LOCUS       NM_001114759            1628 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 683 (ZNF683), transcript variant
            1, mRNA.
ACCESSION   NM_001114759
VERSION     NM_001114759.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1628)
  AUTHORS   Kitakaze,M., Uemura,M., Hara,T., Chijimatsu,R., Motooka,D.,
            Hirai,T., Konno,M., Okuzaki,D., Sekido,Y., Hata,T., Ogino,T.,
            Takahashi,H., Miyoshi,N., Ofusa,K., Mizushima,T., Eguchi,H.,
            Doki,Y. and Ishii,H.
  TITLE     Cancer-specific tissue-resident memory T-cells express ZNF683 in
            colorectal cancer
  JOURNAL   Br J Cancer 128 (10), 1828-1837 (2023)
   PUBMED   36869093
  REMARK    GeneRIF: Cancer-specific tissue-resident memory T-cells express
            ZNF683 in colorectal cancer.
REFERENCE   2  (bases 1 to 1628)
  AUTHORS   Li,X., Chen,M., Wan,Y., Zhong,L., Han,X., Chen,X., Xiao,F., Liu,J.,
            Zhang,Y., Zhu,D., Xiang,J., Liu,J., Huang,H. and Hou,J.
  TITLE     Single-cell transcriptome profiling reveals the key role of ZNF683
            in natural killer cell exhaustion in multiple myeloma
  JOURNAL   Clin Transl Med 12 (10), e1065 (2022)
   PUBMED   36245253
  REMARK    GeneRIF: Single-cell transcriptome profiling reveals the key role
            of ZNF683 in natural killer cell exhaustion in multiple myeloma.
REFERENCE   3  (bases 1 to 1628)
  AUTHORS   Lu,Y., Zhang,M.X., Pang,W., Song,T.Z., Zheng,H.Y., Tian,R.R. and
            Zheng,Y.T.
  TITLE     Transcription Factor ZNF683 Inhibits SIV/HIV Replication through
            Regulating IFNgamma Secretion of CD8+ T Cells
  JOURNAL   Viruses 14 (4), 719 (2022)
   PUBMED   35458449
  REMARK    GeneRIF: Transcription Factor ZNF683 Inhibits SIV/HIV Replication
            through Regulating IFNgamma Secretion of CD8+ T Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1628)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1628)
  AUTHORS   Kragten,N.A.M., Behr,F.M., Vieira Braga,F.A., Remmerswaal,E.B.M.,
            Wesselink,T.H., Oja,A.E., Hombrink,P., Kallies,A., van Lier,R.A.W.,
            Stark,R. and van Gisbergen,K.P.J.M.
  TITLE     Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme
            B in CD8 T cells
  JOURNAL   Eur J Immunol 48 (10), 1644-1662 (2018)
   PUBMED   30051906
  REMARK    GeneRIF: These findings suggest that Blimp-1 initiates cytotoxic
            effector function and that Hobit maintains cytotoxicity in a
            deployment-ready modus in tissue-resident memory CD8 T cells.
REFERENCE   6  (bases 1 to 1628)
  AUTHORS   Lunemann,S., Martrus,G., Goebels,H., Kautz,T., Langeneckert,A.,
            Salzberger,W., Koch,M., J Bunders,M., Nashan,B., van
            Gisbergen,K.P.J.M. and Altfeld,M.
  TITLE     Hobit expression by a subset of human liver-resident CD56bright
            Natural Killer cells
  JOURNAL   Sci Rep 7 (1), 6676 (2017)
   PUBMED   28751776
  REMARK    GeneRIF: Transcription factor Hobit identifies a subset of NK cells
            in Human livers that express a distinct set of adhesion molecules
            and chemokine receptors consistent with tissue residency. These
            data suggest that Hobit is involved in regulating tissue-residency
            of human intrahepatic CD56bright NK cells in a subset of NK cells
            in inflamed livers.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1628)
  AUTHORS   Braun,J., Frentsch,M. and Thiel,A.
