LOCUS       NM_001321356            4401 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 667 (ZNF667), transcript variant
            2, mRNA.
ACCESSION   NM_001321356 NR_030740
VERSION     NM_001321356.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4401)
  AUTHORS   Wang,W., Shang,W., Zou,J., Liu,K., Liu,M., Qiu,X., Zhang,H.,
            Wang,K. and Wang,N.
  TITLE     ZNF667 facilitates angiogenesis after myocardial ischemia through
            transcriptional regulation of VASH1 and Wnt signaling pathway
  JOURNAL   Int J Mol Med 50 (4) (2022)
   PUBMED   36043524
  REMARK    GeneRIF: ZNF667 facilitates angiogenesis after myocardial ischemia
            through transcriptional regulation of VASH1 and Wnt signaling
            pathway.
REFERENCE   2  (bases 1 to 4401)
  AUTHORS   Liu,Y., Zong,Y., Shan,H., Lin,Y., Xia,W., Wang,N., Zhou,L., Gao,Y.,
            Ma,X. and Jiang,C.
  TITLE     MicroRNA-23b-3p participates in steroid-induced osteonecrosis of
            the femoral head by suppressing ZNF667 expression
  JOURNAL   Steroids 163, 108709 (2020)
   PUBMED   32730776
  REMARK    GeneRIF: MicroRNA-23b-3p participates in steroid-induced
            osteonecrosis of the femoral head by suppressing ZNF667 expression.
REFERENCE   3  (bases 1 to 4401)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4401)
  AUTHORS   Liu,M., Wang,Z., Sun,H., Jiang,B., Liu,K. and Xiao,X.
  TITLE     Effect of MIPU1 gene interference on biological behavior of U251
            cell line
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 45 (2), 109-114 (2020)
   PUBMED   32386033
  REMARK    GeneRIF: Down-regulation of MIPU1 can promote apoptosis while
            inhibit the proliferation, invasion, and migration of U251 cells
REFERENCE   5  (bases 1 to 4401)
  AUTHORS   Dong,Z., Li,S., Wu,X., Niu,Y., Liang,X., Yang,L., Guo,Y., Shen,S.,
            Liang,J. and Guo,W.
  TITLE     Aberrant hypermethylation-mediated downregulation of antisense
            lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with
            progression and prognosis of esophageal squamous cell carcinoma
  JOURNAL   Cell Death Dis 10 (12), 930 (2019)
   PUBMED   31804468
  REMARK    GeneRIF: Aberrant hypermethylation-mediated downregulation of
            antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate
            with progression and prognosis of esophageal squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4401)
  AUTHORS   Meng,W., Cui,W., Zhao,L., Chi,W., Cao,H. and Wang,B.
  TITLE     Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667
            promote the malignant progression of laryngeal squamous cell
            carcinoma
  JOURNAL   J Biomed Sci 26 (1), 13 (2019)
   PUBMED   30684967
  REMARK    GeneRIF: ZNF667-AS1 and ZNF667 are both down-regulated by
            hypermethylation, and they serve as tumor suppressor genes in LSCC.
            ZNF667-AS1 regulates the expression of ZNF667 in cis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4401)
  AUTHORS   Cheng,K., Chen,Z., Liu,L., Zhao,Y., Zhang,S., Wang,Q., Deng,Z.,
            Tan,S. and Ye,Q.
  TITLE     ZNF667 Serves as a Putative Oncogene in Human Hepatocellular
            Carcinoma
  JOURNAL   Cell Physiol Biochem 41 (6), 2523-2533 (2017)
   PUBMED   28472789
  REMARK    GeneRIF: ZNF667 promote the cell proliferation, invasion and
            migration mainly via interference expression of Bcl-2 and BAX.
REFERENCE   8  (bases 1 to 4401)
  AUTHORS   Wang,G., Jiang,L., Song,J., Zhou,S.F., Zhang,H., Wang,K. and
            Xiao,X.
