LOCUS       NM_001033723           14386 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens zinc finger protein 704 (ZNF704), transcript variant
            1, mRNA.
ACCESSION   NM_001033723
VERSION     NM_001033723.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14386)
  AUTHORS   Wang,D., Yang,S., Lyu,M., Xu,L., Zhong,S. and Yu,D.
  TITLE     Circular RNA HSDL2 promotes breast cancer progression via miR-7978
            ZNF704 axis and regulating hippo signaling pathway
  JOURNAL   Breast Cancer Res 26 (1), 105 (2024)
   PUBMED   38937788
  REMARK    GeneRIF: Circular RNA HSDL2 promotes breast cancer progression via
            miR-7978 ZNF704 axis and regulating hippo signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14386)
  AUTHORS   Yang,C., Wu,J., Liu,X., Wang,Y., Liu,B., Chen,X., Wu,X., Yan,D.,
            Han,L., Liu,S., Shan,L. and Shang,Y.
  TITLE     Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis
  JOURNAL   Cancer Res 80 (19), 4114-4128 (2020)
   PUBMED   32651256
  REMARK    GeneRIF: Circadian Rhythm Is Disrupted by ZNF704 in Breast
            Carcinogenesis.
REFERENCE   3  (bases 1 to 14386)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 14386)
  AUTHORS   Cheng,A., Zhao,S., FitzGerald,L.M., Wright,J.L., Kolb,S.,
            Karnes,R.J., Jenkins,R.B., Davicioni,E., Ostrander,E.A., Feng,Z.,
            Fan,J.B., Dai,J.Y. and Stanford,J.L.
  TITLE     A four-gene transcript score to predict metastatic-lethal
            progression in men treated for localized prostate cancer:
            Development and validation studies
  JOURNAL   Prostate 79 (14), 1589-1596 (2019)
   PUBMED   31376183
  REMARK    GeneRIF: tumor marker zinc finger protein 704 as part of a four
            gene transcript score has prognostic value for metastatic-lethal
            progression in men treated for localized prostate cancer
REFERENCE   5  (bases 1 to 14386)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131274.1, BX112159.1, AC022598.10, BC004287.1 and BM683148.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001033723.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131274.1, SRR7346977.2555627.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327835.7/ ENSP00000331462.3
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3624              AK131274.1         1-3624
            3625-3990           BX112159.1         70-435
            3991-4303           AK131274.1         3991-4303
            4304-11224          AC022598.10        37701-44621         c
            11225-14380         BC004287.1         1-3156
            14381-14386         BM683148.1         18-23               c
FEATURES             Location/Qualifiers
     source          1..14386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..14386
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /note="zinc finger protein 704"