  TITLE     Hobit and human effector T-cell differentiation: The beginning of a
            long journey
  JOURNAL   Eur J Immunol 45 (10), 2762-2765 (2015)
   PUBMED   26440905
  REMARK    GeneRIF: Hobit's function in human T cells is highly adapted to
            lifelong, periodic challenges with varying, physiological doses of
            pathogens.
            Review article
REFERENCE   8  (bases 1 to 1628)
  AUTHORS   Vieira Braga,F.A., Hertoghs,K.M., Kragten,N.A., Doody,G.M.,
            Barnes,N.A., Remmerswaal,E.B., Hsiao,C.C., Moerland,P.D.,
            Wouters,D., Derks,I.A., van Stijn,A., Demkes,M., Hamann,J.,
            Eldering,E., Nolte,M.A., Tooze,R.M., ten Berge,I.J., van
            Gisbergen,K.P. and van Lier,R.A.
  TITLE     Blimp-1 homolog Hobit identifies effector-type lymphocytes in
            humans
  JOURNAL   Eur J Immunol 45 (10), 2945-2958 (2015)
   PUBMED   26179882
  REMARK    GeneRIF: These data implicate Hobit as a novel transcriptional
            regulator in quiescent human effector-type CD8(+) T cells that
            regulates their immediate effector functions.
REFERENCE   9  (bases 1 to 1628)
  AUTHORS   van Gisbergen,K.P., Kragten,N.A., Hertoghs,K.M., Wensveen,F.M.,
            Jonjic,S., Hamann,J., Nolte,M.A. and van Lier,R.A.
  TITLE     Mouse Hobit is a homolog of the transcriptional repressor Blimp-1
            that regulates NKT cell effector differentiation
  JOURNAL   Nat Immunol 13 (9), 864-871 (2012)
   PUBMED   22885984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB444885.1, BC028731.2 and BC029505.1.
            
            On Jan 21, 2020 this sequence version replaced NM_001114759.2.
            
            Transcript Variant: This variant (1) encodes shorter isoform (1).
            Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028731.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349618.8/ ENSP00000344095.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DB444885.1         45-63
            20-1625             BC028731.2         5-1610
            1626-1628           BC029505.1         1708-1710
FEATURES             Location/Qualifiers
     source          1..1628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1628
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /note="zinc finger protein 683"
                     /db_xref="GeneID:257101"
                     /db_xref="HGNC:HGNC:28495"
                     /db_xref="MIM:616775"
     exon            1..82
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /inference="alignment:Splign:2.1.0"
     exon            83..210
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1611
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hypothetical protein MGC33414; homolog of Blimp-1 in T
                     cells; homolog of Blimp-1 in T-cell; tissue-resident
                     T-cell transcription regulator protein ZNF683"
                     /codon_start=1
                     /product="tissue-resident T-cell transcription regulator
                     protein ZNF683 isoform 1"
                     /protein_id="NP_001108231.1"
                     /db_xref="CCDS:CCDS279.2"
                     /db_xref="GeneID:257101"
                     /db_xref="HGNC:HGNC:28495"
                     /db_xref="MIM:616775"
