LOCUS       NM_198535               6758 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 699 (ZNF699), mRNA.
ACCESSION   NM_198535
VERSION     NM_198535.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6758)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6758)
  AUTHORS   Ali,M.A., Way,M.J., Marks,M., Guerrini,I., Thomson,A.D., Strang,J.,
            McQuillin,A. and Morgan,M.Y.
  TITLE     Phenotypic heterogeneity in study populations may significantly
            confound the results of genetic association studies on alcohol
            dependence
  JOURNAL   Psychiatr Genet 25 (6), 234-240 (2015)
   PUBMED   26368818
  REMARK    GeneRIF: Results show no associations between polymorphisms in
            ZNF699 and alcohol dependence per se but s significant allelic
            association was found between rs7254880 in ZNF699 and
            alcohol-related cirrhosis.
REFERENCE   3  (bases 1 to 6758)
  AUTHORS   Riley,B.P., Kalsi,G., Kuo,P.H., Vladimirov,V., Thiselton,D.L.,
            Vittum,J., Wormley,B., Grotewiel,M.S., Patterson,D.G.,
            Sullivan,P.F., van den Oord,E., Walsh,D., Kendler,K.S. and
            Prescott,C.A.
  TITLE     Alcohol dependence is associated with the ZNF699 gene, a human
            locus related to Drosophila hangover, in the Irish Affected Sib
            Pair Study of Alcohol Dependence (IASPSAD) sample
  JOURNAL   Mol Psychiatry 11 (11), 1025-1031 (2006)
   PUBMED   16940975
  REMARK    GeneRIF: In analyses of genetically independent cases and controls,
            four of the seven single markers show strong evidence for
            association with alcohol dependence, and the most significant
            single marker, rs7254880, tags an associated haplotype with
            frequency 0.071.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011451.6, BX280105.1 and BC109267.1.
            
            On May 17, 2019 this sequence version replaced NM_198535.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.122233.1,
                                           SRR1803614.30764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267761 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000591998.6/ ENSP00000467723.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC011451.6         160055-160178
            125-149             BX280105.1         1-25
            150-150             AC011451.6         160204-160204
            151-494             BX280105.1         27-370
            495-2588            BC109267.1         1-2094
            2589-6758           AC011451.6         174584-178753
FEATURES             Location/Qualifiers
     source          1..6758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..6758
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="zinc finger protein 699"
                     /db_xref="GeneID:374879"
                     /db_xref="HGNC:HGNC:24750"
                     /db_xref="MIM:609571"
     exon            1..489
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /inference="alignment:Splign:2.1.0"
     exon            490..542
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /inference="alignment:Splign:2.1.0"
     CDS             495..2423
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="hangover, Drosophila, homolog of; hangover homolog"
                     /codon_start=1
                     /product="zinc finger protein 699"
                     /protein_id="NP_940937.1"
                     /db_xref="CCDS:CCDS42495.1"
                     /db_xref="GeneID:374879"
