LOCUS       NP_001138837             606 aa            linear   PRI 30-APR-2025
DEFINITION  zinc finger protein 652 [Homo sapiens].
ACCESSION   NP_001138837
VERSION     NP_001138837.1
DBSOURCE    REFSEQ: accession NM_001145365.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 606)
  AUTHORS   Ke,H., Zhang,J., Wang,F. and Xiong,Y.
  TITLE     ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate
            Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in
            Bladder Cancer via Targeting miR-3666
  JOURNAL   J Immunol Res 2021, 7608178 (2021)
   PUBMED   34926705
  REMARK    GeneRIF: ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to
            Modulate Tumorigenic Properties and Nature Killer Cell-Mediated
            Toxicity in Bladder Cancer via Targeting miR-3666.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 606)
  AUTHORS   Cheng,C., Zhang,H., Dai,Z. and Zheng,J.
  TITLE     Circular RNA circVRK1 suppresses the proliferation, migration and
            invasion of osteosarcoma cells by regulating zinc finger protein
            ZNF652 expression via microRNA miR-337-3p
  JOURNAL   Bioengineered 12 (1), 5411-5427 (2021)
   PUBMED   34424826
  REMARK    GeneRIF: Circular RNA circVRK1 suppresses the proliferation,
            migration and invasion of osteosarcoma cells by regulating zinc
            finger protein ZNF652 expression via microRNA miR-337-3p.
REFERENCE   3  (residues 1 to 606)
  AUTHORS   Laitinen,V.H., Rantapero,T., Fischer,D., Vuorinen,E.M.,
            Tammela,T.L., Wahlfors,T. and Schleutker,J.
  CONSRTM   PRACTICAL Consortium
  TITLE     Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and
            sequence variants associated with a genetic predisposition to
            prostate cancer
  JOURNAL   Int J Cancer 136 (10), 2316-2327 (2015)
   PUBMED   25335771
  REMARK    GeneRIF: Genetic association studies identify a novel variant in
            ZNF652 gene suggesting its role in prostate cancer.
REFERENCE   4  (residues 1 to 606)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   5  (residues 1 to 606)
  AUTHORS   Coviello,A.D., Haring,R., Wellons,M., Vaidya,D., Lehtimaki,T.,
            Keildson,S., Lunetta,K.L., He,C., Fornage,M., Lagou,V., Mangino,M.,
            Onland-Moret,N.C., Chen,B., Eriksson,J., Garcia,M., Liu,Y.M.,
            Koster,A., Lohman,K., Lyytikainen,L.P., Petersen,A.K., Prescott,J.,
            Stolk,L., Vandenput,L., Wood,A.R., Zhuang,W.V., Ruokonen,A.,
            Hartikainen,A.L., Pouta,A., Bandinelli,S., Biffar,R., Brabant,G.,
            Cox,D.G., Chen,Y., Cummings,S., Ferrucci,L., Gunter,M.J.,
            Hankinson,S.E., Martikainen,H., Hofman,A., Homuth,G., Illig,T.,
            Jansson,J.O., Johnson,A.D., Karasik,D., Karlsson,M., Kettunen,J.,
            Kiel,D.P., Kraft,P., Liu,J., Ljunggren,O., Lorentzon,M., Maggio,M.,
            Markus,M.R., Mellstrom,D., Miljkovic,I., Mirel,D., Nelson,S., Morin
            Papunen,L., Peeters,P.H., Prokopenko,I., Raffel,L., Reincke,M.,
            Reiner,A.P., Rexrode,K., Rivadeneira,F., Schwartz,S.M.,
            Siscovick,D., Soranzo,N., Stockl,D., Tworoger,S.,
            Uitterlinden,A.G., van Gils,C.H., Vasan,R.S., Wichmann,H.E.,
            Zhai,G., Bhasin,S., Bidlingmaier,M., Chanock,S.J., De Vivo,I.,
            Harris,T.B., Hunter,D.J., Kahonen,M., Liu,S., Ouyang,P.,
            Spector,T.D., van der Schouw,Y.T., Viikari,J., Wallaschofski,H.,
            McCarthy,M.I., Frayling,T.M., Murray,A., Franks,S., Jarvelin,M.R.,
            de Jong,F.H., Raitakari,O., Teumer,A., Ohlsson,C., Murabito,J.M.
            and Perry,J.R.
  TITLE     A genome-wide association meta-analysis of circulating sex
            hormone-binding globulin reveals multiple Loci implicated in sex
            steroid hormone regulation
  JOURNAL   PLoS Genet 8 (7), e1002805 (2012)
   PUBMED   22829776
REFERENCE   6  (residues 1 to 606)
  AUTHORS   Callen,D.F., Ricciardelli,C., Butler,M., Stapleton,A., Stahl,J.,
            Kench,J.G., Horsfall,D.J., Tilley,W.D., Schulz,R., Nesland,J.M.,
            Neilsen,P.M., Kumar,R. and Holm,R.