                     /db_xref="GeneID:619279"
                     /db_xref="HGNC:HGNC:32291"
     exon            1..211
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..453
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1471
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 704 isoform 1"
                     /protein_id="NP_001028895.1"
                     /db_xref="CCDS:CCDS34913.1"
                     /db_xref="GeneID:619279"
                     /db_xref="HGNC:HGNC:32291"
                     /translation="MTFTFQSEDLKRDCGKKMSHQHVFSLAMEEDVKTADTKKASRIL
                     DHEKENTRSICLLEQKRKVVSSNIDVPPARKSSEELDMDKVTAAMVLTSLSTSPLVRS
                     PPVRPNESLSGSWKEGGCVPSSTSSSGYWSWSAPSDQSNPSTPSPPLSADSFKPFRSP
                     AQPDDGIDEAEASNLLFDEPIPRKRKNSMKVMFKCLWKNCGKVLSTAAGIQKHIRTIH
                     LGRVGDSDYSDGEEDFYYTEIKLNTDSVADGLSSLAPVSPSQSLASPPTFPIPDSSRT
                     ETPCAKTETKLMTPLSRSAPTTLYLVHTDHAYQATPPVTIPGSAKFTPNGSSFSISWQ
                     SPPVTFTGIPVSPTHHPVGTGEQRQHAHTVLSSPPRGTVSLRKPRGEGKKCRKVYGME
                     NRDMWCTACRWKKACQRFLD"
     exon            454..557
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..790
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..891
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1159
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1264
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1359
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..14386
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14359..14364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /note="hexamer: AATAAA"
     polyA_site      14386
                     /gene="ZNF704"
                     /gene_synonym="Gig1"
                     /note="major polyA site"
ORIGIN      
        1 acacaagctc aggagtagct gccatgcaca tcagtgtcca ttaaaatgac ttgtagcaaa
       61 tctctacgtt caaagtctaa ctttgacaga caaccttact tccagcgaag tctactcccc
      121 tccctccgga gggaagaatg ggctgcggtt aagcgtttgc cctggtgtca gggccaactg
      181 cttcgaagcg ccagactttc ggagactgtg ggtggggagc attaagcggg aaatgacctt
      241 cacatttcag tcagaggact taaaacgtga ctgtggtaaa aaaatgtctc atcaacacgt
      301 gttttccttg gccatggagg aagatgtgaa aacagcagac accaaaaaag ccagccggat
      361 ccttgaccat gaaaaagaaa acactcgctc catctgtctc cttgagcaaa aaagaaaagt
      421 tgtttcctcc aacattgatg ttcctccagc aaggaaatct tcagaggaac tagacatgga
      481 caaggtgaca gcagcaatgg tactaaccag cttgtcgact agccctttgg ttcgaagtcc
      541 tcccgtgcgg ccgaacgaga gcctcagcgg atcctggaag gagggcggct gcgtgccttc
      601 cagcaccagc agcagcggct actggagctg gagcgccccc agcgaccagt ccaacccgtc
      661 cacgccgtcg ccgccgctct cggctgacag cttcaagccc ttccgcagcc ccgcgcagcc
      721 agacgacggc atcgacgagg cggaggccag caacctgctc ttcgacgagc ccattcccag
      781 gaaaagaaag aattccatga aggtgatgtt caaatgcctc tggaaaaact gtgggaaggt
