LOCUS       NM_017865               1942 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 692 (ZNF692), transcript variant
            2, mRNA.
ACCESSION   NM_017865
VERSION     NM_017865.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Zheng,D., Wei,Z., Zhang,C., Liu,W., Gong,C., Wu,F. and Guo,W.
  TITLE     ZNF692 promotes osteosarcoma cell proliferation, migration, and
            invasion through TNK2-mediated activation of the MEK/ERK pathway
  JOURNAL   Biol Direct 19 (1), 28 (2024)
   PUBMED   38650011
  REMARK    GeneRIF: ZNF692 promotes osteosarcoma cell proliferation,
            migration, and invasion through TNK2-mediated activation of the
            MEK/ERK pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   Brown,I.N., Levario,A., Jiang,C., Stachera,W., Rodriguez,E.,
            Hao,Y.H., Woodruff,J.B., Lafita-Navarro,M.C. and Conacci-Sorrell,M.
  TITLE     ZNF692 regulates nucleolar morphology by interacting with NPM1 and
            modifying its self-assembly properties
  JOURNAL   J Biol Chem 300 (3), 105773 (2024)
   PUBMED   38382671
  REMARK    GeneRIF: ZNF692 regulates nucleolar morphology by interacting with
            NPM1 and modifying its self-assembly properties.
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Chen,H., Li,Y., Wu,G., Zeng,Q., Huang,H. and Zhang,G.
  TITLE     ZNF692 promotes cell proliferation, invasion and migration of human
            prostate cancer cells by targeting the EMT signaling pathway
  JOURNAL   Eur J Med Res 29 (1), 88 (2024)
   PUBMED   38291502
  REMARK    GeneRIF: ZNF692 promotes cell proliferation, invasion and migration
            of human prostate cancer cells by targeting the EMT signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Cai,H., Chen,S., Wu,Z., Wang,F., Tang,S., Li,D., Wang,D. and Guo,W.
  TITLE     Comprehensive analysis of ZNF692 as a potential biomarker
            associated with immune infiltration in a pan cancer analysis and
            validation in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 15 (22), 13041-13058 (2023)
   PUBMED   37980166
  REMARK    GeneRIF: Comprehensive analysis of ZNF692 as a potential biomarker
            associated with immune infiltration in a pan cancer analysis and
            validation in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 1942)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1942)
  AUTHORS   Xing,Y., Ren,S., Ai,L., Sun,W., Zhao,Z., Jiang,F., Zhu,Y. and
            Piao,D.
  TITLE     ZNF692 promotes colon adenocarcinoma cell growth and metastasis by
            activating the PI3K/AKT pathway
  JOURNAL   Int J Oncol 54 (5), 1691-1703 (2019)
   PUBMED   30816443
  REMARK    GeneRIF: Results found that ZNF692 was upregulated in colon
            adenocarcinoma (COAD) tissues and cells and that high ZNF692
            expression was significantly correlated with lymph node metastasis,
            distant metastasis and tumor stage in COAD patients. Furthermore,
            ZNF692 promoted COAD cell proliferation, migration and invasion via
            the PI3K/AKT pathway, suggesting that ZNF692 may serve as a novel
            oncogene for COAD.
REFERENCE   7  (bases 1 to 1942)
  AUTHORS   Zhu,B., Pan,Y., Zheng,X., Zhang,Q., Wu,Y., Luo,J., Li,Q., Lu,E.,
            Xu,L., Jin,G. and Ren,B.
  TITLE     A clinical, biologic and mechanistic analysis of the role of ZNF692
            in cervical cancer
  JOURNAL   Gynecol Oncol 152 (2), 396-407 (2019)
   PUBMED   30466806
  REMARK    GeneRIF: ZNF692 promotes CC cells proliferation and invasion
            through suppressing p27(kip1) transcription by directly binding its
            promoter region.
REFERENCE   8  (bases 1 to 1942)
  AUTHORS   Zhang,Q., Zheng,X., Sun,Q., Shi,R., Wang,J., Zhu,B., Xu,L.,
            Zhang,G. and Ren,B.
