LOCUS       NM_207404               5381 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 662 (ZNF662), transcript variant
            1, mRNA.
ACCESSION   NM_207404
VERSION     NM_207404.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5381)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5381)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5381)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5381)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127779.1, AC092043.3 and AK090754.1.
            
            On May 17, 2019 this sequence version replaced NM_207404.3.
            
            Transcript Variant: This variant (1) uses an alternate 5' exon,
            uses an alternate in-frame splice junction at the 5' end of an
            exon, and contains an alternate in-frame exon compared to variant
            2. The resulting isoform (1) is shorter at the N-terminus, contains
            a single alternate aa, and contains an alternate segment compared
            to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440367.7/ ENSP00000405047.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-827               AK127779.1         233-1059
            828-5239            AC092043.3         118611-123022
            5240-5380           AK090754.1         2649-2789
            5381-5381           AC092043.3         123164-123164
FEATURES             Location/Qualifiers
     source          1..5381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..5381
                     /gene="ZNF662"
                     /note="zinc finger protein 662"
                     /db_xref="GeneID:389114"
                     /db_xref="HGNC:HGNC:31930"
     exon            1..27
                     /gene="ZNF662"
                     /inference="alignment:Splign:2.1.0"
     exon            28..154
                     /gene="ZNF662"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1401
                     /gene="ZNF662"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 662 isoform 1"
                     /protein_id="NP_997287.2"
                     /db_xref="CCDS:CCDS2708.1"
                     /db_xref="GeneID:389114"
                     /db_xref="HGNC:HGNC:31930"
                     /translation="MLENYGAVASLAAFPFPKPALISQLERGETPWCSVPRGALDGEA
                     PRGISSGYPFLKPAGISHPEQVEEPLNLKLQGEGPSLICPEGVLKRKKEDFILKEEII
                     EEAQDLMVLSSGPQWCGSQELWFGKTCEEKSRLGRWPGYLNGGRMESSTNDIIEVIVK
                     DEMISVEESSGNTDVNNLLGIHHKILNEQIFYICEECGKCFDQNEDFDQHQKTHNGEK
                     VYGCKECGKAFSFRSHCIAHQRIHSGVKPYECQECAKAFVWKSNLIRHQRIHTGEKPF
                     ECKECGKGFSQNTSLTQHQRIHTGEKPYTCKECGKSFTRNPALLRHQRMHTGEKPYEC
                     KDCGKGFMWNSDLSQHQRVHTGDKPHECTDCGKSFFCKAHLIRHQRIHTGERPYKCND
                     CGKAFSQNSVLIKHQRRHARDKPYNCQISHLLEH"
     exon            155..271
                     /gene="ZNF662"
                     /inference="alignment:Splign:2.1.0"
     exon            272..373
                     /gene="ZNF662"
                     /inference="alignment:Splign:2.1.0"
     exon            374..5381
                     /gene="ZNF662"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3669..3674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF662"
                     /note="hexamer: AATAAA"
     polyA_site      3688
                     /gene="ZNF662"
                     /note="major polyA site"
     regulatory      5363..5368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF662"
