LOCUS       NM_001145365           11628 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 652 (ZNF652), transcript variant
            1, mRNA.
ACCESSION   NM_001145365
VERSION     NM_001145365.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11628)
  AUTHORS   Ke,H., Zhang,J., Wang,F. and Xiong,Y.
  TITLE     ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate
            Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in
            Bladder Cancer via Targeting miR-3666
  JOURNAL   J Immunol Res 2021, 7608178 (2021)
   PUBMED   34926705
  REMARK    GeneRIF: ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to
            Modulate Tumorigenic Properties and Nature Killer Cell-Mediated
            Toxicity in Bladder Cancer via Targeting miR-3666.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11628)
  AUTHORS   Cheng,C., Zhang,H., Dai,Z. and Zheng,J.
  TITLE     Circular RNA circVRK1 suppresses the proliferation, migration and
            invasion of osteosarcoma cells by regulating zinc finger protein
            ZNF652 expression via microRNA miR-337-3p
  JOURNAL   Bioengineered 12 (1), 5411-5427 (2021)
   PUBMED   34424826
  REMARK    GeneRIF: Circular RNA circVRK1 suppresses the proliferation,
            migration and invasion of osteosarcoma cells by regulating zinc
            finger protein ZNF652 expression via microRNA miR-337-3p.
REFERENCE   3  (bases 1 to 11628)
  AUTHORS   Laitinen,V.H., Rantapero,T., Fischer,D., Vuorinen,E.M.,
            Tammela,T.L., Wahlfors,T. and Schleutker,J.
  CONSRTM   PRACTICAL Consortium
  TITLE     Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and
            sequence variants associated with a genetic predisposition to
            prostate cancer
  JOURNAL   Int J Cancer 136 (10), 2316-2327 (2015)
   PUBMED   25335771
  REMARK    GeneRIF: Genetic association studies identify a novel variant in
            ZNF652 gene suggesting its role in prostate cancer.
REFERENCE   4  (bases 1 to 11628)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   5  (bases 1 to 11628)
  AUTHORS   Coviello,A.D., Haring,R., Wellons,M., Vaidya,D., Lehtimaki,T.,
            Keildson,S., Lunetta,K.L., He,C., Fornage,M., Lagou,V., Mangino,M.,
            Onland-Moret,N.C., Chen,B., Eriksson,J., Garcia,M., Liu,Y.M.,
            Koster,A., Lohman,K., Lyytikainen,L.P., Petersen,A.K., Prescott,J.,
            Stolk,L., Vandenput,L., Wood,A.R., Zhuang,W.V., Ruokonen,A.,
            Hartikainen,A.L., Pouta,A., Bandinelli,S., Biffar,R., Brabant,G.,
            Cox,D.G., Chen,Y., Cummings,S., Ferrucci,L., Gunter,M.J.,
            Hankinson,S.E., Martikainen,H., Hofman,A., Homuth,G., Illig,T.,
            Jansson,J.O., Johnson,A.D., Karasik,D., Karlsson,M., Kettunen,J.,
            Kiel,D.P., Kraft,P., Liu,J., Ljunggren,O., Lorentzon,M., Maggio,M.,
            Markus,M.R., Mellstrom,D., Miljkovic,I., Mirel,D., Nelson,S., Morin
            Papunen,L., Peeters,P.H., Prokopenko,I., Raffel,L., Reincke,M.,
            Reiner,A.P., Rexrode,K., Rivadeneira,F., Schwartz,S.M.,
            Siscovick,D., Soranzo,N., Stockl,D., Tworoger,S.,
            Uitterlinden,A.G., van Gils,C.H., Vasan,R.S., Wichmann,H.E.,
            Zhai,G., Bhasin,S., Bidlingmaier,M., Chanock,S.J., De Vivo,I.,
            Harris,T.B., Hunter,D.J., Kahonen,M., Liu,S., Ouyang,P.,
            Spector,T.D., van der Schouw,Y.T., Viikari,J., Wallaschofski,H.,
            McCarthy,M.I., Frayling,T.M., Murray,A., Franks,S., Jarvelin,M.R.,
            de Jong,F.H., Raitakari,O., Teumer,A., Ohlsson,C., Murabito,J.M.
            and Perry,J.R.
