LOCUS       NM_016096               2672 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 706 (ZNF706), transcript variant
            2, mRNA.
ACCESSION   NM_016096 NM_001042511
VERSION     NM_016096.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Chu,J., Jiang,J., Fan,X., Liu,J., Gao,K., Jiang,Y., Li,M., Xi,W.,
            Zhang,L., Bian,K., Yang,A. and Zhang,R.
  TITLE     A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer
            progression and redox balance in human hepatocellular carcinoma
  JOURNAL   Cell Death Differ 31 (10), 1333-1348 (2024)
   PUBMED   38862581
  REMARK    GeneRIF: A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes
            to cancer progression and redox balance in human hepatocellular
            carcinoma.
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Sahoo,B.R., Kocman,V., Clark,N., Myers,N., Deng,X., Wong,E.L.,
            Yang,H.J., Kotar,A., Guzman,B.B., Dominguez,D., Plavec,J. and
            Bardwell,J.C.A.
  TITLE     Protein G-quadruplex interactions and their effects on phase
            transitions and protein aggregation
  JOURNAL   Nucleic Acids Res 52 (8), 4702-4722 (2024)
   PUBMED   38572746
  REMARK    GeneRIF: Protein G-quadruplex interactions and their effects on
            phase transitions and protein aggregation.
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Dossena,S., Gandini,R., Tamma,G., Vezzoli,V., Nofziger,C.,
            Tamplenizza,M., Salvioni,E., Bernardinelli,E., Meyer,G.,
            Valenti,G., Wolf-Watz,M., Furst,J. and Paulmichl,M.
  TITLE     The molecular and functional interaction between ICln and HSPC038
            proteins modulates the regulation of cell volume
  JOURNAL   J Biol Chem 286 (47), 40659-40670 (2011)
   PUBMED   21917931
  REMARK    GeneRIF: functional interaction between ICln and HSPC038
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Bukszar,J., Khachane,A.N.,
            Keefe,R.S., Perkins,D.O., McEvoy,J.P., Stroup,T.S., Vann,R.E.,
            Beardsley,P.M., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genome-wide pharmacogenomic study of neurocognition as an indicator
            of antipsychotic treatment response in schizophrenia
  JOURNAL   Neuropsychopharmacology 36 (3), 616-626 (2011)
   PUBMED   21107309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001330.3 and AP003469.3.
            
            On Feb 27, 2020 this sequence version replaced NM_016096.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068524.1, SRR18074968.3323056.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311212.9/ ENSP00000311768.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AP001330.3         155393-155631
            240-376             AP003469.3         136518-136654       c
            377-484             AP003469.3         134901-135008       c
            485-2672            AP003469.3         131963-134150       c
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..2672
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /note="zinc finger protein 706"
                     /db_xref="GeneID:51123"
                     /db_xref="HGNC:HGNC:24992"
                     /db_xref="MIM:619526"
     exon            1..239
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /inference="alignment:Splign:2.1.0"
     exon            240..376
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..472
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /codon_start=1
                     /product="zinc finger protein 706"
                     /protein_id="NP_057180.1"
                     /db_xref="CCDS:CCDS6291.1"
                     /db_xref="GeneID:51123"
                     /db_xref="HGNC:HGNC:24992"
                     /db_xref="MIM:619526"
                     /translation="MARGQQKIQSQQKNAKKQAGQKKKQGHDQKAAAKAALIYTCTVC
                     RTQMPDPKTFKQHFESKHPKTPLPPELADVQA"
     exon            377..484
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /inference="alignment:Splign:2.1.0"
