LOCUS       NM_001009992            3649 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens zinc finger protein 648 (ZNF648), mRNA.
ACCESSION   NM_001009992 XM_060597
VERSION     NM_001009992.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3649)
  AUTHORS   Ferguson,D.C.J., Mokim,J.H., Meinders,M., Moody,E.R.R.,
            Williams,T.A., Cooke,S., Trakarnsanga,K., Daniels,D.E.,
            Ferrer-Vicens,I., Shoemark,D., Tipgomut,C., Macinnes,K.A.,
            Wilson,M.C., Singleton,B.K. and Frayne,J.
  TITLE     Characterization and evolutionary origin of novel C2H2 zinc finger
            protein (ZNF648) required for both erythroid and megakaryocyte
            differentiation in humans
  JOURNAL   Haematologica 106 (11), 2859-2873 (2021)
   PUBMED   33054117
  REMARK    GeneRIF: Characterization and evolutionary origin of novel
            C<sub>2</sub>H<sub>2</sub> zinc finger protein (ZNF648) required
            for both erythroid and megakaryocyte differentiation in humans.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3649)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3649)
  AUTHORS   Leger,P.D., Johnson,D.H., Robbins,G.K., Shafer,R.W., Clifford,D.B.,
            Li,J., McLaren,P.J. and Haas,D.W.
  TITLE     Genome-wide association study of peripheral neuropathy with
            D-drug-containing regimens in AIDS Clinical Trials Group protocol
            384
  JOURNAL   J Neurovirol 20 (3), 304-308 (2014)
   PUBMED   24554482
REFERENCE   4  (bases 1 to 3649)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   5  (bases 1 to 3649)
  AUTHORS   Qi,L., Qi,Q., Prudente,S., Mendonca,C., Andreozzi,F., di Pietro,N.,
            Sturma,M., Novelli,V., Mannino,G.C., Formoso,G., Gervino,E.V.,
            Hauser,T.H., Muehlschlegel,J.D., Niewczas,M.A., Krolewski,A.S.,
            Biolo,G., Pandolfi,A., Rimm,E., Sesti,G., Trischitta,V., Hu,F. and
            Doria,A.
  TITLE     Association between a genetic variant related to glutamic acid
            metabolism and coronary heart disease in individuals with type 2
            diabetes
  JOURNAL   JAMA 310 (8), 821-828 (2013)
   PUBMED   23982368
REFERENCE   6  (bases 1 to 3649)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355482.13.
            
            On Jan 22, 2005 this sequence version replaced XM_060597.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128654.1, BC137223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339948.3/ ENSP00000344129.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL355482.13        11264-11408         c
            146-3649            AL355482.13        4266-7769           c
FEATURES             Location/Qualifiers
     source          1..3649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..3649
                     /gene="ZNF648"
                     /note="zinc finger protein 648"
                     /db_xref="GeneID:127665"
                     /db_xref="HGNC:HGNC:18190"
     exon            1..145
                     /gene="ZNF648"
                     /inference="alignment:Splign:2.1.0"