  TITLE     ZNF692 promotes proliferation and cell mobility in lung
            adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 490 (4), 1189-1196 (2017)
   PUBMED   28669730
  REMARK    GeneRIF: The results show that ZNF692 is expressed in LUAD tissues
            compared to adjacent normal tissues, and hyper-expression of ZNF692
            in LUAD is an independent risk factor for worse overall survival in
            LUAD patients (HR: 8.800, 95%CI: 1.082-71.560, P = 0.042) by Tissue
            Microarray stain assay (TMA).
REFERENCE   9  (bases 1 to 1942)
  AUTHORS   Shirai,T., Inoue,E., Ishimi,Y. and Yamauchi,J.
  TITLE     AICAR response element binding protein (AREBP), a key modulator of
            hepatic glucose production regulated by AMPK in vivo
  JOURNAL   Biochem Biophys Res Commun 414 (2), 287-291 (2011)
   PUBMED   21910974
REFERENCE   10 (bases 1 to 1942)
  AUTHORS   Inoue,E. and Yamauchi,J.
  TITLE     AMP-activated protein kinase regulates PEPCK gene expression by
            direct phosphorylation of a novel zinc finger transcription factor
  JOURNAL   Biochem Biophys Res Commun 351 (4), 793-799 (2006)
   PUBMED   17097062
  REMARK    GeneRIF: cloning and characterization of a novel zinc finger
            transcription factor referred to as AREBP. AREBP is phosphorylated
            at Ser(470) by AMPK.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA319079.1 and BC002948.1.
            
            On Jun 2, 2019 this sequence version replaced NM_017865.3.
            
            Transcript Variant: This variant (2) contains a different first
            exon, which results in the use of a downstream start codon,
            compared to variant 1. The resulting protein (isoform 2) has a
            shorter N-terminus when it is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3449623.1, BC002948.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306601.9/ ENSP00000305483.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA319079.1         34-46
            14-1942             BC002948.1         1-1929
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1942
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /note="zinc finger protein 692"
                     /db_xref="GeneID:55657"
                     /db_xref="HGNC:HGNC:26049"
                     /db_xref="MIM:617758"
     exon            1..168
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            169..359
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1740
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /note="isoform 2 is encoded by transcript variant 2; AICAR
                     responsive element binding protein"
                     /codon_start=1
                     /product="zinc finger protein 692 isoform 2"
                     /protein_id="NP_060335.2"
                     /db_xref="CCDS:CCDS31127.1"
                     /db_xref="GeneID:55657"
                     /db_xref="HGNC:HGNC:26049"
                     /db_xref="MIM:617758"
                     /translation="MASSPAVDVSCRRREKRRQLDARRSKCRIRLGGHMEQWCLLKER
                     LGFSLHSQLAKFLLDRYTSSGCVLCAGPEPLPPKGLQYLVLLSHAHSRECSLVPGLRG
                     PGGQDGGLVWECSAGHTFSWGPSLSPTPSEAPKPASLPHTTRRSWCSEATSGQELADL
                     ESEHDERTQEARLPRRVGPPPETFPPPGEEEGEEEEDNDEDEEEMLSDASLWTYSSSP
                     DDSEPDAPRLLPSPVTCTPKEGETPPAPAALSSPLAVPALSASSLSSRAPPPAEVRVQ
                     PQLSRTPQAAQQTEALASTGSQAQSAPTPAWDEDTAQIGPKRIRKAAKRELMPCDFPG
                     CGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNFKKHLKEHMKLHSDTRDYICE