     exon            485..2672
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /inference="alignment:Splign:2.1.0"
     regulatory      762..767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /note="hexamer: AATAAA"
     polyA_site      796
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /note="major polyA site"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /note="hexamer: ATTAAA"
     polyA_site      2672
                     /gene="ZNF706"
                     /gene_synonym="HSPC038; PNAS-106; PNAS-113"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcggcgt gcgcgggcac gaggcgtagt ggtctcccct aaggctgagg cggcggcggg
       61 cgcgcggcgg cggcgggcgt gcgaggctgt tgtgctcccg gctctcgtgt ttcccctcct
      121 gagcgggtgg aggaggccca agcggtgctg ggcgcgctcc cccttccttt ccctccggcg
      181 tcctctcccg gccctctcgc gctgcactgt ctctccgacg caagactgtc ccggcccgga
      241 tatggctcgt ggacagcaga aaattcagtc tcagcagaaa aatgccaaaa agcaagctgg
      301 acaaaagaag aaacaaggac atgaccaaaa ggctgctgcc aaagctgcct taatatatac
      361 ctgcactgtc tgtaggacac aaatgccaga ccctaagacc ttcaagcagc actttgagag
      421 caagcatcct aagactccac ttcctccaga attagctgat gttcaggcat aaggttgttt
      481 acaggtgaat tcatgacacc tttgactctt ctactgtctc agaccttagg taacatacct
      541 gcagctgctt ttctaacaaa ctgttgatca gcaaaaataa aggggctaca gaaacactca
      601 tttttatgct gttccctctt gggcttcatg caaagacaat tctgtgtaaa tgtacagttg
      661 actctgattt ggaaatatga aaatcagtcc atccttgtta taaaaaattt ttttacaatt
      721 gtaattatat tgatgttcat attgtgtaaa ataactcatt taataaaata gtactttgat
      781 ttacgacatc acaggataaa tggttttaga aattctgttc taactttcca cattatttgc
      841 cttataaaaa tctaatgaat tcatcagcta gaattgcaag tgcaattctt atatcccttt
      901 ctctgctcag tggcaggttc ctcagttaaa ctagagcaga ctgattcatt aaaattgtgc
      961 atacgatttt atgggcagct gatgatctag gtgaaaaatg acttatctgc tgccttagta
     1021 tattgcggtt atgtgtcatt gtacccctct gatcatttcc tgtgtttgag ttggaatatt
     1081 taaaattgca gtatgacctg gctctaactg ccagtcaggt gtaccctgta gataactgat
     1141 agcttcctaa aagcggttgg attgtcagtg agcccttgtg aaaggttagg ttctaatgta
     1201 tatgccgtaa tgaaataatc attaagccta ttgtttaatg caaaatatgg aacaaatgtg
     1261 aactggtaaa ggtcgatctt gatactatat tctttgaaaa ttcttgaagt tctttaattt
     1321 gaaattgaaa cattaatttt tgaggttttt ggaagttact atttggccat ttttacaaat
     1381 ggattttgca ttaacaggaa gattggaatg acttgtggct ggattaattc ccagaaccct
     1441 ctccctcctt tcttttctaa gtgagttgtt gattttagga gtttgctttg tgctgttacc
     1501 taaaatcaga gactggtgta cagtatgact tccatctgaa cttgaaaagt attaaaatgg
     1561 gtcaatattc acattctttt agatctcagg atgggaaaat gggtttgttc agatggatat
     1621 ggtaaatctt acccaattaa ggaaggctaa ttttagagtt cttctaattt gcttgtgtca
     1681 actcttaact tgtaaaactg ctgttaactc ggtttaaatt tttaaattaa tataatagaa
     1741 agaacactaa aatacttact ggtaactgct tagagccatt tatctgatcc tgtggattac
     1801 agaatgcatt ccctcttctg ctgtagctta tcattgcttt gttttgtagc tctgcatatt
     1861 ttgcccacct tgtcttccct gtaagtttaa gacgtttcca aggaaaagct tcagggctga
     1921 tagtttctta gcaattccta ttcttatgcc cttactttaa aatagtcctt ttattttgtg
     1981 tattttattt cctaagtttc agatgtaata tctgttgttt cctaacatgt cgattaccag
     2041 aacgttagaa ttttacctaa tttcttgtgg atattgcaga agttctggtt aaatcacaac
     2101 ttaaaagttt ttaaaagtgc tttgagcata tgtatatgtt tagtgacaaa tcatataaaa
     2161 ccattcacaa gttttggttt tttttttttc gtttgtttta gtgactaatt caggatgaaa
     2221 gtttttttgt tcttgtattt aacccttttt tataagcagc tgaagacacc atatttaaca
     2281 ctatatctca gtgataggga aatagctgca ttgatcttac atgagcataa tcatccttat
     2341 acttcatgag gggattatta gtacaatccc cattttactg tgtttgagtt aaaaaccaaa
     2401 catccctgta atttaatttg aagattcttt aacagattgc agcaaagttc attataaaac
     2461 tgttatggtg tcttcaaaga cttgataaaa taacactgag agagaattgg tccatttgta
     2521 tgctgtattt ctattacttg ccaaaaggaa tggggttaag attaaacttg tttccattct
     2581 cttcacatgg atattcatcc ccatgtttaa ctgacacact gggggctcag ttgtgtgctg
     2641 taatgtctta ttaaagaaga tattaaagaa aa
//
