LOCUS       NM_024706               2685 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 668 (ZNF668), transcript variant
            2, mRNA.
ACCESSION   NM_024706
VERSION     NM_024706.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Alsaif,H.S., Al Ali,H., Faqeih,E., Ramadan,S.M., Barth,M.,
            Colin,E., Prouteau,C., Bonneau,D., Ziegler,A. and Alkuraya,F.S.
  TITLE     ZNF668 deficiency causes a recognizable disorder of DNA damage
            repair
  JOURNAL   Hum Genet 140 (9), 1395-1401 (2021)
   PUBMED   34313816
  REMARK    GeneRIF: ZNF668 deficiency causes a recognizable disorder of DNA
            damage repair.
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Hu,R., Wang,E., Peng,G., Dai,H. and Lin,S.Y.
  TITLE     Zinc finger protein 668 interacts with Tip60 to promote H2AX
            acetylation after DNA damage
  JOURNAL   Cell Cycle 12 (13), 2033-2041 (2013)
   PUBMED   23777805
  REMARK    GeneRIF: ZNF668 is a key molecule that links chromatin relaxation
            with DNA damage response in DNA repair control.
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Hu,R., Peng,G., Dai,H., Breuer,E.K., Stemke-Hale,K., Li,K.,
            Gonzalez-Angulo,A.M., Mills,G.B. and Lin,S.Y.
  TITLE     ZNF668 functions as a tumor suppressor by regulating p53 stability
            and function in breast cancer
  JOURNAL   Cancer Res 71 (20), 6524-6534 (2011)
   PUBMED   21852383
  REMARK    GeneRIF: ZNF668 was identified as a novel breast tumor suppressor
            protein that regeulates the stability p53 tumor suppression
            proteins.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135050.3, BC021997.2, AB209710.2 and AK023541.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024706.4.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 4
            all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.456559.1,
                                           SRR1660805.33910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300849.5/ ENSP00000300849.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC135050.3         130062-130118       c
            58-590              BC021997.2         1-533
            591-2681            AB209710.2         1-2091
            2682-2685           AK023541.1         1981-1984
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2685
                     /gene="ZNF668"
                     /gene_synonym="NEDGEF"
                     /note="zinc finger protein 668"
                     /db_xref="GeneID:79759"
                     /db_xref="HGNC:HGNC:25821"
                     /db_xref="MIM:617103"
     exon            1..582
                     /gene="ZNF668"
                     /gene_synonym="NEDGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            583..1251
                     /gene="ZNF668"
                     /gene_synonym="NEDGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..2464
                     /gene="ZNF668"
                     /gene_synonym="NEDGEF"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 668 isoform a"
                     /protein_id="NP_078982.3"
                     /db_xref="CCDS:CCDS10701.1"
                     /db_xref="GeneID:79759"
                     /db_xref="HGNC:HGNC:25821"
                     /db_xref="MIM:617103"
                     /translation="MEVEAAEARSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATH
                     GPADCSEEVAEVKPKPETEAKAEEASGEKVSGSAAKPRPYACPLCPKAYKTAPELRSH
                     GRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQR
                     GHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSH
                     TGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSG
                     EKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAMHRRVHTGDR
                     PFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPF
                     HCNACGKSFVVSSSLRKHERTHRSSEAAGVPPAQELVVGLALPVGVAGESSAAPAAGA
                     GLGDPPAGLLGLPPESGGVMATQWQVVGMTVEHVECQDAGVREAPGPLEGAGEAGGEE