  TITLE     A genome-wide association meta-analysis of circulating sex
            hormone-binding globulin reveals multiple Loci implicated in sex
            steroid hormone regulation
  JOURNAL   PLoS Genet 8 (7), e1002805 (2012)
   PUBMED   22829776
REFERENCE   6  (bases 1 to 11628)
  AUTHORS   Callen,D.F., Ricciardelli,C., Butler,M., Stapleton,A., Stahl,J.,
            Kench,J.G., Horsfall,D.J., Tilley,W.D., Schulz,R., Nesland,J.M.,
            Neilsen,P.M., Kumar,R. and Holm,R.
  TITLE     Co-expression of the androgen receptor and the transcription factor
            ZNF652 is related to prostate cancer outcome
  JOURNAL   Oncol Rep 23 (4), 1045-1052 (2010)
   PUBMED   20204290
  REMARK    GeneRIF: High levels of expression of both the androgen receptor
            and ZNF652 in clinically organ-defined prostate cancer are
            associated with a statistically increased risk of relapse
REFERENCE   7  (bases 1 to 11628)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 11628)
  AUTHORS   Kumar,R., Cheney,K.M., McKirdy,R., Neilsen,P.M., Schulz,R.B.,
            Lee,J., Cohen,J., Booker,G.W. and Callen,D.F.
  TITLE     CBFA2T3-ZNF652 corepressor complex regulates transcription of the
            E-box gene HEB
  JOURNAL   J Biol Chem 283 (27), 19026-19038 (2008)
   PUBMED   18456661
  REMARK    GeneRIF: CBFA2T3 interacts with ZNF652 to repress HEB expression,
            and in addition CBFA2T3 interacts with the HEB protein to inhibit
            its activator function.
REFERENCE   9  (bases 1 to 11628)
  AUTHORS   Kumar,R., Manning,J., Spendlove,H.E., Kremmidiotis,G., McKirdy,R.,
            Lee,J., Millband,D.N., Cheney,K.M., Stampfer,M.R., Dwivedi,P.P.,
            Morris,H.A. and Callen,D.F.
  TITLE     ZNF652, a novel zinc finger protein, interacts with the putative
            breast tumor suppressor CBFA2T3 to repress transcription
  JOURNAL   Mol Cancer Res 4 (9), 655-665 (2006)
   PUBMED   16966434
REFERENCE   10 (bases 1 to 11628)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091180.20, DN998934.1, AK292667.1, BC152440.1 and AC004797.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001145365.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.13342.1, AK292667.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430262.3/ ENSP00000416305.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC091180.20        69201-69336         c
            137-828             DN998934.1         8-699
            829-1558            AK292667.1         683-1412
            1559-4778           BC152440.1         1278-4497
            4779-11628          AC004797.1         25276-32125
FEATURES             Location/Qualifiers
     source          1..11628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32-q21.33"
     gene            1..11628
                     /gene="ZNF652"
                     /note="zinc finger protein 652"
                     /db_xref="GeneID:22834"
                     /db_xref="HGNC:HGNC:29147"
