LOCUS       NM_024833               2431 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 671 (ZNF671), transcript variant
            1, mRNA.
ACCESSION   NM_024833
VERSION     NM_024833.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Zhang,W., Liu,T., Li,X., Li,T., Ma,X., Zhao,D. and Zhao,X.
  TITLE     Increased methylation of ZNF671 suppresses tumor progression by
            promoting MAPK6 transcription in laryngeal carcinoma
  JOURNAL   Int J Biol Sci 19 (8), 2443-2457 (2023)
   PUBMED   37215982
  REMARK    GeneRIF: Increased methylation of ZNF671 suppresses tumor
            progression by promoting MAPK6 transcription in laryngeal
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Wang,Y., Chen,F.R., Wei,C.C., Sun,L.L., Liu,C.Y., Yang,L.B. and
            Guo,X.Y.
  TITLE     Zinc finger protein 671 has a cancer-inhibiting function in
            colorectal carcinoma via the deactivation of Notch signaling
  JOURNAL   Toxicol Appl Pharmacol 458, 116326 (2023)
   PUBMED   36436566
  REMARK    GeneRIF: Zinc finger protein 671 has a cancer-inhibiting function
            in colorectal carcinoma via the deactivation of Notch signaling.
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Mase,S., Shinjo,K., Totani,H., Katsushima,K., Arakawa,A.,
            Takahashi,S., Lai,H.C., Lin,R.I., Chan,M.W.Y., Sugiura-Ogasawara,M.
            and Kondo,Y.
  TITLE     ZNF671 DNA methylation as a molecular predictor for the early
            recurrence of serous ovarian cancer
  JOURNAL   Cancer Sci 110 (3), 1105-1116 (2019)
   PUBMED   30633424
  REMARK    GeneRIF: ZNF671 functions as a tumor suppressor in ovarian cancer.
REFERENCE   4  (bases 1 to 2431)
  AUTHORS   Zhang,J., Wen,X., Liu,N., Li,Y.Q., Tang,X.R., Wang,Y.Q., He,Q.M.,
            Yang,X.J., Zhang,P.P., Ma,J. and Sun,Y.
  TITLE     Epigenetic mediated zinc finger protein 671 downregulation promotes
            cell proliferation and tumorigenicity in nasopharyngeal carcinoma
            by inhibiting cell cycle arrest
  JOURNAL   J Exp Clin Cancer Res 36 (1), 147 (2017)
   PUBMED   29052525
  REMARK    GeneRIF: Data show that mRNA and protein expression of ZNF671 are
            down-regulated in nasopharyngeal cancer (NPC) tissues and cell
            lines. Its downregulation promotes NPC cell proliferation and
            tumorigenicity by facilitating cell cycle progression. These
            results suggest that ZNF671 is a potential tumor suppressor which
            epigenetically silenced by promoter methylation in NPC.
            Erratum:[J Exp Clin Cancer Res. 2021 Dec 15;40(1):394. doi:
            10.1186/s13046-021-02205-0.. PMID: 34911540]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2431)
  AUTHORS   Zhao,W., Mo,Y., Wang,S., Midorikawa,K., Ma,N., Hiraku,Y.,
            Oikawa,S., Huang,G., Zhang,Z., Murata,M. and Takeuchi,K.
  TITLE     Quantitation of DNA methylation in Epstein-Barr virus-associated
            nasopharyngeal carcinoma by bisulfite amplicon sequencing
  JOURNAL   BMC Cancer 17 (1), 489 (2017)
   PUBMED   28716111
  REMARK    GeneRIF: In particular, methylation levels of ITGA4, RERG, and
            ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients
            from non-cancer nasopharyngeal epithelium (NNE) subjects.  We
            identified the DNA methylation rates of previously unidentified NPC
            candidate genes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2431)
  AUTHORS   Yeh,C.M., Chen,P.C., Hsieh,H.Y., Jou,Y.C., Lin,C.T., Tsai,M.H.,
            Huang,W.Y., Wang,Y.T., Lin,R.I., Chen,S.S., Tung,C.L., Wu,S.F.,
            Chang,D.C., Shen,C.H., Hsu,C.D. and Chan,M.W.
