LOCUS       NM_138286               6497 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 681 (ZNF681), mRNA.
ACCESSION   NM_138286
VERSION     NM_138286.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6497)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122869.1, BC062216.1, AC073544.4 and BU726573.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138286.2.
            
            Summary: This gene encodes a protein containing the krueppel
            associated box (KRAB) and zinc-finger domains, which may be
            involved in transcriptional regulation. Non-functional alleles of
            this gene are present in alternate genome assemblies including
            T2T-CHM13v1.1, resulting from a 'TG' deletion (rs61397759) which
            causes a frameshift and a premature stop codon. [provided by
            RefSeq, Sep 2022].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA517774.1, SRR1660803.149246.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402377.3/ ENSP00000384000.3
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AK122869.1         5-333
            330-391             BC062216.1         170-231
            392-6483            AC073544.4         158843-164934       c
            6484-6497           BU726573.1         17-30               c
FEATURES             Location/Qualifiers
     source          1..6497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..6497
                     /gene="ZNF681"
                     /note="zinc finger protein 681"
                     /db_xref="GeneID:148213"
                     /db_xref="HGNC:HGNC:26457"
     exon            1..145
                     /gene="ZNF681"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2080
                     /gene="ZNF681"
                     /codon_start=1
                     /product="zinc finger protein 681"
                     /protein_id="NP_612143.2"
                     /db_xref="CCDS:CCDS12414.2"
                     /db_xref="GeneID:148213"
                     /db_xref="HGNC:HGNC:26457"
                     /translation="MEPLKFRDVAIEFSLEEWQCLDTIQQNLYRNVMLENYRNLVFLG
                     IVVSKPDLITCLEQEKEPWTRKRHRMVAEPPVICSHFAQDFSPEQNIKDSFQKVTPRR
                     YGKCEHENLQLSKSVDECKVQKGGYNGLNQCLPTTQSKIFQCDKYMKIFHKFSNLNGH
                     KVRHTRKKPFKYKEFGKSFCIFSNLTQHKIICTRVNFYKCEDCGKAFNGSSIFTKHKR
                     IHIGEKSYICEECGKACNQFTNLTTHKIIYTRDKLYKREECSKAFNLSSHITTHTIIH
                     TGENPYKREECDKAFNQSLTLTTHKIIHTREKLNEYKECGKAFNQSSHLTRHKIIHTG
                     EKPYKCEECGKAFNQSSHLTRHKIIHTGEKPYRCEECGKAFRQSSHLTTHKIIHTGEK
                     PYKCEECGKAFNKSSHLTRHKSIHTGEKPYQCEKCGKASNQSSNLTEHKNIHTEEKPY
                     KCEECGKAFNQFSNLTTHKRIHTGEKPYKCEECGKAFNQSSILTTHKRIHTGEKSYKC
                     EECGKAFYRSSKLTEHKKIHTGEKPYTCEECGKAFNHSSHLATHKVIHTGEKPYQCEE
                     CGKAFNQSSHLTRHKRIHTGEKPYQCEKCGKAFNQSSNLTGHKKIHTGEKLYKPKRCN
                     SDFENTSKFSKHKRNYAGEKS"
     exon            146..272
                     /gene="ZNF681"
                     /inference="alignment:Splign:2.1.0"
