LOCUS       NM_024733               4158 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 665 (ZNF665), transcript variant
            4, mRNA.
ACCESSION   NM_024733
VERSION     NM_024733.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Wan,Y.I., Shrine,N.R., Soler Artigas,M., Wain,L.V., Blakey,J.D.,
            Moffatt,M.F., Bush,A., Chung,K.F., Cookson,W.O., Strachan,D.P.,
            Heaney,L., Al-Momani,B.A., Mansur,A.H., Manney,S., Thomson,N.C.,
            Chaudhuri,R., Brightling,C.E., Bafadhel,M., Singapuri,A., Niven,R.,
            Simpson,A., Holloway,J.W., Howarth,P.H., Hui,J., Musk,A.W.,
            James,A.L., Brown,M.A., Baltic,S., Ferreira,M.A., Thompson,P.J.,
            Tobin,M.D., Sayers,I. and Hall,I.P.
  CONSRTM   Australian Asthma Genetics Consortium
  TITLE     Genome-wide association study to identify genetic determinants of
            severe asthma
  JOURNAL   Thorax 67 (9), 762-768 (2012)
   PUBMED   22561531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092070.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024733.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832507.1, SRR3476690.839333.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396424.5/ ENSP00000379702.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC092070.2         51649-51695         c
            48-107              AC092070.2         41221-41280         c
            108-234             AC092070.2         33782-33908         c
            235-4158            AC092070.2         20761-24684         c
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..4158
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /note="zinc finger protein 665"
                     /db_xref="GeneID:79788"
                     /db_xref="HGNC:HGNC:25885"
     exon            1..47
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /inference="alignment:Splign:2.1.0"
     exon            48..107
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2129
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="zinc finger protein 665 isoform 3"
                     /protein_id="NP_079009.3"
                     /db_xref="CCDS:CCDS46169.1"
                     /db_xref="GeneID:79788"
                     /db_xref="HGNC:HGNC:25885"
                     /translation="MALPQGQLTFKDVAIEFSQEEWTCLDPAQKTLYRDVMLENYRNL
                     VSLDISCKCVNTDLPPKGKNNMGEAFYTVKLERLESCDTVGLSFQEVQKNTYDFECQW
                     KDDEGNYKTVLMLQKENLPGRRAQRDRRAAGNRHIENQLGVSFQSHLPELQQFQHEGK
                     IYEYNQVEKSPNNRGKHYKCDECGKVFSQNSRLTSHKRIHTGEKPYQCNKCGKAFTVR
                     SNLTIHQVIHTGEKPYKCNECGKVFSQPSNLAGHQRIHTGEKPYKCNECGKAFRAHSK
                     LTTHQVIHTGEKPYKCKECGKCFTQNSHLASHRRIHTGEKPYKCNECGKAFSVRSSLT
                     THQTIHTGEKPYKCNECGKVFRHNSYLAKHRRIHTGEKPYKCNECGKAFSMHSNLTKH
                     QIIHTGEKPFKCNECVKVFTQYSHLANHRRIHTGEKPYRCDECGKAFSVRSSLTTHQA
                     IHTGEKPYKCNDCGKVFTQNSHLASHRGIHSGEKPYKCDECGKAFSQTSQLARHWRVH