      841 gctgagcact gcagcaggta tccagaaaca catccgaacc atccatctgg ggcgcgttgg
      901 agactctgac tacagtgatg gagaagagga cttttactac actgagatca agctcaacac
      961 agactcagtg gcagacgggc tgagcagcct ggccccggtc tcaccttccc agtccctggc
     1021 ttcacctcct actttcccca tcccagattc aagccgaaca gaaactcctt gtgccaaaac
     1081 ggagactaag ttgatgacgc cgttgagccg ctcagctccc accaccctct acctcgtgca
     1141 cactgaccat gcttaccagg ccacaccccc tgtgaccatt ccaggatcgg ccaagttcac
     1201 ccccaatggc agcagcttca gcatttcctg gcaatctcct ccggtcactt tcacaggcat
     1261 cccagtgtca cccacacatc atccggtggg cacaggagag cagagacagc atgcgcacac
     1321 ggtcctgtcc tccccaccca gaggcacagt cagcttaagg aagcccaggg gagagggcaa
     1381 aaagtgtcgg aaggtgtacg ggatggagaa ccgagacatg tggtgtaccg cctgccgctg
     1441 gaagaaggcc tgccagaggt tcctcgactg agagaccccc aggcagaggg gctcagggcc
     1501 ctgagccgct cctgccctgg cctgccactg caggtgttgg aaagagcttt tcctactgaa
     1561 taaaacacag ttgaagccag gaaaagccct ttcaggaacc ttggaggaat aacagcaaaa
     1621 acacagaaaa attgtttaag tcaccaccta tgacaaaaga aagttgctct tactgagaac
     1681 ccagcttgga gcagctataa ctagtttttt ttccttcaaa agaaaagtca actttttttg
     1741 ctgtatgtct agacttaaaa ctgtggactt ctgtagcaat tgaaccaaca aagcccattt
     1801 tacctagaaa ggaggcatat tttgataagc tttctgaatt atgccatttt caagattttt
     1861 ttgacactta aaaaacaagc tacaggttat tcagtagcat ttgtacaaag atcaatactt
     1921 acttttgttg tgaataatct tttccgtatc ttccatttga cttcttggag cagtatatgt
     1981 caggatgtgt tgcaagacag cgcagcactc tgggcatctt ttctatggct ttttgtttgt
     2041 ttttctttta agaatggccc cacactgaac catggtagag ctattagttt gtagggcccc
     2101 agatggcata aactcgagaa gggattgtcc acggaaatca ccagcagact tcagcccgaa
     2161 gctgagttca ggaagtccag ctgtcactgt tgggaaacat ctaggagtct tccttggatc
     2221 cataagaagc tcttccccta aaggcagcac agctaactct actctctacc tgccacaact
     2281 cagtcaagaa ttggcacctg tagccatctg ggtaagcctc gatgcttctt tcagggatgt
     2341 gacacaaatg gcaactcgga gctatttgtt actgcttgtc tgtcaagatt gtagccaggt
     2401 taatgggtca ttttccttct ctccagactc caccactgac tgatttcaga agaggtagag
     2461 aactccaaac tgtcccagca ggtttgcttt agacaacaga gcacagccca catggcccta
     2521 cctgttcaga aagtcatgtt agatcaacaa accacttcca ttctgagtgc acttttatag
     2581 gttttatgct ttagcatgtc cgggagatga gttaattaac aatataaaca ttatgtgagt
     2641 aaatggaagg tccaaacttt aagtttttct tataaaaata ttggagctat tcatttaaga
     2701 atttgctcaa aagggaacat aacgccaaaa ggaaaatgca tgtaggtata ggaatttctc
     2761 agtttagtag ggccagggct tgcactatgt tccatttatt gggcttcgta acttacttgc
     2821 ttgtttgttt gggggatagt ggtgtgggga gaggggagtc gtcaagccct ataaataagc
     2881 tcattctcta tctacccgac tctcaattgc cctgctaaag agttatttct cctataccta
     2941 tgcaaagtag gaagagcacc ttataggagg cactgtatag ggacagggga catgggatca
     3001 gccataggaa tgttaaatga aattgcacag aggaaagttt aatatatgtc tagagattat
