LOCUS       NM_021916               6940 bp    mRNA    linear   PRI 22-JAN-2024
DEFINITION  Homo sapiens zinc finger protein 70 (ZNF70), mRNA.
ACCESSION   NM_021916 NM_181436
VERSION     NM_021916.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6940)
  AUTHORS   Zhang,Z., Li,M., Tai,Y., Xing,Y., Zuo,H., Jin,X. and Ma,J.
  TITLE     ZNF70 regulates IL-1beta secretion of macrophages to promote the
            proliferation of HCT116 cells via activation of NLRP3 inflammasome
            and STAT3 pathway in colitis-associated colorectal cancer
  JOURNAL   Cell Signal 114, 110979 (2024)
   PUBMED   38000525
  REMARK    GeneRIF: ZNF70 regulates IL-1beta secretion of macrophages to
            promote the proliferation of HCT116 cells via activation of NLRP3
            inflammasome and STAT3 pathway in colitis-associated colorectal
            cancer.
REFERENCE   2  (bases 1 to 6940)
  AUTHORS   Han,G.L., Wang,J., Guo,K., Chen,J.K., Shang,R.X. and Jiang,T.
  TITLE     miRNA-574-5p downregulates ZNF70 and influences the progression of
            human esophageal squamous cell carcinoma through reactive oxygen
            species generation and MAPK pathway activation
  JOURNAL   Anticancer Drugs 31 (3), 282-291 (2020)
   PUBMED   32053575
  REMARK    GeneRIF: miRNA-574-5p downregulates ZNF70 and influences the
            progression of human esophageal squamous cell carcinoma through
            reactive oxygen species generation and MAPK pathway activation.
REFERENCE   3  (bases 1 to 6940)
  AUTHORS   Watanabe,K., Nakayama,K., Ohta,S., Tago,K., Boonvisut,S.,
            Millings,E.J., Fischer,S.G., LeDuc,C.A., Leibel,R.L. and Iwamoto,S.
  TITLE     ZNF70, a novel ILDR2-interacting protein, contributes to the
            regulation of HES1 gene expression
  JOURNAL   Biochem Biophys Res Commun 477 (4), 712-716 (2016)
   PUBMED   27353377
  REMARK    GeneRIF: We demonstrated that ZNF70 interacts with ZFP64 and
            activates HES1 transcription by binding to the HES1 promoter. In
            addition, HES1 gene expression is increased in ILDR2-knockdown
            HepG2 cells, in which ZNF70 is translocated from the cytoplasm to
            the nucleus, suggesting that ZNF70 migration to the nucleus after
            dissociating from the ILDR2-ZNF70 complex activates HES1
            transcription. These results support a novel link betwee
REFERENCE   4  (bases 1 to 6940)
  AUTHORS   Aubry,M., Marineau,C., Zhang,F.R., Zahed,L., Figlewicz,D.,
            Delattre,O., Thomas,G., de Jong,P.J., Julien,J.P. and Rouleau,G.A.
  TITLE     Cloning of six new genes with zinc finger motifs mapping to short
            and long arms of human acrocentric chromosome 22 (p and q11.2)
  JOURNAL   Genomics 13 (3), 641-648 (1992)
   PUBMED   1639391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000348.1, BC040161.1 and AK122721.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021916.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040161.1, SRR1803612.243713.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341976.5/ ENSP00000339314.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AP000348.1         19046-19065         c
            21-3537             BC040161.1         1-3517
            3538-4038           AK122721.1         3086-3586
            4039-6940           AP000348.1         6635-9536           c
FEATURES             Location/Qualifiers
     source          1..6940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..6940
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /note="zinc finger protein 70"
