LOCUS       NM_182609               3512 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 677 (ZNF677), transcript variant
            2, mRNA.
ACCESSION   NM_182609
VERSION     NM_182609.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3512)
  AUTHORS   Zhang,Z., Zhang,Y., Hu,X., Chen,Y., Zhuang,L. and Zhang,S.
  TITLE     ZNF677 inhibits oral squamous cell carcinoma growth and tumor
            stemness by regulating FOXO3a
  JOURNAL   Hum Cell 36 (4), 1464-1476 (2023)
   PUBMED   37129799
  REMARK    GeneRIF: ZNF677 inhibits oral squamous cell carcinoma growth and
            tumor stemness by regulating FOXO3a.
REFERENCE   2  (bases 1 to 3512)
  AUTHORS   Li,A., Cao,C., Gan,Y., Wang,X., Wu,T., Zhang,Q., Liu,Y., Yao,L. and
            Zhang,Q.
  TITLE     ZNF677 suppresses renal cell carcinoma progression through
            N6-methyladenosine and transcriptional repression of CDKN3
  JOURNAL   Clin Transl Med 12 (6), e906 (2022)
   PUBMED   35678231
  REMARK    GeneRIF: ZNF677 suppresses renal cell carcinoma progression through
            N6-methyladenosine and transcriptional repression of CDKN3.
REFERENCE   3  (bases 1 to 3512)
  AUTHORS   Liang,W., Chen,S., Yang,G., Feng,J., Ling,Q., Wu,B., Yan,H. and
            Cheng,J.
  TITLE     Overexpression of zinc-finger protein 677 inhibits proliferation
            and invasion by and induces apoptosis in clear cell renal cell
            carcinoma
  JOURNAL   Bioengineered 13 (3), 5292-5304 (2022)
   PUBMED   35164660
  REMARK    GeneRIF: Overexpression of zinc-finger protein 677 inhibits
            proliferation and invasion by and induces apoptosis in clear cell
            renal cell carcinoma.
REFERENCE   4  (bases 1 to 3512)
  AUTHORS   Siraj,A.K., Parvathareddy,S.K., Siraj,N., Al-Obaisi,K.,
            Aldughaither,S.M., AlManea,H.M., AlHussaini,H.F., Al-Dayel,F. and
            Al-Kuraya,K.S.
  TITLE     Loss of ZNF677 expression is a predictive biomarker for lymph node
            metastasis in Middle Eastern Colorectal Cancer
  JOURNAL   Sci Rep 11 (1), 22346 (2021)
   PUBMED   34785764
  REMARK    GeneRIF: Loss of ZNF677 expression is a predictive biomarker for
            lymph node metastasis in Middle Eastern Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3512)
  AUTHORS   Bidar,N., Rezaei,T., Amini,M., Jebelli,A., Mokhtarzadeh,A. and
            Baradaran,B.
  TITLE     ZNF677 downregulation by promoter hypermethylation as a driver
            event through gastric tumorigenesis
  JOURNAL   Exp Mol Pathol 121, 104663 (2021)
   PUBMED   34171355
  REMARK    GeneRIF: ZNF677 downregulation by promoter hypermethylation as a
            driver event through gastric tumorigenesis.
REFERENCE   6  (bases 1 to 3512)
  AUTHORS   Siraj,A.K., Poyil,P.K., Parvathareddy,S.K., Alobaisi,K.,
            Ahmed,S.O., Al-Sobhi,S.S., Al-Dayel,F. and Al-Kuraya,K.S.
  TITLE     Loss of ZNF677 Expression Is an Independent Predictor for Distant
            Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients
  JOURNAL   Int J Mol Sci 22 (15), 7833 (2021)
   PUBMED   34360599
  REMARK    GeneRIF: Loss of ZNF677 Expression Is an Independent Predictor for
            Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma
            Patients.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3512)
  AUTHORS   Li,Y., Yang,Q., Guan,H., Shi,B., Ji,M. and Hou,P.
  TITLE     ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid
            Cancer
  JOURNAL   Cancer Res 78 (18), 5216-5228 (2018)
   PUBMED   29997231
  REMARK    GeneRIF: ZNF677 functions as a tumor suppressor and is frequently
            silenced via promoter methylation in thyroid cancer
REFERENCE   8  (bases 1 to 3512)
  AUTHORS   Heller,G., Altenberger,C., Schmid,B., Marhold,M., Tomasich,E.,
            Ziegler,B., Mullauer,L., Minichsdorfer,C., Lang,G.,
            End-Pfutzenreuter,A., Dome,B., Arns,B.M., Fong,K.M., Wright,C.M.,
            Yang,I.A., Klepetko,W., Zielinski,C.C. and Zochbauer-Muller,S.
  TITLE     DNA methylation transcriptionally regulates the putative tumor cell
            growth suppressor ZNF677 in non-small cell lung cancers
  JOURNAL   Oncotarget 6 (1), 394-408 (2015)
   PUBMED   25504438
  REMARK    GeneRIF: our results demonstrate that ZNF677 is trancriptionally
            regulated by methylation in non-small cell lung cancers and suggest
            that ZNF677 has tumor cell growth suppressing properties
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092070.2.
