LOCUS       NM_138494               4518 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 655 (ZNF655), transcript variant
            1, mRNA.
ACCESSION   NM_138494
VERSION     NM_138494.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4518)
  AUTHORS   Fan,S., Liu,Y., Lin,Z., Zhang,Y., Zhang,N., Zhao,Y., Zhou,J.,
            Mao,A., Wang,L., Feng,Y., He,X., Wang,L. and Pan,Q.
  TITLE     ZNF655 promotes the progression of hepatocellular carcinoma through
            PSMB8
  JOURNAL   Cell Biol Int 47 (9), 1535-1546 (2023)
   PUBMED   37272200
  REMARK    GeneRIF: ZNF655 promotes the progression of hepatocellular
            carcinoma through PSMB8.
REFERENCE   2  (bases 1 to 4518)
  AUTHORS   Teng,Z., Yao,J., Zhu,L., Zhao,L. and Chen,G.
  TITLE     ZNF655 is involved in development and progression of non-small-cell
            lung cancer
  JOURNAL   Life Sci 280, 119727 (2021)
   PUBMED   34144060
  REMARK    GeneRIF: ZNF655 is involved in development and progression of
            non-small-cell lung cancer.
REFERENCE   3  (bases 1 to 4518)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4518)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4518)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4518)
  AUTHORS   Thompson,E.E., Kuttab-Boulos,H., Yang,L., Roe,B.A. and Di Rienzo,A.
  TITLE     Sequence diversity and haplotype structure at the human CYP3A
            cluster
  JOURNAL   Pharmacogenomics J 6 (2), 105-114 (2006)
   PUBMED   16314882
REFERENCE   7  (bases 1 to 4518)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 4518)
  AUTHORS   Houlard,M., Romero-Portillo,F., Germani,A., Depaux,A.,
            Regnier-Ricard,F., Gisselbrecht,S. and Varin-Blank,N.
  TITLE     Characterization of VIK-1: a new Vav-interacting Kruppel-like
            protein
  JOURNAL   Oncogene 24 (1), 28-38 (2005)
   PUBMED   15558030
REFERENCE   9  (bases 1 to 4518)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
REFERENCE   10 (bases 1 to 4518)
  AUTHORS   Laity,J.H., Lee,B.M. and Wright,P.E.
  TITLE     Zinc finger proteins: new insights into structural and functional
            diversity
  JOURNAL   Curr Opin Struct Biol 11 (1), 39-46 (2001)
   PUBMED   11179890
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063478.1, BC037407.1,
            AK128057.1, CR749270.1 and BC024770.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138494.2.
            
            Summary: This gene encodes a zinc finger protein. The zinc finger
            proteins are involved in DNA binding and protein-protein
            interactions. Multiple alternatively spliced transcript variants
            encoding distinct isoforms have been found for this gene. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon, compared to variant 7. Both variants 1 and 3 encode the same
            isoform (a), which is shorter than isoform f.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA235102.1, SRR1803614.97013.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252713.9/ ENSP00000252713.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               BC063478.1         221-529
            310-328             BC037407.1         320-338
            329-1890            AK128057.1         1613-3174
            1891-3946           CR749270.1         1719-3774
            3947-4518           BC024770.1         3513-4084
FEATURES             Location/Qualifiers
     source          1..4518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..4518
                     /gene="ZNF655"
                     /gene_synonym="VIK; VIK-1"
                     /note="zinc finger protein 655"
                     /db_xref="GeneID:79027"
                     /db_xref="HGNC:HGNC:30899"
                     /db_xref="MIM:617891"
     exon            1..146
                     /gene="ZNF655"