     3061 acatacactt ttttaagcgt aaaaagaaga catctagtaa tgacagatat tctttttata
     3121 tacaagcaaa agaaagtata aggaggttct acagtgcaac atccacaatc tgtgcattca
     3181 catattatgg gacttttatt ttttaaactc tcatataaat tttttaaaat tactccttgg
     3241 aagagatcct ggtttttttc ttcatttatt tttttcttta aaaacattta ttttaagaga
     3301 agagaaaaag agcttcatct aattttgcat cttgattacc aatcagtact agtcacagca
     3361 ccagcaatac tgtatgtttt agactgacaa ggtcagccag gaaatggcat ttttttaaac
     3421 gcagaaatgt gtttgtttcc tctactctaa cacgtccttt ctcctcctgg tgtcctgtca
     3481 ccccccatgc agcaccactg atgcgagatg atgctctggc ctggtccagg aagccctgag
     3541 ccatgggcag attgcccagt ggccttgggc ggccagagct tgtcacctgt ttaaacaagt
     3601 tcaccatgtg tttaaatgac agggtacagt cctggaccag aggtttttct cttcagcaaa
     3661 gctccctggc ccttgatcgt tggactgtta ctaatagaaa aagattcaag tcatgaagta
     3721 taaaatccat cccccatccc agaactttga aacacaagga gggagagatc tttgctatgg
     3781 agcagtcctg gagcaaagcc ccgtggcttc cacccccaga tatatacccc ataagtagtg
     3841 ctgagctcca gcttagctga gccaagctca gtccttatct ggtgttcagc cagtgcacag
     3901 gtataagcag aactacagag ctgaatgtag cttccctggg atctcttctc ctttctaaag
     3961 catttttcac acagttctgt acctcctacc caagttgggg ctgctttctg cctgctagcc
     4021 cacggctctg tgtactttct tttctggctt caggtgcaga cagaccctca gtaccttcct
     4081 ggacacagac acatattccc tggaccaagg cgtggaataa ctagtagacc accaagccac
     4141 aggtggctgg tcttgaagaa aagggattat actccttaca ggccacccag aaagctatga
     4201 attccaatat acaccactga tcgtgcaagt tagggttttt tttttttaaa cgtagcatta
     4261 ttttgttata ttttggaact aaatgaagtg ccaaattaac cagacattcg tttgatgcca
     4321 tctctgtgga accaagttct ctgtgtgtgt tcgtttggct gggaggaggg ggaggactgg
     4381 gcagactgct cccacagcag gctggcagtg gaactggagc cctggccacc gcagggagct
     4441 cagaggccaa tctacgcaaa aggcatgcaa aacaatggat tctggtccca aaatatttct
     4501 aagtaaggca tgatgtagcc ttttgatttt ttttttatcc tttgacaccc cagccttcag
     4561 aaaaggtttt tcatctctct ccaaagaagt catttcatag tgactgacag gacattctcc
     4621 agagagcgac aaagcagagt ggccagcagg cagtggtgtt aagccttggg ccttcccagc
     4681 agatgtgtgc tgcattggtg ggtgggaggc agtgtgacag cctggagaaa acacacaggt
     4741 agcaagggag tcagggggga ggtacaagag ggctgtggac acctggctct tgctcatctt
     4801 cttggtgctg atcagctggt ggtcaccatc cctaagtacc tcccagggag ctgccatttt
     4861 ctcctctggg agcagctgcc tgaagcaagg agagaatgac ctgaagggaa gtacctccgg
     4921 ccaagagtgc agggctgctg tgcctagcct gagcgggcca tctctagcag atatggactt
     4981 ctctccacca cactagctga aaagttttct cccttggttg gcaaaagcca gtgtcaggaa
     5041 aaaagctgtg ggtttctgac caagaatgtg tgcgcttagc tgcaaagtgc ctgtcagcag
     5101 ctccaggcac caacaaggtg cccttttatt agacaattcc tgcccgaaca taaccatatt
     5161 gcagatgaaa attttcaata gagaatgaca caattcttga cctttctaaa aacttttcaa
     5221 agagatagtc acatgtgtat atgttgcaaa agatttttga aactgaaatg tcctccatta
     5281 aatctcaaga gcactcgagt tttaagtctg ctgtttctgg tgtcacacta agacacactt
