LOCUS       NM_001001411            2946 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 676 (ZNF676), mRNA.
ACCESSION   NM_001001411
VERSION     NM_001001411.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Jiang,T., Wang,Y., Zhu,M., Wang,Y., Huang,M., Jin,G., Guo,X.,
            Sha,J., Dai,J. and Hu,Z.
  TITLE     Transcriptome-wide association study revealed two novel genes
            associated with nonobstructive azoospermia in a Chinese population
  JOURNAL   Fertil Steril 108 (6), 1056-1062 (2017)
   PUBMED   29202958
  REMARK    GeneRIF: Transcriptome wide association study results identified
            two novel genes as statistically significantly associated with
            nonobstructive azoospermia susceptibility: PILRA and ZNF676.
REFERENCE   2  (bases 1 to 2946)
  AUTHORS   Mangino,M., Hwang,S.J., Spector,T.D., Hunt,S.C., Kimura,M.,
            Fitzpatrick,A.L., Christiansen,L., Petersen,I., Elbers,C.C.,
            Harris,T., Chen,W., Srinivasan,S.R., Kark,J.D., Benetos,A., El
            Shamieh,S., Visvikis-Siest,S., Christensen,K., Berenson,G.S.,
            Valdes,A.M., Vinuela,A., Garcia,M., Arnett,D.K., Broeckel,U.,
            Province,M.A., Pankow,J.S., Kammerer,C., Liu,Y., Nalls,M.,
            Tishkoff,S., Thomas,F., Ziv,E., Psaty,B.M., Bis,J.C., Rotter,J.I.,
            Taylor,K.D., Smith,E., Schork,N.J., Levy,D. and Aviv,A.
  TITLE     Genome-wide meta-analysis points to CTC1 and ZNF676 as genes
            regulating telomere homeostasis in humans
  JOURNAL   Hum Mol Genet 21 (24), 5385-5394 (2012)
   PUBMED   23001564
  REMARK    GeneRIF: Genome-wide meta-analysis points to CTC1 and ZNF676 as
            genes regulating telomere homeostasis in humans.
REFERENCE   3  (bases 1 to 2946)
  AUTHORS   Levy,D., Neuhausen,S.L., Hunt,S.C., Kimura,M., Hwang,S.J., Chen,W.,
            Bis,J.C., Fitzpatrick,A.L., Smith,E., Johnson,A.D., Gardner,J.P.,
            Srinivasan,S.R., Schork,N., Rotter,J.I., Herbig,U., Psaty,B.M.,
            Sastrasinh,M., Murray,S.S., Vasan,R.S., Province,M.A., Glazer,N.L.,
            Lu,X., Cao,X., Kronmal,R., Mangino,M., Soranzo,N., Spector,T.D.,
            Berenson,G.S. and Aviv,A.
  TITLE     Genome-wide association identifies OBFC1 as a locus involved in
            human leukocyte telomere biology
  JOURNAL   Proc Natl Acad Sci U S A 107 (20), 9293-9298 (2010)
   PUBMED   20421499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX281304.1, AC073539.3 and AK097798.1.
            
            On May 17, 2019 this sequence version replaced NM_001001411.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX281304.1, AI092258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397121.3/ ENSP00000380310.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               BX281304.1         1-492
            493-1011            AC073539.3         119125-119643
            1012-2934           AK097798.1         159-2081
            2935-2946           AC073539.3         121567-121578
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..2946
                     /gene="ZNF676"
                     /note="zinc finger protein 676"
                     /db_xref="GeneID:163223"
                     /db_xref="HGNC:HGNC:20429"
     exon            1..352
                     /gene="ZNF676"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..2085
                     /gene="ZNF676"
                     /codon_start=1
                     /product="zinc finger protein 676"
                     /protein_id="NP_001001411.2"
                     /db_xref="CCDS:CCDS42539.1"
                     /db_xref="GeneID:163223"
                     /db_xref="HGNC:HGNC:20429"
                     /translation="MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWNMKRHEMVEEPPV
                     ICSHFSQEFWPEQGIEDSFQKMILRRYDKCGHENLHLKISCTNVDECNVHKEGYNKLN
                     QSLTTTQSKVFQCGKYANVFHKCSNSNRHKIRHTGEKGLKCKEYVRSFCMLSHLSQHE
                     RIYTRENSYKCEENGKAFNWSSTLTYYKSIHTGEKPYKCEECGKAFSKFSILTKHKVI
                     HTGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEECGKGFSSVSTLNTHKAIHA
                     EEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAGE
                     KPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEGCGKAFSKVSTLNTHKAIHAEEKP
                     YKCEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAGEKPYK
                     CEECGKAFTWSSSFTKHKRIHAAEKPYKCEECGKGFSTFSILTKHKIIHTGEKRYKCE
                     ECGKAFSWSSILTEHKIIHTGEKPYKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEEC
                     GKAFKSSSTVSYHKKIHTGENP"
     exon            353..448
                     /gene="ZNF676"
                     /inference="alignment:Splign:2.1.0"
     exon            449..2946
                     /gene="ZNF676"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF676"
                     /note="hexamer: AATAAA"
     polyA_site      2946
                     /gene="ZNF676"
                     /note="major polyA site"
ORIGIN      
        1 attacatata cacagatgtt atggatctta taccactttc ttttctcaga gttagagaat
       61 acattagtga acatttctgt gttgaaaact attttattga ataatttcag tcattcatat
      121 aagtcagaac cagctctctc tactctctcc attttacctt gagtcacatt aaaagttctg
      181 cccatgacca attggtaaat atatgtgttt gtgtgtgttt tccagggagc attgacattt
      241 agggatgtgg ccatagaatt ctctctggag gagtggcaat gcctggattc tacacagcag
      301 aatttatata ggaatgtgat gttagagaac tacagaaacc tggtcttcct gggtattgct
      361 gcctttaagc cagacctgat catttttctg gagcaaggaa aagagccctg gaatatgaag
      421 agacatgaga tggtggaaga acccccagtt atatgttctc atttttccca agagttttgg
      481 ccagagcaag gcatagaaga ttctttccaa aaaatgatat tgagaagata tgacaaatgt
      541 ggacatgaga atttacactt aaaaattagt tgtaccaatg tggatgagtg taacgtgcac
      601 aaagaaggtt ataataaact taaccagagt ttaacaacta cacagagcaa agtatttcaa
      661 tgtggcaaat atgcaaacgt ctttcataaa tgttcaaatt caaacagaca taagataagg
      721 catactggag agaaaggttt gaaatgtaaa gaatatgtca gatcattttg catgctttca
      781 cacctatctc aacatgaaag aatttatact agagagaatt cctacaaatg tgaagaaaat
      841 ggcaaagctt ttaactggtc ctcaaccctt acttattata agagtattca tactggagag
      901 aaaccctaca aatgtgaaga atgtggcaaa gcctttagta agttctcaat ccttactaaa
      961 cataaggtaa ttcatactgg agagaaaccc tacaaatgtg aagaatgtgg caaagctttt
     1021 aatcgatcct caatccttac taaacataag ataattcata ctggagagaa accctacaaa
     1081 tgtgaagaat gtggcaaagg atttagtagc gtctcaaccc ttaatacaca taaggcaatt
     1141 catgctgaag agaagcccta caaatgtgaa gaatgtggca aagcttccaa ctcgtcctca
     1201 aagctcatgg aacataagag aattcatact ggagagaaac cctacaagtg tgaagaatgt
     1261 ggcaaagcct tcagctggtc ctcaagcctt actgaacaca agagaattca tgctggagag
     1321 aaaccctaca aatgtgaaga atgcgggaaa gcttttaatc gatcctcaat ccttactaaa
     1381 cataagatta ttcatactgg agagaaaccc tacaaatgtg aaggatgtgg caaagccttt
     1441 agtaaggtct caacccttaa tacacataag gcaattcatg ctgaagagaa gccctacaaa
     1501 tgtgaagaat gtggcaaagc ttccaactca tcctcaaagc tcatggaaca taagagaatt
     1561 catactggag agaaacccta caagtgtgaa gaatgtggca aagccttcag ctggtcctca
     1621 agccttactg aacacaagag aattcatgct ggagagaaac cctacaaatg tgaagaatgt
     1681 ggcaaagcct tcacctggtc ctcaagcttt actaaacaca agagaattca tgctgcagag
     1741 aaaccttaca aatgtgaaga atgtggcaaa ggctttagta cgttctcaat ccttactaaa
     1801 cataagataa ttcatactgg agagaaacgc tacaaatgtg aagaatgtgg caaagccttc
     1861 agctggtcct cgatccttac tgaacataag ataattcata ctggagagaa accctacaaa
     1921 tgtgaagaat gtggcaaagc cttcagcaga tcctcaagcc ttactagaca caagagaatt
     1981 catactggag agaaacccta caaatgtgaa gaatgtggca aagcttttaa gtcatcctca
     2041 actgttagtt atcataagaa aattcatact ggagagaatc cctaaaaatg tgaagaatgt
     2101 ggtaaatcct tcagctgatt ctcagtctag taaacataag aaaattcata ctggagagaa
     2161 aatctacaaa ggtgaagaat gtggcaaagc ttttaaacag tcctcaatct ttattacaca
     2221 taagaaaatt catgctggag agaaacacta caaacgtgaa gaatgtgaca aaggcttcaa
     2281 ccggtcctca aaccttgtgg aacataagag aattcatact ggagagaaac cctacaaatg
     2341 cgaagaatgt gataaagact tcaactgttc ctcacacctt actactcata aaagaattca
     2401 tactggagga aaagccctac aaatgtgaaa aacgtggcaa agcttttcat tagttctcaa
     2461 cccttactga acataaggga atttatacag gagggaaacc ctacaaatgt gaagaatgtg
     2521 gcaagccttt tagctgttcc tcaatcctta ctaaacattc atgtaattca tactggaggg
     2581 aattcctata attgtgtgga atgtggcaaa gcctttaacc agtccttaag gcttactaca
     2641 tataagacaa ctcatactgg agagaaacca tgcatgtgtg aagaatgtgg gaaagcctct
     2701 aacagatcct caattcttaa gaaacatagg ctaattcata catgagagac tctacaaacc
     2761 tgaaagatgt gacaatgctt ttggcaacac ctcagacttt tctgaatata aaagaaatca
     2821 tatgaatgag aaatcctaga aatgtgaaga atgtgacaaa gcctttaaat ggctgtcaca
     2881 cttgattgta ggtaagataa tatactggag aaaactacta gaataaacaa tgtggcacac
     2941 atttaa
//