                     /db_xref="MIM:613907"
     exon            1..342
                     /gene="ZNF652"
                     /inference="alignment:Splign:2.1.0"
     exon            343..1500
                     /gene="ZNF652"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..2421
                     /gene="ZNF652"
                     /codon_start=1
                     /product="zinc finger protein 652"
                     /protein_id="NP_001138837.1"
                     /db_xref="CCDS:CCDS32677.1"
                     /db_xref="GeneID:22834"
                     /db_xref="HGNC:HGNC:29147"
                     /db_xref="MIM:613907"
                     /translation="MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQEL
                     DLSTKVYKRESGSPYSVLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDD
                     TEEEEEEVSYKREQIIVEVNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEE
                     EATDDSNDYGENEKQKKKEKIVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVE
                     PPKRKKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDK
                     CGKKFVLESELSLHQQTDCEKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEIC
                     EKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDE
                     RFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSF
                     TSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPL
                     TTSPATPVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSHLHIHPHPHHPHHLPIPP
                     VPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKNSSAQHH"
     exon            1501..1648
                     /gene="ZNF652"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1764
                     /gene="ZNF652"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1909
                     /gene="ZNF652"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..11628
                     /gene="ZNF652"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6246..6251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF652"
                     /note="hexamer: AATAAA"
     polyA_site      6269
                     /gene="ZNF652"
     regulatory      7076..7081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF652"
                     /note="hexamer: TATAAA"
     polyA_site      7095
                     /gene="ZNF652"
                     /note="major polyA site"
     regulatory      7272..7277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF652"
                     /note="hexamer: AATAAA"
     polyA_site      7294
                     /gene="ZNF652"
     regulatory      7711..7716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF652"
                     /note="hexamer: AATATA"
     polyA_site      7732
                     /gene="ZNF652"
     regulatory      9838..9843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF652"
                     /note="hexamer: CATAAA"
