LOCUS       NM_018260               5230 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 701 (ZNF701), transcript variant
            2, mRNA.
ACCESSION   NM_018260
VERSION     NM_018260.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5230)
  AUTHORS   Dada,O., Adanty,C., Dai,N., Zai,C., Gerretsen,P., Graff,A. and de
            Luca,V.
  TITLE     Mediating effect of genome-wide DNA methylation on suicidal
            ideation induced by perceived stress
  JOURNAL   Psychiatr Genet 31 (5), 168-176 (2021)
   PUBMED   34050117
  REMARK    GeneRIF: Mediating effect of genome-wide DNA methylation on
            suicidal ideation induced by perceived stress.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022150.6.
            
            On Feb 27, 2020 this sequence version replaced NM_018260.2.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, lacks an alternate exon, and uses a downstream
            start codon, compared to variant 1. The resulting isoform (2) has a
            shorter N-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1439134.1,
                                           SRR18074967.2416138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391785.8/ ENSP00000375662.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC022150.6         79847-79890
            45-130              AC022150.6         83637-83722
            131-257             AC022150.6         85455-85581
            258-5230            AC022150.6         91762-96734
FEATURES             Location/Qualifiers
     source          1..5230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..5230
                     /gene="ZNF701"
                     /note="zinc finger protein 701"
                     /db_xref="GeneID:55762"
                     /db_xref="HGNC:HGNC:25597"
     exon            1..44
                     /gene="ZNF701"
                     /inference="alignment:Splign:2.1.0"
     exon            45..130
                     /gene="ZNF701"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1513
                     /gene="ZNF701"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 701 isoform 2"
                     /protein_id="NP_060730.2"
                     /db_xref="CCDS:CCDS33092.1"
                     /db_xref="GeneID:55762"
                     /db_xref="HGNC:HGNC:25597"
                     /translation="MALLQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNL
                     VSLDTSSKCMMKMFSSTGQGNTEVVHTGTLQIHASHHIGDTCFQEIEKDIHDFVFQWQ
                     ENETNGHEALMTKTKKLMSSTERHDQRHAGNKPIKNELGSSFHSHLPEVHIFHPEGKI
                     GNQVEKAINDAFSVSASQRISCRPKTRISNKYRNNFLQSSLLTQKREVHTREKSFQRN
                     ESGKAFNGSSLLKKHQIIHLGDKQYKCDVCGKDFHQKRYLACHRCHTGENPYTCNECG
                     KTFSHNSALLVHKAIHTGEKPYKCNECGKVFNQQSNLARHHRVHTGEKPYKCEECDKV
                     FSRKSHLERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHTVIHTGEKPYKCNECGKTFV
                     QNSSLVMHKVIHTGEKRYKCNECGKVFNHKSNLACHRRLHTGEKPYKCNECGKVFNRK
                     SNLERHHRLHTGKKS"
     exon            131..257
                     /gene="ZNF701"
                     /inference="alignment:Splign:2.1.0"
     exon            258..5230
                     /gene="ZNF701"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5210..5215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF701"