                     /gene_synonym="VIK; VIK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            147..309
                     /gene="ZNF655"
                     /gene_synonym="VIK; VIK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1649
                     /gene="ZNF655"
                     /gene_synonym="VIK; VIK-1"
                     /note="isoform a is encoded by transcript variant 1; vav-1
                     interacting Kruppel-like protein"
                     /codon_start=1
                     /product="zinc finger protein 655 isoform a"
                     /protein_id="NP_612503.1"
                     /db_xref="CCDS:CCDS5669.1"
                     /db_xref="GeneID:79027"
                     /db_xref="HGNC:HGNC:30899"
                     /db_xref="MIM:617891"
                     /translation="MEEIPAQEAAGSPRVQFQSLETQSECLSPEPQFVQDTDMEQGLT
                     GDGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPETREVYKSEDRLERLQEI
                     LRKFLYLEREFRQITISKETFTSEKNNECHEPEKSFSLDSTIDADQRVLRIQNTDDND
                     KYDMSFNQNSASGKHEHLNLTEDFQSSECKESLMDLSHLNKWESIPNTEKSYKCDVCG
                     KIFHQSSALTRHQRIHTREKPYKCKECEKSFSQSSSLSRHKRIHTREKPYKCEASDKS
                     CEASDKSCSPSSGIIQHKKIHTRAKSYKCSSCERVFSRSVHLTQHQKIHKEMPCKCTV
                     CGSDFCHTSYLLEHQRVHHEEKAYEYDEYGLAYIKQQGIHFREKPYTCSECGKDFRLN
                     SHLIQHQRIHTGEKAHECNECGKAFSQTSCLIQHHKMHRKEKSYECNEYEGSFSHSSD
                     LILQQEVLTRQKAFDCDVWEKNSSQRAHLVQHQSIHTKENS"
     exon            310..4518
                     /gene="ZNF655"
                     /gene_synonym="VIK; VIK-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4491..4496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF655"
                     /gene_synonym="VIK; VIK-1"
                     /note="hexamer: AATAAA"
     polyA_site      4518
                     /gene="ZNF655"
                     /gene_synonym="VIK; VIK-1"
                     /note="major polyA site"
ORIGIN      
        1 attcgggacc ctgcactccg tcgccggaag tgccaccgag aagcgccggc ctcggggctg
       61 tctacagcgg cccgggagag gctgtggtgg ccccgagcgc gagtgtgtag gtgacaggac
      121 agcggccagg cccgcccctc ccctcgtgat ggtcattgtc ctccagagca gtgatggagg
      181 aaataccagc ccaggaagca gcagggtcac caagggtcca gtttcagtct ttggagaccc
      241 agtctgagtg tctgtcccca gagcctcagt ttgtgcagga caccgacatg gaacagggac
      301 tcactgggga tggagagacc agagaagaga acaagctgtt gattcctaag cagaaaattt
      361 cggaagaagt gcattcatac aaagtgagag taggaagact caaacacgat attacccaag
      421 ttcctgagac tagagaagtg tataagtctg aggacagatt agaaagactt caggaaattc
      481 taaggaaatt tctgtacctg gagagagagt ttaggcaaat aacaatcagc aaggaaacct
      541 tcaccagtga gaagaacaat gaatgtcatg aacccgaaaa aagcttcagt ctggactcta
      601 ctattgatgc agatcagaga gttcttagaa tacagaatac cgatgacaat gataagtatg
      661 acatgagctt caaccagaat tcagcctctg gtaaacatga acacttaaat ctaacagagg
      721 attttcagag tagtgaatgt aaggaaagct taatggatct ctcccacctt aataaatggg
      781 agagcatccc taacactgag aaatcctata aatgtgatgt atgtgggaaa attttccatc
      841 agagctcagc ccttactaga catcagagaa tccatactag agagaagccc tacaaatgta
      901 aagaatgtga aaagtctttc agtcagagct caagtcttag tcgacataaa agaatacaca
      961 ctagagaaaa accttacaaa tgtgaagcat ctgataaatc ctgtgaagcg tctgataaat
     1021 cctgtagtcc aagctcaggc ataattcagc ataagaaaat tcacaccaga gccaaatctt
     1081 acaaatgtag cagttgtgaa agagtcttca gtcgtagtgt ccaccttact caacatcaga
     1141 aaattcacaa agagatgccc tgtaagtgta ctgtatgtgg cagtgacttc tgccatactt
     1201 catacctact tgaacatcag agggtccatc atgaagagaa agcctatgag tatgatgaat
     1261 atgggttggc ctatattaaa caacaaggaa ttcatttcag agaaaagccc tatacgtgta
     1321 gtgaatgtgg aaaagacttc agattgaatt cacatcttat tcagcatcaa agaattcaca
     1381 caggagagaa agcacatgaa tgtaatgaat gtggaaaagc tttcagtcaa acctcatgcc
     1441 ttattcagca tcacaaaatg cataggaaag agaaatcgta tgaatgtaat gagtatgagg
