LOCUS       NM_173658               5834 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 660 (ZNF660), mRNA.
ACCESSION   NM_173658
VERSION     NM_173658.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5834)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5834)
  AUTHORS   Haldrup,C., Pedersen,A.L., Ogaard,N., Strand,S.H., Hoyer,S.,
            Borre,M., Orntoft,T.F. and Sorensen,K.D.
  TITLE     Biomarker potential of ST6GALNAC3 and ZNF660 promoter
            hypermethylation in prostate cancer tissue and liquid biopsies
  JOURNAL   Mol Oncol 12 (4), 545-560 (2018)
   PUBMED   29465788
  REMARK    GeneRIF: Biomarker potential of ST6GALNAC3 and ZNF660 promoter
            hypermethylation in prostate cancer tissue and liquid biopsies
REFERENCE   3  (bases 1 to 5834)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK094189.1, BC075094.2 and
            AC099669.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_173658.3.
            
            Summary: This gene encodes a protein that contains multiple C2H2
            zinc finger domains, and is located in a cluster of zinc-finger
            encoding genes on chromosome 3. Naturally-occurring readthrough
            transcription is observed between this gene and the downstream zinc
            finger protein 197 gene and is represented by GeneID:110354863.
            [provided by RefSeq, May 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094189.1, SRR1660803.250530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322734.2/ ENSP00000324605.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               AK094189.1         1-503
            504-1369            BC075094.2         195-1060
            1370-2205           AK094189.1         1370-2205
            2206-5834           AC099669.2         152765-156393
FEATURES             Location/Qualifiers
     source          1..5834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5834
                     /gene="ZNF660"
                     /note="zinc finger protein 660"
                     /db_xref="GeneID:285349"
                     /db_xref="HGNC:HGNC:26720"
     exon            1..44
                     /gene="ZNF660"
                     /inference="alignment:Splign:2.1.0"
     exon            45..153
                     /gene="ZNF660"
                     /inference="alignment:Splign:2.1.0"
     exon            154..5834
                     /gene="ZNF660"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1329
                     /gene="ZNF660"
                     /codon_start=1
                     /product="zinc finger protein 660"
                     /protein_id="NP_775929.2"
                     /db_xref="CCDS:CCDS2716.1"
                     /db_xref="GeneID:285349"
                     /db_xref="HGNC:HGNC:26720"
                     /translation="MRRKTRNFKHKTVKDNKVLTEGSDQESEKDNSQCCDPATNERVQ
                     AEKRQYVCTECGKAFSQSANLTVHERIHTGEKPYKCKECGKAFSHSSNLVVHRRIHTG
                     LKPYTCSECGKSFSGKSHLIRHQGIHSGEKTYECKECGKAFSRSSGLISHHRVHTGEK
                     PYSCIECGKAFSRSSNLTQHQRMHRGKKVYKCKECGKTCGSNTKIMDHQRIHTGEKPY
                     ECDECGKTFILRKTLNEHQRLHRREKPYKCNECGKAFTSNRNLVDHQRVHTGEKPYKC
                     NECGKTFRQTSQVILHLRTHTKEKPYKCSECGKAYRYSSQLIQHQRKHNEEKETS"
     regulatory      5810..5815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF660"
                     /note="hexamer: AATAAA"
     polyA_site      5834
                     /gene="ZNF660"
                     /note="major polyA site"
ORIGIN      
        1 agttccttct gcgctttgtt caagatgtgg gtctggcgct ttcgtgactc aagaccctct