     exon            273..368
                     /gene="ZNF681"
                     /inference="alignment:Splign:2.1.0"
     exon            369..6497
                     /gene="ZNF681"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2315..2320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF681"
                     /note="hexamer: AATAAA"
     polyA_site      2336
                     /gene="ZNF681"
                     /note="major polyA site"
     regulatory      5754..5759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF681"
                     /note="hexamer: ATTAAA"
     regulatory      5771..5776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF681"
                     /note="hexamer: AGTAAA"
     polyA_site      5777
                     /gene="ZNF681"
                     /note="major polyA site"
     polyA_site      5797
                     /gene="ZNF681"
     regulatory      6471..6476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF681"
                     /note="hexamer: AATAAA"
     polyA_site      6497
                     /gene="ZNF681"
ORIGIN      
        1 gtctctccct tcagcccgag ctccgggtct cgtcttcact gctctgtgtc ctcttcttct
       61 agaggcccag cctctatggc cctctgacct gcaggtattg gcgatccata gctaagacgc
      121 caggtccccc ggaaacctag aaatggaacc attgaaattt agggatgtgg ccatagaatt
      181 ctctctggag gagtggcaat gcctggacac tatacagcag aatttatata ggaatgtgat
      241 gttagagaac tacagaaacc tggtcttctt gggtattgtt gtctctaagc cagacctgat
      301 cacctgtctg gaacaagaaa aagagccttg gactagaaag agacatagga tggtggccga
      361 acccccagtt atttgttctc attttgccca agacttttca ccagagcaga acataaaaga
      421 ttctttccaa aaagtgacac caagaagata tggaaaatgt gaacatgaga atttacagtt
      481 aagtaaaagt gtggatgagt gcaaagtgca aaaaggaggt tataatggac ttaaccaatg
      541 tttgccaact acccagagca aaatatttca atgtgataaa tatatgaaaa tctttcataa
      601 attttcaaat ttaaatggac ataaggtaag acacaccaga aaaaaacctt ttaaatataa
      661 agaatttggc aaatcatttt gcatattttc aaacctaact caacataaaa taatttgtac
      721 tagagtaaat ttctacaaat gtgaagactg tggaaaagcc tttaatggat cctcaatctt
      781 tactaaacat aaaagaattc atattggaga gaaatcgtac atatgtgaag aatgtggcaa
      841 agcctgtaac cagttcacaa accttactac acataagata atttatacta gagacaaact
      901 ctacaaacgt gaagaatgta gcaaagcctt taacctgtcg tcacacatta caacacatac
      961 aataattcat actggagaga atccctacaa acgtgaagaa tgtgacaaag cctttaatca
     1021 gtccttaacc cttactacac ataagataat tcataccaga gagaaactca atgaatataa
     1081 ggaatgtggc aaagctttca accagtcctc acaccttacc agacataaga taattcatac
     1141 tggagagaaa ccctacaaat gtgaagaatg tggcaaagcc tttaaccagt cctcacacct
     1201 taccagacat aagataattc atactggaga gaagccctac agatgtgaag aatgtggcaa
     1261 agcctttagg cagtcctcac accttactac acataagata attcatactg gagagaaacc
     1321 ctacaaatgt gaagaatgtg gcaaagcttt taacaagtcc tcacacctta ctagacataa
     1381 gagcattcat actggagaaa aaccctacca gtgtgaaaaa tgtggcaaag cttctaacca
     1441 atcctcaaac cttactgaac ataagaatat tcatactgaa gagaaaccat acaaatgtga
     1501 agaatgtggg aaagccttta accagttctc aaaccttact acacataaaa gaattcatac