                     /translation="MKEESAAQLGCCHRPMALGGTGGSLSPSLDFQLFRGDQVFSACR
                     PLPDMVDAHGPSCASWLCPLPLAPGRSALLACLQDLDLNLCTPQPAPLGTDLQGLQED
                     ALSMKHEPPGLQASSTDDKKFTVKYPQNKDKLGKQPERAGEGAPCPAFSSHNSSSPPP
                     LQNRKSPSPLAFCPCPPVNSISKELPFLLHAFYPGYPLLLPPPHLFTYGALPSDQCPH
                     LLMLPQDPSYPTMAMPSLLMMVNELGHPSARWETLLPYPGAFQASGQALPSQARNPGA
                     GAAPTDSPGLERGGMASPAKRVPLSSQTGTAALPYPLKKKNGKILYECNICGKSFGQL
                     SNLKVHLRVHSGERPFQCALCQKSFTQLAHLQKHHLVHTGERPHKCSVCHKRFSSSSN
                     LKTHLRLHSGARPFQCSVCRSRFTQHIHLKLHHRLHAPQPCGLVHTQLPLASLACLAQ
                     WHQGALDLMAVASEKHMGYDIDEVKVSSTSQGKARAVSLSSAGTPLVMGQDQNN"
     exon            211..415
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /inference="alignment:Splign:2.1.0"
     exon            416..1110
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1239
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1628
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /note="hexamer: ATTAAA"
     polyA_site      1628
                     /gene="ZNF683"
                     /gene_synonym="Hobit"
                     /note="major polyA site"
ORIGIN      
        1 atggtcttct aactgaggaa cctgagcaga tgccttgacc cagaccagag acccaagcca
       61 aggaaagccc atgatcacca gacaggtaat ggggatatga aggaagaatc agctgcacaa
      121 ttaggttgtt gtcataggcc catggccctg ggaggtacag ggggctccct gtcccccagc
      181 ctggacttcc agctcttccg aggtgaccag gtcttctcag cctgcagacc acttccagac
      241 atggtggatg ctcatggccc atcctgtgcc agctggctgt gtcccttgcc cctggcaccg
      301 ggcaggtctg cactgctggc ctgcctacag gacctggacc tgaacctgtg caccccacag
      361 ccggcacccc tgggcacaga cctgcagggc ctccaagagg acgccttgag catgaagcac
      421 gagccaccag ggctgcaggc cagctccacc gatgacaaga aattcacagt caagtaccca
      481 cagaacaagg acaagctggg aaaacagcca gaaagagctg gcgagggggc cccctgccca
      541 gccttctcct ctcataacag ctcttcccca ccaccgctgc agaacagaaa gagccccagc
      601 cccttggctt tctgcccctg tccccctgtc aactccatct ccaaggagct cccatttctc
      661 ctccacgcct tctaccctgg atacccactt ctcctgcctc caccccacct gttcacctat
      721 ggggccctac cttctgacca atgtccccac ctcctcatgc tgccccaaga cccctcctac
      781 cccaccatgg ctatgcctag cctgctgatg atggtcaatg agctggggca ccccagcgct
      841 cggtgggaga ccctgcttcc ctacccaggg gccttccaag cctctggcca agctctgcct
      901 tcccaggccc gaaatccagg tgctggagct gccccaaccg actccccagg cctggagcgt
      961 ggtggcatgg catctccagc aaagcgggtc ccattgagtt cccagacagg caccgcagcc
     1021 ttgccttacc cgctgaaaaa gaagaatggc aaaatcctgt acgagtgcaa catatgtggc
     1081 aagagctttg ggcagctctc caatctcaag gtccacctgc gtgtgcacag tggagagcgt
     1141 ccattccagt gtgccttgtg ccagaagagc ttcactcaac ttgcccacct gcagaagcac
     1201 cacctggtgc acactgggga gcggccccac aagtgctcgg tgtgccacaa gcgcttcagc
     1261 agctccagta acctcaagac ccacctgcgc ctgcactccg gggcccggcc cttccagtgc
     1321 agtgtctgcc ggagtcgctt cacccagcac atccacctga agctgcacca tcggctgcat
     1381 gccccacagc cctgtggcct ggtgcacacc cagctgcccc tggcctctct ggcctgcctt
     1441 gcccaatggc accagggggc actagatctt atggcggtgg catctgagaa acacatgggc
     1501 tatgacatag atgaggtcaa agtgtcctcg acatcccagg ggaaagcaag agcagtgagc
     1561 ctgagcagtg ccgggactcc cctggtgatg gggcaggacc agaacaatta aaaatgtttc
     1621 ttctgtca
//
