LOCUS       NM_001367909            8543 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 678 (ZNF678), transcript variant
            2, mRNA.
ACCESSION   NM_001367909 NR_033184
VERSION     NM_001367909.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8543)
  AUTHORS   Lee,J.J., Essers,J.B., Kugathasan,S., Escher,J.C., Lettre,G.,
            Butler,J.L., Stephens,M.C., Ramoni,M.F., Grand,R.J. and
            Hirschhorn,J.
  TITLE     Association of linear growth impairment in pediatric Crohn's
            disease and a known height locus: a pilot study
  JOURNAL   Ann Hum Genet 74 (6), 489-497 (2010)
   PUBMED   20846217
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 8543)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8543)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL451054.22 and AL592310.6.
            
            On Dec 28, 2018 this sequence version replaced NR_033184.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA783759.1, SRR1660803.244406.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343776.10/ ENSP00000344828.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AL451054.22        124301-124469
            170-296             AL592310.6         61722-61848
            297-417             AL592310.6         66134-66254
            418-8543            AL592310.6         69514-77639
FEATURES             Location/Qualifiers
     source          1..8543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..8543
                     /gene="ZNF678"
                     /note="zinc finger protein 678"
                     /db_xref="GeneID:339500"
                     /db_xref="HGNC:HGNC:28652"
     exon            1..169
                     /gene="ZNF678"
                     /inference="alignment:Splign:2.1.0"
     exon            170..296
                     /gene="ZNF678"
                     /inference="alignment:Splign:2.1.0"
     exon            297..417
                     /gene="ZNF678"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..1910
                     /gene="ZNF678"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hypothetical protein MGC42493"
                     /codon_start=1
                     /product="zinc finger protein 678 isoform 2"
                     /protein_id="NP_001354838.1"
                     /db_xref="CCDS:CCDS1560.1"
                     /db_xref="GeneID:339500"
                     /db_xref="HGNC:HGNC:28652"
                     /translation="MGTISLCIGVCAFEGANTSTSFYKLVYTAILSYSIQDLLPEQDM
                     KDLCQKVTLTRHRSWGLDNLHLVKDWRTVNEGKGQKEYCNRLTQCSSTKSKIFQCIEC
                     GRNFSWRSILTEHKRIHTGEKPYKCEECGKVFNRCSNLTKHKRIHTGEKPYKCDECGK
                     VFNWWSQLTNHKKIHTGEKPYKCDECDKVFNWWSQLTSHKKIHSGEKPYPCEECGKAF
                     TQFSNLTQHKRIHTGEKPYKCKECCKAFNKFSNLTQHKRIHTGEKPYKCEECGNVFNE
                     CSHLTRHRRIHTGEKPYKCEECGKAFTQFASLTRHKRIHTGEKPYQCEECGKTFNRCS