     1561 tggagagaaa ccctacaaat gtgaagaatg tggcaaagct tttaaccagt cctcaatcct
     1621 tactacacat aagagaattc atactggaga gaaatcctac aaatgtgaag aatgtggcaa
     1681 agctttctat cgatcctcaa aacttactga acataagaaa attcatactg gagagaaacc
     1741 ctacacatgt gaagaatgtg gcaaagcctt taaccattcc tcacatcttg ctacacataa
     1801 ggtaattcat actggagaga aaccctacca atgtgaagaa tgtggtaaag cctttaacca
     1861 gtcctcacac cttactagac ataagagaat tcatactgga gagaaaccct accaatgtga
     1921 aaaatgtggc aaagctttta accagtcctc aaaccttact ggacataaga aaattcatac
     1981 tggtgagaaa ctctacaaac ctaaaagatg taacagtgat tttgaaaaca cttcaaagtt
     2041 ttctaaacat aaaagaaatt atgctggtga gaaatcttag aaatgtgaag aatgtaacaa
     2101 aacctttaaa agttgtcaca cttgattgtg cataagataa ttcatactaa aaaaaaacct
     2161 acaagtgtga agaatgtggc aaaactttta accaatgctc acaccttatt gcacaggaaa
     2221 gcatttgtac tagaaaaaaa tttcaaatat acagaatgtg aaaaagccat taatatctgt
     2281 tcacatctta ctcaacatca gagatttcat acttaataaa agcattatac atgcaattac
     2341 tgtcaaaaat ctttcagaaa atataagcct ctaaagtgaa gagtattcat tttgaagaca
     2401 cacattatga acataaggag ggttgtggta cctttacttg tatcacagat ctcattgtac
     2461 acattttgtg ctagaggaaa accatggagc agttgcttaa actttgtgca acataaggaa
     2521 atttatattg gagaaaaacc ctgcaaatgt aataaatttg ggaaaacatt ttttcaaaaa
     2581 cgacagctta gaaaacacta gagggttcat actaaaatct atttttgcag atgcagtaaa
     2641 tatgaaaaaa tatttaatcc aaaattctat gtaaatatca gataattcac agtagaaata
     2701 gttaaggcac tgacacttca ggcattacac taaatcagat tgctgagtat agaaaagaat
     2761 ctaaaactaa agttggtaaa tgaattattt gtatataaca ttataagaag tagaaaattt
     2821 ttgcagagtt gtaactacat tcaaactatc ctttgaaaaa aattaggttt tatgaaaagt
     2881 gaataatgtc atttaactca agttatgctc ttcattccta ttgtattcac atgtgaaagc
     2941 atgtgactta attgttgctg catcaaagat gagagattct ttgttattag gtgtgcatta
     3001 tttacgacct tttttagtga aagagttaag gacattaaaa tgtaagatgc aagatgaaaa
     3061 tgtaagtgga gaggctcttt ctggttaatt tataatattg actgatgcat gaggtaggag
     3121 ttcagataaa tatcctgtgt tatattgaga aaaaaaattt tctggtatat cattttacta
     3181 attgtacttt tttttttttt gagacagagt tttgctcttg ttgcccaggc tggagtgcaa
     3241 tggtgtgatc ttggctcacc aaaacctcca cctcccaggt tcaagggatt ctcctgcctc
     3301 agcctcccga gtagctggga ttacaggcat gtgccaccat gcccggctaa ttttgtattt
     3361 ttaatagaga tggggtttct ctatgttggt caggctggtc tcaaactccc gacctcgggt
     3421 gatccaccca cctcggcctc ccaaagtgct gggattacag gcgcgagtca ccatgcctgg
     3481 ccaattgtac ttttatgtaa taaaatgtag tacattttaa aatttttaga taatgtgtga
     3541 acttattaat caggcttttt aaaaaacatg ttaagaccat cgtgcattca atgaagcatt
     3601 attatgccat taaatttaac ttatcccatc ttactcaagg gtataggtaa atgatggtaa
     3661 ctatacacta tttaataaga taatggacta acatttctag taatctgttt tgccagtggc
     3721 tttaaattgc aaataagtca gagaatatta ttcctgtagg ttgaattatt actcattttt
     3781 tcttatttaa acttattttt cttaattttt gtgggtacat agtatgtgta aatatggcat
     3841 atatggcata ttttgataca ggtatataat atgtaataat tacatatggg taaatgaaat
     3901 attcattacc tgcagcattt attgtttgta tttgtttgta ttataaacta attctgcact
     3961 tttcggtttt tttttgagac gagtctcact atgtcaccca ggctgtgcac gcctgggtgc