            
            On Jul 21, 2020 this sequence version replaced NM_182609.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-3 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050038.1, AK308120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598513.6/ ENSP00000469391.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC092070.2         113171-113210       c
            41-111              AC092070.2         111423-111493       c
            112-181             AC092070.2         109873-109942       c
            182-335             AC092070.2         102081-102234       c
            336-3512            AC092070.2         93718-96894         c
FEATURES             Location/Qualifiers
     source          1..3512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3512
                     /gene="ZNF677"
                     /note="zinc finger protein 677"
                     /db_xref="GeneID:342926"
                     /db_xref="HGNC:HGNC:28730"
     exon            1..40
                     /gene="ZNF677"
                     /inference="alignment:Splign:2.1.0"
     exon            41..111
                     /gene="ZNF677"
                     /inference="alignment:Splign:2.1.0"
     exon            112..181
                     /gene="ZNF677"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1921
                     /gene="ZNF677"
                     /note="isoform a is encoded by transcript variant 2;
                     hypothetical protein MGC48625"
                     /codon_start=1
                     /product="zinc finger protein 677 isoform a"
                     /protein_id="NP_872415.1"
                     /db_xref="CCDS:CCDS12861.1"
                     /db_xref="GeneID:342926"
                     /db_xref="HGNC:HGNC:28730"
                     /translation="MALSQGLFTFKDVAIEFSQEEWECLDPAQRALYRDVMLENYRNL
                     LSLDEDNIPPEDDISVGFTSKGLSPKENNKEELYHLVILERKESHGINNFDLKEVWEN
                     MPKFDSLWDYDVKNYKGMPLTCNKNLTHRKDQQHNKSSIHFSLKQSVSIRDSAHQYFI
                     HDKPFIRNLLKLKNNIRYAGNKYVKCFENKIGLSLQAQLAELQRFQTGEKMYECNPVE
                     KSINSSSVSPLPPCVKNICNKYRKILKYPLLHTQYGRTHIREKSYKCNDCGKAFSKSS
                     NLTNHQRIHSGQRPYKCNECGKAFNQCSNLTRHQRVHTGEKPYQCNICGKVCSQNSNL
                     ASHQRMHTGEKPYKCNECGKAFIQRSHLWGHERIHTGEKPYKCNECDKAFAERSSLTQ
                     HKRIHTGEKPYICNECGKAFKQCSHLTRHQNIHPGEKPHKCNVCGRAFIQSSSLVEHQ
                     RIHTGEKPYKCNKCDKAFIKRSHLWGHQRTHTGEKPYKCTECGKAFTERSNLTQHKKI
                     HTGEKPYKCTECGKAFTQFANLTRHQKIHIEKKHCKHNIHGNALFQSSNLGDHQKSYN
                     REKHIKYNETKIKYSSCT"
     exon            182..335
                     /gene="ZNF677"
                     /inference="alignment:Splign:2.1.0"
     exon            336..3512
                     /gene="ZNF677"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3486..3491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF677"
                     /note="hexamer: AATATA"
     polyA_site      3512
                     /gene="ZNF677"
                     /note="major polyA site"
ORIGIN      
        1 gacccggaag cggatctcgc ggggctactg gcgctctcgg cccacacaat atgacctcgg
       61 ggaggatgcg aggaagatga actgtgatga tccacttctt cttaatgaat gactgactta
      121 cctgagaaag aaactcagag gaagaggaaa gaaagaagag gagggaatgg ctctttctca
      181 gggactgttt acattcaagg atgtggccat agaattctct caagaggagt gggagtgcct
      241 ggaccctgcc cagagggcct tgtacaggga cgtgatgttg gagaactaca ggaacctgct
      301 ttctctcgat gaggataaca tccctccaga agatgatatt tctgttggat ttacaagcaa
      361 gggattatca ccaaaggaaa ataataaaga ggaattatac catctggtga tattagaaag
      421 aaaggaaagc catggcatca acaattttga cctcaaggaa gtctgggaaa atatgcctaa
      481 gtttgacagc ctgtgggact atgatgtaaa aaattacaaa ggaatgcctt tgacctgtaa