                     /note="hexamer: AATAAA"
     polyA_site      5381
                     /gene="ZNF662"
ORIGIN      
        1 ggcctcccgg atgctggggc ctggcgggag tcagtgacct tcgaggatgt ggccgtctac
       61 ttctctgaga acgaatggat cggcctgggc cctgctcaga gagccctgta cagggatgtg
      121 atgctggaga attatggggc tgtggcttcc ctggcagcat ttccatttcc caaaccggct
      181 ctgatttccc agctggagcg aggggaaaca ccctggtgct cggttcctcg gggagctctg
      241 gatggagagg ccccaagggg catctcctca ggatatccat ttctaaagcc tgctgggatt
      301 tcccatcctg agcaggtgga agagccatta aacctgaaac tgcaaggaga gggtccaagc
      361 ctgatttgtc cggagggtgt gttgaagagg aagaaagaag attttattct gaaggaggaa
      421 attattgagg aagcacagga cctcatggtc ctatcaagtg gaccccagtg gtgtggatcc
      481 caggaattat ggtttgggaa aacctgtgaa gagaaaagca ggttagggag atggcctggt
      541 tacctcaatg ggggacgtat ggaaagttct acaaatgata ttatagaagt gattgtcaag
      601 gatgagatga tctcagtaga agagagttca gggaatactg atgtcaataa cctccttggt
      661 atacatcaca aaattctaaa tgagcaaata ttctatatat gtgaggaatg cggcaagtgt
      721 tttgatcaaa atgaggactt tgatcaacac cagaaaactc ataatggaga gaaggtctat
      781 ggatgtaagg aatgtgggaa ggctttcagt tttcgatcac attgcattgc acatcagaga
      841 attcacagtg gggtgaaacc ctatgaatgt caagaatgtg ctaaggcctt tgtttggaag
      901 tcaaacctga ttcgtcacca gagaatacat actggagaga aaccctttga atgtaaggaa
      961 tgtgggaagg gctttagtca gaacacaagc cttacgcaac atcaacggat ccacactggt
     1021 gagaaaccat acacatgtaa ggaatgtggg aaaagcttta ctcgaaaccc agcccttctt
     1081 cgacatcaga gaatgcacac tggggagaag ccttacgaat gtaaggactg tgggaagggc
     1141 ttcatgtgga actcagatct ttctcagcac cagagggtcc acactgggga caagcctcat
     1201 gaatgtactg actgtgggaa aagcttcttt tgcaaggcac atcttattcg acatcaaaga
     1261 atccatactg gggaaagacc ctataaatgt aatgactgtg ggaaggcctt cagtcagaat
     1321 tctgtcttaa ttaagcacca gaggcgccat gctagagaca aaccctataa ctgtcagatc
     1381 tctcaccttc ttgaacatta gagagtgcat aatggtgata cttgtttata attcttatgc
     1441 tgcaggaacc ctagagacaa aatgagatga ccattcacaa tttgctgtaa cccttaactt
     1501 aaatagccag tattatcttg cccttttgaa catttaccat gtactctagc aagactggtc
     1561 cctctgttct atgatgtttt aacaaggcat catttagttg ggcagctact ctgtatcagg
     1621 tgctaaccac tttacataca ttaatttgca taacaatcct attaaggtag gtgctcttct
     1681 ccccatttta caaatgagaa atctgagttg aaagaggtta taaaactcat tcagggttgc
     1741 tcagttagta agttatagag ttgaaattgg agccaggcct atctgactgc agagtttact
     1801 gttctttact taattgtaca tatttatgtc tctgcccatt tttatttgct tattttcctg
     1861 tgcttttagt ttcccttcat cactcagatc tagctccttc aactaagaag atctctcttc
     1921 ctcttctact tgtaatcagt accacccaag ttagtattta attatgtgcc atcttatatt
     1981 tttctaatag tctcatgtct tttaatctta accccagcta aatgactctg aggaccaaca
     2041 gtacatttct tttatgtttt tcaaatcctg aaacattaat ctttgactag atataacatg
     2101 ctcatgataa aaaagaattg aaatagttga aaagggtgtt cagtgaaaag taaatttcct
     2161 tgtcattcct atctcttgag ttctccccag aggcaatcac tgctactggt tgtgtatctc
     2221 tgtagatact ctttgtatac aagtgtttat tagtattgct tttcataatt ctgtctcact
     2281 gaaaacctta tttgatggaa gcaacattgc agttaaattg tgaactctaa gaccttttct
     2341 tcagaagttg ctttcctttt gaggccacca aagtaattta gggaaacagc agagggtaat
     2401 ccaggtcttt tttttttttt tttttttttt agacagagtc tcactctgtt gctctggctg
     2461 gagtgcagtg gtgctatctc agctcactgc aagctccacc tcctgggttc atgccattct
     2521 tctgcctcag cctcccaagt agctgggact acaggtgccc gccaccatgc ctggctaata
     2581 ttttttattt ttagtagaga cggggtttca ccatgttagc caggctggtc tcgatctcct
