LOCUS       NM_178558               2993 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 680 (ZNF680), transcript variant
            1, mRNA.
ACCESSION   NM_178558
VERSION     NM_178558.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA669757.1, BC030700.1 and AC016769.10.
            
            On Nov 22, 2018 this sequence version replaced NM_178558.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq was created from transcript and genomic
            sequence data because transcript sequence consistent with the
            reference genome assembly was not available for all regions of the
            RefSeq transcript. The extent of this transcript is supported by
            transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122937.1, BC030700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309683.11/ ENSP00000309330.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               DA669757.1         57-426
            371-1105            BC030700.1         411-1145
            1106-2993           AC016769.10        16754-18641         c
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..2993
                     /gene="ZNF680"
                     /note="zinc finger protein 680"
                     /db_xref="GeneID:340252"
                     /db_xref="HGNC:HGNC:26897"
     exon            1..147
                     /gene="ZNF680"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1710
                     /gene="ZNF680"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 680 isoform 1"
                     /protein_id="NP_848653.2"
                     /db_xref="CCDS:CCDS34644.1"
                     /db_xref="GeneID:340252"
                     /db_xref="HGNC:HGNC:26897"
                     /translation="MPGPPGSLEMGPLTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFE
                     NYRNLVFLGIAVSKPHLITCLEQGKEPWNRKRQEMVAKPPVIYSHFTEDLWPEHSIKD
                     SFQKVILRGYGKCGHENLQLRISCKSVDESKVFKEGYNELNQCLRTTQSKIFQCDKYV
                     KVFHKFSNSNSHKKRNTGKKVFKCKECGKSFCMLSHLTQHIRIHTRENSYKCEECGKV
                     LNWFSELIKHKGIHMGEKPYKCEECGKAFNQSSTLIKHKKIHIEEKPFKCEECGKAFS
                     LFSILSKHKIIHTGDKPYKCDECHKAFNWFATLTNHKRIHTGEKPFKCEECGKDFNQF
                     SNLTKHKKIHTGEKPYKCEECGKAFNQFANLTRHKKIHTGEKSYKCEECGKAFIQSSN
                     LTEHMRIHTGEKPYKCEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKGFTLFSTLT
                     NHKVIHTGEKSYKCDECGNVFNWPATLANHKRIHAREKPYKCEECGKAFNRSSHLTRH
                     KKIHTGEKLYKPEKCDNNFDNT"
     exon            148..274
                     /gene="ZNF680"
                     /inference="alignment:Splign:2.1.0"
     exon            275..370
                     /gene="ZNF680"
                     /inference="alignment:Splign:2.1.0"
     exon            371..2993
                     /gene="ZNF680"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF680"
                     /note="hexamer: ATTAAA"
     polyA_site      2993
                     /gene="ZNF680"
                     /note="major polyA site"
ORIGIN      
        1 gtctctagct gctgcgggag ctccaggtct agtctttact gctctgtgta ttctgctcct
       61 agaggcccag cctctgtgac tccgttatct gcaggtattg ggagatgcac agctaagatg
      121 ccaggaccac ctggaagcct agaaatggga ccactgacat ttagggatgt ggccatagaa
      181 ttctctctgg aggagtggca atgcctggac actgcacaac ggaatttata taggaaagtg
      241 atgtttgaga actacagaaa cctggtcttc ctgggtattg ctgtctctaa gcctcacctg