     polyA_site      9860
                     /gene="ZNF652"
     regulatory      9928..9933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF652"
                     /note="hexamer: AATAAA"
     polyA_site      9963
                     /gene="ZNF652"
ORIGIN      
        1 gctcgcctcc ctccctgccc cctccggcac acacatccac acacgcacac cccctcccct
       61 gccgcccgcc ccgcgctgcc cgccccgccg gccccgctcg ccctcgcgcg ctgggaaggg
      121 agtcgcgaga cgtcggagcg gcggccacgt agcgctgcgg cggcagcggc agcggccgag
      181 gccgggtctg aggagcggcc ctgaggacag acgttgggca gggggggagg ggctggccca
      241 gccggcggtt gtgactcgag cgccgcggct gcaggccccc gccgcaggga tggaccgccg
      301 aggcggcggc cggggcggcg gaggcggagg cggccggccc ggataagatg ctcccaagtc
      361 ccttgcagct ctcttcagaa gaaaaatcac tagtgctctg ctcttgccat aataccaaac
      421 ctttttgact catgctttgg tgctgcaaca ctggaagaat tgcacacagt ttccaggaat
      481 atcttttttt catttgagtg attctttgtg gatgagaaaa gatttgagtc ttaataatta
      541 ccttgtttta aagctatttc tttatagtct gaactgttta ataaattggg ccacttacca
      601 atgagccaca cagccagttc ttgtcaggag ctggttgaaa actgtgctgt gcatgtagca
      661 ggaatggcac aagaagatag ccgtcgtggt caagtgccat cttcctttta tcatggtgcc
      721 aaccaagaac ttgacctgtc caccaaagtg tacaaaaggg aatcaggaag tccttattct
      781 gtgttagtgg acaccaagat gagcaaaccg catctccatg aaacagaaga acagccatat
      841 ttcagggaga caagagcagt gtctgacgtg catgctgtta aggaagaccg ggagaattct
      901 gatgacacag aggaggaaga ggaagaagtc tcttacaaaa gggagcagat catagtggag
      961 gtaaacctta ataatcaaac attaaatgta tctaaagggg aaaagggtgt ctcttctcag
     1021 tccaaagaga ctcctgttct taagacaagc agtgaggagg aagaggaaga gagtgaggaa
     1081 gaggccacag atgacagcaa tgactatgga gagaatgaaa agcagaagaa aaaggagaag
     1141 atagtagaga aagtcagcgt tacacaaagg agaaccagga gagctgcctc tgttgccgca
     1201 gctaccactt cccctactcc cagaactaca agaggtcgta ggaagagtgt agagccacct
     1261 aagcgtaaga agcgggccac aaaggagccc aaagcaccag tccagaaagc taagtgtgaa
     1321 gagaaagaga ctctgacctg tgagaagtgc cccagggtat ttaacactcg ctggtacctg
     1381 gagaagcaca tgaacgttac tcataggcgc atgcagattt gtgataaatg tggcaagaag
     1441 tttgtcctgg aaagtgagct gtcccttcac cagcaaacag actgtgaaaa aaacattcag
     1501 tgtgtttcct gtaacaaatc gttcaagaaa ctctggtccc ttcatgaaca tatcaagatc
     1561 gtccatggat atgcagaaaa gaaattttcc tgtgaaattt gtgagaagaa attctatacc
     1621 atggctcatg tgcggaaaca catggttgca cacacaaaag acatgccatt tacatgcgaa
     1681 acctgtggaa aatcattcaa acgcagtatg tcactcaagg tgcactcctt gcagcattct
     1741 ggagagaagc cctttagatg cgagaactgt gacgaaaggt ttcagtacaa gtaccagcta
     1801 cgctcccaca tgagcattca tattgggcac aaacagttca tgtgccagtg gtgtggcaag
     1861 gatttcaaca tgaagcagta cttcgacgaa cacatgaaaa cacacactgg agagaaaccc
     1921 tttatctgtg aaatctgtgg caaaagcttc accagccgcc ccaacatgaa gagacaccgc
     1981 agaactcaca caggcgagaa gccctatcca tgtgatgtgt gtggccagcg gttccgcttc
     2041 tcgaacatgc ttaaggccca caaggagaag tgctttcggg tgaccagccc cgtgaatgtg
     2101 ccacctgctg tccagatccc acttacaact tccccagcca ccccagttcc ttctgtggtg
