LOCUS       NM_001351733            7584 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ZNF660-ZNF197 readthrough (ZNF660-ZNF197), transcript
            variant 2, mRNA.
ACCESSION   NM_001351733
VERSION     NM_001351733.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7584)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 7584)
  AUTHORS   Li,Z., Wang,D., Na,X., Schoen,S.R., Messing,E.M. and Wu,G.
  TITLE     The VHL protein recruits a novel KRAB-A domain protein to repress
            HIF-1alpha transcriptional activity
  JOURNAL   EMBO J 22 (8), 1857-1867 (2003)
   PUBMED   12682018
REFERENCE   3  (bases 1 to 7584)
  AUTHORS   Gonsky,R., Knauf,J.A., Elisei,R., Wang,J.W., Su,S. and Fagin,J.A.
  TITLE     Identification of rapid turnover transcripts overexpressed in
            thyroid tumors and thyroid cancer cell lines: use of a targeted
            differential RNA display method to select for mRNA subsets
  JOURNAL   Nucleic Acids Res 25 (19), 3823-3831 (1997)
   PUBMED   9380504
REFERENCE   4  (bases 1 to 7584)
  AUTHORS   Pengue,G., Calabro,V., Cannada-Bartoli,P., De Luca,P., Esposito,T.,
            Taillon-Miller,P., LaForgia,S., Druck,T., Huebner,K., D'Urso,M. et
            al.
  TITLE     YAC-assisted cloning of transcribed sequences from the human
            chromosome 3p21 region
  JOURNAL   Hum Mol Genet 2 (6), 791-796 (1993)
   PUBMED   8353497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099669.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001351733.1.
            
            Summary: This gene represents naturally-occurring readthrough
            transcription between the adjacent zinc finger protein 660 (ZNF660)
            and zinc finger protein 197 (ZNF197) genes. Readthrough transcripts
            may encode proteins similar to the proteins encoded by ZNF197.
            [provided by RefSeq, May 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1797195.1,
                                           SRR1660805.43750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 10168, 285349
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC099669.2         141663-141706
            45-153              AC099669.2         142804-142912
            154-633             AC099669.2         185764-186243
            634-793             AC099669.2         187761-187920
            794-885             AC099669.2         188804-188895
            886-1012            AC099669.2         189172-189298
            1013-7584           AC099669.2         198599-205170
FEATURES             Location/Qualifiers
     source          1..7584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..7584
                     /gene="ZNF660-ZNF197"
                     /note="ZNF660-ZNF197 readthrough"
                     /db_xref="GeneID:110354863"
     exon            1..44
                     /gene="ZNF660-ZNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            45..153
                     /gene="ZNF660-ZNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            154..633
                     /gene="ZNF660-ZNF197"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..3333