                     /note="hexamer: AATAAA"
     polyA_site      5230
                     /gene="ZNF701"
                     /note="major polyA site"
ORIGIN      
        1 agaccaggaa gcggatcccg tggagtgaag gtcgcaccgc ggcggattga cttctaaaga
       61 cttggtacgt gaggaaaaaa cacggaagag gaagaggaaa gcaaaggagt cagggatggc
      121 tcttcttcag ggtctactga cattcaggga tgtggccata gaattctctc aggaggagtg
      181 gaaatgcctg gaccctgctc agaggactct atacagagac gtgatgctgg agaattatag
      241 gaacctggtc tccctggata cctcttccaa atgcatgatg aagatgttct catcaacagg
      301 acaaggcaat acagaagtgg tccacacagg gacattgcaa atacatgcaa gtcatcacat
      361 tggagatact tgcttccagg aaattgagaa agatattcat gactttgtgt ttcagtggca
      421 agaaaatgaa acaaatggcc atgaagcact catgacaaaa accaaaaagt tgatgagtag
      481 tacagagcga catgatcaaa ggcatgctgg aaacaaacct attaaaaatg agcttggatc
      541 aagctttcat tcgcatctgc ctgaagtgca catatttcac cccgaaggga aaattggtaa
      601 tcaagttgag aaggctatca acgatgcttt ctcagtttca gcatcccaac gaatttcctg
      661 taggccaaaa actcgtattt ctaataagta taggaataat ttcctccagt cttcattact
      721 cacacaaaaa cgggaagtac acacaagaga aaaatctttc caacgtaatg agagtggcaa
      781 agcctttaat ggtagctcac tcttaaaaaa acatcagata atccatttag gagacaaaca
      841 gtataaatgt gatgtatgcg gcaaggactt tcatcagaag cgataccttg catgccatag
      901 atgtcacact ggtgagaatc cttacacgtg taatgagtgt ggcaagacat tcagtcacaa
      961 ttcagccctg ttagttcaca aggcaattca tactggagag aaaccttaca agtgtaatga
     1021 atgtggcaag gtttttaatc aacaatcaaa ccttgcacgt catcatagag ttcatactgg
     1081 agagaaacct tacaaatgtg aagaatgtga caaagttttc agtcgcaaat cacaccttga
     1141 aagacatagg agaattcaca ctggagagaa accatacaaa tgtaaggttt gtgacaaggc
     1201 tttcagacgt gattcacacc tggcacaaca tactgtaatt cacactggag agaaacctta
     1261 caagtgtaat gagtgtggca agacctttgt tcaaaattca tctcttgtaa tgcataaggt
     1321 cattcatact ggagagaaac gttacaagtg taatgaatgt ggcaaggttt ttaatcacaa
     1381 atcaaacctt gcatgtcatc gtagacttca tactggagag aaaccttaca agtgtaatga
     1441 atgtggcaag gtttttaatc gaaaatcaaa ccttgaacgt catcatagac ttcatactgg
     1501 aaagaaatct tagaagtgta aatttgcaag gtttttaggc aacagtcaaa ccttgcatgt
     1561 catcatagac tttatactgg agagaaacct tacaaatgtg aagaatgtga caaaagtttt
     1621 caatttcaaa tcactccttg aaatacatag gagagttcat actggagaga aaccatacaa
     1681 atgtaaggtt tgtgacaagg atttcgggtg tgattcacac ctggcccaac atactggaat
     1741 tcacactgga aaggaactgt acaagtgtaa tgagtgtggc agagcctttg gtggtcagtc
     1801 aacacttact caccatcaag caatccatgg tatagggaaa cttgactaat gtaatgattg
     1861 tcacaaagtc ttcagtaata ttacagccat tgcaaaacat tggagaatcc ataatgaagg
     1921 aggtcttaca agtgtaataa atgtggcaag tttttcagac atcattcata acttgcagtt
     1981 cattggcgat cttatacagg agagaaatct tacaaatgtg atgattgtgg caaggtcttc
     2041 agtcaagctt catcttttgc aaaacgggag aattcataca ggagagaaac ctcacaagtg
     2101 tgatgattgt gagcaaagcc tttacttcac gttcacacca cattagatat cagaggatcc
     2161 atactggaca gaaatcttac aaacgtccta tgtgtggcaa ggtcttcagt ccgaggttac
     2221 tccttgcaga atatcataac gttcattttt gaggtaatag ttacaaatgc ggtgagcaca
     2281 gcaaaccatc aaggattgac agtagagtca attcagaatt gacttgagtt tgagttgact
     2341 taaaacattc agttgaagca ttaattgaca ttaaagtgtt tatgttaaga ggattgggcc
     2401 aggcgtgtgg ctcacgcctg taaatccagc actttaggag cccaaggtgg atagatcact
     2461 tgaggtcatg agtttgagat cagcctggcc aacagacgtg agtcactttt cccagcctgc
     2521 tttttgtttc tttaacaaaa accaataggg gtttttatag gtattgtgtt gaatctgaat