     2161 aacacagcca caaccccaac ccctccaatc aatatgaatc ctgtaagcac tcttccccct
     2221 cggcccatcc cccacccctt ctcacacctg cacatccacc cacaccctca ccacccacac
     2281 caccttccca tccctccagt ccctcacctc ccgccacctc cagctctctt taagagtgag
     2341 cctttaaatc atagaggcca gagtgaggac aactttctgc ggcacctggc agagaagaac
     2401 agttcagcac agcatcatta acatccgtct ccttagtgtg ttctccagga gacacgtccc
     2461 catgtgtgag cgtgcacaga gggagtcggt gagcatttcc ttagttctca gactctcctc
     2521 cgcctctacc aagagcttcg ccagtgtcac tgaatcaaca gatccaaggg aatgaacaag
     2581 aagactacct tgagctcaca gagggactgt catctaaacc aggggaacca ctgaactaaa
     2641 gcccaatttg cttgcatttt ctgatgactt ttataagttt caaatactca gacttgtgga
     2701 attttataat ttcatatcag ctgatgaggt atgcttgctt ttatatccca gacttctcct
     2761 caaagagggg ataggcctgg tttcctttgt actaatcggg aaggctgtga gattaatcca
     2821 gagcattaat tgtatcactg tgtatggtaa ggaattcttt tcagcttttg gtgccagcta
     2881 cagagttgag ctggccatgt ttcacagtat atcaagcatt atagagaaag acagaaattt
     2941 tcttctttgt gtagctctcc taacgcactc tttattttac tacagaaatt attttagagt
     3001 ttttgtatag acttctttgg tagtctgttt ctaaaatgaa atgtatttca ataagcagtg
     3061 taattttttc agtgtagctg aacctatgtt gtaaaataga aaaaaatttt tataatcatc
     3121 aaaatgtgat tcttaaagat gcatataact tctataattc aaagctattc ttacatccgt
     3181 acaactcaaa aggtgcttca gagactagat gtatctgaga gggtctccag accaggttac
     3241 tgcaaaaatg aggttttgct ttcaggattt ggcgtaaata cttggtagtt ttgacatctc
     3301 tgcttaacac tcaagagagg ctccctaatg tgctcctgtc ctccatgttc tgcttggctt
     3361 cgttagtgca ttacatgaaa tgatttgcag gggatggggc cttttccagg gaagtcacct
     3421 aaagcttgca tgttttgaaa atttgaataa ggctgtttgc tgacaggagg aggaagtagt
     3481 ggagatcatt tcatctcagt cacgtctgtt tctcacttcc cttaggaatt gtgttgatgt
     3541 ttaactttta tgggatgaca aattgaaatc gctcattttg aggttgcttt atttttctag
     3601 aattgttata agaagctaaa atagtaaact taaaatcaca aacatgacat tgctgatagt
     3661 ggctgagaaa ttcagatgag aagacaaatt ggttatgaat tttgaaatat ctattatatg
     3721 taaaatgtgg atatgttcac aaccttgagc tattttaaca cagtttaaat atagtgaggg
     3781 aaaactccta agttttactg ccctgtcctc tgcaaattat gtaataccag cattcttagg
     3841 cgataaagag agcagcacct ctagtacctt taggcagatt actttttcaa gtttggggaa
     3901 cttcaaaaga ccataatcaa ccaggagctt attataggaa aggctgaaca gaagggctag
     3961 tgtattgatt acacttaaca gatcatattt atccagactc agtatagctt aaaattttgt
     4021 atttctttat ctgagagaac tgagttccca ggctaaatca cttacctccc accccctctc
     4081 caattttttt tttaagagac aaggtcttgc tatgttgccc aggctagagt gcagtggcta
     4141 ttcacaggtg cagttatagc acactacagc ctccaactct tgggttcaag caaccctgcc
     4201 tcagctaacc aagtagctgg gactacaggt gcatgctacc atgcccagtc cattttttaa
     4261 tcttgaaatt tcttcatttt tctttcttcg gtttcttaaa atctttgcct gaatcagaac
     4321 gctggctttt atttattttt ttatttttaa tattaaatgt gcagatatgc ttcgagcact
     4381 tttctaacta atgagctctg tggtaagaaa aaatgaactc tttcaattga gattaagtcc
     4441 atatttttca aacatcacgt tctctattgg ctttttggtt tagtgtttct aaattttctc