                     TGEKPYKCNECGKAFSVHSSLTIHQTIHTGQKPYKCNDCGKVFRHNSYLAIHQRIHTG
                     EKPYKCNECGKAFSVHSNLATHQVIHTGEKPYKCNECGKVFTQNSHLANHRRIHTGEK
                     PYRCNECGKAFSVRSTLTTHMAVHTGDKPYKCNQCGKVFTQNSNLAKHRRIHSG"
     exon            108..234
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /inference="alignment:Splign:2.1.0"
     exon            235..4158
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4135..4140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /note="hexamer: AATAAA"
     polyA_site      4158
                     /gene="ZNF665"
                     /gene_synonym="ZFP160L"
                     /note="major polyA site"
ORIGIN      
        1 gcaaacccgg aagcagatct cttggagtga aggctgttag tcgccgcgta gaaccctgga
       61 agaagaggaa gaggaaggca aaggagtcag ggatggctct tcctcaggga cagttgacat
      121 tcaaggatgt ggccatagaa ttctctcagg aggagtggac atgcctggac cctgctcaga
      181 agactttgta cagggacgtc atgttggaga attataggaa cctggtctcc ctggatatct
      241 cttgtaaatg tgtaaacacg gatttgccac caaaggggaa gaacaatatg ggagaagcgt
      301 tctacacggt gaagttggag agacttgaaa gctgtgacac tgtaggcttg tccttccagg
      361 aagttcagaa aaatacatac gactttgagt gtcagtggaa agatgatgaa ggaaattata
      421 aaacagtact tatgttgcaa aaagaaaatc tccctggtag aagagctcaa cgtgatagaa
      481 gggctgcagg aaacaggcat attgaaaatc agcttggagt aagctttcag tcacatctcc
      541 ctgaactgca gcaatttcaa catgaaggga aaatttatga atacaatcaa gttgagaagt
      601 ctcctaataa tcgaggaaaa cattataaat gtgatgaatg tggcaaggtc ttcagtcaaa
      661 actcacggct aacaagtcat aagagaattc atactggaga gaagccttac cagtgtaata
      721 agtgtggcaa agcctttact gttcgttcaa acctaacaat ccatcaggtc atccatactg
      781 gagaaaaacc ttacaaatgt aatgaatgtg gaaaggtctt cagtcaacct tcaaaccttg
      841 caggtcatca gagaattcat actggagaga aaccttacaa gtgtaatgag tgtggcaaag
      901 cctttagagc acattcaaaa ctaactacac atcaggtcat ccatactgga gaaaaacctt
      961 acaaatgtaa ggaatgtggc aagtgcttca ctcaaaattc acaccttgca agtcatcgaa
     1021 gaattcatac tggggagaag ccttacaagt gtaatgagtg tggcaaagcc tttagtgttc
     1081 gctcaagcct gactacccat cagacaatcc acactggaga aaaaccttac aaatgtaatg
     1141 aatgtggcaa ggtcttcagg cacaattcat accttgcaaa gcatcggcga attcatactg
     1201 gtgagaaacc ttacaagtgt aatgagtgtg ggaaagcctt cagtatgcat tcaaacttaa
     1261 ctaagcatca gatcatccat accggagaaa agcctttcaa atgtaatgaa tgcgtcaagg
     1321 ttttcactca gtattcacac ttagcaaatc atcgaagaat tcatactgga gagaaacctt
     1381 acaggtgtga tgagtgtggc aaagccttta gtgtgcgatc aagcctaact acccatcagg
     1441 caattcatac tggagaaaag ccttacaaat gtaatgactg cggtaaggtc ttcacacaaa
     1501 attcacacct tgcaagtcat cggggaattc attctggaga gaaaccttac aagtgtgatg
     1561 aatgtggtaa agccttcagt caaacatcac aacttgcaag gcattggaga gttcatactg
     1621 gagaaaaacc ttacaagtgt aatgagtgtg gcaaagcctt tagtgttcat tcaagcctaa
     1681 ctatacatca gacaatacat actggacaaa aaccatacaa atgtaatgat tgcggcaagg
     1741 tcttcagaca caattcgtac cttgcaattc atcagagaat tcacactggt gagaaacctt
