LOCUS       NM_033213               4197 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 670 (ZNF670), transcript variant
            1, mRNA.
ACCESSION   NM_033213
VERSION     NM_033213.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4197)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4197)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4197)
  AUTHORS   Fernandes,G.W., Bocco,B.M.L.C., Fonseca,T.L., McAninch,E.A., Jo,S.,
            Lartey,L.J., O-Sullivan,I., Unterman,T.G., Preite,N.Z., Voigt,R.M.,
            Forsyth,C.B., Keshavarzian,A., Sinko,R., Goldfine,A.B., Patti,M.E.,
            Ribeiro,M.O., Gereben,B. and Bianco,A.C.
  TITLE     The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic
            Steatosis and Hypercholesterolemia
  JOURNAL   Cell Rep 22 (2), 523-534 (2018)
   PUBMED   29320745
REFERENCE   4  (bases 1 to 4197)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   5  (bases 1 to 4197)
  AUTHORS   Niu,N., Schaid,D.J., Abo,R.P., Kalari,K., Fridley,B.L., Feng,Q.,
            Jenkins,G., Batzler,A., Brisbin,A.G., Cunningham,J.M., Li,L.,
            Sun,Z., Yang,P. and Wang,L.
  TITLE     Genetic association with overall survival of taxane-treated lung
            cancer patients - a genome-wide association study in human
            lymphoblastoid cell lines followed by a clinical association study
  JOURNAL   BMC Cancer 12, 422 (2012)
   PUBMED   23006423
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4197)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4197)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   8  (bases 1 to 4197)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA757117.1, BC005360.1, AL512637.18 and DB367437.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033213.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.216124.1,
                                           SRR1660807.121475.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366503.3/ ENSP00000355459.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               DA757117.1         3-215
            214-1962            BC005360.1         163-1911
            1963-3768           AL512637.18        52677-54482         c
            3769-4196           DB367437.1         1-428               c
            4197-4197           AL512637.18        52248-52248         c
FEATURES             Location/Qualifiers
     source          1..4197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..4197
                     /gene="ZNF670"
                     /note="zinc finger protein 670"
                     /db_xref="GeneID:93474"
                     /db_xref="HGNC:HGNC:28167"
     exon            1..218
                     /gene="ZNF670"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1385
                     /gene="ZNF670"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 670 isoform 1"
                     /protein_id="NP_149990.1"
                     /db_xref="CCDS:CCDS31087.1"
                     /db_xref="GeneID:93474"
                     /db_xref="HGNC:HGNC:28167"
                     /translation="MDSVSFEDVAVAFTQEEWALLDPSQKNLYRDVMQEIFRNLASVG
                     NKSEDQNIQDDFKNPGRNLSSHVVERLFEIKEGSQYGETFSQDSNLNLNKKVSTGVKP
                     CECSVCGKVFICHSALHRHILSHIGNKLFECEECPEKLYHCKQCGKAFISLTSVDRHM
