LOCUS       NM_020832               4795 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens zinc finger protein 687 (ZNF687), transcript variant
            2, mRNA.
ACCESSION   NM_020832
VERSION     NM_020832.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4795)
  AUTHORS   Li,J., Li,S., Xing,X., Liu,N., Lai,S., Liao,D. and Li,J.
  TITLE     FTO-mediated ZNF687 accelerates tumor growth, metastasis, and
            angiogenesis in colorectal cancer through the Wnt/beta-catenin
            pathway
  JOURNAL   Biotechnol Appl Biochem 71 (2), 245-255 (2024)
   PUBMED   37983718
  REMARK    GeneRIF: FTO-mediated ZNF687 accelerates tumor growth, metastasis,
            and angiogenesis in colorectal cancer through the Wnt/beta-catenin
            pathway.
REFERENCE   2  (bases 1 to 4795)
  AUTHORS   Li,M., Liu,Z., Hou,Z., Wang,X., Shi,H., Li,Y., Xiao,X., Tang,Z.,
            Yang,J., Luo,Y., Zhang,M. and Chen,M.
  TITLE     Oncogenic zinc finger protein ZNF687 accelerates lung
            adenocarcinoma cell proliferation and tumor progression by
            activating the PI3K/AKT signaling pathway
  JOURNAL   Thorac Cancer 14 (14), 1223-1238 (2023)
   PUBMED   36944484
  REMARK    GeneRIF: Oncogenic zinc finger protein ZNF687 accelerates lung
            adenocarcinoma cell proliferation and tumor progression by
            activating the PI3K/AKT signaling pathway.
REFERENCE   3  (bases 1 to 4795)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   4  (bases 1 to 4795)
  AUTHORS   Scotto di Carlo,F., Pazzaglia,L., Mumm,S., Benassi,M.S., De
            Chiara,A., Franchi,A., Parafioriti,A., Righi,A., Esposito,T.,
            Whyte,M.P. and Gianfrancesco,F.
  TITLE     ZNF687 Mutations in an Extended Cohort of Neoplastic
            Transformations in Paget's Disease of Bone: Implications for
            Clinical Pathology
  JOURNAL   J Bone Miner Res 35 (10), 1974-1980 (2020)
   PUBMED   32106343
  REMARK    GeneRIF: ZNF687 Mutations in an Extended Cohort of Neoplastic
            Transformations in Paget's Disease of Bone: Implications for
            Clinical Pathology.
REFERENCE   5  (bases 1 to 4795)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4795)
  AUTHORS   Divisato,G., Formicola,D., Esposito,T., Merlotti,D., Pazzaglia,L.,
            Del Fattore,A., Siris,E., Orcel,P., Brown,J.P., Nuti,R.,
            Strazzullo,P., Benassi,M.S., Cancela,M.L., Michou,L., Rendina,D.,
            Gennari,L. and Gianfrancesco,F.
  TITLE     ZNF687 Mutations in Severe Paget Disease of Bone Associated with
            Giant Cell Tumor
  JOURNAL   Am J Hum Genet 98 (2), 275-286 (2016)
   PUBMED   26849110
  REMARK    GeneRIF: ZNF687 Expression increased in paget disease of bone
            Affected Individuals.
REFERENCE   7  (bases 1 to 4795)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   8  (bases 1 to 4795)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   9  (bases 1 to 4795)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   10 (bases 1 to 4795)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391069.11, AB037862.1,
            BC032463.1 and CR749307.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020832.2.
            
            Summary: This gene encodes C2H2 zinc finger protein. The encoded
            protein may play a role in bone differentiation and development.