                     /db_xref="GeneID:7621"
                     /db_xref="HGNC:HGNC:13140"
                     /db_xref="MIM:194544"
     exon            1..402
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /inference="alignment:Splign:2.1.0"
     exon            403..6940
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..1822
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /note="zinc finger protein N27C7-1"
                     /codon_start=1
                     /product="zinc finger protein 70"
                     /protein_id="NP_068735.1"
                     /db_xref="CCDS:CCDS13812.1"
                     /db_xref="GeneID:7621"
                     /db_xref="HGNC:HGNC:13140"
                     /db_xref="MIM:194544"
                     /translation="MEVPPATKFGETFAFENRLESQQGLFPGEDLGDPFLQERGLEQM
                     AVIYKEIPLGEQDEENDDYEGNFSLCSSPVQHQSIPPGTRPQDDELFGQTFLQKSDLS
                     MCQIIHSEEPSPCDCAETDRGDSGPNAPHRTPQPAKPYACRECGKAFSQSSHLLRHLV
                     IHTGEKPYECCECGKAFSQSSHLLRHQIIHTGEKPYECRECGKAFRQSSALTQHQKIH
                     TGKRPYECRECGKDFSRSSSLRKHERIHTGERPYQCKECGKSFNQSSGLSQHRKIHTL
                     KKPHECDLCGKAFCHRSHLIRHQRIHTGKKPYKCDECGKAFSQSSNLIEHRKTHTGEK
                     PYKCQKCGKAFSQSSSLIEHQRIHTGEKPYECCQCGKAFCHSSALIQHQRIHTGKKPY
                     TCECGKAFRHRSALIEHYKTHTREKPYVCNLCGKSFRGSSHLIRHQKIHSGEKL"
     regulatory      6464..6469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /note="hexamer: TATAAA"
     polyA_site      6490
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /note="major polyA site"
     regulatory      6915..6920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /note="hexamer: AATAAA"
     polyA_site      6940
                     /gene="ZNF70"
                     /gene_synonym="Cos17"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcagcag ctgctgtgga gccaggcagc gtcggccgcg tcggccgcgg gttggagcag
       61 ctcaggtgcg gccccgcccc gcccgcctgc ggccccgccc cggcccaggt gagctgcccc
      121 gccccggccc aggtgagtgg ccccgcgtcc gccggtgtga cctgagtccg cctgaccacc
      181 tgtccctccg gtggccctgg gtgtgcgtgt ccccaatcgc ggggaagcct gtaggggcgc
      241 cacgtcgccg cctgggcagc gtgtgcgggt ccgtggcaac tcttgggccc ccagccagga
      301 aaccttgact gcactaagag tttgcagggt gcccaggccc tagggactct ctggaggatg
      361 ggatgacaga tgcaggagga cccggagaag gccccgacag agattgtgag aacagtaagt
      421 gtggcccaaa gaagaacatt tttaaagaaa tacaaccatt ggggatgata gcagattcac
      481 aatggaggtt cccccagcaa caaagtttgg tgagaccttt gcatttgaga acaggttaga
      541 gtcacaacaa gggcttttcc caggggagga cctgggggac ccttttcttc aggaaagagg
      601 tttggagcaa atggctgtga tctacaagga gatccctctt ggtgagcagg acgaagaaaa
      661 tgatgattac gaggggaatt tcagtttgtg ctcaagccct gttcagcatc aaagtatccc
      721 cccaggaacc agaccccagg atgatgagct cttcggacaa accttcctcc agaaatccga
      781 cctcagcatg tgtcagataa tccacagtga agagcccagt ccatgcgatt gtgcagaaac
      841 agacagaggg gactcaggac ctaacgcacc tcacagaacc ccacaaccag ccaagcccta
      901 tgcgtgtcga gagtgtggga aggccttcag ccagagctcg cacctgctcc gacacctggt
      961 gatccacact ggggagaagc cctatgagtg ctgtgagtgc gggaaggcct tcagccagag
     1021 ctcccacctg ctcaggcacc agatcatcca caccggggag aagccctacg agtgccggga
     1081 gtgtgggaag gccttccgcc agagctcagc cctcacgcaa caccaaaaga tccacaccgg
     1141 aaagaggccc tacgagtgca gggaatgcgg gaaagatttc agccggagct ccagcctcag
     1201 aaaacacgag agaattcata caggagagag accttatcag tgtaaggaat gtgggaaatc
     1261 cttcaaccag agctcaggcc tgagccagca tcggaagatc cacaccctaa agaaacctca
