LOCUS       NM_033160               4016 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 658 (ZNF658), transcript variant
            2, mRNA.
ACCESSION   NM_033160 XM_936455
VERSION     NM_033160.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Francis,M., Cheng,H., Ma,P. and Grider,A.
  TITLE     Genomic Characterization of the Zinc Transcriptional Regulatory
            Element Reveals Potential Functional Roles of ZNF658
  JOURNAL   Biol Trace Elem Res 192 (2), 83-90 (2019)
   PUBMED   30734197
  REMARK    GeneRIF: Genomic Characterization of the Zinc Transcriptional
            Regulatory Element Reveals Potential Functional Roles of ZNF658
REFERENCE   2  (bases 1 to 4016)
  AUTHORS   Ogo,O.A., Tyson,J., Cockell,S.J., Howard,A., Valentine,R.A. and
            Ford,D.
  TITLE     The zinc finger protein ZNF658 regulates the transcription of genes
            involved in zinc homeostasis and affects ribosome biogenesis
            through the zinc transcriptional regulatory element
  JOURNAL   Mol Cell Biol 35 (6), 977-987 (2015)
   PUBMED   25582195
REFERENCE   3  (bases 1 to 4016)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA103495.1, AK057375.1, BX664608.6, AL110217.1 and AL353770.18.
            
            On Aug 13, 2020 this sequence version replaced NM_033160.6.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057375.1, SRR18074967.1400012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621410.5/ ENSP00000482447.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DA103495.1         1-53
            54-317              AK057375.1         1-264
            318-318             BX664608.6         156159-156159
            319-395             AK057375.1         266-342
            396-396             BX664608.6         165307-165307
            397-1543            AK057375.1         344-1490
            1544-3363           AL110217.1         314-2133
            3364-3364           AL353770.18        12498-12498
            3365-4016           AL110217.1         2135-2786
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..4016
                     /gene="ZNF658"
                     /note="zinc finger protein 658"
                     /db_xref="GeneID:26149"
                     /db_xref="HGNC:HGNC:25226"
                     /db_xref="MIM:616290"
     exon            1..112
                     /gene="ZNF658"
                     /inference="alignment:Splign:2.1.0"
     exon            113..171
                     /gene="ZNF658"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..3336
                     /gene="ZNF658"
                     /codon_start=1
                     /product="zinc finger protein 658"
                     /protein_id="NP_149350.3"
                     /db_xref="CCDS:CCDS75846.1"
                     /db_xref="GeneID:26149"
                     /db_xref="HGNC:HGNC:25226"
                     /db_xref="MIM:616290"
                     /translation="MNMSQASVSFQDVTVEFTREEWQHLGPVERTLYRDVMLENYSHL
                     ISVGYCITKPKVISKLEKGEEPWSLEDEFLNQRYPGYFKVDHIKGIREKQEKPLWQEI
                     FISDADKTLSKEGQKVLEKPFNLEIAPELSEKISCKCDSHRMNLPVASQLIISERKYS
                     RKKTEYMNVCEKLQLDIKHEKAHAEEKSYEHGENAKAFSYKKDQHWKFQTLEESFECD
                     GSGQGLYDKTICITPQSFLTGEKSCKDDEFRKNFDKITLFNHMRTDTRGKCSDLNEYG