                     VTHTSNGPYKGPVYEKPFDFPSVFQMPQSTYTGEKTYKCKHCDKAFNYSSYLREHERT
                     HTGEKPYACKKCGKSFTFSSSLRQHERSHTGEKPYECKECGKAFSRSTYLGIHERTHT
                     GEKPYECIKCGKAFRCSRVLRVHERTHSGEKPYECKQCGKAFKYSSNLCEHERTHTGV
                     KPYGCKECGKSFTSSSALRSHERTHTGEKPYECKKCGKAFSCSSSLRKHERAYMW"
     exon            219..345
                     /gene="ZNF670"
                     /inference="alignment:Splign:2.1.0"
     exon            346..406
                     /gene="ZNF670"
                     /inference="alignment:Splign:2.1.0"
     exon            407..4197
                     /gene="ZNF670"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF670"
                     /note="hexamer: AATAAA"
     polyA_site      2050
                     /gene="ZNF670"
                     /note="major polyA site"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF670"
                     /note="hexamer: AATAAA"
     polyA_site      3283
                     /gene="ZNF670"
                     /note="major polyA site"
     regulatory      4177..4182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF670"
                     /note="hexamer: AACAAG"
     polyA_site      4197
                     /gene="ZNF670"
ORIGIN      
        1 actctcaagc gcgccgcgaa aggagggagc agcttccggg acctggcgcg gcttttgtgt
       61 tgggcagcgc gaatgtggcg agctcggtgc gtctccgctg ctccttcccc ttatccctgg
      121 gaggtccaag tggtcccgcg gcagcttctg ttgctctggg acctgcaggt cccggaaggt
      181 ccttagggag gaccccagac accggagact gggaaatgga ttcagtgtca tttgaagatg
      241 tggctgtggc ctttactcag gaggagtggg ctttgctgga tccttctcaa aagaatctct
      301 acagagatgt gatgcaagaa atcttcagga acctggcttc tgtaggaaac aaatcagaag
      361 accagaatat ccaagatgac ttcaaaaatc ctgggagaaa tctaagcagt catgtggtag
      421 agagactgtt tgaaattaaa gaaggcagtc aatatggaga aaccttcagc caggattcaa
      481 atttgaatct gaataagaaa gtttctactg gagtaaagcc atgtgaatgc agtgtgtgtg
      541 gaaaagtctt catatgtcat tcagcccttc ataggcacat cctgtctcac attggaaaca
      601 aactatttga gtgtgaggaa tgtccagaga agttatatca ttgcaaacaa tgtgggaaag
      661 cctttatctc tctcaccagt gttgacagac acatggtaac acacactagt aatgggcctt
      721 ataagggtcc agtgtatgag aagccttttg attttcctag tgtatttcaa atgcctcaga
      781 gcacttacac tggagagaaa acatataaat gtaaacattg tgataaagcc ttcaattatt
      841 caagttatct tcgtgaacat gaaagaactc atactggaga gaaaccctat gcatgtaaga
      901 aatgtggtaa atcattcact ttttccagtt ctcttcgcca acatgaaaga tctcatactg
      961 gagagaaacc ctatgaatgt aaggaatgtg gcaaagcctt cagtcgttcc acttacttgg
     1021 gaatacatga aagaacgcat actggagaaa aaccctatga atgtataaaa tgtggcaaag
     1081 cctttagatg ttccagagtc ctcagagtcc atgaaaggac tcacagtgga gaaaagccct
     1141 atgaatgtaa acaatgtggt aaagccttca aatattctag taacctatgt gagcatgaaa
     1201 gaactcacac tggagtgaaa ccttatggat gtaaggaatg tggtaagtcg tttacttctt
     1261 ccagtgccct tcgaagccat gaaaggactc atactggaga aaaaccctat gaatgtaaga
     1321 aatgtggtaa agccttcagt tgttccagtt cccttcgaaa gcatgaaaga gcttatatgt
     1381 ggtaaaaaac aacaacaaca aaacacctct gtcaatgtaa gaagtgtgtt aaagctttca
     1441 gttattctag tttcattaga acacgtgaaa aaattaaaaa ctcaaattag agagaaaccc
     1501 aacacatgta aggaagatta gaatgtatgc aattttccta gttcccttct aaaacttaga
     1561 aggacccgtc ctgggaaaga acgtcataaa atacgaaaaa tgtgttagaa cactttattt