     1801 ataagtgtaa tgagtgcggc aaagcattta gtgtacattc aaacctagct acccatcagg
     1861 tcatccatac tggagaaaaa ccttacaaat gtaatgaatg tggcaaggtc ttcactcaaa
     1921 attcacatct tgcaaatcat agaagaattc acactggaga aaaaccttat aggtgtaatg
     1981 agtgtgggaa agccttcagt gttcgttcaa ccctaactac ccatatggca gtccatactg
     2041 gagacaaacc ttacaaatgt aaccaatgtg gcaaggtctt tactcaaaat tcaaaccttg
     2101 caaaacatcg aagaattcat agtggataga aaccttacaa aggacgccgg gcgtggtggc
     2161 tcacgcctgt aatcccagca ctttgggagg ccgaggcggg gggatcacct gaggtctcga
     2221 gttcgagacc aggctggcca acacggtgaa acgctgtctc tactaaaaat acaaaaatta
     2281 gctgggtgtg gtggtgcacg cctgtaatcc cagctactcg ggaggctgag gcaggagaat
     2341 cacttgaacc tgggaggcgg aggttgcagt gagcgagatc atgccattgc actccagcct
     2401 gggcaacagg agtgaaactc catctccaaa aaaaaaaaaa aaaaaaaagt aaccttacaa
     2461 aggagtgcgg ccagtttttc agccacaaat tctttcacaa catcagagaa ttcattcttg
     2521 agacaattct tacaaataca gtgactgtgg caaactcctg atgagtttaa gcattaacag
     2581 acatcagagt tcaaatcctg tgaatatact atgtatgaca gaagctttat ccaggtctca
     2641 gagctcaata cgcatcaaaa gatacatctt tgatgaagtc acacaaacgt aacatgcatg
     2701 ctgagactat tactcctgga ccacaactgt aggtgaggat tcataggaag agtagaactc
     2761 agtctctagt ttcctcataa ccctctgata ttatatactt cagcataatc agaagtccaa
     2821 atgtgttaaa actcattaca tgatacatat caaaggttgt aggatgtttg gaaatggcca
     2881 attactttca gcttataaaa tgttttgttg aagtatttaa gatttattga aaaggctact
     2941 atttataact tccaaccaga actttgcaat gtgctgattt tatacatgat tatacgccta
     3001 acatggtgtt gttcgggaaa gaatcaaagg atggaagggc tcactcactt cattaggtga
     3061 ggattatttc tctccaagct cctgaagaaa aaagactctg ccttttaaaa ttaaatatag
     3121 tctgaattag agagcacttg gaaagggcag aggatgatga actatgatgt cactcatcat
     3181 ccttattgca ctgcaggtgc ccttcttctg acagaagagc actgtgggta tgggaagaaa
     3241 ttctctactg gccgggcaca gtggctcacg cctgtaatgc cagcactttg ggaggccaag
     3301 gtgggtggat cacctgaggt cgggagttcg agaccagcct gaccaacatg gagaaacccc
     3361 atctctacta aaaatacaaa attagccagg catggtggcg catgcctgta atcccagcta
     3421 ctcaggaggc tgaggcagga gactcgcttg aacccgggag gcagaggttg tggtgagccg
     3481 agatcatgcc actgcactcc agtctgggca ataagagcga aactctgact caaaaaaaga
     3541 aagaaagaaa ttctctacca gtagaccatg aaatagagcc aggaagacac tcggattttt
     3601 attagaggag agtaatagct tattagggac tgatgtgtgg tacaaataat gcagaaaagt
     3661 ggaggctacc ttctccatca aatgccaata gctgttgcat agcaaagatt gatttttttt
     3721 tttttttttg agatggagtc ttgttctgtt gcccaggctg gagtgcagtg atgcaatctc
     3781 agctcaccgc aacctccgcc tcctgggttt tagcgattct cctgcctcag cctcccaagt
     3841 agctgggatt acagacatgc accaccacgc ctggctaatg tttgtatttt tagtagagat
     3901 ggagtttcac tatgtttgcc aggctggtct cgaactcctg acctcataat ccgcccacct
     3961 tggcctgcca aagtgctggg attacgggct ggagccaccg tgcccggccg gccgagcata
     4021 agaagtttaa tcaaagtaac cagaatccca tgtttgttac taggatttac attaactgct
     4081 ggaatcacat tttgctacta tttaagaatg catcatagat ttaatgtttt aactaataaa
     4141 atttgatgta ttttataa
//