     5341 ttgaaagcag ccctgggttc tgaattagtt ggcactgctg aatccatgtt cccccttcat
     5401 cagactccaa agtgcagcat tcacttgcaa aggttgagag aaaagtggcc agaattgtac
     5461 atataacaga gaataccttg agaatagtag caaaatactg taaataatat tcatttcctc
     5521 agggaaaaat aaagggcatg caaaaatagg tctggagact cctgaaacta ggaagaattt
     5581 tgttatcact aaagtctttt atagtcagaa caattttttt ttcaaatgaa catggtatca
     5641 tttcaagaca aatttatgtg aactgggcag tactgacatt tgtgaggcat aggggagtgc
     5701 cctgggaaaa cggtttggag ctgacctgta gcctaaggct aacatttgaa ccacaggtgc
     5761 aatgcctggg ggtgggggag ggggacgggg tgggggtggt attcctagac tcacgtaagg
     5821 ctttttctga atgtaattgt gaatacaaag ccttgctggt cctttttatc attacccaat
     5881 ggatgactgt ttattagcta tcagcagaat tccgtaggcg aaagcaagcc gtgaacgatg
     5941 tacattttgc tttaatagca tgttagcgaa caaacttcca tggacttttg tggacaaggt
     6001 gctgcttttt ctcatgaccc tgtagaattg ctatcgacca catcttctgt agcactgacc
     6061 tgtgtgaact cagggaagaa tttgtgcata caaatgagtg gaaacagagc aggattcatg
     6121 aatatgaatg agaatgtgaa tcattttgga gaatgccctg ggcacacggg tcaactggaa
     6181 atttcatttc tctaagaaag tagccctacc agcggcacgg actgttcctg ttcctcatac
     6241 ctgtggggat tcctccatat tggaactgtt tcatgtatct tttttgcatt gtaactagcc
     6301 aaacctgaag tcagtaaata aaatgagatt agcacttttt ttaggtacca gttgtatcac
     6361 tgagtaatgc acaccaatag agcaagaaag tataaaatgt atttaagacc aactggtttg
     6421 cttattatga ctgactttga aaaagcccat atccaatgat atacatgctt taaaaggtat
     6481 atctatcgta ggaccaggaa ccaaaatggg aattttactt ctggtcctgt tttgtaaata
     6541 gttccttttt ttgaagacaa tctcatgttt tataactttt gttgtgggtc tgagaatcac
     6601 aatggtaata tgtcttggca aaacataacc tttaaataca aaaacaatta taacttaatt
     6661 ttccaaataa aacaagaaat acactgatta ggcttctaca gttctaagag acatgacact
     6721 ttggtaataa gcgtcagtac tctacttctc aagttaactg gaaatatttt acaagatgca
     6781 gtgttttgta atcacaaaga acgcagacat tttgtgagaa atgaccttgg ttttatacat
     6841 tgtagcttat tttttaaaat atagtatttt accaggcagg aagtattaat attataagta
     6901 attcttgctc accaaacaaa gggctatgtc tcttttaagc aaatgttttg atgcatatct
     6961 ttttaattaa ccctctgcag caagggtaga aatacagatc agatggaatg ggtattatag
     7021 gagaatcaag atagcaacag ctactccttt taccattact agtgtgtttt caaagtatgg
     7081 aaaaagatgc ctgaagagtc attttatata ttttaaatct aaaaagtgtt aacaggtatg
     7141 cttataggcc atgggagaaa tattcttata aattttttag tgtaaaatga taaattctgt
     7201 gtcacaaaga caagtttacc acttgaccta ccagaatcac agatacttgc atttaactag
     7261 caagtatcat ttggtggaaa tttctaaaat catagtagac aggcccaaag atagaattct
     7321 taggtgatca gtagtgttta aaataatttt gtcctcagca ctaactatat aactgtaatt
     7381 tctacataag aacaagtgct tccaaaatat agtggaggga aaaaataaaa aaggaaaata
     7441 aaaaaacaaa acaaaaagaa caagtgcttg atttttcact gtgaagaact agcaggcaca
     7501 tgaggttgtg atcagaaagt gactgagttc ccaagaacca ggaaacagag gggagttgtg
     7561 aagagtttat taaaactgta caaataattc agagctttgc caaaaccatt tcataatgct
