LOCUS       NM_001350134            6460 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 654 (ZNF654), transcript variant
            1, mRNA.
ACCESSION   NM_001350134
VERSION     NM_001350134.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6460)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 6460)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119733.2, AC128650.6 and AA767937.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001350134.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.78973.1,
                                           SRR1660803.186892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636215.2/ ENSP00000490842.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC119733.2         72465-72715
            252-397             AC119733.2         99467-99612
            398-479             AC119733.2         126325-126406
            480-615             AC119733.2         139344-139479
            616-818             AC119733.2         142019-142221
            819-958             AC119733.2         142897-143036
            959-1100            AC119733.2         148271-148412
            1101-3444           AC119733.2         151915-154258
            3445-6170           AC128650.6         115210-117935       c
            6171-6460           AA767937.1         25-314              c
FEATURES             Location/Qualifiers
     source          1..6460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p11.1"
     gene            1..6460
                     /gene="ZNF654"
                     /note="zinc finger protein 654"
                     /db_xref="GeneID:55279"
                     /db_xref="HGNC:HGNC:25612"
     exon            1..251
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3452
                     /gene="ZNF654"
                     /note="isoform 1 is encoded by transcript variant 1;
                     melanoma-associated antigen"
                     /codon_start=1
                     /product="zinc finger protein 654 isoform 1"
                     /protein_id="NP_001337063.1"
                     /db_xref="CCDS:CCDS87110.1"
                     /db_xref="GeneID:55279"
                     /db_xref="HGNC:HGNC:25612"
                     /translation="MAEEESDQEAERLGEELVAIVESPLGPVGLRAAGDGRGGAGSGN
                     CGGGVGISSRDYCRRFCQVVEDYAGRWQVPLPQLQVLQTALCCFTTASASFPDECEHV
                     QYVLSSLAVSFFELLLFFGRDEFYEEPLKDILGSFQECQNHLRRYGNVNLELVTRIIR
                     DGGPWEDPVLQAVLKAQPASQEIVNKYLSSENPLFFELRARYLIACERIPEAMALIKS
                     CINHPEISKDLYFHQALFTCLFMSPVEDQLFREHLLKTDCKSGIDIICNAEKEGKTML
                     ALQLCESFLIPQLQNGDMYCIWELIFIWSKLQLKSNPSKQVFVDQCYQLLRTATNVRV
                     IFPFMKIIKDEVEEEGLQICVEICGCALQLDLHDDPKTKCLIYKTIAHFLPNDLEILR
                     ICALSIFFLERSLEAYRTVEELYKRPDEEYNEGTSSVQNRVRFELLPILKKGLFFDPE
                     FWNFVMIKKNCVALLSDKSAVRFLNESTLENNAGNLKRTEEQQGLDEGFDSLTDQSTG
                     ETDPDDVSGVQPKGHINTKKNLTALSTSKVDHNVPRHRCMLCNKEFLGGHIVRHAQAH
                     QKKGSFACVICGRKFRNRGLMQKHLKNHVKKIQRQQIAAAQQDDQEVTALEEINCSSS
                     SISFENGNSDSKDLEVETLTASSEGNKEVIPEHVAEFIEIPISVPEDVIENVIENGSP