                     /gene="ZNF660-ZNF197"
                     /note="isoform 1 is encoded by transcript variant 2;
                     pVHL-associated KRAB domain-containing protein; zinc
                     finger protein with KRAB and SCAN domains 9; zinc finger
                     protein 197"
                     /codon_start=1
                     /product="zinc finger protein 197 isoform 1"
                     /protein_id="NP_001338662.1"
                     /db_xref="GeneID:110354863"
                     /translation="MTRENVAHNALRQEGLVKGKDDTWKWGTSFQGSSSSVWETSHLH
                     FRQLRYHETSGPQEALSRLRELCRRWLRPEARTKAQILELLVLEQFLSILPGEIRTWV
                     QLHHPGSGEEAVALVEELQKDLDGPAIQVPVLVKDQDTLQKVVSAPGTTLPPVLPGSH
                     IAAEICPHPPTDLVAFNLQDPQHDSPAPEASALSQEENPRNQLMALMLLTAQPQELVM
                     FEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSLEWETMTENEEVTSKPSSSQR
                     ADSHKGTSKRLQGSVPQVLDFEEECEWQVLASQWGNETDERADTVKKVSLCERDKKKR
                     TPPEKQGQKWKELGDSLTFGSAISESLIGTEGKKFYKCDMCCKHFNKISHLINHRRIH
                     TGEKPHKCKECGKGFIQRSSLLMHLRNHSGEKPYKCNECGKAFSQSAYLLNHQRIHTG
                     EKPYKCKECGKGFYRHSGLIIHLRRHSGERPYKCNECGKVFSQNAYLIDHQRLHKGEE
                     PYKCNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLIDHQRLHSAENPY
                     KCKECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKC
                     TECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRFHTGENLYECKD
                     CGKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCG
                     KAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIEHKRIHSGEKPYECDECGKC
                     FILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGKGFT
                     YNRNLIEHQRIHSGEKTYECHVCRKVLTSSRNLMVHQRIHTGEKPYKCNECGKDFSQN
                     KNLVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCSKVFRQRKN
                     LTVHQKIHTDEKPCECDVSEKEFSQTSNLHLQQKIHTIEEFSWLQNTNESKIEIQKI"
     exon            634..793
                     /gene="ZNF660-ZNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            794..885
                     /gene="ZNF660-ZNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1012
                     /gene="ZNF660-ZNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..7584
                     /gene="ZNF660-ZNF197"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6733..6738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF660-ZNF197"
                     /note="hexamer: AATAAA"
     polyA_site      6757
                     /gene="ZNF660-ZNF197"
     regulatory      7561..7566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF660-ZNF197"
                     /note="hexamer: AATAAA"
     polyA_site      7584
                     /gene="ZNF660-ZNF197"
                     /note="major polyA site"
ORIGIN      
        1 agttccttct gcgctttgtt caagatgtgg gtctggcgct ttcgtgactc aagaccctct
       61 taggaacttc ttcactgaac tcaaggagga gatcaggcaa gatctgtgct gtgcagatcc
      121 tttggattga ggctgctgtg cacaggaata tgggtcttgt agatgatact ctccaagctg