                     TSCDKTTAVEYNKVHMAMTHYECNERGINFSRKSPLTQSQRTITGWSAFESNKCEENF
                     SQSSAHIVHQKTQAGDKFGEHNECTDALYQKLDFTAHQRIHTEDKFYLSDEHGKCRKS
                     FYRKAHLIQHQRPHSGEKTYQYEECAKSFCSSSHPIQHPGTYVGFKLYECNECGKAFC
                     QNSNLSKHLRIHTKEKPCDNNGCGRSYKSPLIGHQKTDAEMELCGGSEYGKTSHLKGH
                     QRILMGEKPYECIECGKTFSKTSHLRAHQRIHTGEKPYECVECEKTFSHKTHLSVHQR
                     VHTGEKPYECNDCGKSFTYNSALRAHQRIHTGEKPYECSDCEKTFAHNSALRAHHRIH
                     TGEKPYECNECGRSFAHISVLKAHQRIHTGEKPYECNECGRSFTYNSALRAHQRIHTG
                     RKPYECSDCEKTFAHNSALKIHQRIHTGEKPYECNECEKTFAHNSALRAHQNIHTGEK
                     LYECSECGKTFFQKTRLSTHRRIHTGEKPYECSKCGKTFSQKSYLSGHERIHTGEKPY
                     ECNVCGKTFVYKAALIVHQRIHTGEKPYECNQCGKTFSQRTHLCAHQRIHTGEKPYEC
                     NECGKTFADNSALRAHHRIHTGEKPYECNDCGKTFSKTSHLRAHLRTRSGEKPYECSE
                     CGKTFSEKSYVSAHQRVHTGEKPYECNVCGKPFAHNSTLRVHQRIHTGEKSYECNDCG
                     KTFSQKSHLSAHQRIHTGEKPYECNECGKAFAQNSTLRVHQRIHTGEKPYECDECGKT
                     FVRKAALRVHHTRMHTREKTLACNGFGKS"
     exon            172..298
                     /gene="ZNF658"
                     /inference="alignment:Splign:2.1.0"
     exon            299..394
                     /gene="ZNF658"
                     /inference="alignment:Splign:2.1.0"
     exon            395..4016
                     /gene="ZNF658"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3992..3997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF658"
                     /note="hexamer: AATAAA"
     polyA_site      4016
                     /gene="ZNF658"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgcatgt gtaaacccag ccccacctcc tgccgtctgc cctcccgggc ctgaaaggga
       61 cacggtgtcc gagtctttag gtctgcgcgg gagccgaggc tgcgcacctg ggctgaacct
      121 ccacagtcct ctacactctt ccaggagcag cagaaaatga acatgtctca ggcatcagtg
      181 tcattccagg acgtgactgt ggaattcacc cgggaggagt ggcagcacct gggccctgtc
      241 gagaggacgc tgtacagaga tgtgatgctg gagaactaca gccacctcat ctcagtggga
      301 tattgcatta ctaaacctaa ggtgatctcc aagttggaga aaggagaaga gccatggtct
      361 ttagaagatg aattcctgaa ccagaggtac ccagggtatt ttaaagttga tcacatcaaa
      421 gggatccggg aaaaacaaga aaaacctctg tggcaagaaa tattcatcag tgatgctgac
      481 aaaacattga gtaaagaagg acagaaagtt ttagaaaaac catttaatct ggaaatagct
      541 ccagagcttt cagaaaaaat atcctgtaaa tgtgactcac acagaatgaa tttgccagtt
      601 gcttctcaat taattataag tgaaagaaaa tattcaagaa agaagactga atacatgaat
      661 gtgtgtgaga aactgcagct tgatattaag catgagaaag ctcatgctga agagaaatct
      721 tatgaacatg gtgaaaatgc taaagctttc agttataaga aagatcagca ttggaaattt
      781 caaactttgg aggaatcttt tgaatgtgat ggatctggac aaggtttata tgataagaca
      841 atttgtatta cacctcagag ttttctaaca ggagaaaagt cctgtaagga tgatgaattt
      901 agaaaaaact ttgataaaat cactttattt aaccacatga gaactgacac aagggggaaa
      961 tgctctgatc ttaatgaata tgggacatcc tgtgacaaaa ccaccgctgt tgaatacaat
     1021 aaagttcaca tggctatgac acactatgag tgtaatgaaa gggggattaa tttcagtagg
     1081 aagtcacccc tcactcaatc tcagagaact attacaggat ggagtgcttt tgaaagcaat
     1141 aaatgtgaag aaaattttag ccagagctca gcccatatag tacatcagaa aacacaagct
     1201 ggagataaat ttggtgaaca taatgaatgt acagatgccc tctaccagaa attagacttt
     1261 acagcacatc agagaattca cacagaagat aaattctacc tttctgatga acatgggaaa
     1321 tgcagaaaat ccttttaccg gaaagcacac ctcattcagc atcagaggcc ccactcagga
