LOCUS       NM_025069               3316 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 703 (ZNF703), mRNA.
ACCESSION   NM_025069 XM_940783 XM_944793
VERSION     NM_025069.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3316)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3316)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3316)
  AUTHORS   Klaestad,E., Sawicka,J.E., Engstrom,M.J., Ytterhus,B., Valla,M. and
            Bofin,A.M.
  TITLE     ZNF703 gene copy number and protein expression in breast cancer;
            associations with proliferation, prognosis and luminal subtypes
  JOURNAL   Breast Cancer Res Treat 186 (1), 65-77 (2021)
   PUBMED   33389351
  REMARK    GeneRIF: ZNF703 gene copy number and protein expression in breast
            cancer; associations with proliferation, prognosis and luminal
            subtypes.
REFERENCE   4  (bases 1 to 3316)
  AUTHORS   Wang,S., Wang,C., Hu,Y., Li,X., Jin,S., Liu,O., Gou,R., Zhuang,Y.,
            Guo,Q., Nie,X., Zhu,L., Liu,J. and Lin,B.
  TITLE     ZNF703 promotes tumor progression in ovarian cancer by interacting
            with HE4 and epigenetically regulating PEA15
  JOURNAL   J Exp Clin Cancer Res 39 (1), 264 (2020)
   PUBMED   33246486
  REMARK    GeneRIF: ZNF703 promotes tumor progression in ovarian cancer by
            interacting with HE4 and epigenetically regulating PEA15.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3316)
  AUTHORS   Wang,J., Zhu,L.S., Luo,Y., Wang,C.H., Wei,Y.Y. and Zhou,L.M.
  TITLE     Transcription factor ZNF703 activates linc-UBC1 to stimulate the
            progression of glioma
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (6), 3183-3189 (2020)
   PUBMED   32271436
  REMARK    GeneRIF: Transcription factor ZNF703 activates linc-UBC1 to
            stimulate the progression of glioma.
REFERENCE   6  (bases 1 to 3316)
  AUTHORS   Slorach,E.M., Chou,J. and Werb,Z.
  TITLE     Zeppo1 is a novel metastasis promoter that represses E-cadherin
            expression and regulates p120-catenin isoform expression and
            localization
  JOURNAL   Genes Dev 25 (5), 471-484 (2011)
   PUBMED   21317240
REFERENCE   7  (bases 1 to 3316)
  AUTHORS   Sircoulomb,F., Nicolas,N., Ferrari,A., Finetti,P., Bekhouche,I.,
            Rousselet,E., Lonigro,A., Adelaide,J., Baudelet,E., Esteyries,S.,
            Wicinski,J., Audebert,S., Charafe-Jauffret,E., Jacquemier,J.,
            Lopez,M., Borg,J.P., Sotiriou,C., Popovici,C., Bertucci,F.,
            Birnbaum,D., Chaffanet,M. and Ginestier,C.
  TITLE     ZNF703 gene amplification at 8p12 specifies luminal B breast cancer
  JOURNAL   EMBO Mol Med 3 (3), 153-166 (2011)
   PUBMED   21328542
  REMARK    GeneRIF: ZNF703 expression results in the activation of stem
            cell-related gene expression leading to an increase in cancer stem
            cells.
            Erratum:[EMBO Mol Med. 2011 Mar;3(3). doi:10.1002/emmm.201000121]
REFERENCE   8  (bases 1 to 3316)
  AUTHORS   Kwek,S.S., Roy,R., Zhou,H., Climent,J., Martinez-Climent,J.A.,
            Fridlyand,J. and Albertson,D.G.
  TITLE     Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate
            with two major pathways in oncogenesis
  JOURNAL   Oncogene 28 (17), 1892-1903 (2009)
   PUBMED   19330026
  REMARK    GeneRIF: Data show that FGFR1 and DDHD2 at 8p12 cooperated
            functionally with MYC, whereas CCND1 and ZNF703 cooperated with a
            dominant negative form of TP53.
REFERENCE   9  (bases 1 to 3316)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 3316)
  AUTHORS   Garcia,M.J., Pole,J.C., Chin,S.F., Teschendorff,A., Naderi,A.,
            Ozdag,H., Vias,M., Kranjac,T., Subkhankulova,T., Paish,C.,
            Ellis,I., Brenton,J.D., Edwards,P.A. and Caldas,C.