      181 taaggaagaa gtcaaggatt aaggagacct ggactggaga ggagcctttt tcaaaaaaca
      241 acaatgacaa gagaaaatgt agcccacaat gctctgagac aagagggcct tgtgaagggg
      301 aaggatgata cctggaaatg gggaaccagc ttccaaggaa gtagctcctc tgtttgggag
      361 acctcccacc tacactttag acaattacgt taccatgaga catctggacc ccaggaagcc
      421 ctgagccggc tcagggaact ctgtcgccgg tggctgagac cagaagcacg caccaaggca
      481 cagatcctgg agctgctggt gctggagcag tttctgagca tcctgcctgg ggagattcgg
      541 acctgggtac agctccatca ccctggaagt ggcgaggagg ctgtggccct ggtagaggag
      601 ctgcagaaag accttgatgg accagcaata caagttccag tccttgtcaa ggatcaggac
      661 actctccaga aggtggtgag tgccccagga acaacacttc ctcctgtact tcctggcagc
      721 cacatagcag ctgaaatttg cccgcatcct cctactgacc tagtggcatt caacctccag
      781 gatcctcagc atgattctcc tgcccctgaa gcttctgccc tttcccagga agagaaccca
      841 agaaatcaat taatggcact tatgctccta acagcccagc cccaggagtt ggtgatgttc
      901 gaggaggtgt cagtatgctt cacttcagag gaatgggcat gtctgggccc aatccagagg
      961 gccttgtact gggatgtgat gctggagaat tatggaaatg tgacctccct agaatgggag
     1021 accatgaccg agaatgagga ggtgacatca aagccaagta gttctcaaag agcagactct
     1081 cataaaggaa catcaaaaag acttcaagga agtgttcccc aggtccttga ttttgaagaa
     1141 gagtgtgaat ggcaagtttt ggcaagtcag tggggaaatg aaacagatga aagggcagat
     1201 acagtgaaga aagtttccct ttgtgaacga gacaagaaga aaaggactcc accagagaaa
     1261 caaggccaaa agtggaagga attaggagac agcttgactt tcggttcagc tatttctgaa
     1321 agtttaatag gtactgaagg aaagaagttt tataaatgtg atatgtgttg taaacatttt
     1381 aataaaatct cccatcttat aaaccatcgg agaatccaca ctggtgagaa acctcataaa
     1441 tgtaaggaat gtggaaaagg ctttattcag cgttcgagcc ttctaatgca tttacggaac
     1501 cattcagggg agaaacctta taaatgtaat gaatgtggga aagcattttc tcaaagtgct
     1561 taccttctaa accatcagag gatccacact ggggagaaac cttataagtg taaggagtgt
     1621 ggaaagggct tctataggca ctcaggccta attatacatc taaggcgcca ttcaggggag
     1681 agaccttata agtgtaatga atgtgggaaa gtcttctctc agaatgctta cctcattgac
     1741 catcagaggc tccacaaagg ggaagaacct tataaatgta ataagtgtca gaaagctttc
     1801 attctgaaga agagcctcat tctgcaccag agaatccact ctggggaaaa accctataaa
     1861 tgtgatgaat gtggaaagac ctttgctcag accacttatc ttattgacca tcagcgactc
     1921 cacagtgcag agaaccctta caagtgtaaa gaatgtggaa aagttttcat tcgaagcaaa
     1981 agcctcctct tacatcagag agtccacaca gaaaagaaaa cctttggttg taaaaagtgt
     2041 gggaagattt tcagttctaa gtcaaacttc attgaccata agaggatgca cagcagagag
     2101 aaaccttaca aatgcactga atgtgggaaa gcctttactc aaagtgctta cctttttgac
     2161 caccagagac tccacaatgg ggagaagccc tatgaatgta atgaatgtgg gaaagttttt
     2221 attctgaaga agagcctcat tttacatcaa aggttccaca ctggagagaa tctctatgaa
     2281 tgtaaagatt gtggtaaggt cttcggttca aacagaaacc tcattgacca tgagagactc
     2341 cacaatgggg agaagccata tgaatgtcga gagtgtggga aaacctttat tatgagcaaa
     2401 agttttatgg tccatcagaa actccataca caagagaaag cctacaaatg tgaggattgt
     2461 gggaaggctt tcagttacaa ttcaagcctg cttgtacatc ggagaatcca caccggagaa
     2521 aaaccctttg aatgcagtga gtgtggaaga gctttcagtt caaacagaaa cctcattgag
     2581 cataagagaa tccacagtgg tgagaaaccc tatgagtgtg atgagtgtgg caaatgcttc
