LOCUS       NM_003416               2760 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 7 (ZNF7), transcript variant 2,
            mRNA.
ACCESSION   NM_003416
VERSION     NM_003416.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2760)
  AUTHORS   Esteve-Codina,A., Alameda,F., Carrato,C., Pineda,E., Arpi,O.,
            Martinez-Garcia,M., Mallo,M., Gut,M., Dabad,M., Tortosa,A., Del
            Barco,S., Capellades,J., Puig,J., Gallego,O., Pujol,T., Oleaga,L.,
            Gil-Gil,M., de Quintana-Schmidt,C., Valduvieco,I.,
            Martinez-Cardus,A., Bellosillo,B., Munoz-Marmol,A.M., Esteve,A.,
            Domenech,M., Camins,A., Craven-Bartle,J., Villa,S., Marruecos,J.,
            Domenech,S., de la Iglesia,N. and Balana,C.
  TITLE     RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger
            Marker of Survival than Molecular Subtypes in G-CIMP-negative
            Glioblastoma
  JOURNAL   Clin Cancer Res 27 (2), 645-655 (2021)
   PUBMED   33106291
  REMARK    GeneRIF: RNA sequencing and Immunohistochemistry Reveal ZFN7 as a
            Stronger Marker of Survival than Molecular Subtypes in
            G-CIMP-negative Glioblastoma.
REFERENCE   2  (bases 1 to 2760)
  AUTHORS   Polykratis,A., Martens,A., Eren,R.O., Shirasaki,Y., Yamagishi,M.,
            Yamaguchi,Y., Uemura,S., Miura,M., Holzmann,B., Kollias,G.,
            Armaka,M., van Loo,G. and Pasparakis,M.
  TITLE     A20 prevents inflammasome-dependent arthritis by inhibiting
            macrophage necroptosis through its ZnF7 ubiquitin-binding domain
  JOURNAL   Nat Cell Biol 21 (6), 731-742 (2019)
   PUBMED   31086261
  REMARK    GeneRIF: Single-cell imaging revealed that RIPK3-dependent death
            caused inflammasome-dependent IL-1beta release from
            lipopolysaccharide-stimulated A20-deficient macrophages.
            Importantly, mutation of the A20 ZnF7 ubiquitin binding domain
            caused arthritis in mice, arguing that ZnF7-dependent inhibition of
            necroptosis is critical for A20 anti-inflammatory function in vivo.
REFERENCE   3  (bases 1 to 2760)
  AUTHORS   Malhotra,A., Igo,R.P. Jr., Thameem,F., Kao,W.H., Abboud,H.E.,
            Adler,S.G., Arar,N.H., Bowden,D.W., Duggirala,R., Freedman,B.I.,
            Goddard,K.A., Ipp,E., Iyengar,S.K., Kimmel,P.L., Knowler,W.C.,
            Kohn,O., Leehey,D., Meoni,L.A., Nelson,R.G., Nicholas,S.B.,
            Parekh,R.S., Rich,S.S., Chen,Y.D., Saad,M.F., Scavini,M.,
            Schelling,J.R., Sedor,J.R., Shah,V.O., Taylor,K.D.,
            Thornley-Brown,D., Zager,P.G., Horvath,A. and Hanson,R.L.
  CONSRTM   Family Investigation of Nephropathy and Diabetes Research Group
  TITLE     Genome-wide linkage scans for type 2 diabetes mellitus in four
            ethnically diverse populations-significant evidence for linkage on
            chromosome 4q in African Americans: the Family Investigation of
            Nephropathy and Diabetes Research Group
  JOURNAL   Diabetes Metab Res Rev 25 (8), 740-747 (2009)
   PUBMED   19795399
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2760)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 2760)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   6  (bases 1 to 2760)
  AUTHORS   Witte,S. and Krawinkel,U.
  TITLE     Specific interactions of the autoantigen L7 with multi-zinc finger
            protein ZNF7 and ribosomal protein S7
  JOURNAL   J Biol Chem 272 (35), 22243-22247 (1997)
   PUBMED   9268371
REFERENCE   7  (bases 1 to 2760)
  AUTHORS   Fukunaga,R. and Hunter,T.
  TITLE     MNK1, a new MAP kinase-activated protein kinase, isolated by a
            novel expression screening method for identifying protein kinase
            substrates
  JOURNAL   EMBO J 16 (8), 1921-1933 (1997)
   PUBMED   9155018
REFERENCE   8  (bases 1 to 2760)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
REFERENCE   9  (bases 1 to 2760)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
REFERENCE   10 (bases 1 to 2760)
  AUTHORS   Lania,L., Donti,E., Pannuti,A., Pascucci,A., Pengue,G.,
            Feliciello,I., La Mantia,G., Lanfrancone,L. and Pelicci,P.G.