     7621 gtacagtttt ttcaagccca ctcactgtta aaacaagaaa gcaccttttc tttctaagat
     7681 tttagtaatc caaaagctag cctaattagc caagtatgca gataacatca aaagcaaagc
     7741 tgagatagaa cagccataca cccgttgggc agctcttatg aggtggtcag aaggtcactc
     7801 agaccttggt ttcaaatagg ctttagaatc tgcacacttg aggactagaa atgcacagag
     7861 ttagggaaag ccatgtacag gcttggctcc tagtctttga gatgaggcgt cttgcaaatc
     7921 tctgttttca ctccttggaa tgtctccatt gttagcatta aagtccccaa gaagttttta
     7981 ttgctgtacg gttttgaacc caatgagtct catttccaaa agattcctaa ttctatatag
     8041 gagaggttgc aaatgtcagt gcctcagaag gaccaggcaa gttctgtaaa tgattgatgt
     8101 ggataaggca aagaggaaca caagaatggt ggagaccagg ttgaactgca gaacacatgc
     8161 cctctttgaa ggggtgccca cactcagctc tagacaatca gaaccatgca gaaatcaggc
     8221 ccagggctgc tagatcttct gacgtggaag tatgatatta cctgacacgt aagtgttgac
     8281 aactaactca aactcttggc caacactgtg cagaccaaag agaagctgta cacagacagg
     8341 tgcagcctgc agcccccagt ttcaactatt gggaaaagtg gatttcacat tccacagttg
     8401 tcaggtcagg ttcatccatc agccccacaa actcacatgt cggcactatc tgggcaacta
     8461 aaataaaaga ggggaaagag atcatttctc cccagatatc attctcatgg cagacttgaa
     8521 tatagatacg ctgagttatc cagctctctc actctgcctc cttttggcat gcccaggctg
     8581 tgccccgtaa agtgttgaat cactgttatc ctaattttct tagtgttttc taccgtggcc
     8641 actgtgatga ggggctggca aagagcagcc tcgtgccttc cgagaaggct gccaggagcc
     8701 tctgaagctt gaagcgagca cacattgcct ccttgtgcca aagcccttgg ccagcctccc
     8761 cacactcctt ccctctccat ccggcctcat gagtcttcgt taccaagtaa aattaccact
     8821 gcttcacctc tgatacagca gaagccttgc ttcagaactg gtaggcattt aggctatttc
     8881 agagtgtcca ctaacctcaa aaggaggttt ttccacatac aaaaccctag catctttgag
     8941 gggaaagcaa aatgagaata aattatgtca tgaaaaaaat tagaagttgc ttccttcatt
     9001 tagatggact aagttatttt aaactctatc ttacatcaga gtcctgatgg tgttgggata
     9061 gtcactgacc ctttcacgta tgtaataaga tacgtctcgt tcacacacta tttcatttga
     9121 tctttgtaag aacccagtgt agaataggaa tatttaaaat caacattacc cacctccaag
     9181 gccaacccag agtagtcttg aacctgagtc agcctcagta ttgcttgcaa ggaagaggga
     9241 aggggctcat taaaggcctg gctcaaacct tagtcttcca gactgactag ggacgtaaga
     9301 agacccaggg acccaccatg ttctcaaacc atctattcag tccaggcctt tcagcataga
     9361 cataaagagc ccacccgtta ctcagtcatg ttgccaagtg caaactgatt tatccccaga
     9421 tgaatccctt tactgtagca gatccctaat ccctaaattt cagccaattt ggtagttaat
     9481 tataggagtt tattagctaa atgtatgttc tgagtaaaag ttttgactct ttggggaaaa
     9541 tttattttgc tgctagcata caacatttgc tatgtatata aacttaagtc aatgccagaa
     9601 attttaaaac cagctcaaat ttataatctg taatgatcaa atcaaaacat actgtaaact
     9661 cagagttgga aacgcctggt aatatggtta agtcatgttt aaatatgaat gcaatttaaa
     9721 tgacattggc aatgcctgag atttctttca ttgtgaatga ttaaaaggca gtccaatata
     9781 tgaatggatt tcatcttacc tttctcccgt taatttacta ggtgtaacat cttgagtgta