  TITLE     Methylomics analysis identifies ZNF671 as an epigenetically
            repressed novel tumor suppressor and a potential non-invasive
            biomarker for the detection of urothelial carcinoma
  JOURNAL   Oncotarget 6 (30), 29555-29572 (2015)
   PUBMED   26320192
  REMARK    GeneRIF: Data show that ZNF671, an epigenetically silenced tumor
            suppressor, represents a potential predictor for urothelial
            carcinoma (UC) relapse and non-invasive biomarker that could assist
            in UC clinical decision-making.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB104548.1, BC025728.1 and AK027159.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024833.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1017144.1,
                                           SRR3476690.1142518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317398.10/ ENSP00000321848.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DB104548.1         4-53
            51-1698             BC025728.1         1-1648
            1699-1742           AK027159.1         1690-1733
            1743-2431           BC025728.1         1692-2380
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2431
                     /gene="ZNF671"
                     /note="zinc finger protein 671"
                     /db_xref="GeneID:79891"
                     /db_xref="HGNC:HGNC:26279"
     exon            1..234
                     /gene="ZNF671"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1701
                     /gene="ZNF671"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 671 isoform 1"
                     /protein_id="NP_079109.2"
                     /db_xref="CCDS:CCDS12961.1"
                     /db_xref="GeneID:79891"
                     /db_xref="HGNC:HGNC:26279"
                     /translation="MLSPVSRDASDALQGRKCLRPRSRRLPLPAAVRAHGPMAELTDS
                     ARGCVVFEDVFVYFSREEWELLDDAQRLLYHDVMLENFALLASLGIAFSRSRAVMKLE
                     RGEEPWVYDQVDMTSATEREAQRGLRPGCWHGVEDEEVSSEQSIFVAGVSEVRTLMAE
                     LESHPCDICGPILKDTLHLAKYHGGKARQKPYLCGACGKQFWFSTDFDQHQNQPNGGK
                     LFPRKEGRDSVKSCRVHVPEKTLTCGKGRRDFSATSGLLQHQASLSSMKPHKSTKLVS
                     GFLMGQRYHRCGECGKAFTRKDTLARHQRIHTGERPYECNECGKFFSQSYDLFKHQTV
                     HTGERPYECSECGKFFRQISGLIEHRRVHTGERLYQCGKCGKFFSSKSNLIRHQEVHT
                     GARPYVCSECGKEFSRKHTLVLHQRTHTGERPYECSECGKAFSQSSHLNVHWRIHSSD
                     YECSRCGKAFSCISKLIQHQKVHSGEKPYECSKCGKAFTQRPNLIRHWKVHTGERPYV
                     CSECGREFIRKQTLVLHQRVHAGEKL"
     exon            235..361
                     /gene="ZNF671"
                     /inference="alignment:Splign:2.1.0"
     exon            362..484
                     /gene="ZNF671"
                     /inference="alignment:Splign:2.1.0"
     exon            485..2431
                     /gene="ZNF671"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF671"
                     /note="hexamer: AATAAA"
     polyA_site      2431
                     /gene="ZNF671"
                     /note="major polyA site"