       61 taggaacttc ttcactgaac tcaaggagga gatcaggcaa gatctgtgct gtgcagatcc
      121 tttggattga ggctgctgtg cacaggaata tggatggtga aactgggact gaggaggagt
      181 taattccaaa gcatcattcc tgaaaaatca gaatcataca tactttcaag agaattccac
      241 agagacattg cccaggaagt caaaatttag aaggctcctc tgaagggaaa gagaagacta
      301 gagaggacac tggtatgttc caagcaggag aaaatgagga gaaagacaag aaatttcaaa
      361 cataagacag ttaaagacaa taaagtactc acagaaggga gtgaccaaga atctgaaaaa
      421 gacaatagtc agtgctgtga ccctgcaaca aatgagagag ttcaggctga aaagagacag
      481 tatgtatgta ctgagtgtgg gaaagccttt agtcagagtg caaacctcac agtacatgag
      541 cgaatccaca cgggagagaa accctataag tgtaaggagt gtggaaaagc tttcagtcat
      601 agctctaacc ttgttgttca tcggagaatc cacactggac tgaagcccta tacatgcagt
      661 gaatgtggga aatctttcag tggaaagtca catcttattc ggcaccaggg aatccacagt
      721 ggggagaaaa cttatgaatg taaagagtgt gggaaagcct ttagtcggag ttcgggcctt
      781 atatcacatc acagagttca caccggagag aagccctatt cttgtattga gtgtgggaaa
      841 gcctttagcc gtagttcaaa ccttactcaa catcagcgaa tgcacagagg aaaaaaagtt
      901 tacaaatgta aggagtgtgg gaaaacatgt ggttctaata caaagattat ggaccatcag
      961 agaattcaca ctggagagaa gccttatgaa tgtgatgagt gtggaaaaac tttcatctta
     1021 aggaaaactc ttaatgaaca ccagagactt catcgtagag agaaacctta caaatgtaat
     1081 gagtgtggga aggcttttac ttctaatcga aaccttgttg atcatcagag agttcacact
     1141 ggagagaaac cctataaatg taatgaatgt gggaaaacct tcaggcagac ttctcaagtt
     1201 attctacact tgagaaccca cactaaggag aaaccctata aatgtagtga gtgtgggaaa
     1261 gcctatcggt atagttcaca gcttattcaa caccagagga aacataatga ggagaaagaa
     1321 acctcataaa taacaaatat tgtgggtagt agggctgact gctgcttttc taaaaagtag
     1381 ttctttagta tcaactttaa ttctacttct aagaatcata ctctacttct aagaaaataa
     1441 ttagaagtag acaaagatta atgaaaggga tgttcatgac agcatcatat acgactgaaa
     1501 gaagaaaact agattttcaa cattacaggg ttgaaatgaa tgatgagcta tccatatgat
     1561 ggttctgcag ccattgcaaa catttttaaa gacaatttaa tgccatgggg aaatgattgg
     1621 ataagacgga agataatgac atacaatcca aaatttaaaa aaatattttt gcataggaaa
     1681 aattgagaag gaagtaaacc aaaatgttaa cagtgatcat ctctgggcga taggattata
     1741 ggtgatttct attttcttct gtatactttt ctatgctttc tagattatct acatgagaat
     1801 atactaattt tatatgcaag aaaaaaagca cagtattttt taaatgcaat gaagacgtgc
     1861 ttattttcac tcagcagtgt tatgaaaggc acgtagtata tagagcccaa agccctggga
     1921 ttgcaccctg acactggcat ttagcagcag tggaaccgcg agcaagtccc ttccttttag
     1981 agcgtgtttc ctgttaagta aaatcataaa caccgatcct ttgtcctttt tagttttaag
     2041 acaagctgac tttagagttg tcaacaaaat atataataac actgttaggt taaaagaaca
     2101 cagcaaaaat tcactgaacc ctcctttccc acagttctgg aaggatctgc agatgatgga
     2161 gaactaccta ggcttcatct tttcaacata tgtctacaca accagaaaaa aatgaaattg
     2221 aaacaactgt agactcaaaa acttcagata cagtcaccag ttaatataaa actagtggga
     2281 gactctgcct tcacatggta tatagagttt aaaggctaaa agtacaaact ttggggttgg
     2341 agatatccat gttctaaccc cagttctacc atgaactagc ttgtcagttt tggacaagtc
     2401 acttaactgc tctgagcctc agacctgtgt gtaaaaaagg aacaattacc taccttacaa
     2461 ggttgttgtg aggattaagt gagtaatgca tgaaatatat gataagccag acacgtggta
     2521 aatgataaaa tcttaagtat aggacattgt agcagtgttt ctaaacactt tagggagagt
     2581 gattaaagag aatttttgtg taaggtagta cttaggatat tttcagatgt attgaacaga
     2641 ataccaagta ctagcagcct agaccttaag aacattgatt gattgcttaa ggggaatcta
     2701 gaggtaagca gtgctatgtt tggtttggca actcagcact tcatcacact tctctcttaa
     2761 ctccataatt ttcagcatgt tgactttcat ttttcataac ctcatggtgg caagacagtg
     2821 gccacagctg catcttgcct tcacacaact ccttcagatt gggaactgga aaaggagctg
     2881 aggctttctc atctggtttc ttccttttgt cactgagaaa aatctttccc tgaagaaggg