                     FCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHQRKHAETVAALRFPC
                     EFCGKRFEKPDSVAAHRSKSHPALLLAPQESPSGPLEPCPSISAPGPLGSSEGSRPSA
                     SPQAPTLLPQQ"
     exon            360..391
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            392..655
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            656..704
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            705..839
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1061
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1139
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1218
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1333
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1433
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1942
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /note="hexamer: AATAAA"
     polyA_site      1942
                     /gene="ZNF692"
                     /gene_synonym="AREBP; Zfp692"
                     /note="major polyA site"
ORIGIN      
        1 agttccgggc tacagcagcc gacgccgaga ggcaccgttt cttcttaaaa gagaaacgct
       61 gcgcgcgcga ggtgggcccc tgtcttccag cagctccggg cctgctcgct aggcccggga
      121 ggcgcaggcg caggcgcagt gggggtgagg gcgcgtgggg gcgcacagcc tctggtgcac
      181 atggcttcct ccccggcggt ggacgtgtcc tgcaggcggc gggagaagcg gcggcagctg
      241 gacgcgcgcc gcagcaagtg ccgcatccgc ctgggcggcc acatggagca gtggtgcctc
      301 ctcaaggagc ggctgggctt ctccctgcac tcgcagctcg ccaagttcct gttggaccgg
      361 tacacttctt caggctgtgt cctctgtgca ggtcctgagc ctttgcctcc aaaaggtctg
      421 cagtatctgg tgctcttgtc tcatgcccac agccgagagt gcagcctggt gcccgggctt
      481 cgggggcctg gcggccaaga tggggggctt gtgtgggagt gctcagcagg ccataccttc
      541 tcctggggac cctctttgag ccctacacct tcagaggcac ccaagccagc ctcccttcca
      601 catactactc ggagaagttg gtgttccgag gccacgagtg ggcaggagct tgcagatttg
      661 gaatctgagc atgatgagag gactcaagag gccaggttgc ccaggagggt gggaccccca
      721 ccagagacct tcccacctcc aggagaggaa gagggtgagg aagaagagga caatgatgag
      781 gatgaagagg agatgctcag tgatgccagc ttatggacct acagctcctc cccagatgat
      841 agtgagcctg atgcccccag actactgcct tcccctgtca cctgcacacc taaagagggg
      901 gagacaccac cagcccctgc agcactctcc agtcctcttg ctgtgccggc cttgtcagca
      961 tcctcattga gttccagagc tcctccacct gcagaagtca gggtgcagcc acagctcagc
     1021 aggacccctc aagcggccca gcagactgag gccctggcca gcactgggag tcaggcccag
     1081 tctgctccaa ccccggcctg ggatgaggac actgcacaaa ttggccccaa gagaattagg
     1141 aaagctgcca aaagagagct gatgccttgt gacttccctg gctgtggaag gatcttctcc
     1201 aaccggcagt atttgaatca ccacaaaaag taccagcaca tccaccagaa gtctttctcc
     1261 tgcccagagc cagcctgtgg gaagtctttc aactttaaga aacacctgaa ggagcacatg
     1321 aagctgcaca gtgacacccg ggactacatc tgtgagttct gcgcccggtc tttccgcact
     1381 agcagcaacc ttgtcatcca cagacgtatc cacactggag aaaaacccct gcagtgtgag
     1441 atatgcgggt ttacctgccg ccagaaggct tccctgaact ggcaccagcg caagcatgca
     1501 gagacggtgg ctgccttgcg cttcccctgt gaattctgcg gcaagcgctt tgagaagcca
     1561 gacagtgttg cagcccaccg tagcaaaagt cacccagccc tgcttctagc ccctcaagag
     1621 tcacccagtg gtcccctaga gccctgtccc agcatctctg cccctgggcc tctgggatcc
     1681 agcgaggggt ccaggccctc tgcatctcct caggctccaa ccctgcttcc tcagcaatga
     1741 gctctcctcc agctttggct ttgggaagcc agactccagg gactgaaaag gagcaacaag
     1801 gagagggtct gcttgagaaa tgccagatgc ttggtcccca ggaactaagg cgacagagtg
     1861 cagggtgggg gcaagactgg gctgtagggg agctggacta ctttagtctt cctaaaggac
     1921 aaaataaaca gtattttatg ca
//