     4501 cttctgattt tgcctgtctt atataatgag cataggaaaa ttttggaatg aggcagaaaa
     4561 gtatatcaag acatacttcc tggttttgga tgtaagtttt aaagaatggt atttttaata
     4621 tttgtacaca ttctttgagc acccaggtac ccaagccaat aaggaaagtt aattccttgc
     4681 atatgactgt tatatcttta gtggttgtct ccctctccct ccacagtctc cttggcattc
     4741 catgacaagt ttgtcaacct acacttttat atagacatat cattatttca tggtcaagcc
     4801 tgtagtatta aaatgatttt tttaaaagat gtaaactgtg cttagttaat tggttatatt
     4861 ttgttctgtt tttttttttt tttttttttt ttttttgagg cagagtcttg ttctgttgcc
     4921 tgggctggag tgcagtggcg tgatcttggc tcactgcaac ccccgccccc cgggttcaag
     4981 tgattctcct gcctcagcct cccgagtagc tggaattaca ggcatgcgcc agcacgcccg
     5041 gctaagtttt gtatttttgg cagagatggg gtttcaccat attggccagg ctggtctcaa
     5101 actcctgacc ttgtgatccg cccacctcag cctccgaaag tgctgggatt acaggcgtga
     5161 gccaccacgt ccaactgcct tattttgttc tgaataaatt tacagtattg ggcagcaatt
     5221 ctggattcta gacttgagac cacagaatca accatttcat gaggttgtac tgtaattata
     5281 cactggaata ttcaggtagt catctttgat ttttcattca agtaaatata gccataagaa
     5341 aatatctgct atacaggaaa accagtatta agcaaatacc accatcctta acagaaacaa
     5401 aaatatatat atatattatt tttaaaaatt agcattgtca tacagtacaa ttcttagtga
     5461 agtgtattgt ggaacaattt agaaacttcc tttttttccc ctagattaag gatactttcc
     5521 ttgacttgag acttgtggtc ttcaggaaaa ctactcagaa tataatgact cctcatcagt
     5581 atcatattgt atataaataa tgaaatgcat taagaatatt cacaacattg aacccaggag
     5641 gcggagcttg cagtgagccg agattgcgcc actgcgctcc agcctgggca acagagcgag
     5701 actccatctc aaaaaaaaaa aaaaaaagaa tattcacaac attaatgctt ctgaatagaa
     5761 gaactgcagg attaagcctt aaacatatat gtgcaacacg tttaacatgc ttaagactca
     5821 aactcagggt tgaaaatttg gttggggtcc tctttgtaag ataaaagttg cattatgtgg
     5881 tatgttctct tccatatatg ctacagcacc ccatgaattc ttcaaaactt tttacctact
     5941 tgttatctgt ttatgaaaaa aagaattatg gagaagtttg agttctcagc ccttatctgt
     6001 acatgtctgt taaagacaac aaaggctgca tttaagcatt atatagataa caaattgagg
     6061 ctgtctctcg ttacttagtt ttactgtctt caaaggcttg tatcattgct agggttaaga
     6121 cttatttgag gatgagttgg cattgtattt tttgtgtgtg tgggttggtt tgtatttgtt
     6181 tcgtttttat ttttctattt tctctcatag atttatcagt aaaatataaa ctcttcctta
     6241 gccttaataa aggctgctgc tttctcaaat tgagtcagat aggctcattc ggagttagat
     6301 ttttaaattt gaatgaagaa aagacaacaa tttaaaggca tgtggcttca tttccacata
     6361 tatttgtgac tggattctta tttttagcaa gaggggagat cgccacaaaa aaaactttag
     6421 ttcaaagaag actgtgcaaa tcagttacct gtactttcat agtctaccat ttacattaac
     6481 tgttctagat taatgactaa gcatggccat taccataatt acatcatttt tttaaaacca
     6541 catttgttcg aagtatcctt ttctagtggt tagaactgtc cctataattt gattgtccct
     6601 catatactaa ccgaaagcaa aatgctctga tgagatgctt ataaactatg aattttttaa
     6661 ttcttgaaat ttttttcagt ttttatgatt gttgaataga tatgtatgtt tagttccatt
     6721 attatttcac tggaagtttt aaattttgag aagatgaagc agagatagaa atccattgca
     6781 gatatatgta tatttacccc atcttgcagg tttcagttag taaaacacag aatgataggt
     6841 cggttttaat gttttaaaaa aaaactaaaa aactaaagtt agagaaacct ttctgtttga
