LOCUS       NM_138330               2311 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens zinc finger protein 675 (ZNF675), mRNA.
ACCESSION   NM_138330
VERSION     NM_138330.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2311)
  AUTHORS   Lodewijk,G.A., de Geus,M., Guimaraes,R.L.F.P. and Jacobs,F.M.J.
  TITLE     Emergence of the ZNF675 Gene During Primate Evolution-Influenced
            Human Neurodevelopment Through Changing HES1 Autoregulation
  JOURNAL   J Comp Neurol 532 (7), e25648 (2024)
   PUBMED   38958676
  REMARK    GeneRIF: Emergence of the ZNF675 Gene During Primate
            Evolution-Influenced Human Neurodevelopment Through Changing HES1
            Autoregulation.
REFERENCE   2  (bases 1 to 2311)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   3  (bases 1 to 2311)
  AUTHORS   Shin,J.N., Kim,I., Lee,J.S., Koh,G.Y., Lee,Z.H. and Kim,H.H.
  TITLE     A novel zinc finger protein that inhibits osteoclastogenesis and
            the function of tumor necrosis factor receptor-associated factor 6
  JOURNAL   J Biol Chem 277 (10), 8346-8353 (2002)
   PUBMED   11751921
  REMARK    GeneRIF: the novel zinc finger protein TIZ may play a role during
            osteoclast differentiation by modulating TRAF6 signaling activity.
REFERENCE   4  (bases 1 to 2311)
  AUTHORS   Kimura,R., Sato,K., Fujimoto,R. and Nishio,T.
  TITLE     Recognition specificity of self-incompatibility maintained after
            the divergence of Brassica oleracea and Brassica rapa
  JOURNAL   Plant J 29 (2), 215-223 (2002)
   PUBMED   11851921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073544.4 and DA777369.1.
            
            On May 17, 2019 this sequence version replaced NM_138330.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.135255.1,
                                           SRR1660805.196511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161836, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359788.9/ ENSP00000352836.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC073544.4         106665-106846       c
            183-548             DA777369.1         205-570
            549-2206            AC073544.4         72540-74197         c
            2207-2311           AC073544.4         72435-72539         c
FEATURES             Location/Qualifiers
     source          1..2311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..2311
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /note="zinc finger protein 675"
                     /db_xref="GeneID:171392"
                     /db_xref="HGNC:HGNC:30768"
                     /db_xref="MIM:620090"
     exon            1..182
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1886
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /note="TRAF6-binding zinc finger protein; TRAF6 inhibitory
                     zinc finger; TRAF6-inhibitory zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 675"
                     /protein_id="NP_612203.2"
                     /db_xref="CCDS:CCDS32981.1"
                     /db_xref="GeneID:171392"
                     /db_xref="HGNC:HGNC:30768"
                     /db_xref="MIM:620090"
                     /translation="MGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLG
                     IAVSKQDLITCLEQEKEPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRR
                     YEKCGNDNFQLKGCKSVDECKLHKGGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHSD
                     RHKIKHMENKPFKCKECGRSFCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKH
                     KRIYTCEKLYKCQECDRTFNQFSNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKI
                     IHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYICEECGKAFTQSSTLTTHKRIH
                     TGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRSSNLTEHRKIHTE
                     EKPYKCKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKK
                     PYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSLTTHKRIHTGEKPY
                     KCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKHKKIHTGEKLQNW
                     NV"
     exon            183..309
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /inference="alignment:Splign:2.1.0"
     exon            310..405
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /inference="alignment:Splign:2.1.0"
     exon            406..2311
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /note="hexamer: AATAAA"
     polyA_site      2206
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /note="major polyA site"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
                     /note="hexamer: AATATA"
     polyA_site      2250
                     /gene="ZNF675"
                     /gene_synonym="TBZF; TIZ"
ORIGIN      
        1 agacaagatg gcttccggga tttggcggcg cctttgtctc tcgctgcagc cggagctcca
       61 ggtctcgctt tcattgctct gtgtcctctg ctcctagagg tccagcctct gtgggcctgt
      121 gacctgcaga aattgagaga tccacagcta agactccagg accccctgga agcctagaaa
      181 tgggactgtt gacatttagg gatgtggcca tagaattctc tctggaagaa tggcaatgcc
      241 tggacactgc acagcggaat ttatataaaa atgtgatttt agagaactac agaaacctgg
      301 tcttcctggg tattgctgtc tctaagcaag acctgatcac ctgtctggag caagaaaaag
      361 agcctttgac tgtgaagaga catgagatgg tgaatgaacc cccagtaatg tgttctcatt
      421 ttgcccaaga gttttggcca gagcagaaca taaaagattc ttttgaaaaa gtgacactga
      481 gaagatatga aaaatgtgga aatgataatt ttcagttaaa aggctgtaaa agtgtggatg
      541 aatgtaagtt gcacaaggga ggttataatg gacttaacca atgtttacca actatgcaga
      601 gcaaaatgtt tcaatgtgat aaatatgtga aagtctttaa taaattttca cattcagata
      661 gacataagat aaaacatatg gaaaataaac ctttcaaatg taaagaatgt ggcagatcat
      721 tttgcatgct ttcacaccta actcgacatg aaagaaatta taccaaggtg aatttctgca
      781 aatgtgaaga atgtgaaaaa gctgttaacc aatcttcaaa gcttactaaa cataaaagaa
      841 tttatacttg tgagaaactc tacaaatgtc aagaatgtga cagaactttt aaccaattct
      901 caaaccttac tgaatataaa aaagattatg ctcgagagaa accatacaaa tgtgaagaat
      961 gtggcaaagc ctttaaccag tcctcacacc ttactacaca taagataatt catacaggag
     1021 agaaacccta caaatgtgaa gaatgtggca aagcctttaa ccagttctca aatcttacta
     1081 cacataaaaa aattcatact ggagagcaac cctacatatg tgaagaatgt ggcaaggctt
     1141 ttacccaatc ctcaaccctt actacacata agagaattca tactggagaa aaaccctaca
     1201 aatgtgaaga atgtggaaaa gcttttaacc gatcctcaaa acttactgaa cataaaaaca
     1261 ttcatactgg agagcaaccc tacaaatgtg aggaatgcgg caaagctttt aaccgatcct
     1321 caaatcttac ggaacatagg aaaattcata ccgaagagaa accctacaaa tgtaaagaat
     1381 gtggcaaagc ttttaaacac tcctcagccc ttactacaca taagagaatt cacactggag
     1441 agaaacccta caaatgtgaa gaatgtggca aagcttttaa ccgatcctca aaacttactg
     1501 aacataagaa acttcatact ggaaagaaac cctacaaatg tgaagaatgt ggcaaagctt
     1561 ttatccaatc ctcaaaactt actgaacata agaaaattca ttctggagag ataccctaca
     1621 agtgtgaaga atgtggcaaa gcttttaaac actcctcatc ccttactaca cataaaagaa
     1681 ttcatactgg ggagaaaccc tacaaatgtg aagaatgtgg caaagctttt agccgatcct
     1741 caaaacttac tgaacataag ataattcata ctggagagaa accctataaa tgtgagagat
     1801 gtgacaaagc ttttaaccaa tctgcaaacc ttactaaaca taaaaaaata catactggag
     1861 agaaactaca gaactggaat gtgtgataat gattttgaca acacctcaaa tttttctaaa
     1921 tataaaggaa atcatactgg tgaaaaattc tagaaatgta aagaatgtgt caaagacttt
     1981 aaatggtttt cacacttcat tgtatgtaag ataattcata ctggagaaaa ctacaagtgt
     2041 gaagaatttg gcaatactgt taattaaggc tcaaacctta ttgcacagga aagcgtttat
     2101 acttaagaaa aattgtacaa atataaagag tgtaaaatag ccattaatat ctgttgacat
     2161 cttaatatca gaatgttggt acttaataaa agcattataa atgcaattac tgtctaaaga
     2221 ctttaagaaa atataagcct ttaaagtgaa gaagagtatt cgttttgaag acaaagatta
     2281 caaacataaa gagggttgta gtacatttac t
//