                     /db_xref="HGNC:HGNC:24750"
                     /db_xref="MIM:609571"
                     /translation="MEEERKTAELQKNRIQDSVVFEDVAVDFTQEEWALLDLAQRNLY
                     RDVMLENFQNLASLGYPLHTPHLISQWEQEEDLQTVKRELIQGIFMGEHREGFETQLK
                     TNESVASQDICGEKISNEQKIVRFKRNDSWFSSLHENQESCGIDYQNKSHERHLRNHM
                     VENIYECYEENQDGQTFSQVPNLDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHT
                     GSKPYQCKECGKAFHFLACFKKHMKTPTEEKPYECKECTKAFSCSSFFRAHMKIHIGK
                     TNYECKECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHKRIHSGDKP
                     YECKECGKAFSSSSHLIIHIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTGEKPYK
                     CKECGKAYNCPSSLSIHMRKHTGEKPYECLECGKAFYLPTSLNTHVKNQSREKPYECK
                     ECGKAFSCPSSFRAHVRDHTGKIQYECKECGKTFSRSSSLTEHLRTHSGEKPYECKEC
                     GKAFISSSHLTVHIRTHTGEKPYECKKCGKAFIYPSALRIHMRTHTGEKPYECKECGK
                     AFRHSSYLTVHARMHTGEKPFECLECGKAFSCPSSFRRHVRSHTGEKPYECKECGKAF
                     VCPAYFRRHVKTHTRENI"
     exon            543..669
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /inference="alignment:Splign:2.1.0"
     exon            670..780
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /inference="alignment:Splign:2.1.0"
     exon            781..964
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /inference="alignment:Splign:2.1.0"
     exon            965..6758
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3081..3086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="hexamer: GATAAA"
     polyA_site      3101
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="major polyA site"
     regulatory      4344..4349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="hexamer: AATACA"
     regulatory      4349..4354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="hexamer: AATATA"
     polyA_site      4362
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="major polyA site"
     polyA_site      4372
                     /gene="ZNF699"
                     /gene_synonym="DEGCAGS; hang"
                     /note="major polyA site"
ORIGIN      
        1 gcatgcgcga gtcgacagcc ttgtcaccct acgcctccgc ccgcgtctga ggaacatttt
       61 tgcctccgcc cgcttcctgt cctgccctgc cccgccccgc cctgcctgcc ccgggtcggg
      121 tccgcgggag accgagggct gggtttggga atcggcggtc taagggctgc ctccccgcca
      181 ctccttgtcc ggaccccgcg cccggggcct cccgccgccg cggcgcctcc tcagagagcc
      241 cgggtcagct gcccctgtgg ccgcggctgg tcccaaactc actgaatcgg gaactctggt
      301 ctgggtacag aaatcggggt gattctgatg caggcgagag ttggagaacc aatgtcgtag
      361 ttcatcagcc tccgaaagca tcctttgctc tctttccaga aaggaagagc atctctgcca
      421 ttcgtgtctc aaggacaagc gcttcagcct cgttctctgt gagctgatct gtggatcgcg
      481 gcgtgtcggg cgacatggag gaagaaagaa aaactgctga gttacagaaa aatagaatac
      541 aggactcagt agtctttgag gatgtggctg tggactttac ccaggaggaa tgggctttgc
      601 tggatcttgc tcagagaaac ctctacagag atgtgatgct ggaaaacttc cagaacctgg
      661 cctcactagg gtatccgcta cacacacccc atctgatctc ccagtgggaa caagaggagg
      721 acctgcagac agtgaagaga gaacttatcc agggcatctt tatgggagag caccgggaag
      781 gttttgagac tcaacttaaa actaatgaat cagttgcttc acaagatatt tgtggagaaa
      841 aaatatccaa tgaacagaaa atagtaagat tcaaaaggaa tgattcctgg ttctccagtt
      901 tacatgaaaa ccaggagtcc tgtggtattg attatcagaa caaaagccat gagagacatt
      961 tgagaaatca tatggtagag aacatctatg aatgttatga agaaaatcaa gatggacaga
     1021 ctttcagcca agttccaaat cttgattcac tcaagagaaa tactgaagta aaatcctgtg
     1081 aatgccatga gtgtggaaag gccttcgtgg atcattcatc ccttaagagt cacatcaggt