     9841 aagtcattca caggcagttg ggttgtggag ctagaaggag cctcaaaaaa aaactttttg
     9901 gccagactcc tacatcatga acagggtttt tgatgaataa tatttattat tatgtttcta
     9961 aagtaataca gtgttggaga atgaaacagt ttagtccttt cctcttctga tggaaaagaa
    10021 tcatagcgcc gttgccatga caataacagg atgtagaaag acccatgaag aaagaaagaa
    10081 gaaagctatg gttccgaaag caggtaacca cagattttga aaggaggcag agatggtgat
    10141 taaactgtag tccttgtttt ttaaaatgtt ctttcatgtt aggcaccacc acatagttaa
    10201 taactaccaa cttctaaaga gaagatcccc ttgatttatt tatatcatga aaatactaaa
    10261 aatcaattct caagtctaat taactattac attatcttgc taggtccttt tccctaaatt
    10321 tttaattcag aaaattaacc agaattggcc agatgcagtg gttcacgcct ataatcccag
    10381 cactttggga gtccaaggca gatggatcac ttgaggtcag tagttcaaga ccagcctggc
    10441 caacagagga agaaagagtg aaaacaaaag aagaaagagg gaaaccctgt ctttactaaa
    10501 aatacaaaaa ttagtcgggc gtggtggcgc acacctgtaa ttccagctac ttgagaggct
    10561 gaggcaggag aatcccttga aactgcaggc agaggttgca gtgagccaag atttcactgc
    10621 tgcacctggg gtgagactac cattaaggaa ggaaatttcc tttaaacaga aaaaaacaaa
    10681 ggtgctcatc tatttcttct gaattctctc tacatccttg acttaagagg aaaaccagca
    10741 ctcaagaaac agctttaaaa gagaacagtc cccattctag ctaccagtct tgctttcccc
    10801 catcttggca agccccagtg aatttgccat tgaaagatta ccctcccctt tgccctcatc
    10861 tgcctgagct agaggccagg ctgttgttaa tgttttttca gttccaaagc ccctgatggg
    10921 acattcttgt ttctgtgcta ctgctttctc tctcttaaat taaggtgcaa ggggataaat
    10981 attactataa ctgggatgta aggctcagtc agtgtggcta ttccctccct tcgggggaaa
    11041 tattccatct gtctgaacgg ttttaggtga tcatgaggag agcggcttag tcacacagcc
    11101 agccacgctc atcacaaaag atttgttcag actcactgta aagaatgaca aggcagatag
    11161 ctaatccttt cactgtgcct caaagcccgc cgtgcaagtc accaacccta ccggtcctct
    11221 ccacgtgcga ggctaataga gtgatcagaa ccaggaatgt gagctgggtt ccaccttagg
    11281 aggggacaat gaggacagag caagagggct ccatgtttaa ttactccagg ctctgacttc
    11341 tgcccacaat tacagagcat gaaagcagaa ttggccttta gtaagtgaaa aggaagtggc
    11401 tcctgcagca tataattgtt ataatttcgt atttatggaa agagaaaagg acttcagtcc
    11461 actcatgttg ttaagcactt gtccctcact ccactggagc ccccttccta tgttttgggc
    11521 acagatggct gggaccgaga ggaaagagga agagcggctg ccagagtgtg aatatacccc
    11581 tcagggatat acagcggagt ttcatgataa actacccata ctttcccaaa aaaggttgag
    11641 gagcaataca taactttgca gattacaaac ccttgtttta ctttttaaac cttttttcca
    11701 tactctgctt attggaaatc gatggctgtg atgtgaccaa cacctgtgat gatagcaaag
    11761 cccctccttt cacagtctcc tgactgttcg gggaacctcc ttggtcattg gtagaaagct
    11821 ttagaaaaga cttagctttt tagggaagaa ctaaaaaatc tccaaaacat actagtccca
    11881 tgacttcgat aactgaaaat gtcctgggtg taaactaacc caggaatgtg gatcatacat
    11941 gtttttttta aaaaaaatcc ctgaatcaat attttcctac aacacaccct aaaattccta
    12001 tttttgtaat taatggttgg acagtgatca gccatttaaa cataggcttt ctggaataac
    12061 cagacactag aatagtttcc aaagtgtttt gcgtatcaaa atcctatata cttagaagaa
