LOCUS       NM_138783               2154 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 653 (ZNF653), mRNA.
ACCESSION   NM_138783
VERSION     NM_138783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Borud,B., Mellgren,G., Lund,J. and Bakke,M.
  TITLE     Cloning and characterization of a novel zinc finger protein that
            modulates the transcriptional activity of nuclear receptors
  JOURNAL   Mol Endocrinol 17 (11), 2303-2319 (2003)
   PUBMED   12920234
  REMARK    GeneRIF: novel zinc-finger protein that influences gene activation
            through interaction with the functionally important activation
            function-2 domain of nuclear receptors
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131037.1, BC014187.2 and CB241280.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138783.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY072704.1, BC016816.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293771.10/ ENSP00000293771.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK131037.1         85-104
            21-2141             BC014187.2         1-2121
            2142-2154           CB241280.1         18-30               c
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2154
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /note="zinc finger protein 653"
                     /db_xref="GeneID:115950"
                     /db_xref="HGNC:HGNC:25196"
                     /db_xref="MIM:611371"
     exon            1..352
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1901
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /note="zinc finger protein Zip67; 67 kDa zinc finger
                     protein"
                     /codon_start=1
                     /product="zinc finger protein 653"
                     /protein_id="NP_620138.2"
                     /db_xref="CCDS:CCDS12261.1"
                     /db_xref="GeneID:115950"
                     /db_xref="HGNC:HGNC:25196"
                     /db_xref="MIM:611371"
                     /translation="MAERALEPEAEAEAEAGAGGEAAAEEGAAGRKARGRPRLTESDR
                     ARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKP
                     WEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQC
                     EAGHRYFQDLHSPLKPLSDSDPDSDKVGNGLVAGSSDSSSSGSASDSEESPEGQPVKA
                     AAAAAAATPTSPVGSSGLITQEGVHIPFDVHHVESLAEQGTPLCSNPAGNGPEALETV
                     VCVPVPVQVGAGPSALFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEG
                     IHLNMAAGSGVPGSGLGEEVPCAMMEGVAAYTQTEPEGSQPSTMDATAVAGIETKKEK
                     EDLCLLKKEEKEEPVAPELATTVPESAEPEAEADGEELDGSDMSAIIYEIPKEPEKRR
                     RSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKK
                     FYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCR
                     QRASLNWHMKKHTAEVQYNFTCDRCGKRFEKLDSVKFHTLKSHPDHKPT"
     exon            353..396
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     exon            397..612
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     exon            613..1224
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1396
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1508
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1623
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1723
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..2154
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2136..2141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /note="hexamer: ATTAAA"
     polyA_site      2154
                     /gene="ZNF653"
                     /gene_synonym="E430039K05Rik; ZIP67"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtc tggctcctaa caacggggga ggctggtaac cagggtgggg gggatggcgg
       61 agcgggcgct agagcccgag gcggaggcgg aggctgaggc gggcgcgggc ggggaggcag
      121 cagccgagga gggcgcagcg ggccgaaagg cgcggggccg gccgcgactc acggagtcgg
      181 accgggcccg gcgacggctc gagtcccgga agaagtacga cgtgcggcgc gtgtacctgg
      241 gcgaggcgca cgggccctgg gtggacctgc ggcgccgcag cggctggagc gacgccaagc
      301 tcgccgccta cctcatctct ctggagcgcg gccagcggag cggccgccac gggaagcctt
      361 gggagcaggt ccccaaaaag ccaaagcgga agaaaaggcg gcgacgcaac gtgaactgcc
      421 tgaagaacgt ggtgatctgg tacgaggacc acaagcaccg ctgcccgtac gagccgcacc
      481 tggcggagct agaccccact tttggcctgt acaccacggc cgtgtggcag tgcgaagctg
      541 gccaccgcta cttccaggac ctgcattcgc ccctgaagcc cctcagcgac tcagaccctg
      601 acagtgacaa agtgggcaat gggctggtgg ctggcagctc tgactcatcc agctctggct
      661 ctgcctctga ctctgaggag tctcctgagg gccagccggt caaggctgcg gcagcggcag
      721 cggcagcgac gcccaccagc ccggtgggca gcagcgggct catcactcag gagggcgtgc
      781 acattccctt tgacgtccac cacgtggaaa gcctggccga gcagggtacc ccgctgtgct
      841 ccaacccagc aggcaatggg cctgaagccc tggagacagt ggtgtgcgtg ccggtgcctg
      901 tgcaagtggg tgcgggcccc agcgccctct ttgagaacgt gccccaggag gccctgggtg
      961 aggtggtggc cagctgcccc atgccaggca tggtgcccgg ctcacaggtg atcatcattg
     1021 cgggccctgg ttacgacgct ctcacggccg agggcattca cctcaacatg gcagcaggca
     1081 gcggtgtccc cggcagtgga ctgggcgagg aggtgccctg tgccatgatg gagggtgtgg
     1141 cagcctacac ccagacagag cccgagggta gccagcctag caccatggac gccaccgcag
     1201 tagcaggcat cgagaccaag aaagagaagg aggacctgtg cttgctaaag aaggaggaga
     1261 aggaggagcc agtagccccg gagctggcaa caacggtgcc tgagagcgca gagcctgagg
     1321 cagaggcgga cggggaggag ctggacggca gcgacatgtc agccatcatc tatgaaatcc
     1381 ccaaggagcc tgagaagagg cggcggagca agcggtcgcg ggtgatggat gctgacggcc
     1441 tgctcgagat gttccactgc ccatacgagg gctgcagcca agtctacgtg gccctcagca
     1501 gcttccagaa ccacgtcaat cttgtgcatc ggaaaggaaa gaccaaagtg tgccctcatc
     1561 ctggctgtgg caagaagttc tatttatcca accacctgcg gcggcacatg atcatccatt
     1621 caggtgtccg tgaattcacc tgcgagacct gcggcaagtc cttcaagagg aagaaccacc
     1681 tggaggtaca tcggcgcacc cacaccggcg agacccccct gcagtgcgag atctgtggct
     1741 accagtgccg gcagcgcgcg tcgctcaact ggcacatgaa gaagcacact gcggaggtgc
     1801 agtacaactt cacgtgcgat cgctgcggga agcgcttcga gaagctggac agcgtcaagt
     1861 tccacacgct caaaagccac ccggatcaca agcccacctg acccacctga ccactgaccg
     1921 cccctattta ttcgtccgct cggacaccac gcccgggctt gccggggcct ggacagctgc
     1981 gagggccgcc cggaccgcgg gccggaagga ggcgcccccg ccccgcccca gagctgggcc
     2041 ccctgggcag gttccccacc ccgccccacc gcatccttct cggagctggt gcctggggct
     2101 gcattgctgg aactgtgtca agagagcaga gtgagattaa agagcgagaa agga
//