     1141 ctcatactgg aagcaaaccc tatcagtgca aggaatgtgg gaaggccttc cattttcttg
     1201 cttgtttcaa gaagcatatg aaaaccccca ctgaagagaa gccctatgaa tgtaaggaat
     1261 gtaccaaagc cttcagctgt tcctcattct ttagggcaca tatgaagatt cacatcggaa
     1321 agacaaacta tgaatgtaaa gaatgtggga aaggttttag ttgttcctca tcgctcacag
     1381 aacacaaaag aattcacagt ggagataagc cttatgaatg taaggaatgt gggaaggcct
     1441 tcagttgttc ctcctcactc tccaaacaca aaagaattca cagtggagat aagccatatg
     1501 aatgtaagga atgtgggaag gcctttagct cttcctctca ccttataata catataagaa
     1561 ttcacactgg agagaagcct tatgaatgta aagagtgtgg gaaggccttc agcgagtcct
     1621 caaaactcac tgtacatggg aggacacata ctggagagaa accctataaa tgtaaggaat
     1681 gtgggaaagc ctacaattgt ccctcctcct taagtatcca tatgagaaaa cacactggag
     1741 aaaaaccgta tgaatgtctg gaatgtggaa aggccttcta ccttcccact tcccttaata
     1801 cacatgtgaa aaatcaaagt cgagagaaac cctatgaatg taaggaatgt gggaaggcct
     1861 ttagttgtcc ctcgtccttt agagcacatg tgagagatca cactggaaag atacagtatg
     1921 aatgtaagga gtgtgggaag acctttagtc gttcctcatc cctcaccgaa cacctaagaa
     1981 ctcacagcgg agagaagccg tatgaatgta aagaatgtgg gaaagccttt attagttcct
     2041 cccaccttac agtacatatc agaactcaca ctggagagaa accctatgaa tgtaagaaat
     2101 gtgggaaagc ctttatttat ccctcagccc ttaggatcca catgagaacg cacactgggg
     2161 aaaaacccta tgaatgtaag gaatgtggga aagcatttcg tcattcttca taccttactg
     2221 tacatgcaag aatgcacact ggagagaaac cctttgaatg tctggaatgt ggaaaagctt
     2281 tcagttgtcc ctcatccttt cgaaggcatg tgagaagcca cactggagag aaaccctatg
     2341 aatgtaagga atgtgggaaa gcctttgttt gtcctgccta ctttcgaagg catgtgaaaa
     2401 ctcacactag agaaaacata taaatgtaag gaatatggga atgtctgcaa agcttcagat
     2461 cctaggcaac atgtgagatc tcatactgtg gagacaccct atgaatgtaa gaaagtagga
     2521 aattgttgct catcgttttg aagatttgag gacactttag agaaaccctg tgtatgtaag
     2581 tcatgtgcta aagcctttat gaacattgct tattatgtat aagaaaatct ctactagaaa
     2641 tgaagatcag tgcctcatcc ttaaagtaga atgctggctc gttgattacc agtgttttct
     2701 gataggaaca ttgaaggtga taaatttacc ttttcagctc tagccacata ctttttagta
     2761 tgaggtgctt taattttggt tctgatgtaa atatgatttc cattacaaaa tcttttggat
     2821 catggaggac acgaaatatt ttttctgtat aggcagcagt ggtctttttt aaaaaagtgg
     2881 tttctaatta atgttcattg ttctttaaat gggtagtcgt tataatattg acaaaccaat
     2941 ataatattga caaaccaaaa accaaatatt gatttttgtt gatgttttgt ttttagtcta
     3001 catggcagat aatggaactt gcccactcaa tatttttctt cctattcttt tttgctaaga
     3061 gacgttagag tttctgagat gataaatttt tactattaaa agcttttatt gtctagtgag
     3121 taatttcagc agaaattaat ttaatatact atttttatat tttattcttt gtccttgctc
     3181 gtggctggga attggatcca gtgttttgag tgtaaaaatt gtgttacatt aactacattt
     3241 cccagaatca cttttttctc cagttctagg ttagacttgt ctaaaataag agtttgtacg
     3301 agatttggaa ggcataaggg aagaaaaagc tgttatgcta tgtttagtgg ggccatcaga
     3361 cagagagaca gatgtataaa ggcctggtga cctctagttt tcagctcatt tttctgactg
     3421 ttggactcat tgatcaatat ttgctcaaaa ctgaatgtta tagctggacg tgatggtgca
     3481 tacctgtggt cccagctact cagggagctg aggctggagg atcacttgag cccaggagtt
     3541 tgaggctgca gtgaactatg atcatgccac tgcactccag cctgagtgat agagtgagac
     3601 cctttctcaa aaacaaaaca aaacgaaata aaaaaccaaa cattaaatgc ttgcttgacc
     3661 tcagtgtctt ccaaggcagc atctctaaag ctatcaccag atacagcttc ttggattttc
     3721 tagcaagctc tggcattgcc attttgctta tgttgcagtc tttcttacac agtccaatcg
     3781 catcatgtca tgctattcat ggggaaaaat acgttcgcaa gtctcaaaag caagagctgt
     3841 ggagagtgag ggaagttacc cttggtaatt gaggtaagca tccacagggt atcatcctgt
     3901 tttaatggag gaagatttat acttgacacc tttaaacagg aaagatttta ctgctttttt