     exon            146..3649
                     /gene="ZNF648"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1915
                     /gene="ZNF648"
                     /codon_start=1
                     /product="zinc finger protein 648"
                     /protein_id="NP_001009992.1"
                     /db_xref="CCDS:CCDS30952.1"
                     /db_xref="GeneID:127665"
                     /db_xref="HGNC:HGNC:18190"
                     /translation="MAQVDSQDRWGEASPLSSLTEEAHDTQMLSMNLESDDEDGGEAE
                     KEGTADPVACPRGSSPVTHENPDLPWPHPLGKEEEKFSDSSSAGGMGQKPVEMSGKAS
                     WSRDVTKINETQGSPGASRALGSLPSGLAHKLLGQMQPLGDRLPAGDDGYSGANQDAV
                     LDVPPSFPSNGKYLCAHKSVDTSAGNSSLLCFPRPGSNWDLPTQETHTPAQASATPAS
                     LAAAVLAKARNSRKVQNQAGRREGGEAEARPYRCLRGGRAFQKPSKPLSPAETRGGAA
                     KRYACELCGKAYSHRGTLQQHRRLHTGERPYQCSFCDKAYTWSSDHRKHIRTHTGEKP
                     YPCPDCGKAFVRSSDLRKHQRNMHSNNKPFPCSECGLTFNKPLSLLRHQRTHLGAKPF
                     RCPACDREFAVASRMVEHQRVHSGERPFPCPTCGKCFTKSSNLSEHQTLHTGQRPFKC
                     ADCGVAFAQPSRLVRHQRIHTGERPFPCTQCGQAFARSSTLKRHQQIHSGEKGFLCAE
                     CGRAFRIASELAQHIRMHNGERPYQCEDCGQAFTRSNHLQRHRAKHGTCKKEPIPSSS
                     DE"
     regulatory      3628..3633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF648"
                     /note="hexamer: AATAAA"
     polyA_site      3649
                     /gene="ZNF648"
                     /note="major polyA site"
ORIGIN      
        1 ctctgcagcc gctggactgg acacaaagcg tgagagacag agacaccatc tctgctgatt
       61 tgtacctaac tggttcctgt tgctgagagc ccacgtgtca cagaagccag ggcagaggcc
      121 ccacactgct gtctgcattt cccaggtatc ctgagccaag caggatactc ctcctcagag
      181 gagtaggcaa tagaagcgcc tgaacatcat ggcacaagtg gactcccagg acaggtgggg
      241 agaggcgtct cctctcagca gcttgactga ggaagctcat gacacccaga tgctgagcat
      301 gaacttagag agtgacgatg aagatggtgg ggaggccgaa aaagagggca ccgctgaccc
      361 ggtggcctgt ccaaggggca gctccccagt aacacacgaa aatcctgact tgccatggcc
      421 ccatccactg ggcaaagagg aagagaaatt ctctgactcc tccagtgctg ggggcatggg
      481 gcagaaacca gtggaaatgt ctgggaaagc cagttggagc agagatgtga caaagatcaa
      541 cgagacccag ggttccccgg gagcaagcag agctctgggt tcccttccca gtggtctcgc
      601 acacaaattg ttaggtcaga tgcaacctct tggggaccga ctacctgcgg gtgatgatgg
      661 atactcgggg gcaaaccagg acgcagtctt ggatgtccca cccagcttcc ccagcaatgg
      721 aaagtatctc tgtgcgcaca aaagtgtaga cacgtccgca gggaactctt ctctgttgtg
      781 tttccccagg ccggggagca actgggacct tcccacgcaa gagacacata caccagccca
      841 ggcgtcggcc accccagcca gcctggctgc cgcggtcctg gcaaaagcgc ggaacagcag
      901 gaaagtacag aaccaggcgg gccggcgcga gggcggagag gctgaggcgc gtccctacag
      961 gtgcctgcgg ggcgggcggg cctttcagaa gcccagcaag ccgctgagcc ccgcggagac
     1021 gcgcggcggc gccgccaagc gctacgcgtg cgagctatgc gggaaggcct actcccaccg
     1081 cggcacactc cagcagcaca ggcgcctgca cacgggcgag cggccctacc agtgctcctt
     1141 ctgcgacaag gcctacacct ggtcctccga ccaccggaag cacatccgca cccacacagg