ORIGIN      
        1 gtagcggaca ttttgtttct gtcaggctgt ccctggccgg ggttctgtaa cgcttgtgtg
       61 ggccgcaggt ggaggtgttg ggaaagcgcg gaggagatgt tgtccccagt gtcccgagac
      121 gcgtctgatg ctctgcaggg acggaagtgc ctgcgtcccc gatcgagacg cctgccgctc
      181 ccggcagctg tccgcgccca cggtcctatg gcggagctaa cggactccgc gcggggctgt
      241 gtggtctttg aggatgtgtt tgtatacttc tctcgggaag aatgggagct tcttgatgat
      301 gctcagagac ttttgtacca tgatgtgatg ctggagaact ttgcactttt agcctcactg
      361 ggaattgcat tttccagatc acgtgcagtc atgaaactag agcgaggaga agagccctgg
      421 gtgtatgacc aggtggatat gacttcagcc acagaaagag aggcccagag gggacttaga
      481 cctggttgtt ggcatggagt ggaggatgaa gaggtatctt ctgagcagag catttttgta
      541 gcaggagtgt cagaggtcag gactctcatg gcagagctgg agtctcaccc atgtgacata
      601 tgtggcccaa tattgaaaga taccttacac ctggctaaat accatggggg aaaagccagg
      661 cagaaaccat acttgtgtgg ggcatgtgga aagcaattct ggttcagtac agactttgac
      721 cagcaccaga accagcccaa tggagggaaa cttttcccaa ggaaggaggg cagagactct
      781 gtgaaaagct gcagagtcca tgtgccagag aagaccctca catgtgggaa aggtaggaga
      841 gacttttcag ccacatctgg ccttcttcag catcaggcct ctctcagcag catgaagccc
      901 cacaagagca ctaagcttgt gagtggcttt ctcatgggac agaggtatca caggtgtggt
      961 gaatgtggga aagccttcac ccgcaaagac acacttgctc ggcatcagag aatccacact
     1021 ggagaaaggc cttatgagtg taacgaatgt gggaaattct tcagccaaag ctatgacctc
     1081 tttaaacacc agacagttca cactggagaa aggccatacg agtgcagcga atgtgggaaa
     1141 ttctttagac aaatctccgg cctgattgag cacaggcgag ttcacacggg tgaaagactc
     1201 tatcagtgtg gcaaatgtgg gaaatttttt agcagtaagt ctaatctcat tcgacaccag
     1261 gaagttcaca caggagccag gccttatgta tgcagcgaat gtgggaaaga gttcagtcgg
     1321 aaacacacac ttgttctgca ccaacgaact cacactggag aaaggcctta tgagtgcagt
     1381 gaatgtggga aggcctttag ccaaagctcc caccttaatg tacactggag aattcacagc
     1441 agtgattatg agtgtagcag atgtggtaaa gctttcagct gcatctccaa actcattcag
     1501 caccagaaag ttcactctgg agaaaagcct tatgagtgca gcaagtgcgg gaaagccttc
     1561 actcaaagac ccaacctcat caggcactgg aaagtccaca ctggggaaag gccttatgtg
     1621 tgtagtgagt gcgggagaga attcatccgg aaacagacac ttgttctgca ccagagggtt
     1681 catgctggag aaaagcttta agagtgtagc aaatgtgggg gaaagtctta ggccaatgcc
     1741 cctgacttac tatatggtgg ggaactagca gtagttaatg agtgcagcag atgcaggaaa
     1801 gccttcccct ggaggctgaa ccttacccgc cattgggaat ttcacaccgg acacaggcct
     1861 tagcagtcta agcaatgtgc tgtctctgtt cagcccaaca gctcacccta gagtggaact
     1921 ctgggagcag ccattgggag ggaaccatca gtaagaagtg aaacttcata gatatggaca
     1981 ttcccactgg ggagattccc tgtgagtgtc aagtatgtga gatgctttca gcagctgtgt
     2041 tgcacttttt aaatggctat tggcctttgc tggggcagga gccatctgct cctaccatct
     2101 ggcagaatca tactgcgttt accatttacc ccagcatgct tgtgacgggc agacctctct
     2161 tctctcccca gtccctaaaa ggtgttgtga gtggtctcac agcccactag gggtcttaat
     2221 ttcctctctt ttgatgtaaa tggcatggaa ataatcagct ttgttcaaga ggacacagaa
     2281 ggattctgca aatagcctgc agagacttac ctgtgttgat tgatttcata tgatgctcgt
     2341 tatggatata tccaatatcc aagtcaccca gctctggaac tgcctgcttc acattgctca
     2401 tgataataaa ggcctgttct ttaagccacc a
//
