LOCUS       NM_001142572            1706 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 669 (ZNF669), transcript variant
            2, mRNA.
ACCESSION   NM_001142572
VERSION     NM_001142572.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056020.1 and CA447495.1.
            
            On May 21, 2020 this sequence version replaced NM_001142572.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1, which
            results in a protein (isoform 2) that lacks a segment of the
            N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN259377.1, SRR1803611.223216.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448299.7/ ENSP00000404370.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1417              AK056020.1         6-1422
            1418-1706           CA447495.1         19-307              c
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1706
                     /gene="ZNF669"
                     /note="zinc finger protein 669"
                     /db_xref="GeneID:79862"
                     /db_xref="HGNC:HGNC:25736"
     exon            1..160
                     /gene="ZNF669"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1294
                     /gene="ZNF669"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 669 isoform 2"
                     /protein_id="NP_001136044.1"
                     /db_xref="CCDS:CCDS44345.1"
                     /db_xref="GeneID:79862"
                     /db_xref="HGNC:HGNC:25736"
                     /translation="MDSVAFEDVAVNFTQEEWALLDSSQKNLYREVMQETCRNLASVG
                     SQWKDQNIEDHFEKPGKDIRNHIVQRLCESKEDGQYGEVVSQIPNLDLNENISTGLKP
                     CECSICGKVFVRHSLLNRHILAHSGYKPYGEKQYKCEQCGKFFVSVPGVRRHMIMHSG
                     NPAYKCTICGKAFYFLNSVERHQRTHTGEKPYKCKQCGKAFTVSGSCLIHERTHTGEK
                     PYECKECGKTFRFSCSFKTHERTHTGERPYKCTKCDKAFSCSTSLRYHGSIHTGERPY
                     ECKQCGKAFSRLSSLCNHRSTHTGEKPYECKQCDQAFSRLSSLHLHERIHTGEKPYEC
                     KKCGKAYTRSSHLTRHERSHDIEAGCSDSAYNPSTLGGQGVWIA"
     exon            161..287
                     /gene="ZNF669"
                     /inference="alignment:Splign:2.1.0"
     exon            288..348
                     /gene="ZNF669"
                     /inference="alignment:Splign:2.1.0"
     exon            349..1706
                     /gene="ZNF669"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF669"
                     /note="hexamer: AATAAA"
     polyA_site      1393
                     /gene="ZNF669"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF669"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="ZNF669"
                     /note="major polyA site"
ORIGIN      
        1 gtctctcctt cgccggagcc ggctcttcct gttagtctcc gctgctagtt cttggctctg
       61 ggaggcccag gtggctctgc agcagcctct gccaccctgt gacctgcgag tattgggaca
      121 tccctagctg acgccaggac acccgggaag ccgaggaatg gactcggtgg cttttgagga
      181 tgtggctgtg aactttaccc aggaggaatg ggctttgcta gattcttctc agaagaatct
      241 ctacagagaa gtgatgcagg aaacctgcag gaacctggct tctgtaggaa gccaatggaa
      301 agaccagaat attgaagatc acttcgaaaa acctgggaaa gatataagaa atcatatcgt
      361 acagagactg tgtgaaagta aagaagatgg tcagtatgga gaagttgtca gccaaattcc
      421 aaatcttgat ctgaacgaga acatttctac tggattaaaa ccatgtgaat gcagtatttg
      481 tggaaaagtc tttgtacgtc attccctcct taataggcat atcctagctc actcaggata
      541 caaaccatat ggagagaagc aatataaatg tgaacagtgt gggaaattct tcgtttctgt
      601 tccaggtgtt agaagacaca tgataatgca cagtggaaat ccagcttata aatgtacgat
      661 atgtgggaaa gctttttatt ttctcaattc agttgaaaga catcagagaa ctcacacagg
      721 agaaaaaccc tataaatgta aacaatgtgg taaagcattc actgtttccg gttcttgtct
      781 aatacatgaa cgaactcaca ctggagagaa accctacgaa tgtaaggaat gtgggaaaac
      841 attcagattt tcttgttctt ttaagacgca tgaaaggact cacactggag aaagacccta
      901 taaatgtacc aaatgtgata aagccttcag ctgttccact tcccttcgtt accatggaag
      961 cattcatact ggagagagac cctatgagtg taaacaatgt ggcaaagcct ttagtcgttt
     1021 gagttccctt tgtaaccata gaagtactca taccggagag aaaccctatg aatgtaaaca
     1081 atgtgatcaa gccttcagtc gcctcagttc ccttcacctc cacgaaagaa ttcatactgg
     1141 agaaaaaccc tatgaatgta agaaatgcgg taaagcctac actcgttcca gtcaccttac
     1201 tcgccatgaa agaagtcatg atatagaggc tgggtgtagt gactcagcct ataatcccag
     1261 cactttggga ggccaaggcg tgtggattgc ttgagcccag gagttcataa ccagcctgga
     1321 ttaaaacaat gtgaaacaac ctgggcaaca tggtgaaacc ctgtctttac aaaaaataaa
     1381 ataatgccgg gcacggtggc ttacgcctgt aatcccagca ctttgggagg ccgaggcggg
     1441 tggatcacga ggtcaggaga tcgagaccat cctggccaac acggtgaaac cccgtctcta
     1501 ctaaaaatac aaaaaattag ctgggcgtgg tggcagacgc ctgtggtccc agttactcgg
     1561 gaggctgagg caggagaatg gcatgaaccc gggaggcgga acttgcagtg agccgagatc
     1621 gcaccactgc acttcagcct gggtgacaga gtgagactct gtctcaaaaa ataagataaa
     1681 ataaaataaa aaaataatta gctggg
//