     1201 cgagaaaccc tacccgtgtc cagactgcgg gaaggccttc gtgcgctctt cggacctgcg
     1261 caaacaccag cgcaacatgc acagcaacaa taagcccttc ccgtgctccg agtgcggcct
     1321 gaccttcaac aagccgctgt cgctgctgcg ccaccagcgc acgcacctgg gcgccaagcc
     1381 cttccgctgc cccgcctgcg accgggagtt cgctgtggcc agccgcatgg tggagcacca
     1441 gcgcgtgcac tcgggcgagc ggcccttccc ctgccccacc tgcggcaagt gcttcaccaa
     1501 gtcctccaat ctgtccgagc accagacgct gcacaccggc cagaggcctt tcaagtgcgc
     1561 tgactgcggc gtggccttcg cgcagccctc gcgcctcgtg cgccaccagc gcatccacac
     1621 tggcgagagg ccctttcctt gcacgcagtg tggccaggcc tttgcccgct cttcgaccct
     1681 gaagcggcac caacagatcc actccgggga gaagggattc ctctgtgccg agtgcggcag
     1741 ggccttccgc attgcctctg agttggccca gcacatacga atgcacaacg gagagaggcc
     1801 ctaccagtgt gaggactgcg gccaggcctt caccaggtcc aatcacctcc aacgacaccg
     1861 agccaagcac ggcacctgca agaaggagcc catcccttcc tcctctgacg agtgaagata
     1921 gcatcgtcga cctcactact tggaaccttc ccaggtgggc ccactcacat ggtattgcca
     1981 gcctcactgg tcagcctcgc ctcccagcag gtcgcgggtc atcagtggtc catttgatta
     2041 tttatttgat cccttgaaca gaaagtcacc accgagagag cacccaggtg ggtggtttca
     2101 catcagtggt tctgagtgtc cgaggtcata agcaattgga aaagggaaag acaaagtagt
     2161 gggagctgat caaacgttga gttccttggg ttggggaacc tgaatcaatc agaaactgct
     2221 tctagaatta catgctgggc actgggccgg gctccaggga taaggtgggg aaaaagacta
     2281 acctgtccta ccctcaaagc catatgcaaa tactgaaaag aaggcctgag gggctggtcc
     2341 tctttagaga aagatgcttt ttggttttta tataaataaa ggaatcccca gaagtggtcc
     2401 ctatgatgaa ctcccccaaa gcaacgccgt ttttggagga actcaaaccc agtccaacat
     2461 cccatcattt cacttgactg cagaaatggc tttaccctta ggatatatct ttatgagtct
     2521 tggctttgaa gtggagaagg gctttatctt agagaaggtg gtttatgtca tattccagtt
     2581 attctagaag ttcaggacag ccttagcatc tgaaaaagaa gcccattcct ctttatagtg
     2641 gaatttagta agtagatcta acccgagtct cacccacaga attcatataa attcatatat
     2701 gccttctctc tggctgcctc ttttcctgtt tgcactctga gggcttaagt catatgtgat
     2761 atttacaaag caattggccc atttacagag agacatatat aatttctcca caaagccttg
     2821 accatggttc atgaaaccgt ttgggttcat ttaaatttgt ctgaatcatt agtcttgact
     2881 tgaagtgaac aaaacaccct ttgcccaagt gccattggct tgtctgcatt tcaaaatcat
     2941 taaaaccagg tatggaagcc tacgtgctca cagttatcta atgaggttat ttcaaagttt
     3001 gcattactaa cagccattct gcaaagtgta ttgatgtgta tagtgatctg tataaagtca
     3061 gtagttctta gctgaacctc aactgtgagg aatctatgac tccacagatg tccttggtgc
     3121 acataggcaa acggcacttc tcatcttact gaagttaaat aagatattcc ataagaaggt
     3181 atagtgccct ttttggggga gtacctttag tatattccta aaattgccac caaagaatgc
     3241 caaatctgaa tttctcttgg tttccacctg atttggaact agggtgtgac ctctaaatag
     3301 cattctcatg acacatgggg gcgccaaaga gaagtaagag agatagctag atagctagat
     3361 agctagatag tcttgtgtct tgtttgacca aggtaaccgt aataaaagag tccatcccca
     3421 tcctttactg ttgatgtgac cttgggcttc agtttctgca tctgcattgg caaaatagaa
     3481 gtgatagtag taggtaaaag ttagagtgat cctactatat gacggaaact ttggctggat
     3541 gcaagagctt taaattggta gaaaagtcac aagatgagct tgtgactatg aagagagcaa
     3601 aagctaactt ttttttccta gataatcaat aaaatatttg aagactgaa
//