  TITLE     Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced
            apoptosis through inhibition of the expression of the death
            receptor Fas
  JOURNAL   Int J Mol Sci 15 (10), 18206-18220 (2014)
   PUBMED   25310648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4401)
  AUTHORS   Jiang,L., Tang,D., Wang,K., Zhang,H., Yuan,C., Duan,D. and Xiao,X.
  TITLE     Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1
  JOURNAL   Biochem Biophys Res Commun 356 (4), 829-835 (2007)
   PUBMED   17397802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098795.2, AC013256.1 and AC006116.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001321356.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.262995.1,
                                           SRR1803616.13436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504904.8/ ENSP00000439402.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC098795.2         2659-2732           c
            75-187              AC013256.1         34296-34408         c
            188-676             AC013256.1         31983-32471         c
            677-768             AC013256.1         22622-22713         c
            769-895             AC013256.1         20973-21099         c
            896-988             AC013256.1         18439-18531         c
            989-1356            AC013256.1         2658-3025           c
            1357-4401           AC006116.1         163667-166711       c
FEATURES             Location/Qualifiers
     source          1..4401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4401
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /note="zinc finger protein 667"
                     /db_xref="GeneID:63934"
                     /db_xref="HGNC:HGNC:28854"
                     /db_xref="MIM:611024"
     exon            1..74
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /inference="alignment:Splign:2.1.0"
     exon            75..187
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..676
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..768
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /inference="alignment:Splign:2.1.0"
     CDS             736..2568
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     myocardial ischemic preconditioning upregulated 1
                     ortholog"
                     /codon_start=1
                     /product="zinc finger protein 667 isoform 1"
                     /protein_id="NP_001308285.1"
                     /db_xref="CCDS:CCDS12944.1"
                     /db_xref="GeneID:63934"
                     /db_xref="HGNC:HGNC:28854"
                     /db_xref="MIM:611024"
                     /translation="MPSARGKSKSKAPITFGDLAIYFSQEEWEWLSPIQKDLYEDVML
                     ENYRNLVSLGLSFRRPNVITLLEKGKAPWMVEPVRRRRAPDSGSKCETKKLPPNQCNK
                     SGQSICQKLVSAQQKAPTRKSGCNKNSVLVKPKKGHSGKKPLKCNDCGKTFSRSFSLK
                     LHQNIHTGEKPFECSNCRKAFRQISSILLHQRIHSGKKSHECNKCGESFNQRTTLILH
                     MRIHDGKEILDCGKALSQCQSFNIHQKIHVVGNVCQCRKCGKAFNQMSSLLLHKKIHN
                     GKKTHKYNKCGRGFKKKSVFVVHKRIHAGEKIPENAKALSQSLQQRSHHLENPFKCRK
                     CGKLFNRISPLMLHQRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCE
                     KVCNRHSSLIQHQKVHTKKKKLFECKECGKMFSGTANLKIHQNIHSEEKPFKCNKCSK
                     VFGRQSFLIEHQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHTEDRPYECDQCGKAF
                     SQSAHLAQHERIHTGEKPYTCKTCGKAFSQRTSLILHERSHTGEKPYECNECGKAFSS
                     GSDLIRHQRSHSSEKPYECSKCGKAYSRSSSLIRHQNTHSEEKA"
     exon            769..895
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..988
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..4401
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4371..4376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /note="hexamer: AATAAA"
     polyA_site      4401
                     /gene="ZNF667"
                     /gene_synonym="MIPU1"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcag gcgctgagtc cctgctcggc tgtctcggtg gtcgccgccg gggtctgagc
       61 ccgggaagac cgaggttcca gccgtcctca cctcaggagg acatagcttt gtgcctttca
      121 aagccctttc tcatctatca tcagggactc ggaagacgag ccaggtttac agccctgcct
      181 tgatgtgtag tgccgagttc cttgaagaaa attattttat ggacaatgta tgagtctgtt
      241 ttcgtgctgc tgataaagac atacccagac tcacagttct acgtggctgg ggaggcctca
      301 caatcgtgat ggaaggtgaa agacacgtct tacatggcca cagggagaat gagagtccct
      361 gtacagaacc atcagatcac atgagactta ctcactgcca tgagaacagc atgggggaaa
      421 ccgcccccat gattcagtta tctcccaccg ggtccctccc acaacacgtg gaaattatgg
      481 gagctataat tcaagatgag atttgagtgg ggacacagcc agaccatatc agacaagaat
      541 catcttctca aatttggggt gcgtggctga gtgcacacac ctgtgaaaac tgcgggatga
      601 atgcattaca acttcctgga acaagtcatt ttacctaagt aattggaagg ggaaagccaa
      661 ctgatctgct tatctgccct gccttaccag ctctctgccc atctctcagt gtggacccta
      721 aagggggagg aaaggatgcc ttctgcacgg gggaaatcca aatccaaggc acctataaca
      781 tttggggact tagccatcta cttctcccag gaggagtggg aatggctgag ccccattcag
      841 aaggatttgt atgaagatgt catgttggag aattaccgga acctggtctc gcttggtctt
      901 tcctttcgga gaccaaatgt gatcacctta ttggagaaag ggaaagcacc ctggatggta
      961 gagccagtaa gaagacgccg ggctcctgac tcggggtcta aatgtgagac caagaagtta
     1021 cctccaaatc aatgcaacaa atctgggcaa agcatctgcc agaaactagt ttctgcacaa
     1081 caaaaagctc ctacacgaaa gagtggctgc aacaaaaatt cagtcctagt aaaacctaag
     1141 aaagggcatt cagggaagaa acctttaaaa tgtaatgact gtggtaaaac ctttagtcga
     1201 agcttctctc ttaaacttca tcagaacatt catacaggag agaagccttt tgaatgcagt
     1261 aattgtagaa aagctttcag acagatctca tccatcctac ttcatcagag aattcacagt
     1321 ggaaagaaaa gccatgaatg caataaatgt ggggaaagct tcaatcaaag aacaaccctt
     1381 attctacata tgagaattca tgatggaaag gaaattcttg actgtgggaa ggccttgagt
     1441 caatgtcagt ctttcaatat acatcagaaa attcatgttg ttgggaatgt ctgccagtgc
     1501 agaaagtgcg gaaaagcctt caatcagatg tcatcccttt tacttcataa gaaaattcac
     1561 aatggaaaga aaacacataa atataataaa tgtgggagag gcttcaaaaa gaaatcagtc
     1621 tttgttgtac ataaaagaat tcatgctgga gagaaaatcc ctgaaaatgc gaaggcctta
     1681 agtcagagtc tacagcaaag aagtcaccat ttagagaatc cttttaaatg cagaaaatgt
     1741 gggaaattat ttaataggat ttcacccctg atgcttcacc agagaattca cacttcagag
     1801 aaaccgtaca aatgtgataa atgtgacaag ttcttcaggc ggctttcaac ccttattctg