     2641 attctgaaga aaagcctcat tggacatcag agaattcaca cgagggaaaa atcttataaa
     2701 tgcaatgact gtgggaaggt cttcagttac cgctcaaacc ttatagccca tcagaggatc
     2761 catactggtg agaagcccta tgcgtgtagt gagtgtggaa aaggttttac gtacaacaga
     2821 aacctgattg aacatcaaag aattcacagt ggagaaaaaa cctacgaatg tcatgtatgt
     2881 aggaaagtcc ttacctctag tagaaatctt atggtacatc aaagaatcca tactggagag
     2941 aaaccttata aatgtaatga gtgtggaaaa gactttagtc agaataaaaa ccttgttgta
     3001 catcagagaa tgcacactgg ggaaaaacct tatgagtgtg acaagtgtag gaaatccttt
     3061 acttctaaga ggaatttagt tggccaccag agaattcaca caggggagaa accctatggg
     3121 tgtaatgatt gtagtaaagt ttttaggcaa agaaaaaacc ttactgtaca tcagaaaatc
     3181 cacacagatg aaaaaccttg tgaatgtgat gtgtctgaaa aagaattctc tcagacttcc
     3241 aaccttcatc ttcaacagaa aatccatacc attgaggaat tctcttggct acaaaacacc
     3301 aatgagtcca agattgagat tcagaaaatc tagtgtcata tgtaaaatgg aatagaatcc
     3361 ctgcctactt aagtaactgt tggacaaatg atatatattt cttctaagga aaaagtttat
     3421 tatttactct ttactagaca aatgagtagc atatagaaga aagttaatag gccgggcttg
     3481 gtggctcatg cctgtaatcc cagcactttg agaggccgaa gcgagtggat cacctgaggt
     3541 caggattttg agaccagcct gaccaacatg gtgaaacccc atctctacta aaatacaaaa
     3601 attatccggg catgggggca cacaccggta atcccagcta ctcaggaggc tgagacagga
     3661 gagtcgcttg aacctgggag ggcggaggtt gcagtgagcc aggatcgcgc cattgcactc
     3721 cagcctgggc aacaagagcg aaactcttgt ctgaaaaaat aaagttcatc ccaactttca
     3781 agtctacaaa aacataatcc aaatctaata acatagttgt aaatgagagc aacaataaaa
     3841 agtagacatg ggctgggtgc agtggctcac tcctgtagtc ccaggacttt gggaggccga
     3901 ggtgggaaga tcccttgagc ccaggagttc gagacaagcc tgggtaacac ggggagaccc
     3961 gtctttagta aataaaaata aatttattaa taaaactaaa aatttaataa taaaaagtgg
     4021 acattgtttt ttaaaatgtg tatagtatgc attttaaaga tagtgtcact gctgtggaaa
     4081 acctgaacag acagtatgat ccagaatgtc aggtgtggag ttgggcggac aagagtctgc
     4141 tgatgaggac aacctaaaag agcactggat ttggaatcag aagacctacc tttgattcct
     4201 ggctttccct taatggccat gtgatgttat taagtcagcc tctaaagctt tagtttcctg
     4261 tcagtcaaat gttgacatga tacctacctc acagggttgt tgtgagggtt aagtgaaagg
     4321 atctttgtga aagtactttt tgaaatcatt cagttgtcaa taaagttgga taaaagaggt
     4381 tatggtaaaa gtttagaaca tgggatcatg taagtttgtg tattaagtca atattagaat
     4441 gagggggatt ccaggaacct aaaagatact cattttcata agaggaagta tggtgaatag
     4501 ctaactggaa tttagtgttc taagaataat tttgttaaat ttacctttaa aaatatctga
     4561 gggagttact agattatata tctagtttat gtatatggaa aaaaatgtta tggccagcca
     4621 ttaacagtga tgccaaggaa aacaatttat ttcccagctt ttgaatttga aacttaacag
     4681 atggagagtg tcaaaatgga agggcagtgg taccctgctt tccctattca gagggaaaaa
     4741 aatccttgac ccgcagttga gctgatgatc cctgccacag tcattgtgaa ttctaatcaa
     4801 tatttcatca ttgctgtcaa atgatagcct gttactaatg aaacaacatt ctgtcccagc
     4861 actaaattta ctgggacata aatttttcac atggagccaa gctcttcact gattaagcca
     4921 gtgcagaatc cacttgtggg cagtcagtgc ccattacccc ctgtgaacca ttctgtgccc
     4981 ttgagtacat ttgtgggttt aactcagtct atattcttaa gttggtaatt tttatgttgt
     5041 aattctcaaa gttctgtttc tgtagctgga ctatgaataa tacctgaata tgaagattgt