     2581 cacattggct tatataataa caatattgat ttttccaaac catcaatgtg ggttgtatat
     2641 atatgttttt aatcattttg gttaatgttt gtagatttca aggtgtgaaa ttctcagttt
     2701 ttttatgttt attcctaagt atttcttact ttaagatctc tagcaaatgg aagtgttttt
     2761 taattttcgt ttaaattttt tattgtttat ggaaattcaa ttaatttttg gtgctgctat
     2821 tgcattgtgc aaatccactg aatgtgttga ttagttccag tagtattttg gttgactcag
     2881 gccccgccca cctcttcgcc tcccgtctgg cctgacccag gccccgccca cctcctcggg
     2941 ggtctccccg cgggtctggc ttctgtactg tgctgattgg cacagacccg gaagctgatg
     3001 gcatggactg aaggttgccc cgttgagttt gcgcttccca gttctctggt actgctatac
     3061 cggggacgtg ggtgtctcca cagacctgga aattccggcc cctctttctc aactcagagc
     3121 aaattgagac gtccgggtgg gagtccgtga gtcttttcct tttgagttta aagtcgccct
     3181 gaggctggtc ccgtcccggt cttttctgca gtagggccgt gcagacacct cctgtagcga
     3241 aactttcctt ctcaaaaccc ttcccgaccc gtcctcccgc ctcgcgctgt ttcaggtcct
     3301 caccagcgag ttggactctc gccctgggct cctcatcggc gcctggaggg cagcgctgca
     3361 gccccactcc cgggaaggcc gcgtcctctg cctggtcctg ggatcctgca gaccccaccc
     3421 ctgtccgaag gcgccatcgc ccaccacctc cctcctcgtg ccggccctgc ttctccccag
     3481 ttccaacccc aggaaaacgt gcttctcctg gaggcaaccc tctttttcca ccctcgccct
     3541 gttgttcccg gaaggcaggc ctggaatgtg aagtttccag gtagatggat attaaacata
     3601 gaattgaaga aaaaaaaaaa aaccccacaa agtaacaaaa gaatgaagcg gcgaaagcag
     3661 aaatttactc aaccaagaaa gcaccccaca gggtgggggt gggcccaagc gagcgtctcc
     3721 agggccccat ttacaaagtt tttggaggtt attttttttt gaggtcccta tgggctaccc
     3781 cttatctgga tgaagaattt ggcccttggc caaggaaata actgaggtaa attggcctga
     3841 ggccagagca gatgggtgcc ctatgcagat gaaggggtgg ccggtgcttg gccttggcca
     3901 ctcctgggct ctttctcttt ccacctgcga cctggtggaa gggggagggt gttagggaga
     3961 gtagcctttg atcctttgtt actttgggtg ggaagatggg gtttttcctt ttagtctagt
     4021 tttggaaagt tcgcgttaat tggttttaga ttccctgcct ccctagaccc aggacccatg
     4081 tggttttttt tgtttttgtt tttgtttttt tgatggagat ggggtcttac tctgctgcgc
     4141 aggccgaaga gcggtgaccg gatcacagct cactgcagct tcaacctcct gggctcaagg
     4201 gatcctccca cctcagcctg cagagtagct gggaccacag ccgcgcgcca ccacaccgcg
     4261 ccaatttttg tgttcttggt agagaccggg ttttgccttg ttgtctaggt tgggctccaa
     4321 ctgcagggct aaagcgatcc aagagcatca gcctcccaaa gtgctgggat tacaggcttg
     4381 agccaccatg cccgccttat ttcttaattt aaaaaaaaaa atgtatatgt agactgaacg
     4441 cggtggctca tgcctgtcat cccagcactt tgtgaggccg attctcctct atccaggaga
     4501 cgggtttcac cattttgcca ggtttgtctc aaactcctcg gcttaactga tccgcttgct
     4561 ttggccttcc aaagtgctag gattacagga gtgagccacc acacgtagcc agtcctggca
     4621 ttttgtagaa ggatggccaa cgcagcctgt tgacccttcc tggccatcac atgaaaatca
     4681 gcgactcttc cttcttacaa aactcggagc ttctcaggat aacttggtga aacgtccccc
     4741 gctgtgaacc tcagtgagcc cacctgtaat atacaggtga gggagaagac cagaaaagct
     4801 cagtcagagt gacactgacc cctgaaatga tgggcacaat ggagtgtgtg gcttttcctg
     4861 taggacaggg aggtatttag ttgtagtttg aactttaaag gattccagtc ctccgaaaaa
     4921 caggattaga ctcaaatcac cttgaacctt atcatctcat ggctttgacc cacctacatg
     4981 gctccgtgtc ccctgcaggc ctcgccccgg agctctacaa tcctgtgtgc agttgtctcc
     5041 gcagctctct gctgggacat caaacaggca tctccacctt catgtgtcta taagtgactt
     5101 cctaaacccc caaacacatt cccttacagt cctacacatc tcagatgagg gtgacagtgt
     5161 acttctgggt gcttagctga ggttgacacc atgtatttta aatatggaaa ataaattaca
     5221 ttatttgtaa
//