     1621 tcccagccgc tttcaaatat atttttatca gtggttcatt gttaaagaag gtgtctatac
     1681 tttagatttt cagttttttg cagggaatca tggagctgag aatttcacag atactttata
     1741 agccatagta catgagctta ataggctgtg ttttgtttct catcagttaa cataattttt
     1801 gtctattcat ttaaaaattt gttggatccc tagactaagt tgaaatgtat ttctaatagt
     1861 aggcaatttt aattttcatg tagttgttta attgttctct aattaatgga ccaatgaaaa
     1921 atgagttcat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtattctacc tttttatggg
     1981 aaaactactt ttttgttgta aagattttct tctgttttct ttgctaataa agaattgtta
     2041 ttaatttgca tgtatgtgaa gtttatatag tctcatgtac attgttattt tcattttctt
     2101 tcctttattc tgtcatgagt tttggctgtt acttgcatag ttcacttttt taaaaaatgt
     2161 tatgttttta gagagggtct cactttgtca gctaggctga agtgtagtgg taataatagt
     2221 cttagctcac tgcagcctca aattcctggg ctcaagtgat tctcccacct tagcctccta
     2281 tgtagctgga gctacagaca catgccacca tgctcagcta attatataat tttaaaaatt
     2341 ttttatagag atgggatctc gctgtattgt ctaggctggt attgaattcc tggcctcaag
     2401 ctatcctcct gcctcagcct gtctacatgt tggggttact gacatgagct accacacctg
     2461 gcccactttt tactttgaat taagaagaga gaactgtgat tggacagtat gcttgtctaa
     2521 tctgcgtgtg aaagcattca gtctcaccat caagtatatt gtggattttt cataaatatt
     2581 ctcaaacagg ctcaggaagt tttcttgtgt tttttattta ttgtttcatg gtaaaggagt
     2641 gttgaactct tatgacatgt ttttttctgc atctattgag atgatttgtg gtttttggca
     2701 ttctactgat agtctattac gttaactggc tttcagatat aaatatatta tggttatctg
     2761 ggtgaaattt gtcttcatca tggaatataa gtattttatc tacaggttga acatctgtaa
     2821 accccagatt ccaataccaa atctgaaatg ctccgaagtc aaaaactgtt tgagcaccag
     2881 tcttatgctc aacagaaatg ctcattagag gatttttgat atttggatta gggatgctca
     2941 tccagtaagt tttctgcaaa tattccaaaa tgttaaaagt ctgaaatcca aagcacttcc
     3001 gttcccaagt atttcagata agaaacactc aacccatatt gataacgttc aattttccag
     3061 tgtattgttg gggccttttg catttatagt caaattggtg tgccctagta taccatatag
     3121 tatagcatca tctgtatata tagcatgtct acatgtatac ttatatgtgt ataagtagct
     3181 atataatatg tggtatagta cagttttgta agttactatg aattatgcat aactagttta
     3241 tattatgtgt aattagcact acaataaatt gtatattaca ggattatggc attataacat
     3301 actattttga tcttatcagt ctgtagccta acatatttca gttgcctacc attccacaga
     3361 tgcatttaaa caaaccaatt gcatccttat gagaaccaag aagcatctca cgttcttgat
     3421 actacaaagc attcccctta caccctgttt gttctatctg ctccgtagtg caagtcttgt
     3481 gtggaccagc ctcgtttaca gaaccctccc ttttttgtct atgaatgtat gtaactaata
     3541 acttctctca atcttatctg tacactcatg ggtgtcacgt gtttttccca gtagtcttag
     3601 ggtcctaatt tttcctgtca cccatgagac tgtgaaaaca attggcatta ccaacagaat
     3661 gaaccaacca tgactgatga tatcttttca gctttaacta cctgcttttg tctaactggt
     3721 tccataatat aacagaagtc acctgaatta gaaacagcaa ttgatggtgg actttcactt
     3781 tggtctacac agtgctttgt gttatcagct gttgccacct cttcccacag tagaactctc
     3841 aactcctaga catgactggt tgaccagccg ttccccagga ggatgtatgt tccaccttga
     3901 cctgtgtttg gcaggcagtt tccaaggtac cccacattga ggcagtgacc cagcaccttc
     3961 accactgggt tctttattcc tgattatcaa aagtcagact actgctctgt ggtaactgca
     4021 tctcgtttgg ttgccatcac tggatgcttg gagtagccat gtgaacgtta ttactgtaca
     4081 cacttgggac agctccaggg attttgtgtg tgtgaagttg cagaaaggaa gaatgtcccc
     4141 atgctgggga gaattaagca tgtcacctaa ttgtgtaaca agatgacttg tgcaaga
//