     1501 gcagtttcag tcatagctca gatcttatcc tgcaacaaga agtcctcacc agacagaaag
     1561 cctttgattg tgatgtatgg gaaaagaact ccagtcagag agcacatcta gttcaacatc
     1621 agagcattca taccaaagag aactcatgaa tgtaatgaag atgggaagat atttatcaaa
     1681 ttcaggcttc attcagcatc tgagagttca caccagggag aaatcatgta tgtactgcat
     1741 gtggtaaagc cttcagtcat agctcagcca ttgctcagca tcagataatt cacaccagag
     1801 agaaaccctc tgaatgtgac gaatgaagaa aaggtattag tgttaaactc ttaatcgact
     1861 cctgcaaatc tataccagtg agaaatctta caaatgtatt gaatgtggca aatttttcat
     1921 gctattagta ttttcatacc ttagtcacat ttggagaatt cacatgggaa taaaattcca
     1981 ttgctgcaat gaatgtgaaa aagccatcag tcaaagaaac taccttgttt agtatcaaat
     2041 tcacgccatg caaaaagatt ataaatgtaa taagcatgta tgtgtgtgag gagattcagt
     2101 cataacccaa cgctcattca acatcaaaga atttatacct aagagaactt atttgggtgt
     2161 agtaaatggc agatctttca ataggagttt aactagtctt tgtcatatca gaatatccat
     2221 agtagacaag aatttgatgt aacgcaaatg gaaaaactcg acaccacatt tcaggcttta
     2281 cccaacatcg aaataatgga gagaaaattg ttgattattt gtttatgaaa ttgttaatac
     2341 atagtcccaa tctttttcat tgcacaaaaa tctagggttg acttggtaaa tgcagtgaca
     2401 ttttctcatg gagttccttt atttaatatg tattctaagt aggtacgttt atttttactt
     2461 ttttattata attttgatat taaaaagaac agagatgggg tcttgctttg ttgcccaggc
     2521 tggtcttgaa ctcctggcct caagcgatcc tcccacctgt cctcccaaag tgctggggtt
     2581 acaggcgtgt gtcactgtgc tgggcctatt ttatttatag aactcattta agctgttttt
     2641 attttaatat gccctataaa catttttata ttttttgaaa ttggttctta gtgttcacaa
     2701 cttccataag atactgctaa tgcaccagta ttaaaacaca tcgacgtaag tagctcattt
     2761 agctttttct gctgttcttg gcccaagttc tttccaaaac caactcttag gcctgctctt
     2821 tactagggat cttatgtcgt attgctttac agccacaaca cttggattcc tgttgattaa
     2881 cttctccatt ctcttaagca cctttagaag atttagaagt ttcctagttt taagtgtttc
     2941 accagcaagt attccatacc tacttgatgt tgctggtctg gtgtcttatt tcctaaagtg
     3001 aagcatcttt ttttaaaaaa gaatttgatt gacaatatat ccagtccaat ataagtatga
     3061 aggattctct ctcctgagat tgtagcaggc agccaaacat tttcaaatga tgcccaaggt
     3121 tttagctgtc ttgtgtgcat ccacagtctg cgaagaagac atgataagga catcagggag
     3181 ccaacaagac tcctaatagc ctcactacat tcatccagtg cctattctgc atgcctaagc
     3241 ttagagttct tttatatacc tctacggcca gcaaaatgct caggtctgct cttggtaggg
     3301 taaacataaa gaagatacac aggccgggca tggtggctca cacctgtaat cccagcactt
     3361 tgggaggctg aggcggatgg atcacgaggt caggcagtcg agaccatcct ggccaacatg
     3421 gtgaaacccc gtctctacta aaaatacaaa agttagccgg gtgtggtggc acgcgcctgt
     3481 aatcccagct actcaggagg ctgaggcagg agaactgctt gaacctggga ggcggaggtt
     3541 gcagtgagcc gagattgcac cactgcactc cagcctgggc gacagagcag gactctctct
     3601 caaaaaaaca caaaaaaaca aaaacaaaaa accatacaca cacacacaca cacacaaatc
     3661 agcatcataa gggaatgtag ccttccaaca gagatgatgc tgttcgtatg ttaatctcag
     3721 agacagtatt tcaagagagt ggcaggtctg ttcctggtaa aattttaacc attaggattg
     3781 cagataaatg tttgaattct gctcctctct catcaatcca ggacagtatt tgaagtgtga
     3841 gggctttgtg tatagttgtt tatccattac cacatttttg tattttaata gtctacaggc
     3901 tatataaaag aacatggctt tttgactgat aaaagtgatt acagatgttg gctcaagttc
     3961 agggccacca tcatatacct aacaagagtt catgattctt taggtaatgt caaaacattt
     4021 tgtatttttc catcttaagc tttataacat tttgtgagta agacaaatgt tatttaaaat
     4081 tcttgttgtc agtccagcaa ttgaggcttt catagttcag tgttataata ttcagtaggg
     4141 accctcaaca aatatataaa aatatgttgc tcactctata atcctcctat ggctaacctc
     4201 taggatagtt ctgccactat attttacttc tttgccatca gcaagagtag gatttcatca
     4261 aggcaaggta ggaatctaaa tgaaattgat atataaatga attgatctaa atgtaaaagc
     4321 aaatgaaaaa tgcatgtgtt ttttcctgtc aaacatgtat acccttatgt atagagacca
     4381 gtagtcacgt atggtgactg aaacaggatt atgtaatccc taaaaagcag aatatgtaaa
     4441 aatcacatgt atgcgtttgg tttaggaatg tgcttttgta cttccacttg aataaaggtg
     4501 tgtttggtat tctgagaa
//