  TITLE     A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new
            candidate oncogenes
  JOURNAL   Oncogene 24 (33), 5235-5245 (2005)
   PUBMED   15897872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA936465.1, BC032534.1, BM770319.1, BY996877.1 and AA527152.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025069.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024361.1, BC032534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331569.6/ ENSP00000332325.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA936465.1         32-81
            51-2169             BC032534.1         11-2129
            2170-2714           BM770319.1         95-639
            2715-3313           BY996877.1         74-672
            3314-3316           AA527152.1         34-36               c
FEATURES             Location/Qualifiers
     source          1..3316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..3316
                     /gene="ZNF703"
                     /gene_synonym="NLZ1; ZEPPO1; ZNF503L; ZPO1"
                     /note="zinc finger protein 703"
                     /db_xref="GeneID:80139"
                     /db_xref="HGNC:HGNC:25883"
                     /db_xref="MIM:617045"
     exon            1..441
                     /gene="ZNF703"
                     /gene_synonym="NLZ1; ZEPPO1; ZNF503L; ZPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1971
                     /gene="ZNF703"
                     /gene_synonym="NLZ1; ZEPPO1; ZNF503L; ZPO1"
                     /note="zinc finger elbow-related proline domain protein 1"
                     /codon_start=1
                     /product="zinc finger protein 703"
                     /protein_id="NP_079345.1"
                     /db_xref="CCDS:CCDS6094.1"
                     /db_xref="GeneID:80139"
                     /db_xref="HGNC:HGNC:25883"
                     /db_xref="MIM:617045"
                     /translation="MSDSPAGSNPRTPESSGSGSGGGGKRPAVPAAVSLLPPADPLRQ
                     ANRLPIRVLKMLSAHTGHLLHPEYLQPLSSTPVSPIELDAKKSPLALLAQTCSQIGKP
                     DPPPSSKLNSVAAAANGLGAEKDPGRSAPGAASAAAALKQLGDSPAEDKSSFKPYSKG
                     SGGGDSRKDSGSSSVSSTSSSSSSSPGDKAGFRVPSAACPPFPPHGAPVSASSSSSSP
                     GGSRGGSPHHSDCKNGGGVGGGELDKKDQEPKPSPEPAAVSRGGGGEPGAHGGAESGA
                     SGRKSEPPSALVGAGHVAPVSPYKPGHSVFPLPPSSIGYHGSIVGAYAGYPSQFVPGL
                     DPSKSGLVGGQLSGGLGLPPGKPPSSSPLTGASPPSFLQGLCRDPYCLGGYHGASHLG
                     GSSCSTCSAHDPAGPSLKAGGYPLVYPGHPLQPAALSSSAAQAALPGHPLYTYGFMLQ
                     NEPLPHSCNWVAASGPCDKRFATSEELLSHLRTHTALPGAEKLLAAYPGASGLGSAAA
                     AAAAAASCHLHLPPPAAPGSPGSLSLRNPHTLGLSRYHPYGKSHLSTAGGLAVPSLPT
                     AGPYYSPYALYGQRLASASALGYQ"
     exon            442..3316
                     /gene="ZNF703"
                     /gene_synonym="NLZ1; ZEPPO1; ZNF503L; ZPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3290..3295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF703"
                     /gene_synonym="NLZ1; ZEPPO1; ZNF503L; ZPO1"
                     /note="hexamer: AATAAA"
     polyA_site      3291
                     /gene="ZNF703"
                     /gene_synonym="NLZ1; ZEPPO1; ZNF503L; ZPO1"
     polyA_site      3316
                     /gene="ZNF703"
                     /gene_synonym="NLZ1; ZEPPO1; ZNF503L; ZPO1"
                     /note="major polyA site"
ORIGIN      
        1 ggtttttgtg ttgctagccg gggccagcgg cggtggcggc ggcggcggag gcgtcggtgg
       61 aggaggggag gcggcgagga ggcgcagctc ccgctgcacc gcgatcgacg ctgcggagcg
      121 agcccacccg ccccgggagc tcgcctcccc ggtgctcccc cgccctcccc gcccccccag
      181 cggcgctgcc tcctccaaat gagcgattcg cccgctggat ctaacccaag gacacccgaa
      241 agcagcggca gcggcagcgg cggcggcggg aagaggccgg cggtgccggc agcggtgtcc