  TITLE     cDNA isolation, expression analysis, and chromosomal localization
            of two human zinc finger genes
  JOURNAL   Genomics 6 (2), 333-340 (1990)
   PUBMED   2106481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF235103.5 and BC058923.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003416.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.203789.1,
                                           SRR1660809.18333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000532777.6/ ENSP00000432641.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AF235103.5         130524-130537
            15-2196             BC058923.1         1-2182
            2197-2760           AF235103.5         146173-146736
FEATURES             Location/Qualifiers
     source          1..2760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2760
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /note="zinc finger protein 7"
                     /db_xref="GeneID:7553"
                     /db_xref="HGNC:HGNC:13139"
                     /db_xref="MIM:194531"
     exon            1..50
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /inference="alignment:Splign:2.1.0"
     exon            51..98
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2156
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /note="isoform 2 is encoded by transcript variant 2; Zinc
                     finger protein-7 (KOX4); zinc finger protein 7 (KOX 4,
                     clone HF.16); zinc finger protein zfp30; C2-H2 type zinc
                     finger protein; zinc finger protein KOX4; zinc finger
                     protein HF.16"
                     /codon_start=1
                     /product="zinc finger protein 7 isoform 2"
                     /protein_id="NP_003407.1"
                     /db_xref="CCDS:CCDS6435.1"
                     /db_xref="GeneID:7553"
                     /db_xref="HGNC:HGNC:13139"
                     /db_xref="MIM:194531"
                     /translation="MEVVTFGDVAVHFSREEWQCLDPGQRALYREVMLENHSSVAGLA
                     GFLVFKPELISRLEQGEEPWVLDLQGAEGTEAPRTSKTDSTIRTENEQACEDMDILKS
                     ESYGTVVRISPQDFPQNPGFGDVSDSEVWLDSHLGSPGLKVTGFTFQNNCLNEETVVP
                     KTFTKDAPQGCKELGSSGLDCQPLESQGESAEGMSQRCEECGKGIRATSDIALHWEIN
                     TQKISRCQECQKKLSDCLQGKHTNNCHGEKPYECAECGKVFRLCSQLNQHQRIHTGEK
                     PFKCTECGKAFRLSSKLIQHQRIHTGEKPYRCEECGKAFGQSSSLIHHQRIHTGERPY
                     GCRECGKAFSQQSQLVRHQRTHTGERPYPCKECGKAFSQSSTLAQHQRMHTGEKAQIL
                     KASDSPSLVAHQRIHAVEKPFKCDECGKAFRWISRLSQHQLIHTGEKPYKCNKCTKAF
                     GCSSRLIRHQRTHTGEKPFKCDECGKGFVQGSHLIQHQRIHTGEKPYVCNDCGKAFSQ
                     SSSLIYHQRIHKGEKPYECLQCGKAFSMSTQLTIHQRVHTGERPYKCNECGKAFSQNS
                     TLFQHQIIHAGVKPYECSECGKAFSRSSYLIEHQRIHTRAQWFYEYGNALEGSTFVSR
                     KKVNTIKKLHQCEDCEKIFRWRSHLIIHQRIHTGEKPYKCNDCGKAFNRSSRLTQHQK
                     IHMG"
     exon            99..225
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /inference="alignment:Splign:2.1.0"
     exon            226..342
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /inference="alignment:Splign:2.1.0"
     exon            343..2760
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /note="hexamer: AATAAA"
     polyA_site      2209
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /note="major polyA site"
     regulatory      2656..2661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /note="hexamer: AATAAA"
     polyA_site      2678
                     /gene="ZNF7"