     5101 gttttttaat aatgtcaaag tggtgtgttg attatcataa atgttattaa ttcaacccca
     5161 cagtttcttg ggggctggtt cctcattaga gtgaaaggta gccaagagtg aaaactggaa
     5221 ggggcctaag gcttaaagtc ttaagacctg gatgtggttc aggttttgcc atctgcctca
     5281 gaaaaaatct cttcagttct tggagccttg aattcctcat ctgttaaaca ggaggaagaa
     5341 tatctacctc acaaagttct tatgagataa tgaatataaa aatgtttcat ccaggttgtt
     5401 gaatcatccc agcttatata ataattacaa aggacatatg tactttaaca atggagaatg
     5461 ctgtgattta cctcttcacc gagtaacaaa atgtcacatt gcttagattg agacagccca
     5521 cataatgtgc caccttctgt gatgtaataa gctgaaaaat gttcaacctg aatttaatca
     5581 agcttcttgg acctcattgc caggttacag gaaatacagg aggcagagga acaaataaaa
     5641 gacaccacga gaaacagaca catccagaac gtggaatatt gcataagaaa gctgccctgg
     5701 attcttcaaa atattattat gatgaaaaag agaggggagt gaaaattgtt caagctgtct
     5761 tgagtctgct gtgagtttat tataccattc tctgcttttg tgtatgtatg aaaatttcga
     5821 tatgaaaggt ataaaacatg gatgaggagg cttgttttta aaagataata ctagagagcc
     5881 gttaggtact aagaaccaga aatagactca cataaatggc caattgattt ttgacagggg
     5941 caaaagcaat tcaatggagg agggatcgcc ttttcagcaa atactgttgg agtaattgga
     6001 tatccatagg cagtaaacca acaacttcag gacctaggac tgagctaaga aggctcagat
     6061 gactcaaaag catgctcctt agaaggaaaa aaaatgttaa attggacttc atcaaaatta
     6121 agataattta ccctgtaaga gaccttttta caaagatgat attacaggtt gggaaaaaat
     6181 atttgcaaat catatccaac aagggatttg tatgtaaact acataaagaa ctttccaaat
     6241 ttaacagtaa taagtaaata caattagaaa ataagcaaaa gacagacatt tcactgaagt
     6301 atagatagca aataagcaaa tgaaaagatg ttcaacatca ttaggcatga gggaaatgca
     6361 gagtaaaatc gtgagatatc acctatcaga atagcttaac tttttttttt taatggtggt
     6421 aactgctggc aaggatgaag agaaacagga tctcatacat tgctgggaat gtaaaatggt
     6481 acagccactc tggaatataa tttggcagtt tcttgtaaaa ccacacatgt atatgtcatg
     6541 cttcaggaat tgcacttctg agcatttatc ccagagaaat gaaaacttgc gttcacacaa
     6601 aaacctgtat acgaatgttc atagcagctt tatttgtaat ggtcgaaacc tgtaggcaac
     6661 ccatatatcc ttccttaggt ggttaaaaca aattgtggtt tatgtattac catggaatac
     6721 ttgttactct gcaataaaat tgacttattg atatccataa caactcaaat aaatttcaag
     6781 ggaattaatg ctgagtgaaa ataatcacaa aaggccatat tctgtatgaa aatattcata
     6841 taacattctc aaaatgataa aactatagag atgaaaaatg gattaatggt tgccaaaggt
     6901 tagggatggt gggaggaaaa atggggagag ggttggatgg aactattaaa aggtagcacc
     6961 agaaaggtct ttgtggtgat ggaacacttg tgtatcttga ttgcagtggt ggttacacaa
     7021 atctataggt gctataccta tacacacata ctgtaccaat gttgatttcc tttttcattt
     7081 tatgtaagat gtaaccatga ggggaaagtg ggtgaagggt gctatctttg caacttcctg
     7141 tgattctatc atttcaaaat aaaaagtaaa aaccaacaat ggcaacgaaa acccaaaact
     7201 aaagagctgt aaccaactaa agtgtgtgaa actgatttga aaaaaagtta taaaatacat
     7261 gttttaggac agttgggaaa tttgaatatg actggttatt agatggtatt agggaatttt
     7321 tgttgatttt cttacctgtg acggtggtgg tagtttgaag aatattctta atcttaaggg
     7381 atgcatgttg aagtatttgg aatgaagtgt tctgatgttt acaactttca aaaaaatgat
     7441 tttaaatatg tattgagaga tcaggcaaac atagcaaaat gttcattgtt gagtccacat
     7501 ggaaaatacg ggtattcaat gtgccatact ttcaactctt ctgtactctg atattttcaa
     7561 aataaaacat ttgaggggaa atta
//