                     HLSSHKRIHTGEKPYKCEECGRTFTQFSNLTQHKRIHTGEKPYKCKECGKAFNKFSSL
                     TQHRRIHTGVKPYKCEECGKVFKQCSHLTSHKRIHTGEKPYKCKECGKAFYQSSILSK
                     HKRIHTEEKPYKCEECGKAFNQFSSLTRHKRIHTGEKRYKCKECGKGFYQSSIHSKYK
                     RIYTGEEPDKCKKCGSL"
     exon            418..8543
                     /gene="ZNF678"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7298..7303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF678"
                     /note="hexamer: AATAAA"
     polyA_site      7327
                     /gene="ZNF678"
                     /note="major polyA site"
     regulatory      8521..8526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF678"
                     /note="hexamer: AATAAA"
     polyA_site      8543
                     /gene="ZNF678"
ORIGIN      
        1 ctttgtcttg tgctccagct ggagctttgg tcccgtattc tcggctattt atccccagct
       61 gcgggaggcc ctggtgactc tgctgctgca gtgtctggtt tccctgtgac ctgcaggtac
      121 tgggagttac atagctaaga tgccaggaca ccccgaaagc cggaaaacgg gactactggc
      181 attcagtgat gtggtcatag aattctctcc agaggagtgg gcatgcctgg accctgccca
      241 gcgaaatttg tatagggatg tgatgttcga gaactacaga aacctggtct ccctgggact
      301 tccaggacta tgttaaaata gaagcattga taatgggcac aatatcactt tgcattggtg
      361 tctgtgcatt tgaaggagca aacacctcta ccagttttta taaactggtt tatacagcta
      421 ttttatctta ttccattcaa gaccttttgc cagagcagga tatgaaagat ttatgccaaa
      481 aagtgacact gacaagacat agaagctggg gccttgacaa tttgcactta gtgaaagact
      541 ggagaactgt gaatgaaggt aaggggcaga aagaatattg caatagactt actcaatgtt
      601 catcaactaa aagcaaaatc tttcaatgta ttgaatgtgg cagaaatttt agctggaggt
      661 caatccttac tgaacataag agaattcata ctggagagaa gccatacaaa tgtgaagaat
      721 gtggcaaagt tttcaatcga tgttcaaacc taacaaaaca taaaagaatt catactggag
      781 agaaacccta caaatgtgac gaatgtggca aagtttttaa ttggtggtca caactaacta
      841 accataagaa aattcatact ggagagaaac cctacaaatg tgatgaatgt gacaaagttt
      901 ttaattggtg gtcacaacta actagccata agaaaattca tagtggagag aaaccatacc
      961 catgtgaaga atgtggcaaa gcctttaccc agttctcaaa ccttacacaa cataagagaa
     1021 ttcatactgg agagaaaccc tacaaatgca aagaatgttg caaagccttt aacaagttct
     1081 caaaccttac tcaacataag agaattcata ctggagagaa accttacaag tgtgaagaat
     1141 gtggcaacgt ttttaatgag tgctcacacc taactagaca taggagaatt catactggag
     1201 agaaacccta caaatgtgaa gaatgtggca aagcctttac acagtttgca agccttactc
     1261 gtcataaaag aattcatact ggagaaaaac cctaccaatg tgaagaatgt ggcaaaactt
     1321 ttaatcggtg ttcacaccta agtagccata agagaattca tactggagag aaaccctaca
     1381 aatgtgaaga atgtggcaga acctttactc aattctcaaa cctcactcag cataaaagaa
     1441 ttcatactgg agagaaaccc tacaaatgca aagaatgtgg caaagcgttt aacaagttct
     1501 caagccttac tcaacatagg agaattcata ctggagtgaa accctacaaa tgtgaagaat
     1561 gtgggaaagt ttttaaacag tgctctcacc taactagcca taagagaatt catactggag
