LOCUS       NM_145271               1106 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 688 (ZNF688), transcript variant
            1, mRNA.
ACCESSION   NM_145271
VERSION     NM_145271.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1106)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 1106)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1106)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 1106)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122680.1 and BC018997.2.
            
            On Aug 11, 2020 this sequence version replaced NM_145271.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122680.1, BC018997.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223459.11/ ENSP00000223459.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK122680.1         1022-1055
            35-1106             BC018997.2         7-1078
FEATURES             Location/Qualifiers
     source          1..1106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1106
                     /gene="ZNF688"
                     /note="zinc finger protein 688"
                     /db_xref="GeneID:146542"
                     /db_xref="HGNC:HGNC:30489"
     exon            1..281
                     /gene="ZNF688"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..916
                     /gene="ZNF688"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 688 isoform a"
                     /protein_id="NP_660314.1"
                     /db_xref="CCDS:CCDS10684.1"
                     /db_xref="GeneID:146542"
                     /db_xref="HGNC:HGNC:30489"
                     /translation="MAPPPAPLLAPRPGETRPGCRKPGTVSFADVAVYFSPEEWGCLR
                     PAQRALYRDVMQETYGHLGALGFPGPKPALISWMEQESEAWSPAAQDPEKGERLGGAR
                     RGDVPNRKEEEPEEVPRAKGPRKAPVKESPEVLVERNPDPAISVAPARAQPPKNAAWD
                     PTTGAQPPAPIPSMDAQAGQRRHVCTDCGRRFTYPSLLVSHRRMHSGERPFPCPECGM
                     RFKRKFAVEAHQWIHRSCSGGRRGRRPGIRAVPRAPVRGDRDPPVLFRHYPDIFEECG
                     "
     exon            282..395
                     /gene="ZNF688"
                     /inference="alignment:Splign:2.1.0"
     exon            396..1106
                     /gene="ZNF688"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1061..1066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF688"
                     /note="hexamer: AAGAAA"
     polyA_site      1106
                     /gene="ZNF688"
                     /note="major polyA site"
ORIGIN      
        1 ctgtggacaa cgacagctga ggccgggagc ggggaggcgg cggctccagg gacctggcgg
       61 ccgccgatcg gggctgcgag gccccatggc gccgccccca gccccgctcc tggcgccgag
      121 gcccggggag acccggcctg gttgcaggaa gcccgggact gtgagcttcg cggacgtggc
      181 cgtgtacttc tccccggagg agtggggctg tctgcggccc gcgcagaggg ctctgtaccg
      241 ggacgtgatg caggagacct acggccacct gggcgcgctc ggattcccag gccccaaacc
      301 agccctcatc tcttggatgg aacaggagag tgaggcttgg agccccgccg cccaggatcc
      361 tgagaagggg gaaagactgg gaggagctcg gagaggagat gtcccaaaca ggaaggaaga
      421 ggaaccggag gaagtcccaa gagccaaagg gcctagaaag gctcctgtga aggagagtcc
      481 tgaagtgctg gtggaacgca accctgaccc agctattagc gtggccccgg cacgggcaca
      541 gccacccaaa aatgctgcct gggacccgac cacaggagca cagcccccgg cacccatacc
      601 cagcatggat gctcaggccg gccagcggcg ccacgtgtgc acggactgcg gccgccgctt
      661 cacctacccc tcactgctgg tcagccacag gcgcatgcac tcgggggagc ggcctttccc
      721 ctgccccgag tgtggcatgc gcttcaagag gaagttcgca gtggaagcgc accagtggat
      781 ccaccgctcc tgctccgggg ggcggcgggg ccggaggcct gggatccggg ctgtgcctcg
      841 ggcccccgtc cgaggtgacc gggacccgcc tgtgctcttc cggcactacc cagacatctt
      901 cgaggagtgc ggctgagcgg caccgcaggc tggagttgag cctgaccttg gcacgaagga
      961 ctgacggatc cctgaggtgg gccactgagt cggggactcc ggaactgaaa ttcatgccct
     1021 gggctttcct caaggatccc tcaagtttcc aacttgtaaa aagaaaagtg cctgtaaaga
     1081 ttcgaataga ttagacttgc caccca
//