      301 ataacctgtt tggagcaagg aaaagagccc tggaatagga agagacagga gatggtagcc
      361 aaacccccag ttatatattc tcatttcact gaagaccttt ggccagagca tagcataaaa
      421 gattcttttc aaaaagtgat actgagagga tatggaaaat gtggacatga gaatttacaa
      481 ttaagaataa gttgtaaaag tgtggatgag tctaaggtgt tcaaagaagg ttataatgaa
      541 cttaaccaat gtttgagaac tacccagagc aaaatatttc aatgtgataa atacgtgaaa
      601 gtctttcata aattttcaaa ttcaaacagt cataagaaaa gaaatactgg aaagaaggtt
      661 ttcaaatgta aagaatgtgg caaatcattt tgcatgcttt cacatctaac acaacatata
      721 agaattcaca ctagagagaa ttcttacaaa tgtgaggaat gtggcaaagt tcttaactgg
      781 ttctcagagc ttattaaaca taagggaatt catatgggag agaaacccta caaatgtgag
      841 gaatgtggca aagcctttaa ccaatcctca acccttatta aacataagaa aattcatatt
      901 gaagagaaac ccttcaaatg tgaagaatgt ggcaaagcct ttagtttatt ctcaatcctt
      961 agtaaacata agataattca tactggagac aaaccttaca aatgtgatga atgtcacaaa
     1021 gcctttaact ggtttgcaac ccttactaac cataagagaa ttcatactgg agagaaaccc
     1081 ttcaaatgtg aagaatgtgg caaagacttt aaccagtttt caaaccttac taaacataag
     1141 aaaattcata ctggagagaa accctacaaa tgtgaagaat gtggcaaagc ttttaaccag
     1201 tttgcaaacc ttactagaca taagaaaatt catactggag agaaatccta caaatgtgaa
     1261 gaatgcggca aagcttttat acagtcctca aaccttactg aacatatgag aattcatact
     1321 ggagagaaac cctacaaatg tgaagaatgt ggcaaagctt ttaatgggtg ctccagcctt
     1381 actcgacata agagaattca cactagagag aatacctaca aatgtgaaga atgtggcaaa
     1441 ggctttactt tattttcaac ccttactaac cataaagtaa ttcatactgg agagaaatcc
     1501 tacaaatgtg atgaatgtgg caatgttttt aactggcctg caactcttgc taatcataag
     1561 agaattcatg ctagagagaa accctacaaa tgtgaagaat gtggcaaagc ttttaaccgg
     1621 tcctcacacc ttactagaca taagaaaatt catactggtg agaaactcta caaacctgaa
     1681 aaatgtgaca ataattttga taacacctaa aacttttcta aacataaaag acaccatcct
     1741 gttgagaaac cctaaaaatg tgaagaattt gacaaagcct tccaatgatt gttacacttg
     1801 cttgtaggta agataattta tattggagaa aactttataa gtgtaaagaa tgtgacaaaa
     1861 cttaaccaat actcacatct tattgcacag gaaagcattt ttacttgaga aagattgtac
     1921 aagtataaag aatgtgaaaa agtcattgat atcttttcac atcttactca acaccagagt
     1981 ttatacttat taaaagcatt ataaatgcaa ttactgtcaa aagaaatttc agaaaacata
     2041 acactttaaa gtgaagaagc gtgtttattt tgaagacaaa cataacaaat ataaggagca
     2101 taggagggtt gtagtacctt tacttgtatt acaaatctta ttgtacgcat tttgtactag
     2161 agaaaaacac tgaagcagtt gctcaaactt tgttcaacat cagggaattt atattggaga
     2221 aaaatcctgc aaatgtaatg aatttggaaa aacatttttt ttcaaaaact acggcgtaga
     2281 aaacatgaat ttatattgaa atgtgttttt gcagatgcag taagtatgaa aaatatttaa
     2341 tccaaaattg agtctatgta aatattaaat aatttacagt agaaataact aaggcactga
     2401 cactttagac attacactaa aacagagtgt tgagtataaa aaaatctata agttgttaga
     2461 ttatttgtaa ataactttaa aaggagtaga agattctttg gagagttata attacattga
     2521 aagtatactt tttttcttga aaaaattatg gcttatttga aaagtaaata atgatgaaat
     2581 tcaactctca aattacttta tttcattcct attgtattca catgtgaaag catgtgataa
     2641 attgttgctg tgtcagatat aggagagatt cttttttatt agatgggcat tatttatggt
     2701 tttttctgtg gaagagtatg ggcattaaaa tgtaaggttt atgatgaaaa tctaagtgga
     2761 gaggccctgt tagtttactt ttcatattga gtgatgcatg aggtaggtgt ttggagtaat
     2821 attctgcatc atagagaaaa gcatttttaa ttttacttta aattaaatgt aattaaatta
     2881 ctagtgaatc attttactaa ttgtactttt atgctataaa tgcagtacat ttgaaaattt
     2941 ttagattatg tataagctta attttataat taaacatttc tttaacatgt taa
//