     6901 gctactgtat agaaaagaca acttttattg cattgctggt ccacatgata aatatttcaa
     6961 tgctgttcta gactgtatga gaagtactta atgaaaaaag ggatacatta catttaagaa
     7021 ttgtatcagc taattactgt tttaaaaaaa tcaactcatt tggaattctt cggactataa
     7081 aattgagcaa gtaaagtttg ggttttaatt ttcctttgcc tgaaccaaga taggaaatta
     7141 cttaagagtt tttttttttt tttttttttt ttttttttag gaatgaaagg tcataagcca
     7201 ttagaaatag tggcattatt atgcaataac aacaccctag ctaacctgct tttgtcatct
     7261 gtagcactta caataaagaa tgatgacctt ccaaccctgg acactacctc gataaagcaa
     7321 accagagatc ctctctacac tttctatgga agccataaaa gttgccatca atatatccac
     7381 tttcatagtt ctatactttt atactttcta gactttttta tagactttat gatcagatct
     7441 ttttgtctca gaggataggt tttgcaagat tcaaaggaaa atcaaactcc ttggttgttc
     7501 cagctttgaa gcttttgctt cagtaaattt gtttaaagaa ccagatcaca taccatttat
     7561 caaattcttt acttaagtca gaatactttg cagacataca tatttggaaa acaaactgtt
     7621 tcttgttcac tagatagaat ctgtattgta gtaagaaact acttacaagg tggctttctt
     7681 tctgctttgt tactctatgt attactcaat aatatatgta tggtcacagg ttcctggagt
     7741 tgttttattt ctttatgaca gacacatgag tatgcacctc tctctaatcc tctgatgtca
     7801 ctgcagcttc agtctctctc actctgtttt tgagtgcctt caaaatgcca gcatcctgga
     7861 acattctttt cctgatctaa atcctacctc tgactatttc attatccatg aatattggaa
     7921 ttcacccata ttccaatggg cttaactcta caaactagct aaaaccttgg acaagaattt
     7981 tgaccgtatt tctgttttgt tcctccatgt catttttagg ttatattttt aacttttatt
     8041 tatatcttat ttcttcacat atttcgtctc tctgttgaaa gattttatcc ttatttgact
     8101 cttcactttt tttactttca ccagaaattt gacgttcctt taaaattaaa ggtcattgaa
     8161 tgtcttttga acaccttttt ctcaactgaa gtcttcctga atgcctcccc tttctgatga
     8221 aaggatcctg agtgctgctg ttgctctgcc ctgttcccat gtgcccactc ccttccgtac
     8281 acattttgca agactatact ctttatttta gtcaaattaa tttaaaattg ctccctgggt
     8341 ttctgctctc tcatggccct gtccctcaaa aacttctgtt tactttttct agctgttttc
     8401 atctaatttg tttaaaatgt atgatggatc cataatatat gaaggatgta atgaaaagga
     8461 ggttgcagtg ttttatataa tatgatcgag cacctccgtg atgaaacatt tagcaattgg
     8521 ctagtccttc acagccagag tggaagtttg tgctgtggac aggtcttttt actcccttcc
     8581 agttctcctc caaaactgga gaaaaaggaa aaaaaaaaag aactctttca aatgaggaga
     8641 tttgattgca tttttttagg tgaatgaaag cttggagttg agcatttggg ccttagtcag
     8701 catttttcct ttctgactta aaatctcatg tccttttcct taaagttaat agtactcagg
     8761 tttttaagac taataaccac acaaggtggg tatctaagaa ggcagctgtt aatacattct
     8821 ccatctttcc tgtctggcaa caggaaagat attattggtg agatagtgca aaattgtgag
     8881 aattggttat gtttgatgat gaataaattc aagatttttg aaggcttcac tgctatttgg
     8941 gatgggaagg tgagtttaca aaatgaaaaa ggtagatttt tatgttacag aaatcagtaa
     9001 cgggtttctt gttgtgttaa ttacctttca cttgatttgc catgatgttt cttcctcatt
     9061 attgatctag aagtttgcct cttggatagt aactagtaac ttagtatcta ctttaaaatt
     9121 tgtggctttt ctcttcaggg tcccaggcca taaaacaacg gagagctgta cttgcttgtc
     9181 acttggagga accacatcct tgagacagcc tgctgtcttg tatgtcttca gtaggaaact