                     NNSLNNVFKPLTECGDDYEEEEDEEGDYEEDDYDLNQETSVIHKINGTVCHPKDIYAT
                     DQEGNFKCPALGCVRIFKRIGFLNKHAMTVHPTDLNVRQTVMKWSKGKCKFCQRQFED
                     SQHFIDHLNRHSYPNVYFCLHFNCNESFKLPFQLAQHTKSHRIFQAQCSFPECHELFE
                     DLPLLYEHEAQHYLSKTPESSAQPSETILWDVQTDSNPNQEKDSSSNEKQTISLPVST
                     SKSRKESTEPKTCIESMEKKTDSLVQNGNERSDDTVSNISLIDQKMPDIEPNSENNCS
                     SSDIVNGHSEIEQTPLVSSDPALKIDTNRIRTENGSILPSVVPQEHNTLPVSQAPSKP
                     NLTSEHTSYGLILTKPYVRPLPPSYLDERYLSMPKRRKFLTDRVDACSDQDNVYKKSV
                     KRLRCGKCLTTYCNAEALEAHLAQKKCQTLFGFDSDDESA"
     exon            252..397
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     exon            398..479
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     exon            480..615
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     exon            616..818
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     exon            819..958
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1100
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..3444
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..6460
                     /gene="ZNF654"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6439..6444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF654"
                     /note="hexamer: AATAAA"
     polyA_site      6460
                     /gene="ZNF654"
                     /note="major polyA site"
ORIGIN      
        1 agcctaggca tctacggcgg cggcggcggc gcaggggctg gtacgcgctg ggcggcgaga
       61 gcctcatggc ggaggaagag agcgaccaag aggccgaacg cctcggagaa gagcttgtgg
      121 ccattgtgga gtccccgctg ggccctgtgg ggcttagagc tgcgggcgac ggcagaggcg
      181 gcgctggcag cggcaactgc ggcggcggcg tcggaatcag cagtcgggat tactgccgac
      241 gcttctgtca ggtggttgaa gattatgctg gaagatggca ggtccctttg ccacagcttc
      301 aggttcttca gactgccctt tgttgtttta caacagccag tgcatcattc ccagatgaat
      361 gtgagcatgt acaatatgtt ttgagtagcc ttgctgtgag tttctttgag ttgctgctgt
      421 tctttggaag agatgagttt tatgaagagc ccttaaagga tattcttgga tcattccagg
      481 aatgccagaa tcacctccgc agatatggaa atgtgaatct ggaactggtg actcgaatca
      541 ttagagatgg tggcccatgg gaagatccag tgttgcaagc tgtccttaaa gctcagccag
      601 catctcagga gatagtgaac aaatatttaa gttctgaaaa tccactgttc tttgaactac
      661 gtgccagata cctaattgct tgtgaacgca tacccgaagc aatggctctt attaaatctt
      721 gtataaatca cccagaaatc agtaaagact tatacttcca tcaagcactc ttcacatgtc
      781 tgtttatgtc acctgtagaa gatcagctat tccgggagca tttattgaaa actgattgta
      841 agagtggaat tgatatcatc tgtaatgctg aaaaagaagg caaaactatg ttagccttgc
      901 aactctgtga atcctttctt attccacagc tccagaatgg ggatatgtac tgtatctggg
      961 agttgatttt catatggagt aaactacagc ttaaatctaa tccttcaaaa caagtttttg
     1021 tagatcaatg ctaccagctt ttaagaacag caactaatgt gagagtcata tttcctttca
     1081 tgaaaatcat caaagatgag gttgaagaag aaggcttgca aatttgtgtt gaaatatgtg
     1141 gttgtgctct acaactcgac cttcatgatg atcccaaaac taaatgtcta atttataaaa
     1201 caattgcaca ttttttgcca aatgatttgg agatcctcag gatttgtgca ctctcaatat
     1261 tttttctgga gcgctcctta gaagcgtatc gtactgttga agagctttac aaacgtccag
     1321 atgaagaata taatgaaggc acaagtagtg ttcaaaatcg tgttcgtttt gaattgcttc
