LOCUS       NM_138447               3557 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 689 (ZNF689), transcript variant
            1, mRNA.
ACCESSION   NM_138447
VERSION     NM_138447.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Ge,L.P., Jin,X., Ma,D., Wang,Z.Y., Liu,C.L., Zhou,C.Z., Zhao,S.,
            Yu,T.J., Liu,X.Y., Di,G.H., Shao,Z.M. and Jiang,Y.Z.
  TITLE     ZNF689 deficiency promotes intratumor heterogeneity and
            immunotherapy resistance in triple-negative breast cancer
  JOURNAL   Cell Res 34 (1), 58-75 (2024)
   PUBMED   38168642
  REMARK    GeneRIF: ZNF689 deficiency promotes intratumor heterogeneity and
            immunotherapy resistance in triple-negative breast cancer.
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Zhou,R., Liang,J., Chen,Q., Tian,H., Yang,C. and Liu,C.
  TITLE     A 3-Gene Random Forest Model to Diagnose Non-obstructive
            Azoospermia Based on Transcription Factor-Related Henes
  JOURNAL   Reprod Sci 30 (1), 233-246 (2023)
   PUBMED   35715550
  REMARK    GeneRIF: A 3-Gene Random Forest Model to Diagnose Non-obstructive
            Azoospermia Based on Transcription Factor-Related Henes.
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Koh,M., Ahmad,I., Ko,Y., Zhang,Y., Martinez,T.F., Diedrich,J.K.,
            Chu,Q., Moresco,J.J., Erb,M.A., Saghatelian,A., Schultz,P.G. and
            Bollong,M.J.
  TITLE     A short ORF-encoded transcriptional regulator
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33468658
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Shigematsu,S., Fukuda,S., Nakayama,H., Inoue,H., Hiasa,Y., Onji,M.
            and Higashiyama,S.
  TITLE     ZNF689 suppresses apoptosis of hepatocellular carcinoma cells
            through the down-regulation of Bcl-2 family members
  JOURNAL   Exp Cell Res 317 (13), 1851-1859 (2011)
   PUBMED   21624362
  REMARK    GeneRIF: The results indicate that ZNF689 blocks pro-apoptotic
            signaling by suppressing the Bak/Bax/Bid pathway, resulting in the
            progression of liver cancer and resistance to 5-FU. ZNF689 may be a
            promising chemotherapeutic target against liver cancer.
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Silva,F.P., Hamamoto,R., Furukawa,Y. and Nakamura,Y.
  TITLE     TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in
            human hepatocellular carcinomas
  JOURNAL   Oncogene 25 (36), 5063-5070 (2006)
   PUBMED   16568080
  REMARK    GeneRIF: overexpressed TIPUH1 may play a role in
            hepatocarcinogenesis by regulating transcription and/or RNA
            processing of growth control genes
            GeneRIF: TIPUH1 conferred anchorage independent growth and its
            knockdown in HCCs resulted in their growth inhibition. Interacts
            with TIF1beta, hnRNPU, hnRNPF, Nucleolin. May play a role in
            hepatocarcinogenesis by regulating transcription and/or RNA
            processing.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093249.4, DA485303.1, BC014000.2 and AL834299.1.