     1321 cgagtgcgat ctctgtggga aagccttttg tcacaggtca cacctcatcc gacaccagcg
     1381 gatccacact gggaagaaac catacaaatg cgatgagtgc gggaaggcct tcagccagag
     1441 ctccaacctc attgagcacc gcaagaccca cactggcgag aagccctaca aatgccagaa
     1501 gtgtgggaaa gccttcagcc agagctcctc cctcattgag caccagcgca tccacaccgg
     1561 tgagaagccc tacgagtgct gtcagtgtgg caaggccttt tgccacagct ctgcgctgat
     1621 ccagcaccag agaatccaca ccggcaagaa gccctacacc tgcgagtgtg gcaaagcctt
     1681 ccggcaccgg tcagccctca ttgagcacta taaaacccac accagagaga agccctacgt
     1741 gtgcaatctg tgcggcaagt ccttccgggg gagctcgcac ctgattcgcc atcagaagat
     1801 tcattctggg gagaagctat agaaagagga gcccacacaa agcttgaaag cctgtgccag
     1861 atggagcctt tattccacgt cgcgtggtct ccaagacccc acctacctcc ctgatgctga
     1921 atggaaacct tcccacctaa gcgctcttga acatcccact agcaggaagg ccctgtgtgg
     1981 ccctgggcca agcacgccag ctctcagcag gttttctgca tggaagggaa ggtggggtga
     2041 tagggagggc agccagaaaa gacagctggc cttcagtttc tccttcttgc atttgactcc
     2101 caagcctaca ggatttcatt ttgccctgtc ttcacatttc ccagaatcta gaagaataaa
     2161 tgccaagagg gagaaagttg aattaaaccc aggaaaatat cagaagaact ctttaaaaca
     2221 ggctgcagtc tggcactttt agaagacaga aaccacactc acagtccaaa gcagtagaag
     2281 aaaaatgaat tcaaaagtag atgtgtcagc agcaaagtag aattttctca ctgcgttggg
     2341 cattggtggg gacaaccaaa acaggtctgc agagcaaagg caggtctgga gggtgggtct
     2401 tgagattggg gatgagggtg gtgagcccct gggcgtggcc tcttaaccct ctccttagcc
     2461 ctagggcagt ttccctcaga cagctctgtt acaggaggat agagatttga tcctgttggc
     2521 cagaggatgt ttgacaccca gccgtgactc agcctggaca ccggacatga ctgccctcca
     2581 ggaataaccc ctccctgaga catagtgtcc ccaagaccac agtgtgcctt ggacatcagc
     2641 agggcctggg tctggtctgt tctggcaatg atgcagccct cctgccccag tgtcagggga
     2701 cctgggaagc tgggtggctt gttggaggag gctgtgttct aatcagaagg tctgggttca
     2761 agtcctagtt ccaccccctc ctacctgggt gagcttgaac aagtcctgta acttccccag
     2821 gctccattcc cccatccaag agttggggta atgggaactg gccacgtgcc tctaagggtt
     2881 ggtgccaggc tgtcattcag aacacagcca ctgtgaaagt gctttggcaa ctgtgagcag
     2941 tcatggtgac tgaggacaga gacccagagt gacccctgcc ccacccctgt gcatttccac
     3001 ggactggaga gatgttcccg tctggtttct gagcagtggg acctctcatt gaacagggct
     3061 ttctctccct ccaccccttg cagcctgggc tgtgtatgcc tgcggatgca gtgtcccaca
     3121 caaggacact tcctctagga tgccatcctg agcctcctgt agcagcagtg tcattctgca
     3181 cttccacatt ctgtctgtct tccccgcctg ccaactagga gttcacgtgg ggcttgttta
     3241 aacagtacca ttgcttgtgt cccacctgga ccagttcagt cagccccagt ggtggcatgt
     3301 tttaaagctc cccaggtgat tataacttcc tagtgtgcag ccaggctgtg ggccctgtgc
     3361 tgggcttttt tttttgagat ggagtgttgc cctgttgcca ggctggaatg cagtggcgtg
     3421 atcttggctt actgcaagct ctgcctcctg ggttcaagcg attcccctgc ttcagcctcc
     3481 tgagtagctg ggactacagg tgcgtgccac catgcctggc taattttttg tatttttagt
     3541 acagacgggg tttcaccatg ttggccagga tggtctcgat ctcttgacct cgtgatctgc
     3601 ccgccttgac ctcccaaagt gccgggatta caggcatgag cctccacacc tggcccatgc
     3661 tgggtttttg tgcatccctc gacagcttcc aatgtcagcc tgctggcttt ggctgagcag
     3721 agcttgaagg ccattctgtc tcagtgccct cactccctgc tccccgcacc cggagcctca
     3781 gggatgggct caggctgatg gtcagctggg cgcttggaaa gtgtttggct ggggccttgg
     3841 ggatctcttt agtcctggct tcccttgggc tcctcagagc tagtggggaa ggaggcagtc
     3901 taggctgttt tgaagtttcc taaacattta tggctgggct aacatgaact catcatggta
     3961 acactgggta tttcagctga tcagaagctc agcatggcca ttatgcctag ttttgatgaa
     4021 taaacatggg aaagccataa ctgttactaa gtgggtcttg ataggccaga gatttccaaa
     4081 tgacagatat gatgggctgg agaggtcatg gtgggagttc cagccatgcc tctgtccagc