            Mutations in this gene are the cause of Paget disease of bone-6.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032463.1, SRR7346977.2102064.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336715.11/ ENSP00000336620.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL391069.11        19254-19266
            14-16               AB037862.1         1-3
            17-4027             BC032463.1         1-4011
            4028-4524           CR749307.1         4086-4582
            4525-4795           AL391069.11        28861-29131
FEATURES             Location/Qualifiers
     source          1..4795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..4795
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /note="zinc finger protein 687"
                     /db_xref="GeneID:57592"
                     /db_xref="HGNC:HGNC:29277"
                     /db_xref="MIM:610568"
     exon            1..97
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     exon            98..2229
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..3828
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /codon_start=1
                     /product="zinc finger protein 687"
                     /protein_id="NP_065883.1"
                     /db_xref="CCDS:CCDS992.1"
                     /db_xref="GeneID:57592"
                     /db_xref="HGNC:HGNC:29277"
                     /db_xref="MIM:610568"
                     /translation="MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGPGKPE
                     PGVGSESEDTAAASAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGS
                     AGDGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPGTPHSPAPPSGGTWKEKGMEGKTPL
                     DLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSPPL
                     GALKQESCSPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQSPLASP
                     KVPVCQPLKEEDDDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKT
                     IKTSCGNITRTVTQVPSDPDPPAPLAEGAFLAEASLLKLSPATPTSEGPKVVSVQLGD
                     GTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKMIAKNVLGLVPQALP
                     KADGRAGLGTGGQKVNGASVVMVQPSKTATGPSTGGGTVISRTQSSLVEAFNKILNSK
                     NLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHC
                     ARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPV
                     SGPLALPALGKGEGAITSSAITTVAAEAPVLPLSTEPPAAPATSAYTCFRCLECKEQC
                     RDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGG
                     NFLQANFQTHLREACLHVSRRVGYRCPSCSVVFGGVNSIKSHIQTSHCEVFHKCPICP
                     MAFKSGPSAHAHLYSQHPSFQTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVS
                     VFKCPSCPLLFAQKRTMLEHLKNTHQSGRLEETAGKGAGGALLTPKTEPEELAVSQGG
                     AAPATEESSSSSEEEEVPSSPEPPRPAKRPRRELGSKGLKGGGGGPGGWTCGLCHSWF
                     PERDEYVAHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTE
                     GKRTFSSRLILEKHVQVRHGLQLGAQSPGRGTTLARGSSARAQGPGRKRRQSSDSCSE
                     EPDSTTPPAKSPRGGPGSGGHGPLRYRSSSSTEQSLMMGLRVEDGAQQCLDCGLCFAS
                     PGSLSRHRFISHKKRRGVGKASALGLGDGEEEAPPSRSDPDGGDSPLPASGGPLTCKV
                     CGKSCDSPLNLKTHFRTHGMAFIRARQGAVGDN"
     exon            2230..2408
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2585
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2748