            
            On May 17, 2019 this sequence version replaced NM_138447.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.132600.1,
                                           SRR7346977.2131755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMN03267783
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287461.8/ ENSP00000287461.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC093249.4         96730-96732
            4-28                DA485303.1         1-25
            29-2750             BC014000.2         1-2722
            2751-3557           AL834299.1         1554-2360
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..3557
                     /gene="ZNF689"
                     /gene_synonym="TIPUH1"
                     /note="zinc finger protein 689"
                     /db_xref="GeneID:115509"
                     /db_xref="HGNC:HGNC:25173"
                     /db_xref="MIM:618033"
     exon            1..553
                     /gene="ZNF689"
                     /gene_synonym="TIPUH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1851
                     /gene="ZNF689"
                     /gene_synonym="TIPUH1"
                     /note="transcription-involved protein upregulated in HCC
                     1; short ORF-encoded histone-binding protein"
                     /codon_start=1
                     /product="zinc finger protein 689"
                     /protein_id="NP_612456.1"
                     /db_xref="CCDS:CCDS10686.1"
                     /db_xref="GeneID:115509"
                     /db_xref="HGNC:HGNC:25173"
                     /db_xref="MIM:618033"
                     /translation="MAPPSAPLPAQGPGKARPSRKRGRRPRALKFVDVAVYFSPEEWG
                     CLRPAQRALYRDVMRETYGHLGALGCAGPKPALISWLERNTDDWEPAALDPQEYPRGL
                     TVQRKSRTRKKNGEKEVFPPKEAPRKGKRGRRPSKPRLIPRQTSGGPICPDCGCTFPD
                     HQALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVCDQCGKRFSQRK
                     NLSQHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTHTGEKPHQCPSCGRRFAYPSLL
                     AIHQRTHTGEKPYTCLECNRRFRQRTALVIHQRIHTGEKPYPCPDCERRFSSSSRLVS
                     HRRVHSGERPYACEHCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRRSGSLAIHR
                     STHTEEKLHACDDCGRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLAQHQLL
                     HTGEKPFPCLECGRCFRQRWSLAVHKCSPKAPNCSPRSAIGGSSQRGNAH"
     exon            554..667
                     /gene="ZNF689"
                     /gene_synonym="TIPUH1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..3557
                     /gene="ZNF689"
                     /gene_synonym="TIPUH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3536..3541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF689"
                     /gene_synonym="TIPUH1"
                     /note="hexamer: ATTAAA"
     polyA_site      3557
                     /gene="ZNF689"
                     /gene_synonym="TIPUH1"
                     /note="major polyA site"
ORIGIN      
        1 gccattacac ttgagggcaa agaggttagg aagccggcat ggcgctccgg tcaataaaat
       61 cgatagctgg aagctgcctg tgttccaggc aaaggcggtg cggtagcagc gccgccattt
      121 tccccgaagg catcttccgg tgcctttcac ccaagttcgg gcaggagttt cctgaataac
      181 agcaaaaggt ttccgttagc cccgcgggcg accaattccg attccctccg ggcctccccg
      241 gccacgctca gccctggtcc ggcaggggct cctcgatccc aggggccgcc agcgcccgag
      301 ggccgaggcc tggacacgga aggccgtggc gccggcttct cgggtcccat ggcgccacct
      361 tcggctccgc tccctgcgca gggaccagga aaggccagac ccagtcggaa aaggggcagg
      421 aggccgaggg ctctgaagtt cgtggacgtg gccgtgtact tctccccgga ggagtggggc
      481 tgcctgcggc ccgcgcagag ggccctgtac cgggacgtga tgcgggagac ctacggtcac
      541 ctgggcgcgc tcgggtgcgc aggtcccaaa ccagccctca tctcctggtt ggaacgaaac