                     /gene_synonym="HF.16; KOX4; zf30"
                     /note="major polyA site"
ORIGIN      
        1 gtttccggcg gcgtcgcgcg tttgcgagcc tcgggtggtc ctcagggagg gtctctcggc
       61 cagaacacgt ggatgcccac ccaccactga gcctcatgga ggtggtaaca tttggcgatg
      121 tggctgtgca cttctctcgg gaggagtggc agtgtctgga ccctggccag agggccctct
      181 acagggaagt gatgctggag aaccacagca gtgtggctgg actagcagga ttcctggttt
      241 tcaagcctga gctgatctct cggctggagc agggagaaga gccatgggtc ctcgacctgc
      301 agggagcaga ggggacagag gcaccaagga cctccaagac agattctacg attaggactg
      361 aaaatgagca ggcctgtgag gacatggaca tcctaaaatc agaatcctat gggacagtgg
      421 tcagaatctc cccacaggac tttcctcaga atcctggctt tggagacgtt tctgattctg
      481 aggtctggtt agacagtcat ctgggcagtc ccgggctgaa agtgacaggc tttaccttcc
      541 aaaataactg tttgaatgag gagactgtgg ttcccaagac cttcaccaag gacgcacccc
      601 agggatgtaa ggagctggga agcagcggcc tggattgtca gcctcttgaa agtcagggag
      661 agagtgcgga agggatgtcc cagagatgcg aggagtgtgg caaaggcatc agagccactt
      721 cagatatcgc tctgcattgg gaaattaata cacagaaaat tagcagatgt caagaatgcc
      781 aaaaaaagtt atctgactgc ttgcagggga aacatacaaa taactgccat ggagagaagc
      841 cgtacgaatg tgcagagtgt gggaaagtct tcaggctctg ctcgcagctt aatcagcatc
      901 agagaatcca cacgggagag aaacccttta aatgcactga gtgtggaaaa gccttccgcc
      961 tgagctcaaa acttattcag catcaaagaa tccacactgg ggagaagccc tacagatgtg
     1021 aggaatgtgg aaaagctttt ggtcagagct caagcctcat ccaccatcag agaatccaca
     1081 caggagagag gccctatggt tgtcgtgagt gtgggaaagc cttcagccag cagtcgcagc
     1141 tggttagaca ccagagaact cacactgggg agaggcccta cccttgcaag gagtgtggga
     1201 aggccttcag ccagagctcc accctagccc agcatcaaag gatgcatact ggggagaaag
     1261 ctcaaattct aaaagcctca gacagtccaa gccttgttgc acatcagaga attcacgctg
     1321 tagagaaacc atttaagtgt gatgagtgtg ggaaagcttt taggtggatc tctcgcctga
     1381 gtcagcatca gctgattcac actggagaga agccttataa atgcaacaag tgtacaaaag
     1441 cctttggttg tagttcacgg cttattcgcc atcagagaac tcacactgga gaaaaaccat
     1501 ttaaatgtga tgagtgtggc aaaggctttg ttcagggctc acaccttatt cagcatcagc
     1561 gaatccacac tggagagaaa ccctatgtgt gtaatgactg tggaaaagcc ttcagtcaga
     1621 gttccagcct tatttaccat cagagaatcc ataaaggaga gaagccctac gaatgcctcc
     1681 aatgcggaaa agccttcagt atgagcacac agcttacaat acatcaaagg gttcacactg
     1741 gagagaggcc ctataaatgt aatgaatgtg ggaaagcctt cagtcaaaac tcaacccttt
     1801 tccaacacca gataattcat gcaggggtga agccctatga gtgcagtgag tgtggaaaag
     1861 ccttcagccg gagctcatat cttattgaac accagagaat acacactagg gcccagtggt
     1921 tttacgaata tgggaatgcc ctggaagggt ccacctttgt gagccgtaaa aaggttaata
     1981 ctataaagaa actgcatcag tgtgaagact gtgagaagat atttaggtgg cgttcacacc
     2041 taattataca ccagagaatt cacaccgggg agaagcctta taaatgcaat gactgtggca
     2101 aagcttttaa tcgtagctca aggcttaccc agcatcaaaa aattcacatg ggatagacca
     2161 cttacatata aatgtgtata tatgtgaata aacctatagc cttaacttac ttattttata
     2221 tggaatcgtt tatactgaca aacatgtaga atgttggtaa aggttcagaa ttgctctcaa
     2281 gaatatccaa cttcaggccg agtgtggtgg cttatgcctg tcatcccagc actttgggag
     2341 gccaaggcgg gcacatcacg aggtcaggag gttgagacca tcctgggtaa caggtgaaac
     2401 cccatctcta ctaaaaatac aaaaatttag ctgggcgtgg tggcaggcac ctgtggtccc
     2461 agctgctcgg gaggctgagg caggagaatg gcatcagccc aggaggcgga gcttgcagtg
     2521 agctgagatc gcgccactgc actccagcct gggtgacaga gtgagactcc ctctcaaaaa
     2581 aaaaaaaaaa aaaaaaaatc caacttcata caaaatgtat gtttatttcc tgaaatgttt
     2641 gaccttaacc tgttcaataa agcctgtgtc cctcaaaatc agggtgcagt ctgcagtttt
     2701 gagttgacag gtccctgtga atgaggaagc agcacaagga gggctctacg agcgctgcta
//