     1381 caattttgaa aaagggattg ttttttgacc ctgaattttg gaacttcgta atgattaaga
     1441 aaaactgtgt agcattattg agtgataaat cagcagttag atttctaaat gaaagcacac
     1501 tggaaaataa tgcaggtaat ctaaaaagga cggaggaaca gcaaggtttg gatgaagggt
     1561 ttgactctct tacagatcag agcactggag agactgatcc tgatgatgta tctggagtgc
     1621 agcctaaagg tcatattaat acgaagaaaa atcttacagc tctcagtact tccaaagtag
     1681 atcacaatgt cccaaggcat cgttgtatgt tatgtaacaa ggaattttta ggtggtcaca
     1741 ttgtaaggca tgcccaggct catcagaaaa aaggcagttt tgcatgtgta atatgtggta
     1801 ggaaatttag aaacagagga cttatgcaga agcatttgaa gaatcatgtt aagaagatac
     1861 agaggcagca aattgctgca gctcaacagg atgatcagga agtcactgct ttggaagaaa
     1921 taaattgttc tagttcttcc atttcatttg aaaatgggaa ttctgatagt aaggatttgg
     1981 aagtggagac acttactgct tctagtgaag gaaacaaaga agtcatccct gagcatgtgg
     2041 ctgaattcat tgaaattccc ataagtgtac cagaagatgt tattgaaaat gttattgaaa
     2101 atggcagtcc taataattct ttaaataatg ttttcaagcc tttaactgaa tgtggggatg
     2161 attatgagga ggaagaggat gaagaaggtg attatgaaga agatgattat gacctgaatc
     2221 aagaaacttc agtaattcat aaaatcaatg gaactgtgtg ccatccaaaa gacatatatg
     2281 ccacagatca agaaggaaac tttaagtgtc ctgctcttgg ttgtgtccgg atatttaaaa
     2341 gaattgggtt tctaaataaa catgcaatga ccgtacatcc aaccgattta aatgtgcgac
     2401 aaacagtaat gaagtggagc aaaggaaaat gcaaattttg tcaaaggcaa tttgaagatt
     2461 ctcaacattt tatagaccac cttaatagac atagctatcc aaatgtgtat ttttgtttgc
     2521 attttaattg caacgagtcg tttaagctgc cgttccagct tgcccagcac acaaaaagtc
     2581 acaggatatt tcaggctcag tgtagttttc cagaatgcca tgagcttttt gaagatcttc
     2641 ctctgctgta tgaacatgaa gctcaacact atttaagtaa aacaccagag tcatctgcac
     2701 aaccaagtga aacaattctt tgggatgttc agacagactc aaatcctaat caggaaaaag
     2761 actcatctag taatgagaaa caaactatta gtctgccagt ttctactagc aaatcaagga
     2821 aagagtctac agaaccaaag acatgtatag aaagtatgga aaagaaaaca gacagtttag
     2881 ttcagaatgg aaacgaacgt tctgatgaca ctgtttcaaa tataagcttg atagaccaaa
     2941 agatgcctga catagagcca aattctgaaa ataattgtag tagtagtgat atagtcaatg
     3001 gacacagtga aatagagcaa acacctttag tttcatcaga tcctgctttg aaaattgata
     3061 caaacagaat caggacagaa aatggttcca ttttgcccag tgttgtacca caagaacaca
     3121 acaccttgcc agtatctcag gcaccttcca aaccaaatct gacaagtgaa catacttcat
     3181 atggcttaat tttaacaaaa ccatacgtca gaccattgcc tcccagttac cttgatgaac
     3241 ggtatcttag tatgccaaaa cgcagaaaat ttctgactga tagagtagat gcctgttctg
     3301 atcaagataa cgtgtataaa aaatcagtga aaagattaag atgtggcaaa tgcctgacca
     3361 cctactgtaa tgcagaagca cttgaggctc atcttgcaca aaagaaatgt cagacactct
     3421 ttggatttga ttcagatgat gaaagtgcct gatgaaaacg gttcagaaag atctgtcaat
     3481 caagcagtag tgtgaaaaaa gcactataag aaaatgcatc atcagtttgc tatttccctg
     3541 atggccttaa ttttagagtg gtcttggatt actaaagata aagacaaagc acattttcta
     3601 gaatgaactc acagagatgt gctggcttag actccaaaag gattataaaa ctcccaaagt
     3661 accagttttc cagaaaacca cattttacag tttatgatga ttaatagcag cagcatgttc
     3721 agtttcgctt atatgagaaa catgtttagg caactagtca gaaaaccagc tatggcctta
     3781 cagaaaggga aaaattaacc cattattaaa aagtgtgtgt ggggaggggg gctggtttac
     3841 aatattaaac catttaaagt attttattct acaaatgggg tttgttttct tgtcatgcat