                     ADEKPPQFVCRECKETFSTMTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTH
                     SSVRPYTCPHCPKAFLSASDLRKHERTHPVPMGTPTPLEPLVALLGMPEEGPA"
     exon            1252..2685
                     /gene="ZNF668"
                     /gene_synonym="NEDGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2662..2667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF668"
                     /gene_synonym="NEDGEF"
                     /note="hexamer: ATTAAA"
     polyA_site      2685
                     /gene="ZNF668"
                     /gene_synonym="NEDGEF"
                     /note="major polyA site"
ORIGIN      
        1 agccacactt ccggcaagag cagctagaat cgttccggtg catattgaat aggcgcagaa
       61 agggagaaaa agattctaca gccctggcca cagtactttg gtgacacttt tcgtggggct
      121 ctctggagga cttttcccaa ggcagatgga gaaaacttcg tgaaacccac tccttgctat
      181 taaaggaaat gttgtggaat ataattggac ttaggttttg cagagcttga gcatggcctt
      241 tttgtcctcc caccttctgg ttcttgaaga cattgccggt gacctggccc cagactaaca
      301 caaggcgggc gtataccgtc agcctgcctg gcgtcccctt gcctcagcac acacagagac
      361 ctcttgcaag atgcttctct gccgccatag gctggaggtt ccccgggaac tttcccttcc
      421 ttcctagctg aggaagatcc ctcacttccg ctcgccgcgc caccggtccc acctccccgc
      481 cccccgctgg gtcctagcgc cggcccctgt ttggcagggt ccgggctccg tcggtgcgag
      541 gagccgacgc cgacgccacg gagtcagcac aagtctcatc agagaaaccc cgttcaccaa
      601 ggccatggaa gtggaggctg cagaggcccg gtccccagcc cccggctaca agcgctcggg
      661 ccgccgctac aagtgcctgt cctgtaccaa gacatttcca aacgcgccca gggcagcgcg
      721 ccacgctgcc acacatgggc cggcagactg ctctgaagag gtggccgagg tgaagccaaa
      781 gccagagaca gaagctaagg cagaggaagc cagtggggag aaggtgtcag gctccgcggc
      841 caagcctagg ccctatgcgt gtccgctatg ccccaaggcc tacaagacgg cacccgagct
      901 gcgcagccac gggcgcagcc acacggggga gaagcccttt ccgtgccccg agtgcggccg
      961 ccgcttcatg cagcccgtgt gcctgcgcgt gcacctggcc tcgcacgctg gcgaactgcc
     1021 cttccgctgt gcgcactgcc cgaaggccta tggcgcgctc tccaagctca agatccacca
     1081 gcgtggccac acaggcgagc ggccttacgc ctgcgccgac tgcggcaaga gctttgctga
     1141 cccttcagtg ttccgcaagc accggcgtac tcacgctggc ctgcggccct acagctgtga
     1201 gcgttgcggc aaagcctatg cggagctcaa ggacctccgc aaccatgagc ggtcccacac
     1261 cggcgagcgc cccttcctct gctccgagtg cgggaagagc ttctcccgct catcctcgct
     1321 cacgtgccac cagcgcatcc acgcggcaca gaagccctac cgctgcccgg cctgcggcaa
     1381 gggcttcacg cagctcagtt cctaccagag ccacgagcgc acgcactcgg gggagaagcc
     1441 cttcctgtgc ccgcgctgcg gccgcatgtt ctccgacccc tcgagcttcc gtcgccacca
     1501 gcgcgcccat gaaggggtga agccatacca ctgcgagaag tgcggcaagg acttccggca
     1561 gccggcggac ctggccatgc accggcgtgt gcacacaggc gaccggccgt tcaagtgcct
     1621 gcaatgtgac aagacgttcg tggcgtcctg ggacctcaag cggcacgcgc tggtgcactc
     1681 tggccagcgg cccttccgct gtgaggagtg cgggcgagcc ttcgccgagc gtgccagcct
     1741 cacgaagcat agccgggtgc actcggggga gcgccccttc cactgtaacg catgtgggaa
     1801 atcctttgtg gtgtcgtcga gcctgaggaa gcacgagcgg acccatcgaa gcagtgaggc
     1861 cgcgggtgtg ccccctgcac aggagctggt ggtggggttg gcgctgcctg tgggcgtggc
     1921 aggtgagagt tcagccgccc cggcagcagg ggcggggctg ggggaccctc cagcagggct
     1981 gctagggctg cccccggagt caggtggtgt gatggccaca cagtggcagg tggtgggcat
     2041 gacggtggag catgtggaat gccaagatgc tggtgtccgg gaggctcctg gtcccttgga
     2101 aggggcaggc gaggcggggg gtgaggaggc tgacgagaag cccccccagt ttgtgtgccg
     2161 agagtgcaag gagaccttct ccacaatgac gctgctgcgt cggcacgagc gctcacaccc
     2221 ggagctccgg cccttcccct gcacccagtg cggcaagagc ttctctgacc gggctgggct
     2281 gcgcaaacac agccgcactc acagctcagt gcgcccctac acctgccccc attgtcccaa
     2341 ggccttcttg agtgccagcg acttgcgcaa gcatgaacgc acccaccctg tgcccatggg
     2401 gacccccaca cccctggagc ccctggtggc tttgctagga atgcctgaag aggggccggc
     2461 ctgaagccca tgacccccca gcaccacact ccgggagccc agcccccatc gggggcttcc
     2521 tgtacctcct tttgcctggc tctgctcttt agactccaga tccctacccc tcagcaacta
     2581 gctcccctgt cggccagcta agagagctgg gacagtggag gctggcagaa gctgagacgt
     2641 gactgtctag gagtaacact cattaaagct ttcattttgg cacca
//