  TITLE     Co-expression of the androgen receptor and the transcription factor
            ZNF652 is related to prostate cancer outcome
  JOURNAL   Oncol Rep 23 (4), 1045-1052 (2010)
   PUBMED   20204290
  REMARK    GeneRIF: High levels of expression of both the androgen receptor
            and ZNF652 in clinically organ-defined prostate cancer are
            associated with a statistically increased risk of relapse
REFERENCE   7  (residues 1 to 606)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   8  (residues 1 to 606)
  AUTHORS   Kumar,R., Cheney,K.M., McKirdy,R., Neilsen,P.M., Schulz,R.B.,
            Lee,J., Cohen,J., Booker,G.W. and Callen,D.F.
  TITLE     CBFA2T3-ZNF652 corepressor complex regulates transcription of the
            E-box gene HEB
  JOURNAL   J Biol Chem 283 (27), 19026-19038 (2008)
   PUBMED   18456661
  REMARK    GeneRIF: CBFA2T3 interacts with ZNF652 to repress HEB expression,
            and in addition CBFA2T3 interacts with the HEB protein to inhibit
            its activator function.
REFERENCE   9  (residues 1 to 606)
  AUTHORS   Kumar,R., Manning,J., Spendlove,H.E., Kremmidiotis,G., McKirdy,R.,
            Lee,J., Millband,D.N., Cheney,K.M., Stampfer,M.R., Dwivedi,P.P.,
            Morris,H.A. and Callen,D.F.
  TITLE     ZNF652, a novel zinc finger protein, interacts with the putative
            breast tumor suppressor CBFA2T3 to repress transcription
  JOURNAL   Mol Cancer Res 4 (9), 655-665 (2006)
   PUBMED   16966434
REFERENCE   10 (residues 1 to 606)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091180.20, DN998934.1, AK292667.1, BC152440.1 and AC004797.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.13342.1, AK292667.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430262.3/ ENSP00000416305.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32-q21.33"
     Protein         1..606
                     /product="zinc finger protein 652"
                     /calculated_mol_wt=69613
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     Region          71..113
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     Site            100
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A1L1J6; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     Site            103
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:A1L1J6; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     Region          130..235
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     Site            197
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     Site            204
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     Region          <240..304
                     /region_name="PLN03086"
                     /note="PRLI-interacting factor K; Provisional"
                     /db_xref="CDD:178635"
     Region          247..266
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          274..293
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          301..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          331..351
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          359..379
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <381..464
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          387..407
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(392,394,396,398..399,402..403,406,420,422,426..427,
                     430..431,434,448,450,452,454..455,458..459,462)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          415..435
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..>488
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          443..463
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          455..478
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          471..487
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          498..606
                     /region_name="Mediates interaction with CBFA2T3.
                     /evidence=ECO:0000269|PubMed:16966434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2D9.3)"
     CDS             1..606
                     /gene="ZNF652"
                     /coded_by="NM_001145365.3:601..2421"
                     /db_xref="CCDS:CCDS32677.1"
                     /db_xref="GeneID:22834"
                     /db_xref="HGNC:HGNC:29147"
                     /db_xref="MIM:613907"
ORIGIN      
        1 mshtasscqe lvencavhva gmaqedsrrg qvpssfyhga nqeldlstkv ykresgspys
       61 vlvdtkmskp hlheteeqpy fretravsdv havkedrens ddteeeeeev sykreqiive
      121 vnlnnqtlnv skgekgvssq sketpvlkts seeeeeesee eatddsndyg enekqkkkek
      181 ivekvsvtqr rtrraasvaa attsptprtt rgrrksvepp krkkratkep kapvqkakce
      241 eketltcekc prvfntrwyl ekhmnvthrr mqicdkcgkk fvleselslh qqtdcekniq
      301 cvscnksfkk lwslhehiki vhgyaekkfs ceicekkfyt mahvrkhmva htkdmpftce
      361 tcgksfkrsm slkvhslqhs gekpfrcenc derfqykyql rshmsihigh kqfmcqwcgk
      421 dfnmkqyfde hmkthtgekp ficeicgksf tsrpnmkrhr rthtgekpyp cdvcgqrfrf
      481 snmlkahkek cfrvtspvnv ppavqipltt spatpvpsvv ntattptppi nmnpvstlpp
      541 rpiphpfshl hihphphhph hlpippvphl ppppalfkse plnhrgqsed nflrhlaekn
      601 ssaqhh
//