     1621 agaaacccta caaatgtaaa gaatgtggca aagcttttta ccaatcctca atccttagta
     1681 agcataagag aattcatact gaagagaaac cctacaaatg tgaagaatgt ggcaaagcct
     1741 ttaaccagtt ctcaagcctt actcgtcata aaagaattca tactggagag aaacgctaca
     1801 aatgtaaaga atgtggaaaa ggtttttacc aatcctcaat ccatagtaag tataagagaa
     1861 tttatactgg agaggaacct gacaaatgta aaaaatgtgg cagtctttaa aaactgcttc
     1921 attatacatg gcttcactaa tttcatactg aataaaagtg gtatgagcat aatgactgtt
     1981 taaggatgtt tcacaaaatg taagcttcag agtgcacaac actatactga atgaaattta
     2041 taaatataaa agattacaat atctttattt caaagatctt cctgtaaaca gaatctgtac
     2101 tagaggaaaa acccttaaac aattattcag actttattca actttagagg attttacggg
     2161 ggcaaaaaac ctcctacaaa tgtggaaaaa cattttttca agatatatgc cttagaaaac
     2221 accagagttt atagtatagt agaatatatt ttacagatac agtgaataca aacaaatgtc
     2281 caaaattaag tctaaataaa acattacata atttactgta gaaagtacta aggcactaac
     2341 agtttcagat gttactttaa agcagtgttg attgtcgaga ataattcaaa gttaaaatag
     2401 ataatttagt tgtatgtaaa tttaaatgaa tcaagagatg atgtcttttt gaagcacagt
     2461 tacattcatg ttatactttt ttgcattaaa agtttttata tttttgatta tatattttaa
     2521 tattgatata attcatatct caaataactt gatttttatt atatttattg tttatgttaa
     2581 agtatgtggt cagttgttgc tgcataagag ctatgagaag ttcttctata ttagatgacc
     2641 atcatttata tgctttttca tgaatgatta agggcaccga aatgtaacat ttataaggaa
     2701 aatctaagta gaaatgcttt ttgttgatgt ataacagtgt tttaagtaac acattaggta
     2761 ttcagagaag tattttgcat tatagtaata gggaaacatt ttgaatttca gtagtaaatt
     2821 gttttatgag ttgcacatta agataataca gtagcttttg aaatgttatt tttagaatgc
     2881 aatttctttt cataaaacaa aattattttt aatgtgttaa gaatattttg cattgaatga
     2941 agtatatctt gccacaataa ttaacctata ccaccttacc caaagttgta ggtaacagat
     3001 agtaacaata cactactggg taacagtgaa aggacacctc tagtaatctc ttttcccagt
     3061 ggcttttaat ttcaaacaac ttggggaggt tttttttatg tgatatgctt tggttttttt
     3121 gtgccttacc tcatgttgaa atgtgttccc ccatgttgga ggcggggtct agtggaaggt
     3181 gtttaggtca tgggtgtaga ttactcatga atggattggt gttcttacca ctgcagttag
     3241 tgtgttctct gttagttcat gtgaaagctg gttgttaaaa acaaaaacaa acaaacaaaa
     3301 aactgatatt cctcttgctt tgtcttttgc catgataccc ctttgccttt tattatgcat
     3361 aaaagcttcc tgaggcctca tcagaagtta agcagatgtt gatgtcatgc ttgtatagcc
     3421 aacagaactg aggctaataa acctcttttc tgtattaatt tgccagtgtt aagtattccc
     3481 ttctagcagc acaaaatgga ctaacatccc ataggttata tttttatttt tttcttttgt
     3541 aaatactgga caatgatact cttatataat cttcagtata accattataa ttgcccacta
     3601 taaaggagta taatgaaagg ccatgtattt tgaatcacga atgactattt acaaaatgtc
     3661 atactacgtt tttctttgag cctgtgaccc ctctggcctg taaaaacaca tacatacatt
     3721 tagttttgat taacatggag ttaattttat aagtctgtca ctctaaacat aagtgttagc
     3781 tttaagagaa ttacagagca tgtaattgtg tttgagtgta ggtgtgtact tttttgagaa
     3841 gaaaacaaaa atattggaac aaaatataat ttaaaaagta ttggtaattt actagcaaac
     3901 taggaatctc aaagattctg aaagtaaata tttattctct gctttgtatt gaatttactt