     3901 aatcagatta tgtcccctcc cttctggtta aacatggttt aaggaaccgc tgctgtttgg
     3961 tttgtgattg atttagaaac ttatacatta acttaccaca gtgctatcaa ttaaagattg
     4021 taacaggttt ccagatgatt aattaggtca aagttcaatg aatggcacgc cagcattgaa
     4081 aattaaaaaa caaaacaaaa aaaaccacag tgctttgcta ataagctctt gatagaacct
     4141 cccactaacc acttttgtgg tacaaattag ttaacattta aagggcagca gtgtcaataa
     4201 aatagaaaaa aaccgatcag tactctgggg agagatgaaa ggaatctaag actttacagg
     4261 ctttgtagtt gaaggaaaac actgaattgc aaattattca atgtgaataa tggtaaaagc
     4321 acactgggat acttctgttt gtgtatatgt tgggacattg cttgatgatt catagtaagg
     4381 tcctttagac attaatgtga gttatctaag tacagtccta ttaaaataac tggctcaaaa
     4441 aatcagctaa gaatcaggtt gagaaatcat tcattttatt ctattaggag aggtaattcc
     4501 aaaataagcc atactattcc tgttttttta attcattagt gatgactctg gtctgaacag
     4561 taatttttat atgtaaaagg aagtatttac acaaaacatt tgcacaagaa cacagtaaga
     4621 gatacattca agcattgttt tccttagtga tgttattttc ctaagaagat tttaacttaa
     4681 taaagtgtta aaacaataaa tatttttaaa aataccctct cagatgtttt ccatttgtcc
     4741 attattgaaa ggaagatgct taaagacttc cttttactaa tagtgtgtaa atctaaaaca
     4801 gggattaaaa taacaaaaag gcagtgtttc aaaacagatc tcctaatgtc ccaatgtcaa
     4861 atattccagt tattctaaat aataaaatct ttgttcaagg cagataatct catcagaccc
     4921 tattagagct tcttgaatga ggctattacg gaagtgggga atttcttcca ggtagcatcc
     4981 atattttatt aaattaggat ttccagatca tgatagatca gatgattttt ttttaatttc
     5041 ccggttttat tggtttatca tcagcattca ctactatgca atgatggtca taagtccatt
     5101 ccaaatttaa atttgtttct gttatgtagc ctatattagg ctgtggaatt tacatttagg
     5161 taactaaaca cagctcataa ttaaaatctt ttctttaagg tcagctaaaa aaaatgtttc
     5221 ctgtatttct tgatactaaa aatgtaatga tttttatttt agttcattct aaaagtatgt
     5281 cttgtaataa aaagtctgtt tggaaactgg ttcatttgga cagtgaagtc ttttgaaata
     5341 tttctgcttt gtacattttc cagaagttta atattttatc acattttcca caagttgtaa
     5401 caattgatat aaatccatgc ccacaaagta ttccattttc attactttta ctgttcatgc
     5461 caagatgttt caaatatatt ccatttgtaa tctgtcttta acttgaggtt tatttctact
     5521 tttgtgttgc taaaattatt tctgcaagac tgagatcaaa ctggtttata tataactaaa
     5581 tcaaggaatg ttttataaaa ttctatttga ccacactgtc ttaacctcgg tttatatact
     5641 tctcaaatag ctattgaaag aatgtgttca ttttattaca tctgtctttt aaaacataaa
     5701 cctacatcat tttgctttta tagggtgcat aaacttccaa cagttctaat ttgagcgctt
     5761 cagaagaaaa ggaagcttgc ttcttattcc tcagattctt ctttttttct gttttgagga
     5821 tgtattcatc ctacatggac caagtttcaa atctttgttt ttaaataaaa atttccttca
     5881 aaaaattaaa tgttaaattt ctgctgtgtg tcagtaaggt gaagaaaata gcaaatctga
     5941 atttttgctg ctcagatatt atggaggagg taaaaagggg aatctccgtg gacaaggaca
     6001 ctggtacttt gggctttagc catattcatt tttttgaaac caccaattat ataatactta
     6061 aataatttat atcattgaac ttgtgattct tttcaaatca cactgaaggt tcagccgtac
     6121 tcctttcatg tttggtttaa tactgttgta tggatgaaaa acctaaaagg gatgatagtg
     6181 tttatttttt aatttatttg gtactgtaaa acaccttttc agaatgagta aatgctgcat
     6241 atgcattttg gagttgttaa tatgtgaaag atattacaga ttcagcaaga aaggaaattt
     6301 gtgcttcctt gttgaatgtt aaattatttt actttgcatt ttataagagt acaaattaaa
     6361 actgagccat tgaactgcaa taaatcaaca atagtgtctc atttcaagaa attttttgta
     6421 ctgtacatag atttgttcaa taaaacgtcc ttgttggtaa
//