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..3078
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3191
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3333
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..4795
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4497..4502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /note="hexamer: ATTAAA"
     polyA_site      4524
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /note="major polyA site"
     regulatory      4781..4786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
                     /note="hexamer: ATTAAA"
     polyA_site      4795
                     /gene="ZNF687"
                     /gene_synonym="PDB6"
ORIGIN      
        1 aggaagtagc ggcggccgcg gggagggcgg cggtggctgc agcggctgga gcggggtaga
       61 gaccgccggg tctcggcccg caccaggagc ggaacaagtc tgggatctgc cgatatgggg
      121 gatatgaaga cccctgattt tgatgacctc cttgctgcct ttgacatccc tgacattgat
      181 gcgaatgaag ccatccattc tgggccagaa gaaaatgagg ggcctggagg cccagggaag
      241 ccagaaccag gtgtaggaag tgaatctgaa gacacagcag cagcctctgc tggggatggc
      301 cctggagttc cagcccaggc ctctgaccat ggcctgccac cgccagacat ttctgtagtc
      361 agtgtcattg tcaagaacac tgtgtgtccc gagcagtctg aggccctggc tggaggctca
      421 gcaggagacg gggcccaggc tgctggggta actaaagaag ggcctgtggg gcctcatcga
      481 atgcagaatg gttttgggag ccctgaacct tccctcccag gaactcccca ctctcctgct
      541 cctcccagtg ggggcacctg gaaagaaaaa ggcatggaag gcaaaactcc cttggacctg
      601 tttgctcatt ttggccctga gccaggggac cactcagatc cgctgcctcc ctctgcaccc
      661 tctcccactc gggagggggc tctgaccccg cctcctttcc cctcttcctt tgagctggcc
      721 caggagaatg gcccaggcat gcagccacct gtttcttccc caccattggg ggccttgaag
      781 caggagagct gcagccccca tcatccccag gtcctagccc aacaaggctc aggctccagc
      841 cctaaggcca cggacatccc tgccagtgcc tcgcctcccc cagttgctgg ggtgcccttc
      901 ttcaagcagt ctccagggca ccagagccct cttgcctccc ccaaagtgcc cgtctgtcag
      961 cccttgaagg aagaagatga tgatgagggg ccagtggaca agtcttcccc aggaagtccc
     1021 cagagtccct ctagtggggc cgaggctgca gatgaggaca gcaatgactc ccctgcctcc
     1081 agctcctcta ggcctcttaa ggtgcggatc aagaccatta aaacatcctg cgggaatatc
     1141 acaaggactg taactcaggt cccctcagat cctgatccac ctgccccctt ggctgagggg
     1201 gccttcttgg ctgaggctag cctcttgaag ctgtcccctg caacacctac ttctgagggt
     1261 ccaaaggtgg tgagcgtaca gttgggtgat ggtacaaggc tgaaaggcac tgtgctgcct
     1321 gtggccacca tccagaacgc cagtactgcc atgctgatgg cagccagtgt ggctcgcaag
     1381 gctgtggtgc tgcctggggg gactgccacc agccctaaga tgattgctaa gaacgtgcta
     1441 ggcctggtgc cccaagccct gcctaaggct gacgggcggg cagggctggg gactggggga
     1501 cagaaggtga atggtgcctc ggtggtgatg gtgcaacctt caaagacagc tactgggcca
     1561 agtacagggg gcggcacagt gatatcacgg acccagtcca gcctggtgga ggccttcaac
     1621 aagatcctca acagcaagaa cctgctccct gcctataggc caaacctgag cccaccagct
     1681 gaggctgggc tggccctgcc tcccaccggc taccgctgcc tggagtgtgg ggatgccttc
     1741 tcattggaga agagcctggc acggcactat gaccgtcgga gcatgcgcat cgaggtcacc
     1801 tgcaaccact gcgcccgccg cctggtcttc ttcaacaagt gcagcctgct cctgcatgca
     1861 cgtgaacaca aggacaaggg gctcgtcatg cagtgctcac atttggtcat gaggcctgta
     1921 gcccttgacc agatggtggg gcagccggac atcacaccgc tgctgcctgt agctgtccca
     1981 cctgtctctg gacctctggc cttgcctgcc ttgggcaagg gtgagggggc catcacctcc
     2041 tctgccatta ctacagttgc tgctgaggcc cctgtcctgc cgctctccac agagccgcct