     2641 gaccttgtga tccacctgtc tcggcctccc aaagtgctgg gattacaggc ctcagctacc
     2701 acgcctggcc aatccaggtc ttaagagacc tcattgcctt tgttttatga gatatcattc
     2761 tgggattggg aatatgtaaa ctcaactgga gatttttttt cataaaaatt tatatagttc
     2821 cagccctctc attgcttcct atcctaaatc ctcttccagt ctgtccatcc ctcactacca
     2881 tgatagtcta cattctgata agctgtgagg ccactgccaa gggagggaga aatggtcact
     2941 ttctggtggt ggttaatgct ttgttagata gcttcatcca gtcaatagtt gaaaagtttt
     3001 cacataatcc agtattggca tcagagccag aaatgccctc cctaggtcca ggaccaaaga
     3061 taaaacaaac acgaggaaca tgtagcgtct acacaggaaa gtaaagaatt atagaattaa
     3121 ctaattctac ttgaaatcag gagttttata aaacaacatt tttagacgtg gtcatctttt
     3181 attggtttcc atcatctctt ccccttctct ctgggaacag ttacccgggt attctttggg
     3241 aagctatcct ttctcagcta tgtggtttgg caccaccacc atcttcatga gtggaccctg
     3301 tttggcttgt gtcaatcagt ttatcccatc cccttggcca cagagccatt gtgatatgag
     3361 gagatactgg ctcttctgga aaagagaggc ttttcttcat cgagagctac cagaggagat
     3421 attatctgtc ctctgtgtgg cacataggaa aatgtgagac ctagaattat agcaactttt
     3481 tttttctgtt aaaaggggag attctcaagc ttccaggtgc taccatatgg agcctaagga
     3541 taaagccaat accaaagaaa acagtgacta aacagagaga aactaggtcc ttggtgacat
     3601 cttttgagcc actagaccaa gctttacctg aagcagagct acctcagaac ttttcagcta
     3661 tgtgagccaa taaacatctg tcaaacgagt tagagttgag ttttctgtta tttgcaactt
     3721 agccacacta atactgtttt gtgtttgaaa tcactgtttt ctcatacagc tcctcagtgt
     3781 caccttttcc tcttgctcag tagtctcata agcttctcag ttttatctca tctcagttgc
     3841 ttggaagttg agcatctaaa taggtggctt ttgctgggtg cagtggctta cgcctgtaat
     3901 cccatcactt tgggaggcca aggtgggcag atcacctgag attgggagtt caagaccagc
     3961 ctgaccaaca tagagagacc ccgtctctac taaaaataca aaattagcca ggtgtggtgg
     4021 cacatgccag taatctcagc tactcaggag gctgaggcag gagaattgct tgaatctggg
     4081 aggtggaggt tgcagtgagc cgagattgtg ccattgcact ccagcctggg caacaagagt
     4141 gaaactccat ctcaaaaaaa tgaaaataat aaataggtgg ctctcatgac ctaaggttaa
     4201 tttcatgcat actactaagt gatgctttaa gtcataccat tagtgcagga atttttgctc
     4261 cttagttcag ctaaaatctg ggttcttgtc tcatgaccag gaaaaattag tcacagggac
     4321 acattgaaaa gtgaggaggg cagaatttat taagtgaaaa ggaaaactct caacaaaaag
     4381 aggggtcctg catgcaggtt ttccatctca ctaaactgaa taccaggcca ccacacatga
     4441 gctgaagagc ctagtcttct ccccctgcat gaattcctgg tggctacacc ccgttctccc
     4501 agtgtgcagg caggccctta gtctgagcca ctccacatta tttcccttac tgtgtatgtg
     4561 ttaaggaacg gaatttttca tcatgggcat gtttaggcaa tccccctgtg cacaatgacc
     4621 tgggcagcat ttggctgtct cctgattcta tcattccccc ctctaaagaa gtacatctaa
     4681 cttagaataa ggataaggat aagggtagtg atcgatctta actggttcct gctgatgggg
     4741 gcactgtttt gggaaaatag cagtgagatc tccctcagag gcctatctaa gggtccctgg
     4801 taaaaggtgg ccatcatttg aggttccaat tgcatgaaca ttcagagttc aatggcctga
     4861 aggtgagaag agacaaacca ggttattaga agacaatcaa aatgaaacaa agcggggatg
     4921 gtaaggacag ctaaaaaaaa tcctaaggct gctgacacac ccagataact ggtagctata
     4981 gttatgcctg ctaagattgg ggtgtttggg gcttggcttt cgttagctcc cttggtctta
     5041 ttttcccaaa aaagaaacct ccaggttatg ggcaccttat ttagtctaat catctggcag
     5101 gatttgcagg gtaattgccc agaactagaa tattgatcca gatttttaca ttactcatcc
     5161 cttttgctgc ttctgagctg cagccagaga ttgctggttg gttcacagga ataagcagtg
     5221 ttagtttaaa atgtgggcaa aaacttaaaa acaacgaatg agtctaaaat ctaatgacaa
     5281 atatataagt cttgaaacat aatttctctc cagttctcat ttttgttaaa aataaatcat
     5341 gataggactg agttgtttgc aaaataaact ttagtcttgt a
//