     4141 ccctgtcttt gctacgtatg tgaaacattt aacatttaac cagcactcca ttgtccacca
     4201 gaaccctctg tgtaaccagt tggactgact ggatggtgcc ctgggcattg cctgcaagtg
     4261 gcctgtcatt tcaggcctgt ctctatcaag agtgaagaga gaatgctagg atgcagtggg
     4321 gacagcaggc ggcatcaagc aggggtccct gaaagatcta cctcctcttt acacctgccc
     4381 ctcttcccca ccgttatcat ctggcaaatg tctgttacct atctttggtt tctccctccc
     4441 catccttcct gcacacccca gccaaattga tttttaaagc atcattttgc acaagtcacc
     4501 actctcctta aaaccaactt tcaggagctt tcctgcacgt aaaccctcgt ttcagccaac
     4561 ctggtttacc cactctgagc aagccgcatg gagatcaggc cgcccctgcc cactccagca
     4621 tcactcccag ctcataattc tgtgctgttc ttgcattttg aaatgtgcac tttctcctcc
     4681 tctccctccc tctctctttc taatttttgt gtaacgtgga gatgaagatc ccccctctct
     4741 cccaagggtt aacagataaa catggtaaga ccaggttctt ttttggaagt atgaccagag
     4801 cctcattccc tctgttcaaa ttctttcctt gttttattag tttttttttt tttttttttt
     4861 tttttgagac agagtctcac tgtcacccag gctggagtgc agtggtgcga tcttggcttg
     4921 ctgcaacctc tgcctcccgg gttcaagtga ttctcctgcc tcagcctcct gagtagctgg
     4981 gattacaggc atgtgccacc acgcctggct aacttttgta tttttagtag agatggggtt
     5041 tcaccatgtt ggccaggctg gtctcgaact cctgacctcc tgatctgcct gccttggcct
     5101 cctgaagtgt tgggattaca ggcgtgagcc atgtgcccag ccagcttatt agattttttt
     5161 ttttaaactc tctcattcta tttagattct caaacagtgt aaagttataa aagatcatcc
     5221 ctggcaatat tttaatcaat tatcttttaa tttagttgtt ctttgttttt gttgtcctac
     5281 cttttttttt cttttttctt ttttcttttt ttgagatgga gtcttgcttt gtcacccagg
     5341 ctgtagtgca gtggggcgat ctcggcttac tgcaagctct acctcccagg ttcagaccat
     5401 tctcctgcct cagcctccca agtagctggg actacaggca cccgccacca cgcccggcta
     5461 attttttgta tttttaatag agacggggtt tcaccgtgtt agccaagatg gtatctatct
     5521 cctgagctcg tgatccgccc gcctcggcct cccaaagtgc tgggattaca ggtgtgagcc
     5581 accgcgctcg gcattttttt atttcttctt ctccttagag tgacagcttt gtctgcactc
     5641 cgtaagtttt gacgtggtgt tttttgttat agtattaaga atttcctttt gcccaaatgt
     5701 tattatttaa aaatatttct aagtgggccg ggcatggtga ctcacacctg taatcccagc
     5761 actttggaag gccgaggtgg gtggatcacg aggtcaggag tttaagacca gcctggccaa
     5821 catggtgaaa acccgtctct actaaaaata caaaaattaa ctgggcatgg tggcgggtgc
     5881 ctgtaatccc agctacacgg gaggctgagg caggagaatc gcttgaaccc gggaggcgga
     5941 ggttgcagtg agccaagatt gtgccactac ccttcagcct gggtgacagg gcaagactcc
     6001 atctcgggga aaacaacaac aacaaaaaca aaaaatagcc gggagcggtg gctcaagcct
     6061 gtaatcccag cactttggga ggccaagacg ggcagatcat gaggtcagga gatcgaaacc
     6121 atcctggcta acacgatgaa accctgtctc tattaaaaat acaaaaaatt agccgtgcgt
     6181 ggtggctaca ggcagctgtg cgcctgtagt cccagctact tgggaggctg aggcaggaga
     6241 atggtgtgaa cccgggaggc agagcttgca gtgagccgag gtggtgccac tgcactccag
     6301 cctgggcaaa agagctagac tctgtctcaa aaaaaatata tataaaaaaa atttctaagt
     6361 gatgaatgct tagggtattg ctgcttattt cttactgtac tgtggtgtca acatttctaa
     6421 gtgtccatag gacttctttg ggcctgaata tattatcagt ttttataaaa gcatttgtgt
     6481 aatctcaaaa tgtgttttta ttctaccagt tctatttgtt aactcaattt tttcattatt
     6541 ttattcaaat ccatattttc tctgactttc atttacttta gagttcttaa tctgggggtc
     6601 catggcctgc ctaggagtct ttagcatgta ggggtttagg agttgcagac ccctagggat
     6661 cgaacaaagc tgggtatgtg cttgaaggaa ttttgctggg acaaggatct gtagtattta
     6721 ctatattttt aaatgcctct gtgacaccaa agcagttcag aacactcatt tacctgatct
     6781 aatcatagtt tgatgtttgt gtgttatatc tctatgtatt cctgtttcac ttttaatttc
     6841 tgtatgtgta ttgtcgctat gttgtgcagt ttttctcaag tcatttttga gaaataggca
     6901 gggtatgaat tatcaataaa taagtatcat gtttggggca
//