     3961 ctgtaaaatc ttatggctgc tggctcagaa tcttctcatg caaatcctgt ttttttcttg
     4021 tctgttgatc atactaaacc taatgtatag ttttctcatt ccaaagttca tgaaattttc
     4081 tctatattcc tgagaaattc taagaataac tttcataaaa tgtattgatg ttcacaagat
     4141 aattttaaga tgtaattcta caatatgtgt gttactacat tttatttaat tagtatattt
     4201 tatttttgta tttcaattgg agaaccctat tttggccaat ttttacttgg tttttgtttc
     4261 cattttaata ttttacataa ttgaattttt ttcactttat tgagccattt tgtttagatg
     4321 tacactggga aggcttcata attcacaaag ttgttttgac atataaatga ggtgaacaaa
     4381 cacaggaaag tgctaggttt cctgggggta taatagatgc tctataatta gcagtaaata
     4441 ttcttgttta agtcactttt tggctacaag taagagatta gaaatattca gcataaagag
     4501 atggcattaa ctctgcatgt aaagaaaaca catgtatacc caggctgtac aactgcctct
     4561 gaaattaaga ggaattgtgt ttatttcata gttatctctg gtacttcact gttattttat
     4621 tttcaccccc aactatgcgt caatcatagc cctttccctt ctttgcttat tatggctaca
     4681 gatttctcac tgttctctgc agcccatgta atttcataca gtattttgta ggttgtgata
     4741 aggaatttga aatttttaat atagtgaaaa attggattta actggagagt ttgaggacat
     4801 ttttaagtta gaaatgcacc atttgaatca tttaattggc ataattggga tgtactctac
     4861 acagtttata ggattaaatt actgagttag taatgtttgt atgaaagaaa tgttattaga
     4921 ttctaccaca aaatatagta aacatgaaat cagttagaat aggtaaagca ttaataatgg
     4981 taggctatat atcataatca ctatataaag aaacatcaga atttggaaac cccttaagca
     5041 aaaatatatc ttagaaatct taaggacact taatggcaag caaaaaagtt taaatttagt
     5101 tttttataaa ttacatatag cacaatttat gtgtacatgt agaatctttt agtttttagt
     5161 gtttatgtaa tatattagac aataataaac atttacattt atgtttacat ttatatttaa
     5221 tttttcaaat ttaatttaaa tttctaaatg cttctgtgga tttaaatttt ggaataatct
     5281 tttcttcccc attgatactg gaatcttggg aagtttctta ctcatatcac aatatgtttt
     5341 atttaaatgg atgcagctta cattgcagag tttatataaa taatcacata acaagccaat
     5401 tccttagtca ttttctgtat taaaaaactc agagatctag agagcttttg gattgaaata
     5461 tttccttggt gattttggat gcaaacctga tttctgtgtt cacaccatgg ccagagatgg
     5521 gactgttagc accacctgct tctttaatgt cgtccatatg atcagcatca gcaccagaaa
     5581 ctccaggtgt cccaaactta aagtgaaagc catagagtcc tttggtgact cccatgttct
     5641 gtgctggttc tagaacatgc tggtaaatat cagagtttct atgcttatgg ctgataagta
     5701 gacattttta aaaatcataa aaactgtatt ttctatatag ttcagctaag tttatgaaaa
     5761 agatgcagac tcagtatttg gagcattgct atcgctccat gatgtgttta aaaattattt
     5821 ttaaattgac aaaattttat atctacatat atatatatct tgtaacacat gatgtttgaa
     5881 atgcttaatt ctagccaatt aaaaatgctt tacctcaata gttattttta ttgtgagaaa
     5941 ggtcaacatg gtcttggcac ttaaaaaaaa aaaaacaata tattctcaat aactgtattc
     6001 actctgcact acaataggtc tcttgaacta attcctccta gctaacaggc attgtttatc
     6061 atttaacaga taattctcta agcccccttc tcctaaaact tcagcatctc ttaaccttct
     6121 ttctagtctc tacttttatg agatcaactt gtttagattc cacgtgagtg agaccatgag
     6181 gtattcatct ttctgtgttc tgctccattg gtctatttat ctgtttttaa tgccagtatt