     4021 attggcgtgg tctcagctca ctgcaacctc cgcctactgg gttcaagtga ttcttccgcc
     4081 tcagcctcct gagtagttgg gactacaggc gcatgccacc acactcagct aatttttgta
     4141 tttttagtag aaacagtttc actacgttgg ccaggtttgt cttgaactcc tgaccccatg
     4201 attagccccc tcggcctccc aaagtgctgg gattacaggt gggagccacc acacccagcc
     4261 acttttagtt gttttcaaat gtacattaaa ttgttgttgg ctacagggtc tcttttatgg
     4321 tcataagaaa acaatataaa caaaatgcat acatttctga gacctgaatt aacattaaaa
     4381 aattgttata tatttttctt caaacatgtt gcctctctgc ctgcaagcac atacagacta
     4441 ttagttttga tttacacaga gttaaatata tacatatatt actttaaaga taaagcttgg
     4501 gtttaaaaaa attatggagt aaataaatgc cttctttgcg agtatgagtt tctacctagt
     4561 ttcagaagag caatattgaa acaaatcaaa ttattttaat tagatgatga ctgcaaaact
     4621 aaaaaaactt aaaaatgctg aaaacaaatc catactctct gctttgtatt gaattgatta
     4681 ctgtaaaatt gtatggctta taattcagaa tctccctatg caaatttttg tttttacttg
     4741 cctgattctt aggctagacc cataattttc ttgtgtctta catttttttc tcttatttta
     4801 tataagatgc tatgtgagct ggtcagagat tataaaaata atttttataa aattagtgca
     4861 aaaaatttag atttaatttc aaaattagtg tattgttata ttttatgttg ttagaatatt
     4921 ttattttgtt cttttaattg gagaacgctg tataagccta ctttttttag tttttgttcc
     4981 tttcagtttt tataatgaaa ataagtaaat attgattgag cccatttatt taggtgagta
     5041 ctaggggggc ttcctaaatc atgaggatgt ttttatatat aaatatagca aacaaacatg
     5101 acagtgcttt ctgtgtcaca gatgctttat aataagccat aaatattcct gttggagtta
     5161 gtttgtaact tcaagacaga gatggaacat atcaattgtg agaaataaca ttgatttttt
     5221 atgtggagag gacatttatt ttcaggctgc aaagctcagt tttgctgaat taaaaaattg
     5281 tgcttctttt atttcctaat tgtcttagtt ttgtttgtct tattatgtgt atttcagctg
     5341 tgtatgcatc acagccctcc tttttgctgt gctgtggcta cagttttctc actgttctct
     5401 tcacaccatg tcatttcaca tggtatattg taggttttga tgagaaatcg gtatttttaa
     5461 tgcactgcaa gattggtttt aactggagat tttgcatatc aatataattt tctgatcagt
     5521 taaattaaaa caaaaagcat acagtgtcca cagatgaaag gattaaatca tttagcgttg
     5581 tttttctctg tttgttaaag aataatctta ttaaattctt acacaaagtg tggcaaatat
     5641 aaaatttgct tgaaaatata tcttagaaat taaactttta atttaatttt ctacagtata
     5701 cttatgccac aatgtacgtt tccatgcaaa atcttctatt tgtaagtgtg aacattaaac
     5761 attgcaaaat agtaaaatga cctctgtgat tttgaaacct ggagtaatat ttcttttcca
     5821 tattcatatt acaatttgaa gaaattttct cagttttata tgttttttta gtgggtgaag
     5881 ttcagtctac agtttttaca tttagtcacc taactctagc caacttcttg gtcatattct
     5941 ctggaaaaca ttcgaagatc atggcagctt ttagataaaa acattttcta ttattttgcg
     6001 tgcaaacttg tttactgtgt tcacagagtg gccagtcatg agaccataag aaacagctgc
     6061 ccttttagtg tctttcatac cgtctgtaat atataaattg tgcatttatt ctgtgaagca
     6121 tgacattttg aagtatatac acattgtcaa atgcttcatt ctaggtaatt aatgctttac
     6181 ctaacatagt taacattttt gtggtaagag cacatgacaa tgttttagca tttttcagaa
     6241 atacaaatac attgttatga actataggca ccatgcagta caaaagcttt tttgaactta
     6301 tttctcctat tcaactgtaa ttatgtattt gactgacatc tttctaaacc cctctttttt
     6361 ccaaatatgt tggcatctgg tggtcaccat tttattctcc acttcagtta gattaatttt
     6421 tctagaatca tgtaagtgaa ataatttggt taatctatgt aattgaaaat aataaatttt
     6481 tttattttaa agatgaa
//