     1381 gagaaaactt accaatatga ggaatgtgca aaatcctttt gttcaagttc acatcctatt
     1441 cagcatcctg gaacttatgt gggattcaaa ctttatgaat gtaatgaatg tgggaaagct
     1501 ttctgtcaga attcaaacct cagtaaacat ctgagaattc acacaaaaga gaaaccttgt
     1561 gataacaatg gctgtgggag atcttacaag tcacccctca taggacacca gaaaacagat
     1621 gcagagatgg aactctgtgg tggcagtgaa tatgggaaga catcacatct caaaggacat
     1681 cagagaattc tcatggggga gaaaccctat gaatgtattg aatgtgggaa aactttctcc
     1741 aagacatcac atctcagagc acatcagaga attcacacag gtgaaaaacc ctatgaatgt
     1801 gttgaatgtg agaaaacttt ctctcacaag acacacctca gtgtacatca gagagttcac
     1861 acaggggaga aaccctatga atgtaatgac tgtgggaaat cttttaccta taactcagcc
     1921 ctgagagcac atcaaagaat tcacacaggt gagaagccct atgaatgcag tgactgtgag
     1981 aaaacttttg cccataattc agccctcaga gcacatcata gaattcacac gggggagaaa
     2041 ccttatgaat gtaatgaatg tggaaggtct tttgcccata tttctgttct caaggcacat
     2101 caaagaattc acacagggga gaaaccctat gaatgtaatg aatgtgggag atctttcacc
     2161 tacaattcag ccctgagagc acatcagaga attcacacag gtagaaaacc ctatgaatgt
     2221 agtgactgtg agaaaacttt tgcccataat tcagccctca aaatacatca gagaattcac
     2281 acgggggaga aaccctatga atgtaatgaa tgtgagaaaa catttgccca taattcagcc
     2341 cttagagcac atcagaatat ccacacaggg gagaaactct atgaatgtag tgaatgtgga
     2401 aaaacttttt tccagaagac acgcctcagt acacatcgga gaattcacac aggggagaaa
     2461 ccctatgaat gtagcaagtg tgggaaaact ttctcccaga aatcatacct cagtggacat
     2521 gagagaattc acacagggga aaaaccgtat gaatgtaacg tatgtgggaa aacttttgtc
     2581 tataaggcag ccctcatagt gcatcaaaga attcacacag gggagaaacc ctatgaatgt
     2641 aaccaatgtg ggaaaacttt ctcccaaaga acacacctct gtgcacatca gagaattcat
     2701 actggggaaa aaccctatga gtgtaatgaa tgtgggaaaa cgtttgctga taattcagcc
     2761 ctcagggcac atcacagaat tcacacaggg gagaaaccct atgaatgtaa tgactgtggg
     2821 aagactttct ccaagacatc acatctcaga gcacatctta gaactcgctc aggggagaaa
     2881 ccctatgaat gcagtgaatg tgggaaaacc ttctctgaga agtcatatgt tagtgcacat
     2941 cagagagttc atacggggga gaaaccctac gaatgtaatg tatgtgggaa gccatttgcc
     3001 cataattcaa ccctcagagt acatcaaaga attcacacag gggagaaatc ctatgaatgt
     3061 aatgattgtg ggaaaacgtt ctcccagaaa tcacacctta gtgcacacca gagaattcac
     3121 acaggggaga aaccctatga gtgtaatgaa tgcggaaaag cttttgccca aaattcaact
     3181 ctcagagtac accagagaat tcacacaggg gagaaaccct atgaatgtga tgaatgtggg
     3241 aaaacttttg tccgtaaggc agctcttagg gtacatcaca ccagaatgca taccagagag
     3301 aaaaccctag catgtaatgg atttgggaag tcctgaggga atgcatacct taccacataa
     3361 cacgtagtgc agaaactcat gtgacatagg ctgggaactt gtttccctta tccatttcct
     3421 ttttcattag gctcatagtt tgtggaaaaa tcccaatatg ccgtttattc aggtggggct
     3481 gaccatggga tgtggtgcta atgataaata ttacatttac ccttggccct taaaaaaaaa
     3541 aaagaaaaac cctcacagtc ttcctggttc ataagatgga tttggaggtt atttctgcag
     3601 caaacttggg tcctgtgtgt tcaaaaccat agagcacaag gtcaaggaag ctagagtctg
     3661 aaaaacgaac aattcacttc caggtcttca tcagggtttt gtttttgttg ctttaaagca
     3721 agagttaagt ttatagtctg ttaagctctt acaaatttgg cttattagtt aaatggacgt
     3781 agtttagctt aaactttatg ttagagtgag atgaaaccct atgaatataa tcagttttag
     3841 aaaaactaat cagtttattg tgcatcagag acgtcacatg aagaagaaaa cttgtcgaca
     3901 tccaggatga tcaggagcct tcattaaaac agaaatttta gggaaaacca caaaaacctt
     3961 cgtaaagtga attgcattaa acatcaatta taataaaatt tcatattttg aataaa
//