      301 ctcttgccac cggcggaccc cctgcgccag gcgaaccggc tcccgatcag ggtcctgaag
      361 atgctgagcg ctcacaccgg tcacctcctg cacccggagt acctgcagcc gctgtcctcc
      421 actcccgtca gccccattga gctggacgcc aagaagagcc ccttggcgct gctggctcag
      481 acctgctcgc agatcggcaa gccggacccg ccgccctcct ccaaactcaa ctcggtggcg
      541 gcggcggcca acgggctggg agcggagaag gaccccggcc gctcagcccc gggcgccgcc
      601 tccgcagccg cggccctgaa gcagctgggg gactcaccgg ccgaggacaa gtccagcttc
      661 aagccctact ccaagggctc cggcggcggc gactcccgca aagacagcgg ctcctcctcg
      721 gtgtcttcca cctcctcctc gtcctcctcg tccccgggag acaaggcggg cttcagggtc
      781 cccagcgccg cctgcccgcc ctttcccccg catggagcgc cggtctccgc atcctcgtcc
      841 tcgtcgtcgc ccggcggctc ccgcggcggc tccccgcacc actctgactg caagaacggc
      901 ggcggggttg gcggcgggga gctggacaag aaagaccagg agcccaagcc cagcccggag
      961 ccggcagccg tgagccgcgg cggcggtggg gagcccgggg cgcacggtgg cgccgagtcc
     1021 ggggcctccg ggcgcaagtc cgagccgccc tcggcgctgg tgggggccgg ccacgtggcg
     1081 ccggtgtctc cctacaagcc gggccactcg gtgttcccgc tgccgccctc cagcattggc
     1141 taccacggct ccatcgtggg cgcctacgcc ggctacccgt ctcagttcgt gcctggcctg
     1201 gatcctagca agtccggcct cgtgggaggc cagctgtctg ggggcctggg cctgccgccg
     1261 ggcaagcccc ccagctccag cccgctcacc ggggcctccc cgccctcctt cctgcaggga
     1321 ttatgccgcg acccctattg cttgggaggt taccacggcg cctcgcacct cggcggctcc
     1381 agctgctcca cctgcagcgc gcacgaccct gccgggccca gcctgaaggc ggggggctac
     1441 ccgctggtgt accccgggca cccgctgcag cccgccgcgc tctcgtccag cgccgcccag
     1501 gccgcgctcc ccggccaccc gctctacacc tacggcttca tgctgcagaa cgaaccgctg
     1561 ccgcacagct gcaactgggt ggcagccagt gggccgtgcg acaagcgctt cgccacctcg
     1621 gaggagctgc tcagccacct acggacccac acggccctgc cgggagccga gaaacttctg
     1681 gccgcctacc ccggggcctc gggcctgggc agcgccgccg ccgccgccgc cgccgccgcc
     1741 tcctgccatc tgcacctccc cccgcccgcc gcccccggca gccccgggtc gctgtccttg
     1801 cggaatccac acactttggg cctaagccgg taccacccct atggcaagag ccacttatcc
     1861 acagcggggg gcctggccgt gccgtccctc cccacagccg gaccctacta ttcgccatac
     1921 gcgctgtatg gacagagact agcttcagcc tcggcgctgg gataccagta actacagctc
     1981 ttcctccacc ccagccccct caccctcctc cctctccctc ctcctccctc cccacctgcc
     2041 gtcgccgctg caacctccac tactgcttga ccctgccggg attccccacc cagcccttcc
     2101 ccaccggact gtgtatttat ttactataat gttagcttac aagctgggaa tataagtgca
     2161 ttaacggccc acatgagtca atggtatgca aaaagtctgt gttctcccaa ataataatat
     2221 taatcccaca aataacgaca tgatccccgc ccctgttcct ttctgttatt ttttcttaga
     2281 tataagtttt acatttttta ttccttttcc tctttttttg gttttgattg gtttggtttg
     2341 agggagagtt ggggtctttg ggttcttcta gacgttttgt tttcccttcc tggggagttt
     2401 cttgcatgag tcttaactta aaactacgtt tccgccttct ctttttccct cttccccctt
     2461 cattccctct tgtttccttc catttgcggt tctgtttttg ttttttgttt tgttttgttt
     2521 tgttttttcc tttgttgtac aagtaacaga gaggaggttt tttttgtaac tcattttggg
     2581 ggtggagggg gccacctggg tggcaggggc cctggagctc tattgacctg gtacactgct
     2641 ccgggactcc tcccccgcca ccctccgcgc atagggtcct tggtctggac cctgcccccc
     2701 aaaagtaggg ccttgctcct ctaccttgct ctgagcacgg agagccctga ccccaccagt
     2761 aggctcgccc ccagaagggc ccaagtggcc gtctaccgtc accttccaga ctcccgcccc
     2821 taacacccag tggctacagt gcgcctgtcg gggcacctgg agcgctcacc tggttgaatt
     2881 caaagtccca gaaggccccg ctggcgtgaa gccggcccct tacattttgc gaagtgcatt
     2941 atagtccttg tttttctctc cctcgtgggg gcaacgaccc ctcccctggc agtaggggtg
     3001 gggtaggtga ctctcgctag atccctccaa agcagaccgg tggcgatgtc agcggatgtc
     3061 acgagctcgt tagctgcgtt cggggaaggt tggggcgtca gggagctctc ggatcacagc
     3121 agcccccgcc ctctcctagg cctggcccgg cagagccccc agagtggacc ccccagcgac
     3181 tggggtcttc tccccactcc tccctccttc tggtctgatg cggcagcgcg ggggctgcgg
     3241 ggcctgtttg ggacgaacag agctctccct tggtaagact tattttgtta ataaatggaa
     3301 tacttggcta tattca
//