      601 accgatgact gggaaccggc tgctctagat ccgcaggagt acccgagagg gctaacagtc
      661 cagagaaaaa gcagaaccag aaagaagaat ggggagaagg aagtattccc gcctaaggag
      721 gcaccccgaa aggggaagcg aggccggagg cccagcaaac cccgactgat tcctaggcag
      781 acgtccgggg gccccatctg ccctgactgc ggctgtacct tccctgatca tcaggccctg
      841 gagagccaca agtgcgccca gaatctaaaa aagccttacc cttgcccaga ctgtgggcgc
      901 cgcttttcct atccatccct gctggtcagt caccggcggg cacactccgg cgagtgcccc
      961 tatgtttgtg accagtgtgg caaacgtttc tcccagcgca agaacctctc ccagcaccag
     1021 gtcatccata caggggagaa gccctatcac tgccctgact gtggtcgctg cttccggagg
     1081 agccggtcct tggccaatca ccggaccaca cacacaggtg aaaaacccca ccagtgccct
     1141 agctgtggac gtcgcttcgc ctacccctcc ctgctagcca tccaccagcg tacacacacg
     1201 ggagagaagc cctacacttg cctcgagtgc aaccgccgct tccgccagcg cacggccctc
     1261 gtcatccacc agcgcatcca cacgggcgag aagccctacc cgtgcccgga ctgcgagcgg
     1321 cgcttctcct cctcctctcg cctggtcagt caccggcgtg tgcactctgg ggagcgtccc
     1381 tatgcctgcg agcactgtga ggcccgcttc tcccagcgca gcacgctgct ccagcaccag
     1441 ctcttgcaca ccggagagaa gccctacccc tgcccagact gtgggcgtgc cttccggcgg
     1501 agcggctccc tggccatcca tcgcagcacg cacacagagg agaagctgca cgcctgcgac
     1561 gactgtggtc gccgctttgc ctacccctca ctgctggcca gccaccggcg cgtgcactcg
     1621 ggcgagcggc cctatgcctg cgacctttgc tccaagcgtt ttgctcagtg gagccacctg
     1681 gcccagcacc agctgctgca cacgggggag aagcctttcc cctgcctcga gtgtggccgg
     1741 tgcttccgcc agaggtggtc tctggctgtc cacaagtgta gccccaaggc cccaaactgt
     1801 agccctagat ctgctatcgg gggctccagt cagaggggca acgcccatta gaaggggaag
     1861 gactgcctac gttcatttca ttttatggag ggtcccagaa aagggaagga ggagccccag
     1921 gtcatacagg gcagagtcag aactaaaccc gggtctcctg ctgcacagag ctgaactttg
     1981 tatcttgcaa tgcgctggct gcctccctgt gcgtgtctgg aacagtccca ttaggagagg
     2041 tgacgtcatt tgcttaaagt tttccaagct accctatcct aaaatagttt gtgtggatat
     2101 cagggctaaa agttctcccc atctatttta ggggctgtct gcttttctag tctgtccaca
     2161 cagggattac ctgtcatctt gcatgcaatc aggagaatct cataggggca ggaccttccc
     2221 ctactctgcc tcttcctcca tactaggttg gaaaaatctg gtttagccca ctttttgcaa
     2281 cactcctgcc aagtggtctt ctacccattg cttgaaaatc tctcttgaca gggagctcac
     2341 tacctcacaa ggcaggtcat ttcattgtgg gatctataga aggttaagta ccacattctc
     2401 ctctaaacct tgcctacgac atgtttaata cttcatctac atagcagccc ttcagataat
     2461 cacaaccact ttgcccccaa gttttcaggt taagtagcat gaatttggtc attccttaaa
     2521 gacagggttt caatttccac acatgatctc tgcaaacagg cactgggttt tcagtgtcct
     2581 ttttgaaggg tcatataaaa ataaggtaac accacagtgc cactacacct tctggggctg
     2641 gacttgtttc agcagctttg gttgcactga atttggggga gctgcatggt accaggggtt
     2701 tattgggttg cagatatata aatgccctaa acttaaaaaa aaaaaaaaaa gctataaaac
     2761 taagtcttca tcttgtattt ggaaaattgg ttcaagctgg gtatgagaca taagtgtagt
     2821 cagctctggg agaaggttgc tcttaaggag aagcagggac ctgtggttta gcagcaggaa
     2881 gtgcaaatgg gactggcttg tgctctacct ggcagacctg gattggcttc aggcagccag
     2941 tgcctggaaa agcctggaga attgggccgt acttgaccct gattctcatc aggcacagat
     3001 gaatcacagg cacctaagaa tcggcacaga acttccatga ggcctcagtc agcatttttt
     3061 cacaaaatga gctgaggcca ttcaaggagg ctagaaagag ggaactgaat ccagagagga
     3121 agagtctata gtcatcaagt tgtatccatg ccagcctccc tccacagagg tggcagcagc
     3181 gtggctcaat ctgatccacc tccatggcac ccactgggta ggtgcttcat aaagctttac
     3241 cgagttaaat gtgaacaagg cctaccactt tgccttgggc agctgcacca aattagaatt
     3301 tccagatgtg actcatctca tattccaaca gctggagtgg gtcatccttt acccctgtgg
     3361 ctccttccta cagctctcct gatctcagca caagcagggg agcagctggg ggaacacagc
     3421 tttatgtaat tacctctgtt caatatttag caagttgcat tgtaacattg taactgtttg
     3481 tttctccttg gatgatgagc tacccccaag aaggggtcat atcagattgg gtctcattaa
     3541 aatgtctgat gaatgaa
//