    12121 gaactcagga taagaaaaaa tcgctaggtc ccaaagggtt catgactatc atcagatgca
    12181 actgcgagtg gcctacggtc attttttcaa atgagaagac tggagagaga gaacaacagt
    12241 aatcacaaaa cctctgttgc ccttagtcca tgacaatgtt taaggaaact ttaaaaaatt
    12301 aagccatctt ctgaattgtt ttctacacca aatctaaaat attaaaatga aattattaaa
    12361 tatttaaaat ggggtattta gtggaaatgc aatcagtaga aaacattgct ttttagtgcc
    12421 tgctaaacaa gtaaaggaga aagaatgaag agaaaacagc agtccttcct gtgtgacact
    12481 cgtgtggaaa tgacaggcat tcacatgtca ttgagtgcta actcaaaagc taggtggcaa
    12541 tgctgtccaa tgtttagaga tcttttgaaa tataatttta ccaccattca gaggtaagta
    12601 cttgcttaac agaagtcttt aatgttagtg aatgaatgta taaaattata aactatgcat
    12661 tttcaaagag tagcatgtat tttgtatcga atccaagtaa atttttttca tagctaccta
    12721 ccacaactgc aaattattca aaataaactt ggatacatat ccttatgggg atatgggaag
    12781 cccatctata ttctcctact tgatgttttt aaagattgaa actttattct gaaacatcag
    12841 gctctaaaaa attccatcat taagatgaat aaatgggaaa tggtttattt gttacttcgt
    12901 aagcataaat gggaaatgtt ggctgttaga aaatgtgccc agttctttaa aggtggatgt
    12961 tctagtaaca ctggattaac aagcaaacaa aactgcatga agtgaacgaa tatttcattg
    13021 gataaagtta gcataggttt tatctgctgg gtttaattct caatcccaga aaaaaatatt
    13081 cttcaagggg tatcagttat agtttcaaag aacaaaatat gaaaatattg tccagcaaag
    13141 caaatcattg atcttttttc aaaattactt atattttgga aagtctatat agaatatcca
    13201 caaatttctt cagccctctt gttgatttca tattttcatg aaactttttc ccctaataat
    13261 ttgtcttcgc tctttaatca gtgctttact acattactca gcctgaaaaa atatcttttc
    13321 cttcatctga caatgtggaa ataaagaact ccatttctgt cattctggtt ctcttcagtg
    13381 tccattgaga aagtttctca actgtttgta aaatacgggg ggaaaaaaac acgcatttct
    13441 aaacctggta cttaaggtta tactggattg tttgctacct aattagaagt tattggggaa
    13501 ggggcattgt gtctttttat atgattttta gccaaatcca gatgttctga tacacatttc
    13561 tgaatacctg tctgactgta aatacagcct gtggaggttc aggttgataa acctttcacc
    13621 tgactgctcc acagccatgc tccttgccag cttctggcac attgtacata gatttgttga
    13681 atgtttaaat gatgttgttt ttctaaatgc tgttctctaa aacaattttt tgaatttctt
    13741 ttgctttcca ttgttttgga ctttgtgtgt tcgtttttta aaaaaaaaaa tgtttcctaa
    13801 atatttaaca ccaggaaaaa tatttttaaa tacactggtg ctaattgaaa cagaaggaaa
    13861 ttttcagatc gaagatgtac aatgttaaat gttcatacca gttaaactgc actttcccaa
    13921 ggggacagct ggcatctact tgaaatgggc atcaagagac caccaaatgt ttacagtttc
    13981 tgtggcccgt ttaagtgtaa aatgcagaag tggctctgtc cccccagagt taaggatttg
    14041 ctacactggt cctctggaag catttaagta gaagaaaagg cttatagtca gaatcacttt
    14101 agtaatcgtc ttctggtcct tggacttttc tgttctgtaa tgcttgtaac aatgaatatg
    14161 gtgttgccaa tctagtctga tatcattgtt gacctgtact tactttgtgg atggttctac
    14221 ctggggttgc actggcacaa acagagccag aacactggac tttcaaaaga ccattttgac
    14281 ttctacagtg tccacacaca tgaatttaaa tgcacttgta actggttaat taccatgaag
    14341 taagtctaac ttccacttaa taaaagtttt tgtgtatctg cttcta
//