     2941 acggagaggt gttgagcaat caatacaaca gatgttttct atcttcctct gcctttcttt
     3001 atgaccagtc ctccttgaag gtcttagccc atcttccacc aatatttaaa acattttaag
     3061 tgcttagctc aaagtcactc tgaaacactt agaatctccc tatttttaac tcagccattc
     3121 ctctgtgtat acagtgaatc cctaagccca ctgttatctg tcttatgcac atagtgaatt
     3181 agtgtttggg gaatttttga taatatgtta tttagttctc cctctattat acaagaaaat
     3241 tgagtgtcat tgaggttagg tgactggcta gtaagttgtc ggagccagga tttgagctca
     3301 gatctgactt tgaaattcat gctttcttca ttataccaaa gtgcctctgc ccaccatggt
     3361 ggttctgtat gtgagtggaa gaccagttgg cgttttccca ggtagctgcc tctatgaaag
     3421 gtgattgtat ctaacaatta tttgatattt gaccatggtt ttatagggaa gatgttatca
     3481 gtgttctgtg aatggggttt atggcctatc tctgtacctc ataatttagt tttaaggtat
     3541 atatatttct ttcttgctgt taccggaaag aaagaagtga agggtgaagg ttgtatattt
     3601 gtgtgaaaaa aaattactga ttttgtccta ttttgatagg atagtggttt gcacataatt
     3661 tgtgatataa tagtcctttg catggtcatt ccaagcaggg tttggaaggc ctggaacaga
     3721 tttgtagcat tcatggacaa gcctggtcta tcattcctga gcagaattgt tgatgcttta
     3781 tatattgctg agcagatatt ctctgaccaa aacatttttt caccaccatg tcatagtgcc
     3841 taaaactctt tatttagata ggctttcttt tttgtcttag aagactatga tcttcaagag
     3901 tatatctcaa ggaaggatat gatgccatct cataaccaga gaactgaata taggagagct
     3961 tcatatttct tgccccaggc aggcgaggat tatagtctct tgaggaggcc atcacccatc
     4021 ttctaggcta atacctgcct tgagctgtag gaataaacac ttgacagtgg gttcctgcat
     4081 cctttcagat aaacattcag ctataatttg aactgatcac ccacctttct ccgggagtct
     4141 cccagggtta ccaactttta cctcagtcag agtttaggca tgcagctctt accatccttt
     4201 caagcccttt cataataccc tctggaaacc aggaactgtc tcttttaatg tgctttcttt
     4261 ttctttcttt tcttttcttt tctttttttt ttttttttga gatggaatct cgcactgtcg
     4321 cccatgctgg agtgcagtgg cgtgatctca gctctcagct caccgcaacc tccagctccc
     4381 aggttcaagc aattctcctg cctcagcctc ctgagtagct gagattacag gcacctgcca
     4441 ccacacccag ctaatttttg tatttttaat agagataggg tttcaccatg ttggccaggc
     4501 tgatctcgaa ctcctgacct cacaagatcc acctgcctcg gcctcccaaa gtgctgggat
     4561 tataggcatg agccactgca cctggcttta tttatatgtg tatttattta tttatttatt
     4621 tatgagatgg agtgttgctc ttgtcgccca ggctggagtg caatggcgtg atatcggctc
     4681 actgcaacct ctgcctcctg ggttcaagcg attctcctgt ctcagcctcc caagtagctg
     4741 ggattacagg tacctgccac cacacctggc taattttttg tatttttagt agagacgagg
     4801 ttttgccatg ttggtcaggc tggtcttgaa tgaatgtgtt ttcttcacat tcttgttcca
     4861 atggaaaccg ggctgttccc caagggcagt gcttattctg cattcctcaa ttgctggttt
     4921 atgtgtctct caactcatgt acctctctgt actgccattt cttctctctt ctccatcaga
     4981 aacttagctc taatcagtca tggttgcata cacacgtagt cctaggtact caggaggctg
     5041 aggggggagg atcacttgag cccaggagtt cactgttaca gtgagctatg atcacaattc
     5101 tgcactgcag cctaggtcac ggagcaagac cctgtctcag aaacaaaaca gtacaaaaca
     5161 aaaaacccac aaaaacccaa cccagtgctt ttgaaatata tatcactaaa ctactgtgta
     5221 ttgctcattc ttgttatttg gtttcttgtc tactcacatt tattcactta cagttttagt
     5281 accctgaata ttcctgagga atataaagag gcaataattt tagccacaga catcctggtt
     5341 atatagaatt gctcctgtgt agaataaaaa tatatatgct ctttttagtt gagaggaaaa
     5401 tacgaaaatc tcattttata tagccttgag tagagggcaa tacgtaagac aaagaattct
     5461 gcttagagag gaaagtgtcg ccctggactt agaaatcttt tttcatagat ggtgcgtcct
     5521 gtgttaggta ttacttggaa gaaaattgaa gtaaaaaaca gctttaagta actgagtaat
     5581 taggattaat tagtagctgt tgaatctaaa tcccttaaga ctaaatttca ttgcagctct
     5641 gtaccctcag caggacttcc tttcttgatt gttttttcca tttaatataa aatttaaaag
     5701 atgcccatat tgtcagttgt ttttagtcgc cagactgtct ttaatagcct ctgatgttat
     5761 aaaactggag tcatgaaatt gttttgcagg aagtagtgat aattccttca ataaacgtct
     5821 gctattctta taaa
//