     1861 catctaagaa ttcataatgg agaaaaacta tacagatgca ataaatgtga gaaggtctgc
     1921 aatcggcatt catcccttat tcaacatcag aaagttcata caaagaaaaa gaaactattt
     1981 gagtgtaagg aatgtgggaa gatgttttct ggaactgcaa accttaaaat acatcagaat
     2041 attcattctg aagagaaacc tttcaaatgc aataaatgta gtaaagtttt cggccgccaa
     2101 tcatttctta ttgaacatca aagaattcat actggagaaa aaccctacca gtgtgaggaa
     2161 tgtggaaaag ccttcagcca ccgaatatct ctcacacgac ataagagaat tcatactgaa
     2221 gatagaccct atgaatgtga tcagtgtggg aaggccttca gccagagtgc acacctcgcc
     2281 caacatgaaa gaattcacac tggagagaag ccatatacat gcaaaacatg tggtaaggcc
     2341 tttagtcagc gcacatctct tattctacat gaaagaagtc atactggaga gaaaccctat
     2401 gaatgtaatg aatgtgggaa ggcatttagc agtggctcag accttattcg acatcagaga
     2461 agtcattctt cagagaaacc ctatgaatgt agtaaatgtg ggaaggcata tagtcggagt
     2521 tcatccctga ttcgacatca gaatacacat tctgaagaaa aagcctaagg ttgttttaaa
     2581 tctataaaat caacgaatga ggctatcaaa catatggcaa atatgtattt gtctataatg
     2641 taaattttgt gtatatggga ccatttgatg atatgtccca ctttgaaagc caaagagcaa
     2701 aagtcattgg tgattttgac ctcaggattt gaaattaact gaaggaaact cagaagtttg
     2761 gtcagtcatt gtgaatgaag atcatttttc atttgataag aattactggc tgggcgcagt
     2821 ggcttacacc tgtaacccca gcactttggg aggctgagac aggcggatca cgaggtcaag
     2881 agtttgagac cacggtgaaa ccctgtctct actaaaaaat acaaaattag ctgggcgtgg
     2941 tggtgcgcac ctgtaatctc agctactgga gaggctgagg caggagaatc gcttgaaccc
     3001 aggaggtggg ggttgcaccg agcagagatt gcaccactgc actccagtct gggcaacaga
     3061 gcaagactct gtgtcaaaaa aaaaaaaaat taccgatatt ttacttccag catagtttta
     3121 aagataattt attggtcaca tacaacaaaa tagaattgtg aagtccatta tagggctctg
     3181 agcctgattt aaggtcacag aaaaaagaat ttgagtctgt ttctcagatc tagaattatc
     3241 aaatataagg aacttctcgg caaaacaggg tgccactttc agctgacaaa cttgtgggtg
     3301 agaataaaga aaagtgagtc tttaggtaga taaagttgtc actcataatg gtgtgtaaca
     3361 gtagaaacct tactttacca tctccacgga tatgaggata tatgatcttc atggtgtgaa
     3421 cgtctaactt ggctgagaca agctatcagt aaaagaacca agatatagtg aagaatgagg
     3481 atttcagagc caggagaaat cagtattgtt ttatttggaa ataaatcatc tatatttata
     3541 tgagtaaaca ttggtatttt catgtaacaa tactggtatg caataagtgg tgtaatatga
     3601 gttgttatgg actgaatgtt tatgtccctc ccaaaactaa ttatgttaaa atcctcacca
     3661 tcaatgtgat gttacttgga aatgaggcat ttgggaggca attaggatta gatgaggtca
     3721 tgagggtgga gccctcgtga tgggattagt gcctttataa gaagagacat caggctgagc
     3781 ccggtggctc atgcctgtaa tcccagcact ttgggaggcc aaggcgagtg gatcatgagg
     3841 tcaggagatt gagacaatcc tggctaacac ggtgaaaccc cgtctccact gaaaaaaaat
     3901 acaaaaaatt agccaggcac agtggcatgt gcctgtagtc ccagctactc gggaggctga
     3961 aggagaagaa tcgcttgaac ccaggaggcg gaggttgcag tgagccagga tcacgccact
     4021 gtactccacc ctgggcgaca gagcgagact acgtctcaaa aagacatcag aaagcctgct
     4081 tgctctctgc accatgtgag gatgcaggaa gaagccagct gtctacagaa caggaagaga
     4141 accctacgag aacctaacca tgctggcgac ctgttctcag acttccagac ttcagaactg
     4201 tgagaagtaa attgttgttt aagccaccca gtctatgatg ttttgttatg gcagccccag
     4261 ctaatatatg gagtggaaag cctagattta tctactgggt tcttttcctg tcagcagttc
     4321 aacatgtgta gtagctttca gtctctgctg tttgtgccaa atatataaga aataaaatca
     4381 gataactttt ttgtaattgg a
//
