattt tgtactagag aaaaccctga agcagttact taaactttgt tcaacatcag
     2641 ggaattcaga ttggagaaaa accctgcaaa tgtaataaat ttgaaaaaaa agttttccaa
     2701 aactacaact tagacaacac cagagggttc atactgagat atatttttgc agatgcagta
     2761 tatatttaaa acatttaatc caaaataagt ctatgtaaat atcagagaat tcacagtgga
     2821 aatatctaag gtagggccgg gcatggtggc tcacgcctgt aatgccagca ctttgggagg
     2881 ctgaggtggg cagatcatga ggtcaacaga ttgagaccat cctggtcaac atggtaaaac
     2941 cctgtctcta ctaaaaatac aaaaattagc tgggcgtggc ggcacgtgcc tgtagtctca
     3001 gctacttggg acgctgaggc aggaaaatcc gttgaaccca ggaggcagag gttgtagtga
     3061 gccgagattg caccactgca ctccagccgg gtgacagagt gagactccat ctcaaaaaca
     3121 aacaaactaa ggtatggatg cttcagacat tacactatat caaagtgctg actgttaaaa
     3181 atgatcccaa actaacggta gataaattta tttgtacata actttaaaag gagtagaaga
     3241 ttttttggaa gtttgtaatt acattcaaag tatacttttt ttgtttgttt gttttccttg
     3301 agacagagtc tctctctgtc gtccaggctg gagtgcagtg gcacaatctc agctcgctgc
     3361 aacctctgcc tcctgggttc aagcaattct cctgcctcag cctactgagt agctgagatt
     3421 acaggtgcac accaccacgt ccggctgact tttgtatttt tagtagggac ggggtttcac
     3481 catattggtc agggtagtct tgaactcctg acctcatgct ctgcccagct tggcttccca
     3541 aagtgctgtg attacaggct taagccacag cgcccggccc aaagtgttct tttttccttg
     3601 aaaagaagta cagatttttt aaaaagctaa tattgctgtg attcaactct ctagttactt
     3661 gatgctattt cttcatttct attgtattca catgtgaaag catgtgatca gttgtcacgg
     3721 catcaaagat aggagagttt cttttttttt aggtgggcat tatttatgac cttttctttg
     3781 gaagagtaag gacattaaaa tgtaacatgc atgatgaaaa tctaagtgga gatggtattt
     3841 gtggttaatt atgatattga gtggtgcatg aggtaggtgt ttagagtaat attcttttgc
     3901 attatagtaa gaacatttaa gttttgttaa aattaaaaaa ttagtacgtt attttactat
     3961 ttgtactttt atgtaataaa atgcagtaca tttttaaatt ttca
//