     6241 ggactgtttc agttactgta gctttgcagt atatttgact gtcaagtagt gcagtgcttc
     6301 caaccttcag agtcttttac tgtactatat gaatttttgt gttttttttg tgaaaaattt
     6361 tattgatatt ttgatagaca ttatgttaaa tatatacatc attttgtgta acatagactt
     6421 tttagcaata ttaatttggc caatttatga ataagggata acttttcatt tatttatgtt
     6481 taattttata cctcagtttt ctttagcttt taatgtagag atctttaaca tttttgaata
     6541 attttatttg gaagtaaact ttctgtaact attgcaggtg tcaattgttt tctttatttc
     6601 tttttcagat agtttgttgt tagtgtatag aaatgctact gacccttata tcttgatttt
     6661 gtatcctgca actttagtga atttattcta agtattttta aagttttcta tttataagac
     6721 tatgatatct gcaaacaggg acaattattt tctttctttc caatttggtt gtctttggtt
     6781 ttgttttcta atttctctgg cctggaaatt cagtagcatg ttaaataaga gtgatgaagt
     6841 tagatatatt tgccttacta taactcttag aaaaaaggct tacaactttt gaaggtttag
     6901 catgatgtca gatgtccatt tgtcatatat ggcctttatt ggcttgaggt atgtatgttc
     6961 tatatgtaat ttgttttgag attttgtcat aaagtaatgt tgaattttct aaaattcttt
     7021 ttctgcattc acttaaaagt tataattggt tctgagatcc ttcatctttc tcagaatcta
     7081 ggaggatgca tctgtaccta gaggaggaca caaaggcatc atatgttaca ttctcgtgac
     7141 atataatgtc tactgcttat aatgtctact gtgagtttct gactccccaa atgaaattga
     7201 ggcccagaaa ctttcaactg ctttgttcgt tgaataatgc caagtgtctg gaaatgtgac
     7261 tattcagatt aaatgcttaa tgtgtgtgtg ttgactaaat aaatctcaac cagaaccttc
     7321 tcagatattt tgttgaacgt gggacctttg tttttttttg ttgttttgtt ttgttttgtt
     7381 tttgttgttg ttgttgttgt tgtttaccag caggggaccc ctgttttgtc tatgtcaaga
     7441 acaaagacca ggcaaaagaa atgtcaagcc gcatttacaa atgcaaaaat ggacttgttt
     7501 ttgatatgct tttcccaaca ataagggaca tgagtcattg gggcatgtta cagagagttt
     7561 cagtaaaatt cagaaaaaaa taataaatat gaacagccac agcatgccca gaagcctttt
     7621 tatggagcca ggcatggttg acctgctttc catgtctcaa aacattagtc cctacaagaa
     7681 ccctatgagg tttatcttct tttcacccat tttgagagaa gaaaagttca gctcagagag
     7741 ctgcaggaac attggggaca tctccaagtc acagccaata ggtggcagtc atcagtgtgt
     7801 cttggaaggg acaaacattg agcttctgaa cagctactcc agaaactatg gtgctgtggt
     7861 gaagtcctgg ttaggagcct aggaaaatgg tgaaggaaaa gatggtccca gcctgcaaag
     7921 ctgaagtcag gaacccacca ggatctccct tctccctagc ctggtggtcc acatcatgca
     7981 gatttactct agattcagct tagactcatt tttatactac tcgggggaca aggagggaac
     8041 tacagtcagt aacagcagca tgagcctcag gtgctttggg gattgaaatt cagaccagga
     8101 aattccaata catcagtgca tgtggaggac atgagtattt aaggagaagg ttctaggctt
     8161 ccgaagtaaa attggatgtg gaggttgggg attgattcaa acattaatac tttcaagcgt
     8221 ttctatggta tttgtcagct gtggagcaac agcacacatc tgtattaata gcctgtgtta
     8281 agagattact gtgaatcctg aaaaacatcc tcattgtaga gatgagaaaa cacaggcttt
     8341 tgcacatcca atgtctcctt aaagcatgtg gttcagaatt gagaacgtgc agagtgagag
     8401 tggtatgaat tttcctgtaa gctacctgaa gttctgtttg ctgtcatgtg gaagaaaaga
     8461 gccttggaga agttttattt ttttctgttt ggaaagaata cacagagcaa gatgatttac
     8521 aataaacctt ttgacctaac gca
//