      541 caaaaatctc actcacagaa aagatcaaca acataataaa tcctcaatac atttctcttt
      601 aaagcagagt gtttctataa gagatagtgc acaccagtat ttcatccatg acaagccatt
      661 tataaggaat ttgttaaaac tgaaaaataa cataaggtat gccggaaaca aatacgtgaa
      721 gtgttttgaa aataaaattg gattaagctt acaggcacag ctggctgaac tacagagatt
      781 tcaaactggg gagaaaatgt atgaatgtaa tccagttgag aagtctatca atagttcctc
      841 agtttcacca cttcctcctt gtgtcaaaaa catttgtaat aaatatagga agattttgaa
      901 atacccttta ttacatacac agtatgggag aacacacatt agagaaaaat catacaagtg
      961 taatgactgt ggaaaggctt ttagcaaaag ttcgaacctc actaatcatc agagaattca
     1021 ctctggacag agaccttaca aatgtaacga gtgtggcaaa gcctttaacc agtgttcgaa
     1081 cctcactagg catcagagag tccatacagg agagaaacca tatcaatgta atatatgtgg
     1141 caaggtctgt agtcaaaatt caaatcttgc aagtcatcag aggatgcata ctggagagaa
     1201 accttacaaa tgtaatgaat gtggtaaggc atttatccag cgttcacacc tttggggtca
     1261 tgaaagaatt catactggag agaaacctta caaatgtaat gaatgtgaca aagcctttgc
     1321 tgaacgttca agccttaccc aacataagag aatccatact ggagagaagc cttacatatg
     1381 taatgagtgt ggcaaagctt ttaagcagtg ctcacatctc actaggcatc agaatataca
     1441 tcctggagag aaaccacaca aatgtaatgt gtgtggcagg gcttttatcc aaagttcaag
     1501 tcttgtggaa catcagagaa ttcacactgg agaaaaacct tacaaatgta ataaatgtga
     1561 taaagctttt atcaaacgtt cacacctttg gggtcatcag agaactcata ctggagagaa
     1621 accttacaaa tgtactgaat gtggcaaagc ctttactgaa cgttcaaatc ttactcagca
     1681 taagaaaatc catactggag agaaacctta caaatgtact gaatgtggca aagcttttac
     1741 ccaatttgca aacctcacta gacaccagaa aatacacatt gaaaagaaac attgtaaaca
     1801 taatatacat ggtaatgctt tattccaaag ttcaaacctt ggagatcatc aaaaaagtta
     1861 taatagagaa aaacatatca aatataatga gacaaaaatt aagtattcaa gctgtaccta
     1921 gcatcagggg ctccattgtg aaaagaaacc atataaaacg aaaatgtggt aaagccttta
     1981 gctatggctt atgtctcact tgataccaga atatacatct ttgagataaa ccacacaaag
     2041 ataacatgta tggcaaggct tatccaaagt tcaagccttg tggaacatca tagaattctt
     2101 actgtagaga agccttacaa atataatgaa tgtgaacagc tttataaaaa tatttaccct
     2161 attatggtta taacagaaga cattcaggat ggaaaccata caaatgtggc aagtccttta
     2221 agcaatgttc tgacttcagg atacaccatt catattggag agaagcatta caagtgaagg
     2281 tggtaaatta ttttaaattt ctcaatggaa attcatcctt atatgcaagc attttgtcat
     2341 acaaaaattc aggctagagg gaactaagtc ttttttcctt cttgaagatt aagtgattga
     2401 tgttaaattc acagacaatt ttaaaaagtc acaaactcat ggtgtgtgtc agaggagcaa
     2461 ggacatctgt ggaaagatgt aacttcagtg ttaaaaattt tttattcagt tatttcatat
     2521 ttttaaaagt atgaaatctg ttgctgttaa atcttcatgg catgcttttc atttatcatg
     2581 attgtctcaa ggaatggatg taagatggaa gggactactt ccttaggtgt ggcttcttta
     2641 tattactgaa acctggaaaa agcaagaaca ctaatttttt ctttttttgg agacagagtc
     2701 ttgctctgtc acccaggctg gagtgcagtg gcaccatctc agctcactgc aacctctgtc
     2761 tcccgggttc aagcaattct cctgcctcag cctcacgagt agctgggatt acaggcatgc
     2821 gccatcatgc ctggctagtt ttttgttttt ttgtttttgt atttttagta gagacagagt
     2881 ttcgccatgt tggccaggct gatcttgaac tcctgacctc aggtgatcca cctgccttgg
     2941 cctcccaaag tgctgggatt acaggcatga gccaccgtgc ccagccaaga acactaatat
     3001 acaatatact ataagagcat gggggtttgt gccagaagag aggtaaaact attgtctaac
     3061 atatatgctt tatgtggtca ggacccctta gaattgttga tgtgactggg gacctttgtc
     3121 gattatagga gagattggtt acagtacaag atgaccatga aacaagaaga gtagggtggg
     3181 acattgagag attttcatgg aagtgaaatg gtcggttact agagactgca tatgtggtag
     3241 aaagaaatgg agggggaatg atagtcaccc tctcttgaaa ggtagttact gttgcatatc
     3301 acagattatt gaacatagat aggtcttatt tttggaaact gaagagagaa tggttaccat
     3361 agaggacagt tccatcaaaa gaaccagagt agtgttctta taggggattc acatttggcc
     3421 cctgagattg catttgatac cattttattt agaatatatt atacttctta tgtcttaatt
     3481 agtaaaatat aatcattttt agtaaccctg aa
//