     2101 gctgccccgg ccacctctgc ttacacatgc tttcgctgcc tggagtgcaa ggaacagtgc
     2161 cgggacaagg ctggcatggc agctcacttc cagcagctcg gcccccctgc ccctggggcc
     2221 accagcaatg tgtgcccaac ctgccccatg atgctcccca atcgctgcag cttcagcgcc
     2281 caccagcgca tgcataagaa tcgacccccc catgtctgtc ctgagtgtgg gggcaacttc
     2341 ctgcaagcca attttcagac ccatctccgg gaggcctgtc tgcacgtctc tcgccgtgta
     2401 ggatacaggt gccccagctg ttcagtggtg tttgggggtg tgaactccat caagtcccac
     2461 atccagacgt cgcactgcga ggttttccac aagtgcccca tctgccccat ggccttcaag
     2521 tctgggccaa gtgcccatgc ccacctctac tcccagcatc ccagcttcca aactcagcag
     2581 gccaagctga tctacaagtg cgccatgtgc gacacagtct tcactcacaa acccctcctc
     2641 tcctcacact tcgaccagca cttgctgccc cagcgtgtca gtgtctttaa gtgcccgtct
     2701 tgtcctctgc tctttgccca aaaaaggacc atgctggaac atctcaagaa cacccatcag
     2761 tctgggcgct tggaggagac tgctgggaaa ggggccgggg gtgccctgct gacccccaag
     2821 actgagcctg aggagctggc tgtttctcag ggaggggcag cccctgctac tgaggagtcg
     2881 tcttcatctt cagaagagga ggaagtaccc agctcccctg agcccccccg tccagccaaa
     2941 cggcctcggc gggaactagg gagcaaaggc ctcaagggtg ggggtggggg gcctggaggc
     3001 tggacctgtg gcctgtgtca ctcctggttc cctgagcgtg atgaatacgt ggcccacatg
     3061 aagaaggagc atggcaagtc agtgaaaaag ttcccctgtc gcctgtgtga gcgctccttc
     3121 tgctccgccc ccagcctgag gcgccatgtc agagttaatc acgagggcat caagcgagtt
     3181 tacccctgca ggtattgcac agagggaaaa cgcaccttca gcagccgcct gatcctagag
     3241 aaacatgtcc aggtccggca cggcttgcag cttggggccc agtcccctgg ccgggggacc
     3301 accttggctc ggggttccag tgccagagcc caggggccag gtcggaaacg ccgccagtct
     3361 tctgactctt gcagtgagga gcctgacagc acgacaccgc cagccaagtc ccccaggggc
     3421 ggacctggat ctggaggcca tggccctctg cgctaccgga gcagcagctc cacagaacag
     3481 agcctcatga tggggttgag ggtggaggat ggtgcccagc agtgcctcga ctgtggcttg
     3541 tgctttgcct cccctggctc cctgagccga caccgtttca tcagccacaa gaagagacgg
     3601 ggtgtgggta aagccagtgc cctggggctg ggggatgggg aggaagaggc ccctccatca
     3661 aggtctgacc ccgatggtgg agactcaccc ctgcctgctt ctggaggccc actgacctgt
     3721 aaggtctgtg gcaagagctg cgacagccct ctaaacctca agacccactt ccgcacgcat
     3781 ggcatggcgt tcatcagggc tcggcagggg gctgttgggg acaactagtc tccaaggcct
     3841 gggactgacc agccccttcc tcttggagcc tggttttccc tactgctgcc tgatccctcg
     3901 gctggggagt tttcattaac attaatattt tgttaattcc tgtctctcca acctgaagaa
     3961 gaagagcatt tgaggattat tctagttatt tgcaacctcc ctttgggttt ggccctggag
     4021 tcctagtaga gtggaccctc cattcctcct ttctgagccc aacactaatt aattttatgc
     4081 tcctgctgca gaacccccag tgtgggcctg ggggtgggag gatgggactt aggtatgcct
     4141 gctagacagg ttcagggaag gactgatggg ggtgtcatgg atggacacac ctctccacaa
     4201 ttccttcagg catggactgg aactttcctc ctctaggccg ggccctgccc tagtgcccac
     4261 ccccgccccc gcccccgccc aaccccaact cactggcact caagccccct acccctgcag
     4321 tgcctttcac ttcttttttt ccccagaaat ccggggcggg ggggtggggg gttggtaggg
     4381 atgagtcctg tcaagggggc cacaggagag gaggggacag gctctcagga atcctttatt
     4441 cttgtagtaa taataatact aacaaacagt tggggaacta gggagaaaac cagaccatta
     4501 aaactgtttg tggtcgaatc tccattcagg cctctctttt tctgtgactt ggacaatgtg
     4561 gagttgaagc gggtgagaga acatggaagg cccgcccttc tcagggaaga ggtggtagtg
     4621 accaagacag gcagggaaaa agcaaacttc tatgtagtgc cttttgtatc ttggacactg
     4681 aggcatccgt tcatacctca tcacccatct ccccctgcac tcccccagaa aacctggaaa
     4741 tgacacaagt ggctaactaa ggactttatt tcaaacaaaa attaaaaata aaaaa
//