     3961 ttttttttta aatgtaagaa gatgaattgc ttcaggtacc tttagctaca gtattatatt
     4021 ttccctttaa aagtataatc tactactgtg atatttccct cctattatat tttctcttta
     4081 aaagtataac tctactattt ccccataatc actttttatt ttattataca tatactaaca
     4141 tgcatgaagt gtgctaatct tcaatgtaca gcttaatgac atttcatgta tgtacatgtc
     4201 ctggtaaaca gaacatttcc aagactttag gaagttcctt catcctcttt ctcagtgata
     4261 attactccac agggcaacca caattttgac tcttactata attgacttgg tgtgcttgtt
     4321 cttgattttc atccaaatgt taaaatacaa tatatacagt tatgtgtttt gacttctttt
     4381 gctcaacata atgtgtggtt tgacttttaa ttgttctttt gatagatgta tgggcttatt
     4441 tatcttggta tgtgctatat gctcaggaat gaatttactg aatcataggg tagactttaa
     4501 atttagtttt ggtaggtatt gcagttttca aaaaatatcg attccacgaa taatccccaa
     4561 aacaatgcat gaaagttcca gttgtttcac acacctgtcc agctctttct gattatagtc
     4621 atccagcaga cagtgtgcat ttacctgatg tgtaatgatt tcgagtactt ttcgatgtgc
     4681 ttattggcta tttggatttt tttttttttt gagggcacct gttgaaacat ttcatccatt
     4741 tatgatttct tttctttttt tttttttttg agacggactc ttgtgcccag gttggagtgc
     4801 agtggcgtga tcttgctcac tgcaatctcc gcttcctggg ttcaagtgat tctcctgtct
     4861 cagcctcctg agtagctggg attacaggcg tgtgccacca cacctggcta atttttgtat
     4921 tttttagtag agacggggtt tcaccatgtt ggccaggttg gtcttgaact cctgacctca
     4981 ggtgatctgc ccacctcggc ctcccaaagt gctgggatta taggcgtgag ccactgcacc
     5041 cagacttatg gttccttttt aaaaaaaaaa aaaaattgaa aggtttcctt ctggttactt
     5101 gtcctttatt gtatgtatgt atatctatat ctaggtacac atgcatagat atgtataaac
     5161 catgtatcat atattacata tatacataaa atatgtatat tatatataca tacattacag
     5221 ataacatttc ccaatctctg tcttgtcttt tcactcttta aagggaattt gttggtttaa
     5281 ataatttatt actaaaaagt ccttgggtat aacgagcttc agacatggct aaatcctggg
     5341 gctaaaaaaa tgttatctag ttgaattctg tctccctgtc ttggctgtgc atcctcctgc
     5401 attagtgttt cttccaagca ggttgtctct tcatagatgg ccccagaaac tctggctact
     5461 ttcttcccaa cttaaagtct cagggagaaa agagtgattg tctttttgag tggttccaat
     5521 atgatgatca gaattgaatc tcgttggctc tgattggctc acttgcccac tgtactctag
     5581 tcactggcct ggggaatgta atactctcat ttgtttaggg ttagtgcctg ttcttatcca
     5641 gaaactggat tagagtctgc actgactgaa tcatagagtc ctggcagttt tggggcatat
     5701 gcagagggga ggaggaagga gtgggcaggt aggatctaaa agcagtggta atgttagctg
     5761 ttatgctggt cttagcagca agtgggaact gtgaagtctg ggaactcagc cagggttagg
     5821 tagttcctag atagcatttt agaaaggtca ggtgtcatcc attaacatgt gtttagattg
     5881 ctaaagattg ctgcttggcc aggcacagtg gctcatgcct ataatcccag cactttggga
     5941 ggccgaggtg ggcggatcac ctgaggtcag gagtttaaga ccagcctggc caacatggtg
     6001 aaaccctgtc tgtactaaaa aaattagcca ggcgtggtgg cctgtgccta taatctcagc
     6061 tactcaggag gctggggcag gagaatcact tgaacccagg aggtggagtt gcaggtagcc
     6121 aagattgtgc cagtgcactc cagcctgggc aacagaatga gactccgtgt caaaaaaaaa
     6181 aaaaaaaaaa gattgctgct taatctttaa tgagcataaa gatcaacttg agatctgaca
     6241 cctgtttaag aattatttgc ctggaccaag ataatgaatc tactctccta tgtttccttc
     6301 tagattcttt attgtttttt tatgtaggtc tgtgatctac tttgaataat tttttgtagc
     6361 gtgtgaggta ggatcaaggt gtgtgtatat agatttatca aagagaccat ggtttcctct
     6421 ttgctgaggt gatctctgcc tcttggttca tttgtctttt cttgcatcaa taccatacta
     6481 tcttaattta tgttgctttg taatattttt ggaaatctgg tagtgaaagc cttccaactt
     6541 ttttattctt taagattgtc ttgccttctc tgttccccat gtttcctaaa ttaattttgg
     6601 aatctcagga ttaattttca caaatgaatt tttggtacta tgcctgtaat tgcattggtt
     6661 ttataaaata acctgaggat aattgacatc tttacaatat cgagttttcc agttgatgaa
     6721 tatggtataa ttgtccattt acctaggttg tctttaac
//