     9241 tctgacacac acattcaagg gagttcctgc ccctgagaag tgttcccata gctttccagt
     9301 cgcaggttac tttcacacta cgtcagcttc tctggtgaga tcagggatgt tacatattac
     9361 ttgaaaatga tttcatagga agtgaggatg gggcaagaaa ggaggtagaa gctgaatttt
     9421 gcttaacttc agaaggaaat ctgatacttg ccttggctag ttctgatcaa ctaaagagcc
     9481 tgtgtctgta ctggatgtgc caaagagtca agttgtttct ggaatatcca gctcctctga
     9541 atgaacacag cttcctccct acctgtcttt tatgggtgaa aagggaccgt ctgatgagca
     9601 tgatagacat cctgtacagg actcaagact gtttcattgc atttgaaagt tggtgggaag
     9661 tattttattc tgctagagct cctaaccctc ctagaaatat cttttcatgc tctattaatt
     9721 caattcatta gtttaaaaag aaacagtgtg acataatttt ggtgtttact tcttaagttg
     9781 tctccccaag ggcatatatg tagcctctga aaatgggatg atttcttctc aatcttccat
     9841 aaatttgaat atgcatttta ttcatttctt gacatgggct gtgtgactgt tttccatcag
     9901 cagttctggc tttgtccaca agggagcaat aaagtacgtt agctttattc tcaaccttct
     9961 aaagaaagat cccactttta aatctcttct ggaatagcct cttagctcaa agcttattca
    10021 tgtattttga ttatttaaga aattttccct tattacaaag tccagtcgtc gttcatccct
    10081 catgatgcca agcaatgatt gatgtgtggg tgtggagtcc ttgtgggtca ggcatcttaa
    10141 ttaattagac tttttacata ttgatgatcc ccagattgaa agccaggacc ttcccatagg
    10201 ggcgcctttg tgtgctaaag gcagagcagg caggcttctc cactcctatc tcctccgcag
    10261 gccaccacca tcacatctat aggaggaaca agagcactgg gggaactctg gagtatgagt
    10321 aaggaaatgc ttctcacctt ctctgctcca aagagatatc tgttacatca gggaacaagt
    10381 cctctaggtc aggcacttcc tcctgaccag tgcaacgggc actccaggtt agaaactgtg
    10441 tgtgctccct ctctgtcagt tacttgtcta agggctccta tccgtggtca tcagctctct
    10501 ggccatgagt tctgtttgtg cttattgcag cagcatcttc acaacaaaca ggtcagtaat
    10561 caacctggga agggaaaaga cgacagtaaa tattaccccc tgtagagccg ggaggcattt
    10621 acacctggaa tggccttctt aactgatttc tgcctggcca cctcaccccc agccaagtct
    10681 gaacctgagc aataccaggc acagagaggt gtctacttgt aactccaaca cttgacaaaa
    10741 aacaaaactg aagctgtgat tggtttaggc agcaagtggc caggtgcaac ttgtttgttt
    10801 ttatttttgt tttccccaac agtactgaga tcacttgcac ttttcctcat ttcttaagaa
    10861 aatccagttt gcttgccatg acttgtttag cgttaggttt acaaagcttg ttgttgaatg
    10921 ttgaatattt gtccaaagga gtttgacaaa atagaagctg cttggtccct gttctgcctg
    10981 ctaggtcata aggatgaagg ccatgtggct ggggtactta tgtcaagtcc agaatggggc
    11041 agtgtccctc tcctacctct ctgcggagac gcaattgaag gtcaagtaga ctcagtgtag
    11101 ggcaggcagc tgtcatgctg caaagaagtt tagaggagtc tttgggttgg ggaggtgaca
    11161 ggtaggtagg acaggatctc ttaagatggg aaagatactg gggagaggag ggctgcttgg
    11221 ccccagggaa ctgcagtgag gtggaactga gctccgctcc tgaatctcca aaggagccca
    11281 tgctgcccgg cttccctgag tcattttttc cagcatcctg tcagatccct caatgtactg
    11341 atttccccct tgtgttaact ataccgatat tattttttta gcaattgaaa tgcacttttt
    11401 tatttcaact caatcatgat tttaagtata aaaaatttat agattgttaa aactactttt
    11461 ttgtgtattt ttaaccactc aatgtagcat tgtatatttt attcttgtga gactctggta
    11521 caggtgtgcc gcctaatgat ttttctgaga tgctgggcct ttggatgtgt acggtaacca
    11581 acttaatgct aatgttcaaa gtaaaaaaaa aaaaaaaaag cagccata
//
